基本信息

  

 

侯玉柱，博士，教授，博士研究生导师

2011年毕业于中国科学院动物研究所，获理学博士学位；2011-2017年分别于中国科学院动物研究所和芝加哥大学Ludwig肿瘤研究中心从事博士后工作；2018-2019任芝加哥大学肿瘤放疗系讲师；2020年1月至今任西安交通大学基础医学院教授，入选“青年拔尖人才支持计划（A类）”。

研究领域为肿瘤免疫学，尤其是肿瘤放疗和免疫治疗相关的免疫学。具体研究方向主要集中于从分子、细胞及机体整体水平上，研究肿瘤发生、发展及肿瘤治疗过程中的免疫反应机制，包括：（1）研究肿瘤发生、发展及转移过程中的免疫监视与免疫逃逸机制；（2）研究放疗与免疫治疗过程中肿瘤免疫微环境变化以及系统性免疫反应，如远隔效应等。在 Immunity、Science Translational Medicine、Science Immunology、Protein Cell、Journal of Immunology等学术期刊公开发表SCI论文20篇，被引用900余次。

联系方式

通信地址： 西安交通大学基础医学院 

                     陕西省西安市雁塔西路76号微免楼225室

                     西咸新区中国西部科技创新港

                     21号楼4-4148室
邮        编： 710049

联系电话： +8618301198037
电子邮箱： houyuzhu@xjtu.edu.cn

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研究领域

Research Interests:

1. The mechanism of tumor radiotherapy;

2. The abscopal effect of radiotherapy;

3. The mechanism regulating tumor metastasis;

4. The cross-talk between tumor and extramedullary hematopoiesis.

学术论文

1.   Yuzhu Hou, Hua L Liang, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao, Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J Chmura, Wenjun Wu, Sean Z Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R McCall, Everett E Vokes, Sean P Pitroda, Yang-Xin Fu, Ralph R Weichselbaum. Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity. Science Translational Medicine, 2021; 13(528):eabb0130. (IF: 17.956)

2.    Enyu Rao#, Yuzhu Hou#, Xiaona Huang, Liangliang Wang, Jiaai Wang, Wenxin Zheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, Everett E Vokes, Yang-Xin Fu, Ralph R Weichselbaum, Hua Laura Liang. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Science Immunology, 2021. 6(60): eaba8426. (IF: 17.727, Co-first author)

3.    Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng, Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph R Weichselbaum, Yang-Xin Fu. Non-canonical NF-κB antagonizes STING sensor-mediated DNA sensing in radiotherapy. Immunity, 2018; 49(3): 490-503. (IF: 22.553)

4.    Yuzhu Hou, Linnan Zhu, Hongling Tian, Haixi Sun, Lianfeng Zhang, Ruoyu Wang, Yong Zhao. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 2018; doi: 10.1007/s13238-018-0505-z (IF: 10.164)

5.  Yuzhu Hou, Haijiang Lin, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Huifang Guo, Lianfeng Zhang, Qiang Wang, Zhanguo Li, Yong Zhao. The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis. Journal of Immunology, 2014;193(1):130-8 (IF: 4.886)

6.  Yuzhu Hou, Haijiang Lin, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F Godley, Qiang Wang, Zhanguo Li, Yong Zhao. LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression. Arthritis & Rheumatism. 2013; 65(11): 2835-46. (IF: 9.586)