Publications ( Cited by SCI )

Varying the ratio of formic acid to triethylamine impacts on asymmetric transfer hydrogenation of ketones




作者: Zhou, XW; Wu, XF; Yang, BL;Xiao, JL
发表/完成日期: 2012-05-18
期刊名称: JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
期卷: 357
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论文简介
Asymmetric transfer hydrogenation (ATH) is frequently carried out in the azeotropic mixture of formic acid (F) and triethylamine (T), where the FIT molar ratio is 2.5. This study shows that the F/T ratio affects both the reduction rate and enantioselectivity, with the optimum ratio being 0.2 ill the ATH of ketones with the Ru-TsDPEN catalyst. Under such conditions, a range of substrates have been reduced, affording high yields and good to excellent enantioselectivities. In comparison with the common azeotropic F-T system, the reduction is faster. This protocol improves both the classic azeotropic and the aqueous-formate system when using water-insoluble ketones.