1.    Zhou, D., Zeng, M., Gao, Y., A, S., Lyu, J., Wang, W.* ‘Advanced Polymers for Gene Delivery’. Chapter 10 in the book Nucleic Acid Nanotheranostics: Biomedical Applications (ISBN: 9780128144701, Edited by Marco Filice & Jesus Ruiz-Cabello), Elsevier publisher, 2019, 311-364.


 Equal Contribution, * Corresponding Author

1.     Zeng, M., Alshehri, F., Zhou, D.,* Lara-Saez, I., Wang, X., Li, X., A, S., Xu, Q., Zhang, J., Wang, W.* ‘Efficient and Robust Highly Branched Poly(β-Amino Ester)/Minicircle COL7A1 Polymeric Nanoparticles for Gene delivery to Recessive Dystrophic Epidermolysis Bullosa Keratinocytes’. ACS Applied Materials & Interfaces, 2019, DOI: 10.1021/acsami.9b13135 (IF=8.456)

2.     Liu, S.,# Gao, Y.,# Zhou, D.,#* Zeng, M., Alshehri, F., Newland, B., Lyu, J., O’Keeffe-Ahern, J., Greiser, U., Guo, T.,* Zhang, F., Wang, W.* ‘Highly Branched Poly(ß-amino ester) Delivery of Minicircle DNA for Transfection of Nneurodegenerative Related Diseases’. Nature Communications, 2019, 10: 3307 (IF=11.878)

3.        Xu, Q.,# A, S.,# Venet, M., Gao, Y., Zhou, D.,* Wang, W., Zeng, M., Rotella, C., Li, X., Wang, X., Lyu. J., Rodriguez, B., Wang, W.* ‘Bacteria-Resistant Single Chain Cyclized/Knotted Polymer Coatings’ Angewandte Chemie, 2019, 58, 10616-10620 (IF=12.257)

4.       Zeng, M., Zhou, D.,* Alshehri, F., Lara-Saez, I., Lyu, Y., Creagh-Flynn, J., Xu, Q., Zhang, J., Wang, W.* ‘Manipulation of Transgene Expression in Fibroblast Cells by A Multifunctional Linear-Branched Hybrid Poly(β-Amino Ester) Synthesized Through An Oligomer Combination Approach’ Nano Letters, 2019, 19, 381-391 (IF=12.279).

5.   Yong, H., Miao, Y., A, S.,* Quan, D., Ivankovic, A., Singh, K., Zhang, J., Zhou, D., Wang, W.* ‘Branched Polystyrenes from Suspension “Strathclyde” Polymerization Using A vulcanization Accelerator as A Chain Transfer Agent’. Polymer Chemistry, 2019, 10, 885-890 (IF=4.760)

6.      Zhang, J.,# Yong, H.,# A, S., Xu, Q., Miao, Y., Lyu, J., Gao, Y., Zeng, M., Zhou, D.,* Yu, Z., Tai, H., Wang, W.* ‘Structural Design of Robust and Biocompatible Photonic Hydrogels from an In Situ Cross-Linked Hyperbranched Polymer System’. Chemistry of Materials, 2018, 30, 6091-6098 (IF=10.159)

7.       Xu, Q., Venet, M., Wang, W., Creagh-Flynn, J., Wang, X., Li, X., Gao, Y., Zhou, D., Zeng, M., Lara-Saez, I., A, S.,* Tai, H., Wang, W.* ‘Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels’. ACS Applied Materials & Interfaces, 2018, 10, 39494-39504 (IF=8.456)

8.        Xu, Q.,# A, S.,# Gao, Y., Guo, L., Creagh-Flynn, J., Zhou, D., Greiser, U., Dong, Y., Wang, F., Tai, H., Liu, W., Wang, W.,* Wang, W.* ‘Hybrid Injectable Hydrogel from Hyperbranched PEG Macromer as A Stem Cell Delivery and Retention Platform for Diabetic Wound Healing’. Acta Biomaterialia, 2018, 75, 63-74 (IF=6.638)

9.    Xu, Q., A, S.,* McMichael, P., Creagh-Flynn, J., Zhou, D., Gao, Y., Li, X., Wang, X., Wang, W.* ‘Double-Cross-Linked Hydrogel Strengthened by UV Irradiation from a Hyperbranched PEG-Based Trifunctional Polymer’. ACS Macro Letters, 2018, 7, 509-513 (IF=5.775)

10.    A, S., Xu, Q., McMichael, P., Gao, Y., Li, X., Wang, X., Greiser, U., Zhou, D*., Wang, W.* ‘A Facile One-pot Synthesis of Acrylated Hyaluronic Acid’. Chemical Communications, 2018, 54, 1081-1084 (IF=6.164)

11.    Xu, Q., Guo, L., A, S., Gao, Y., Zhou, D., Greiser, U., Creagh-Flynn, J., Zhang, H., Dong, Y., Cutlar, L., Wang, F., Liu, W., Wang, W.,* Wang, W.* ‘Injectable Hyperbranched Poly(β-amino ester) Hydrogels with On-Demand Degradation Profile to Match Wound Healing Process’. Chemical Science, 2018, 9, 2179-2187 (IF=9.556)

12.   O’Keeffe Ahern, J.,# A, S.,# Zhou, D.,* Gao, Y., Lyu, J., Meng, Z., Cutlar, L., Pierucci, L., Wang, W.* ‘Brush-like cationic polymers with low charge density for gene delivery’, Biomacromolecules, 2018, 19, 1410-1415 (IF=5.667)

13.  Huang, X., Zhou, D.,* A, S., Gao, Y., Wang, X., Li, X., Xu, Q., Greiser, U., Yin, G.,* Wang, W. ‘Star Polymers from Single-Chain Cyclized/Knotted Nanoparticles as a Core’, Macromolecular Chemistry and Physics, 2018, 219, 1700473. (IF=2.622)

14.   Liu, S.,# Sun, Z.,# Zhou, D.,* Guo, T.* ‘Alkylated Branched Poly(β-amino esters) Demonstrate Strong DNA Encapsulation, High Nanoparticle Stability and Robust Gene Transfection Efficacy’, Journal of Materials Chemistry B, 2017, 5, 5307-5310 (IF=5.047)

15.    Huang, X., Zhou, D.,* Zeng, M., Alshehri, F., Li, X., O’Keeffe Ahern, J., Gao, Y., Pierucci, L., Greiser, U., Yin, G.,* Wang, W.* ‘Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine’. ACS Macro Letters, 2017, 6, 575-579 (IF=5.775)

16.    Zeng, M., Zhou, D.,* Ng, Singwei., O’Keeffe Ahern, J., Alshehri, F., Gao, Y., Pierucci, L., Greiser, U., Wang, W.* ‘Highly Branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for High Performance Gene Transfection’. Polymers, 2017, 161, 1-11 (IF=3.164)

17.    Liu, S.,# Zhou, D#., Yang, J., Zhou, H., Chen, J., Guo, T.* ‘Bioreducible Zinc(II) Coordinative PEI with Low Molecular Weight for Robust Gene Delivery of Primary and Stem Cells’. Journal of the American Chemical Society, 2017, 139, 5102-5109 (IF=14.695)

18.    Zhou, D.,# Pierucci, L.,# Gao, Y.,# O’Keeffe Ahern, J.,# Huang, X., A, S., Wang, W.* ‘Thermo- and pH-Responsive, Coacervate-forming Hyperbranched Poly(β-amino ester)s for Selective Cell Binding’. ACS Applied Materials & Interfaces, 2017, 9, 5793-5802 (IF=8.456)

19.    A, S., Xu, Q., Zhou, D., Gao, Y., Vasquez, J., Greiser, U., Wang, W., Liu, W., Wang, W.* ‘Hyperbranched PEG-based Multi-NHS Polymer and Bioconjugation with BSA’. Polymer Chemistry, 2017, 8, 1283-1287 (IF=4.760)

20.    Li, S.,# Guo, L.,# Gao, Y., Zhou, D., Wang, W.* ‘Viscoelastic Study of Single Chain Cyclized Polymeric Nanoparticles and Linear Polymers Blends’. Acta Polymerica Sinica, 2017, 2, 386-392 (IF=1.405)

21.    Zhou, D.,# Gao, Y.,# O’Keeffe-Ahern, J., A, S., Xu, Q., Huang, X., Greiser, U., Wang, W.* ‘Development of Branched Poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) with High Gene Transfection Potency across Diverse Cell Types’. ACS Applied Materials & Interfaces, 2016, 34218-34226 (IF=8.456)

22.    Zhou, D.,# Gao, Y.,# A, S., Xu, Q., Meng, Z., Greiser, U., Wang, W.* ‘Anticancer Drug Disulfiram (DS) for In-situ RAFT Polymerization: Controlled Polymerization, Multi-facet Self-assembly and Efficient Drug Delivery’. ACS Macro Letters2016, 5, 1266-1272 (IF=5.775)

23.    Gao, Y.,# Huang, J.Y.,# O’Keeffe-Ahern, J., Cutlar, L., Zhou, D.,* Lin, F.H., Wang, W.* ‘Highly Branched Poly(β-amino esters) for Non-Viral Gene Delivery: High Transfection Efficiency and Low Toxicity Achieved by Increasing Molecular Weight’. Biomacromolecules, 2016, 3640-3647 (IF=5.667)

24.    Liu, S., Gao, Y., A, S., Zhou, D.,* Greiser, U., Guo, T., Guo, R., Wang, W.* ‘Biodegradable Highly Branched Poly(β-amino ester)s for Targeted Cancer Cell Gene Transfection’. ACS Biomaterials Science & Engineering, 2017, 3, 1283-1286 (IF=4.511)

25.    Sun, Z.,* Zhou, D.* ‘PLL/PAE/DNA Ternary Complexes with Enhanced Endosomal Escape Ability for Efficient and Safe Gene Transfection’. New Journal of Chemistry, 2016, 40, 9806-9812 (IF=3.069)

26.    Zhou, D.,# Cutlar, L.,# Gao, Y.,# Wang, W., O’Keeffe-Ahern, J., McMahon, S., Duarte, B., Larcher, F., Rodriguez, B., Greiser, U., Wang, W.* ‘The Transition from Linear to Highly Branched Poly(β-Amino Ester)s: Branching Matters for Gene Delivery’. Science Advances2016, 2, e1600102 (IF=12.804)

27.    Zhou, D.,# Ahmed, A.,# Cutlar, L.,# Gao, Y.,# Igoucheva, O., Newland, B., Alexeeve, V., Greiser, U., Uitto, J., Wang, W.* ‘Highly Branched Poly(β-Amino Ester)s for Targeted Skin Gene Therapy’. Journal of Controlled Release, 2016, 244, 336-346 (IF=7.901)

28.    Cutlar, L.,# Zhou, D.,# Hu, X., Duarte, B., Greiser, U., Larcher, F., Wang, W. 'A Non-Viral Gene Therapy for Treatment of Recessive Dystrophic Epidermolysis Bullosa'. Experimental Dermatology, 2016, 25, 818-820 (IF=2.8688)

29.    Cutlar, L.,# Aied, A.,# Gao, Y.,# Greiser, U., Murauer E. M., Zhou, D.,* Wang, W.* ‘A Knot Polymer Mediated Non-Viral Gene Transfection for Skin Cells'. Biomaterials Science, 2016, 4, 92-95 (IF=5.251)

30.    Liu, S., Yang, J., Ren, H., O’Keeffe-Ahern, J., Zhou, D.,* Zhou, H., Chen, J., Guo, T.* ‘Multifunctional Oligomer Incorporation: A Potent Strategy to Enhance the Transfection Activity of Poly(l-lysine)’. Biomaterial Science, 2016, 4, 522-532 (IF=5.251)

31.    Gao, Y.,# Bohmer, V. I.,# Zhou, D., Zhao, T., Wang, W.,* Paulusse, M. J.* ‘Main-Chain Degradable Single-Chain Cyclized Polymers as Gene Delivery Vectors’. Journal of Controlled Release, 2016, 244, 375-383 (IF=7.901)

32.    Newland, B.,* Wolff, P., Zhou, D., Wang, W., Zhang, H., Rosser, A., Wang, W., Werner, C. 'Synthesis of ROS Scavenging Microspheres from a Dopamine Containing Poly(β-amino ester) for Applications for Neurodegenerative Disorders'. Biomaterial Science, 2016, 4, 400-404 (IF=5.251)

33.    Huang, J.Y., Gao, Y., Cutlar, L., O’Keeffe-Ahern, J., Zhao, T., Lin, F.H., Zhou, D.,* McMahon, S., Greiser, U., Wang, W., Wang,W.* 'Tailoring Highly Branched Poly (β-Amino Ester)s: A Synthetic Platform for Epidermal Gene Therapy', Chemical Communications, 2015, 51, 8473-8476 (IF=6.164)

34.    Cutlar, L.,# Zhou, D.,#* Gao, Y., Zhao, Y., Greiser, U., Wang, W., Wang, W.* Highly Branched Poly(β-Amino Esters): Synthesis and Application in Gene Delivery'. Biomacromolecules, 2015, 16(9), 2609-2617 (IF=5.667)

35.    Gao, Y., Zhou, D., Zhao, T., Wei, X., McMahon, S., O’Keeffe-Ahern, J., WangW., Greiser, U.,     Rodriguez, B., Wang, W.* ‘Intramolecular Cyclization Dominating Homopolymerization of Multivinyl Monomers toward Single Chain Cyclized/knotted Polymeric Nanoparticles'.Macromolecules, 2015, 48, 6882-6889 (IF=5.997)

36.    Gao, Y., Zhao, T., Zhou, D., Greiser, U., Wang, W.* ‘Insights into Relevant Mechanistic Aspects about the Induction Period of Cu0 / Me6TREN Mediated Reversible - Deactivation Radical Polymerization'. Chemical Communications, 2015. 51, 14435-14438 (IF=6.164)

37.    Zhao, T., Zhang, H., Zhou, D., Gao, Y., Dong, Y., Greiser, U., Tai, H., Wang, W.* 'Water Soluble Hyperbranched Polymers from Controlled Radical Homopolymerization of PEG Diacrylate’ RSC Advances, 2015, 5, 33823–33830 (IF=3.049)

38.    Dong, Y.,* Qin, Y., Dubaa M., Killion, J, Gao, Y., Zhao, T., Zhou, D., Duscher, D., Geever, L., Gurtner, G., Wang, W.* ‘A Rapid Crosslinking Injectable Hydrogel for Stem Cell Delivery, from Multifunctional Hyperbranched Polymers via RAFT Homopolymerization of PEGDA'. Polymer Chemistry, 2015. 6, 6182-6192 (IF=4.76)

39.    Zhao, T., Zhang, H., Newland, B., Aied, A., Zhou, D., Wang, W.* ‘Significance of Branching for Transfection: Synthesis of Highly Branched Degradable Functional Poly(Dimethylaminoethyl Methacrylate) by Vinyl Oligomer Combination’. Angewandte Chemie International Edition, 2014, 53, 6095-6100 (IF=12.257)

40.    Liu, S., Zhou, D., Guo, T.* ‘Construction of A Novel Macroporous Imprinted Biosensor Based on Quatz Crystal Microbalance for Ribonuclease A Detection’. Biosensors and Bioelectronics, 2013, 42, 80-86 (IF=9.518)

41.    Hu, Y., Zhou, D., Li, C., Zhou, H., Chen, J., Zhang, Z., Guo, T.* ‘Gene Delivery of PEI Incorporating with Functional Block Copolymer Via Non-covalent Assembly Strategy’. Acta Biomaterialia, 2013, 5003, 5012 (IF=6.638)

42.    Li, C., Guo, T., Zhou, D., Hu, Y., Zhou, H., Wang, S., Chen, J., Zhang, Z., ‘The Target Gene Carrying Validity to HepG2 Cells with the Brush-like Glutathioe Modified Chitosan Compound’. Carbohydrate Polymers, 2012, 89, 46-53 (IF=6.044)

43.    Zhou, D., Li, C., Hu, Y., Zhou, H., Chen, J., Zhang, Z., Guo, T.* ‘PLL/pDNA/P(His-co-DMAEL) Ternary Complexes: Assembly, Stability and Gene Delivery’. Journal of Materials Chemistry, 2012, 22, 10743-10751 (IF=6.626)

44.  Zhou, D., Li, C., Hu, Y., Zhou, H., Chen, J., Zhang, Z., Guo, T.* ‘The Effects of A Multifunctional Oligomer and Its Incorporation Strategies on the Gene Delivery Efficiency of Poly(l-lysine)’. Chemical Communications, 2012, 48, 4594-4596 (IF=6.164)

45.  Zhou, D., Li, C., Hu, Y., Zhou, H., Chen, J., Zhang, Z., Guo, T.* ‘Glycopolymer Modification on Physicochemical and Biological Properties of Poly(l-lysine) for Gene Delivery’. International Journal of Biological Macromolecules, 2012, 50, 965-973 (IF=4.784)

46.  Zhou, D., Guo, T.,* Yang, Y., Zhang, Z. ‘Surface Imprinted Macroporous Film for High Performance Protein Recoginition in Combination with Quartz Crystal Microbalance’. Sensors and Actuators B: Chemical, 2011, 153, 96-102 (IF=6.393)

47.    Li, C., Guo, T.,* Zhou, D., Hu, Y., Zhou, H., Wang, S., Chen, J., Zhang, Z., ‘A Novel Glutathion Modified Chitosan Conjugate for Efficient Gene Delivery’. Journal of Controlled Release, 2011, 154, 177-188 (IF=7.901)

48. Yang, H., Guo, T.,* Zhou, D. ‘Surface hydrophilic modification with well-defined glycopolymer for protein imprinting matrix’. International Journal of Biological Macromolecules, 2011, 48, 432-438 (IF=4.784)


 # Indicates Equal Contribution, * Indicates Corresponding Author

1. Meng, Z., Zhou, D.,* Gao, Y., Zeng, M., Wang, W.* ‘miRNA Delivery for Skin Wound Healing’. Advanced Drug Delivery Reviews, 2018, 129, 308-318 (IF=15.519)

2. Meng, Z., O’Keeffe-Ahern, J., Lyu, J., Pierucci, L., Zhou, D.,* Wang, W.* ‘A new developing class of gene delivery: Messenger RNA-based therapeutics’, Biomaterials Science, 2017, 5, 2381-2392 (IF=5.251)

3. Gao, Y.,# Newland, B.,# Zhou, D.,# Matyjaszewski, K., Wang, W.* ‘Controlled Polymerization of Multivinyl Monomers: toward Single Chain Cyclized/Knotted Polymer Architecture’. Angewandte Chemie, 2017, 56, 450-460 (IF=12.257)

 1.  ‘Highly Branched Poly(Beta-Amino ester)s as New Gene Delivery Vectors’. Zhou, D., Wang, W. The 7th China-Europe Symposium on Biomaterials In Regenerative Medicine (CESB 2019), Guangzhou, China, May 2019

2.  ‘Development of Highly Branched Poly(beta-amino esters) as a New Generation of Gene Delivery Vectors’. Zhou, D., Wang, W. Macro Group UK YRM 2018, Dublin, Ireland, Jul. 2018

3. ‘Highly Branched Poly(Beta-Amino ester)s as New Gene Delivery Vectors’. Zhou, D. Wang, W. The 5th TERMIS World Congress Kyoto, Japan, September 2018

4. ‘A Simple, Efficient Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa’. Cutlar, L., Zhou, D., Hu, X., Duarte, B., Larcher, F. and Wang, W. Bioprocessing of Advanced Cellular Therapies Congress, London, UK, June 2016

5. ‘Highly Branched Poly(β-Amino Ester)s as New Gene Delivery Vectors for the treatment of RDEB’. Zhou, D., Cutlar, L., Aied, A., Uitto, J., Larcher, F. and Wang, W. TERMIS-EU Conference, Uppsala, Sweden, June 2016

6. 'A Simple, Efficient Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa’. Cutlar, L., Zhou, D., Hu, X., Duarte, B., Larcher, F. and Wang, W. Society for Investigative Dermatology 75th Annual Meeting, Scottsdale, Arizona, May 2016

7.    ‘Highly Branched Poly(Beta-Amino ester)s as New Gene Delivery Vectors’. Cutlar, L., Zhou, D., Hu, X., Duarte, B., Larcher, F. and Wang, W. The 14th European Symposium on Controlled Drug Delivery, Amsterdam, Holland, April 2016

8.    ‘Skin Substitute with Adipose-Derived Stem Cells for Wound Healing, from an Injectable Hydrogel System’. Dong, Y., Khong, S., Rodrigues, M., Li, A.Y., Zhou, D., Gao, Y., Brett, E.A., Wang, W. and Gurtner, G.C. 2016 WHS Annual Meeting, Atlanta, Georgia, April 2016

9.    ‘Highly Branched Poly(β-Amino Ester)s as New Gene Delivery Vectors’. Zhou, D., Cutlar, L., Aied, A., Uitto, J., Larcher, F. and Wang, W. 4th TERMIS  World Congress, Boston, MA, U.S.A., September 2015

10.    ‘A Simple Efficient Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa’. Cutlar, L., Zhou, D., Hu, X., Duarte, B., Larcher, F. and Wang, W. DEBRA International, Atlanta, Georgia, May 2015

11. ‘The Controlled/Living Radical Homopolymerization Of Multivinyl Monomers: Toward Single Chain Cyclized Polymers’. Gao, Y., Zhao, T., Zhou D. and Wang, W. International  Conference  on  Advances  in  Functional  Materials, New York,  U.S.A., June 2015

12.    ‘Optimized DNA Constructs for Topical Recessive Dystrophic Epidermolysis Bullosa Gene Therapy’. Cutlar, L., Zhou, D., Hu, X. and Wang, W. UCD Conway Festival of Research and Innovation, Dublin, Ireland, September 2014

13.    ‘Design and Construction of a COL7A1 Minicircle For Non-Viral Gene Therapy to Treat Recessive Dystrophic Epidermolysis Bullosa’, Cutlar, L., Zhou, D., Hu, X. and Wang, W. 3rd Minicircle& DNA Vector Conference, Bielefeld, Germany, May 2014

14.    ‘PEGMA-b-MAH Incorporated PEI Based Ternary Complexes with High Efficiency in Serum for Gene Delivery” Zhou, D., Hu, Y., Guo, T. 7th International Symposium on High-Tech Polymer Materials (HIPM-VII), Xi’an, China, June 2012


1. Wang, W., Zhou, D. ‘Hyperbranched Poly(β-Amino Ester) for Gene Therapy’, Patent No. PCT/EP2015/068153. This patent was licensed to Amryt Pharma PLC in March 2018:

2. Guo, T., Zhou, D., Li, C., Hu, Y. ‘Functional Oligomer Used for Non-Viral Gene Vector Materials and Application Thereof’, Patent No. CN102532411B

3. Guo, T., Li, C., Zhou, D., Hu, Y. ‘Glutathione-Modified Chitosan Copolymer Serving as Non-Viral Gene Carrier Material and Preparation and Application Thereof’, Patent No. CN102140171B

4. Wang, W., Wang, W., Zhou, D., Xu, Q., Zheng, Y., Yu, Z. ‘An well biocompatible injectable hydrogel and preparation method and application thereof’, Patent No.  CN105176080B

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