论文期刊

Hypoglycemic Effect of the Aqueous Extract of Chinese Galls




作者: Jianfneg Xing, Yalin Dong*
发表/完成日期: 2013-03-01
期刊名称: Latin American Journal of Pharmacy
期卷:
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论文简介
SUMMARY. The present study was aimed to investigate the hypoglycemic effect of the aqueous extract of
Chinese galls (AECG) and its possible mechanism. The diabetic mice induced by alloxan were chosen to
study the effect of AECG, which was administered orally for 7 days. The fasting blood glucose levels were
found to be significantly reduced in treated mice. A Caco-2 monolayer cell model was established to examine
the effect of AECG on α-glucosidase activity and to determine the mechanism involved. The effect of
AECG on α-glucosidase activity was measured and glucose uptake and transport were evaluated. AECG
dose-dependently inhibited α-glucosidase activity in Caco-2 monolayers. Furthermore, AECG treated
moderately but significantly suppressed the uptake and transport of glucose. Our data suggest that AECG
possesses the hypoglycemic effect on alloxan induced diabetic mice; the speculated mechanism may be associated
with inhibition of disaccharidase activity, possibly the α-glucosidase enzyme, and with inhibition
of uptake and transport of glucose
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