论文期刊

Developments of combretastatin A-4 derivatives as anticancer agents




作者: Yuanyuan Shan, Yalin Dong*
发表/完成日期: 2011-07-07
期刊名称: Current Medicinal Chemistry
期卷:
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论文简介
Abstract
Tubulin protein is one of several members of a small family of globular proteins. It offers a potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum. Modifications on the CA-4 structure have led to a great number of novel CA-4 derivatives as potent tubulin inhibitors and high cytotoxic anticancer agents is becoming an interesting field, leading to a breakthrough in the treatment of cancer. In this review, the recent developments of novel CA-4 derivatives via the modifications on the A- and B-ring and the double bond as anticancer agents are discussed.
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