基本信息

樊立宏，男，医学博士、研究员、主任医师，博士研究生导师，西安交通大学第二附属医院运营管理部副主任。

 

中国医师协会肩肘外科分会委员，中国医师协会骨关节炎工作委员会执行委员，中国医促会骨科专业委员会脊柱内镜学组委员，陕西省关节外科分会关节镜学组委员，陕西省脊柱外科分会青年委员。

 

多次赴台湾阳明大学干细胞研究中心、澳大利亚Nepean医院、美国德克萨斯州关节置换中心、德国柏林AMEOS医院等著名医疗机构研修学习。受邀在2015世界关节成型大会、亚洲关节年会做专题演讲及壁报交流。

 

在Bone，scientific reports，Journal of Vascular Surgery等国际著名医学期刊发表论文20余篇，主持国家自然科学基金两项，参与国内多项课题的研究，参编参译医学专著三部。

 

专业方向：运动医学与关节镜外科，骨与关节修复重建，人工关节置换与翻修。

 

联系方式：

029-87679292

drfan2140@163.com

西安市西五路157号 西安交通大学第二附属医院骨一科

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研究领域

研究方向：

股骨头坏死的发病及修复机制研究
生物医用材料及干细胞的骨软骨修复
关节疾病与运动损伤的修复及功能重建
 
主持研究课题:
1. PPAR-γ通路在股骨头坏死病理机制中的作用研究（西安交通大学校长科研基金）
2. 骨髓基质干细胞复合异种脱细胞神经基质构建组织工程神经的研究（中央高校基本科研业务费-自由探索项目）
3. HIF-1α和BMP-7基因共转染骨髓间充质干细胞移植治疗股骨头坏死的实验研究（国家自然科学基金-青年项目)
4. 基于3D微结构打印技术构建掺锂β-TCP复合骨髓间充质干细胞的成血管成骨能力研究（中央高校基本科研业务费-学科交叉项目）
5. 3D微结构打印掺锂β-TCP复合microRNA-21转染骨髓间充质干细胞治疗股骨头坏死的实验研究（国家自然科学基金-面上项目81572145，57万)
6. miR-210修饰的BMMSCs来源外泌体复合可注射水凝胶激活PI3K/Akt通路治疗激素性股骨头坏死（国家自然科学基金-面上项目81772355，55万)

7. miR-21修饰的BMMSCs外泌体修复激素性股骨头坏死的机制研究(2017年院人才培养专项科研基金 RC(GG)201705, 6万)

 

8. miR-21修饰的间充质干细胞外泌体调控PTEN/Akt通路修复激素性股骨头坏死的作用及机制研究（2018年陕西省社会发展基金 2018SF-052，6万)

 
学术及科研成果：
Fan LH, Wang KZ, Cheng B, Wang CS, Dang XQ. Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.BMC Neurosci. 2006 Jun 14;7:48.
 
Die J, Wang K, Fan L, Jiang Y, Shi Z. Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions.Brain Res. 2010 Jul 30;1346:251-61.
 
Liu C, Shi Z, Fan L, Zhang C, Wang K, Wang B. Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury.Brain Res. 2011 Feb 16;1374:100-9.
 
Fan L, Wang K, Shi Z, Die J, Wang C, Dang X. Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.J Vasc Surg. 2011 Jul;54(1):192-200.
 
Fan L, Dang X, Shi Z, Zhang C, Wang K. Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.Cell Mol Neurobiol. 2011 Nov;31(8):1187-94.
 
Fan L, Dang X, Wang K. Comparison between bipolar hemiarthroplasty and total hip arthroplasty for unstable intertrochanteric fractures in elderly osteoporotic patients.PLoS One. 2012;7(6):e39531.
 
You W, Gao H, Fan L, Duan D, Wang C, Wang K. Foxc2 regulates osteogenesis and angiogenesis of bone marrow mesenchymal stem cells.BMC Musculoskelet Disord. 2013 Jul 2;14:199.
 
Tian L, Wen Q, Dang X, You W, Fan L, Wang K. Immune response   associated with Toll-like receptor 4 signaling pathway leads to steroid-induced femoral head osteonecrosis.BMC Musculoskelet Disord. 2014 Jan 15;15(1):18.
 
Feng M, Zhang R, Gong F, Yang P, Fan L, Ni J, Bi W, Zhang Y, Wang C, Wang K. Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats. J Steroid Biochem Mol Biol. 2014 Sep 9;144PB:455-462.
 
You W, Fan L, Duan D, Tian L, Dang X, Wang C, Wang K. Foxc2   over-expression in bone marrow mesenchymal stem cells stimulates osteogenic differentiation and inhibits adipogenic differentiation.Mol Cell Biochem. 2014 Jan;386(1-2):125-34.
 
Fan L, Yu Z, Li J, Dang X, Wang K. Schwann-like cells seeded in acellular nerve grafts improve nerve regeneration. BMC Musculoskelet Disord. 2014 May 21;15:165.
 
Fan L, Li J, Yu Z, Dang X, Wang K. The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration.Biomed Res Int. 2014;2014:239356.
 
Fan L, Yu Z, Li J, Dang X, Wang K. Immunoregulation Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Xenogeneic Acellular Nerve Grafts Transplant.Cell Mol Neurobiol. 2014 Jun 17.
 
Fan L, Li J, Yu Z, Dang X, Wang K. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Prevents Steroid-Associated Osteonecrosis of the Femoral Head in Rabbits by Promoting Angiogenesis and Inhibiting Apoptosis. PLoS One. 2014 Sep 22;9(9):e107774.
 
Zhang C, Ma J, Fan L, Zou Y, Dang X, Wang K, Song J. Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating. Tissue Cell. 2015 Jun;47(3):291-300.
 
Yu Z, Fan L, Li J, Ge Z, Dang X, Wang K. Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the β-catenin pathway.Int J Mol Med. 2015 Nov;36(5):1264-72.
 
Fan L, Zhang C, Yu Z, Shi Z, Dang X, Wang K. Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and osteogenesis in rabbit femoral head osteonecrosis. Bone. 2015 Dec;81:544-53.
 
Zefeng Yu，Lihong Fan(*)，Jia Li，Zhaogang Ge，Xiaoqian Dang，Kunzheng Wang(*)，Lithiumprevents rat steroid-related osteonecrosis of the femoral head by β-catenin activation，Endocrine，2016.5.01，52（2）：380~390
 
Li, Jia，Ge, Zhaogang，Fan, Lihong，Wang, Kunzheng，Protective effects of molecular hydrogen on steroid-
induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.，BMC Musculoskelet Disord，2017.2.2，18（1）：58~58
 
Pei JP, Fan LH(*), Nan K1, Li J, Dang XQ, Wang KZ. HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.J Neuroinflammation. 2017 May 3;14(1):97.
 
Pei J, Fan L, Nan K, Li J, Shi Z, Dang X, Wang K. Excessive Activation of TLR4/NF-κB Interactively Suppresses the Canonical Wnt/β-catenin Pathway and Induces SANFH in SD Rats.Sci Rep. 2017 Sep 20;7(1):11928.
 
 
 
授权国家发明专利：
1. 双层仿生颈椎间盘假体及其制造方法 [发明专利] CN200510041794.7
2. 一种复合种子细胞的组织工程神经的制备方法 [发明专利] CN201310364793.0