Research Interesting

Our group current research interests are the development of new synthetic methodologies, strategies and transition-metal catalyzed tandem processes for the rapid construction of biologically active heterocycles.

 

(1) Transition-metal Catalyzed Decarboxylative Cross-coupling Reaction

Transition-metal catalyzed decarboxylative cross-coupling reactions using simple carboxylic acids as coupling partners have emerged as a new type of C-C bond formation reaction. In these reactions, using readily available and stable carboxylic acids instead of organometallic reagents enabled the decarboxylative cross-coupling reactions to proceed with good selectivities and tolerance of functional groups (Scheme 1).

 

Scheme 1Decarboxylative Cross-Coupling Reactions

 

 

 

(2) Synthesis of Heterocycles 

Heterocycles represent a larger group of organic compounds and play a significant role in life processed and in all aspects of pure and applied chemistry. Nitrogen-containing heterocycles are an component of not only some of the most interesting and biologically important natural products, such as alkaloids, carbohydrates, nucleic acids, and antibiotics but include numerous potent pharmaceutical drugs and a large amount of synthetic organic compounds (Scheme 2).

  

Scheme 2. Application of Heterocycles 

                                                                                                                                                                         

Research Project
项目编号 项目名称 项目来源 起讫时间 承担角色 项目类别
- 国家自然科学基金(青年) 国家自然科学基金项目2012-1~负责人纵向项目
- 国家自然科学基金(面上) 国家自然科学基金项目2012-1~骨干成员纵向项目
- 教育部博士点基金 国家教育部项目2012-1~负责人纵向项目
- 西安交通大学新进教师支持计划 国家教育部项目2010-7~负责人纵向项目
- 西安交通大学国际合作项目 国家教育部项目2011-5~负责人纵向项目
- 西安交通大学学科交叉项目 国家教育部项目2012-1~负责人纵向项目
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