Publications

  1. Yucheng Guo, Zhenlin Ouyang, Wenbo He, Jiaxin Zhang, Qian Qin, Min Jiao, Serge Muyldermans, Fang Zheng*, Yurong Wen*. Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin. Front Immunol. 2023 Feb 10;14:1065274.  doi: 10.3389/fimmu.2023.1065274.  eCollection 2023
  2. Qin Q, Liu H, He W, Guo Y, Zhang J, She J, Zheng F, Zhang S, Muyldermans S, Wen Y*. Single Domain Antibody application in bacterial infection diagnosis and neutralization.Front Immunol. 2022 Sep 29;13:1014377. doi: 10.3389/fimmu.2022.1014377. eCollection 2022. PMID: 36248787
  3. Min Jiao, Wenbo He, Zhenlin Ouyang,Qian Qin,Yucheng Guo,Jiaxin Zhang,Yixin Bai,Xiaolong Guo,Qinyue Yu,Junjun She,Peter M. Hwang,Fang Zheng, and Yurong Wen*.Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii. Structure , 1–13 August 3, 2023. (SCI IF ：5.871)
  4. Zheng F; Pang, Y; Li L; Pang Y; Zhang J; Wang X; Raes G. Frontiers in Immunology. 2022，13：978513。（ IF: 8.7，第一作者，综述）
  5. Zhenlin Ouyang#, Fang Zheng#, Li Zhu#, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M Hwang, Junjun She*, Yurong Wen*. Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS. iScience. 2021,24(5): 102476. DOI: https://doi.org/10.1016/j.isci.2021.102476 (Cell子刊, IF: 5.35, 并列第一作者) PMID: 34113820
  6. Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen*, Steve Schoonooghe* and Geert Raes*.Development and characterization of nanobodies targeting the Kupffer cell. Frontiers in Immunology, 2021, 12 : 641819. DOI10.3389/fimmu.2021.641819(IF:7.56, 第一作者 ) PMID: 33692811
  7. Zhenlin Ouyang#, Fang Zheng#, Yingmei Pei, Jinhong Zhou, Keqing Wen, Miao Han, Peter M. Hwang, M. Joanne Lemieux, Yurong Wen*. (2019) Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. Nucleic Acids Research. 2019, 47(21):11418-11429.（IF: 16.97,并列第一作者）DOI10.1093/nar/gkz891 PMID: 31598698
  8.  Fang Zheng, Siyu Luo , Zhenlin Ouyang, Jinhong Zhou, Huanye Mo, Steve Schoonoogh, Serge Muyldermans , Patrick De Baetselier, Geert Raes *,and Yurong Wen*. NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis. International Journal of Molecular sciences. July 2019.20（13） （IF: 5.923, 第一作者）PMID: 31288389 PMCID: PMC6651725 DOI: 10.3390/ijms20133347
  9. Zhenlin Ouyang, Jan Felix, Jinhong Zhou, Yingmei Pei, Bohan Ma, Peter M. Hwang  M. Joanne Lemieux, Irina Gutsche, Fang Zheng#  Yurong Wen#. Trimeric structure of the mouse Kupffer cell C‐type lectin receptor Clec4f. FEBS letters, Augest 2019.541（1）：189-198 （SCI IF：4.12 通讯作者）DOI10.1002/1873-3468.13565 PMID: 31369681
  10. Yurong Wen#*, Zhenlin Ouyang#, Yue Yu, Xiaorong Zhou, Yingmei Pei, Bart Devreese, Paul G. Higgins, Fang Zheng*. Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region. Nucleic Acids Research. SEP 2017,45（16）：9773-9787）（SCI IF：16.97 通讯作者）PMID: 28934482 PMCID: PMC5766154 DOI: 10.1093/nar/gkx624
  11. Wen Y#*, Ouyang Z#, Devreese B, He W, Shao Y, Lu W, Zheng F*.Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. Protein Sci. 2017 Jul 30. 26(10)：2073-2082 （通讯作者 SCI IF：6.72）PMID: 28758290 PMCID: PMC5606546 DOI: 10.1002/pro.3245
  12. Yurong Wen#, Zhenlin Ouyang#, Steve Schoonooghe, Siyu Luo, Patrick De Baetselier, Wuyuan Lu, Serge Muyldermans, Geert Raes, Fang Zheng*. (2017). Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity. Immunobiology. 222(6): 807-813. (IF: 3.14, 通讯作者) PMID: 27889311 DOI: 10.1016/j.imbio.2016.11.008
  13. Zheng Fang#, Sparkes Amanda#, De Baetselier Patrick, Schoonooghe, Steve, Stijlemans Benoit, Muyldermans, Serge, Flamand Veronique, Van Ginderachter Jo A, Devoogdt Nick, Raes Geert, Beschin Alain*. Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. MOLECULAR IMAGING AND BIOLOGY. Feb 2017, 19 (1):49-58.((IF: 3.48, 第一作者) )PMID: 27339464 DOI: 10.1007/s11307-016-0976-3
  14. Zheng F, Perlman H, Matthys P, Wen Y, Lahoutte T, Muyldermans S, Lu S, De Baetselier P, Schoonooghe S, Devoogdt N, Raes G. Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies. Scientific Reports. 2016 Oct 25;6:35966. doi: 10.1038/srep35966. （SCI IF：5.2）
  15. Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin* and Martin Guilliams*. Bone marrow derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. Nature communications. 2016 Jan. （SCI IF：12.5，Nature子刊，SCI 高被引论文, 被引346）
  16. Fang Zheng#, Amanda Sparkes#, Patrick De Baetselier, Steve Schoonooghe, Benoit Stijlemans, Serge Muyldermans,Véronique Flamand, Jo A Van Ginderachter, Nick Devoogdt, Geert Raes, Alain Beschin. Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis. Mol Imaging Biol (2016). DOI: 10.1007/s11307-016-0976-3  （SCI IF：3.1）
  17. Yurong Wen#, Zhenlin Ouyang#, Steve Schoonooghe, Siyu Luo4, Patrick De Baetselier, Wuyuan Lu, Serge Muyldermans, Geert Raes*, Fang Zheng*. Structural evaluation of a Nanobody targeting complement receptor Vsig4 and its cross reactivity. Immunobiology, 2016 . （SCI IF：3.4）
  18. Zheng F, Put S, Bouwens L, Lahoutte T, Matthys P, Muyldermans S, De Baetselier P, Devoogdt N, Raes G, Schoonooghe S*. Molecular imaging with macrophage CRIg-targeting Nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis. Journal of Nuclear Medicine.  2014 May;55(5):824-9. （SCI IF：10.5，影像学领域排名前三期刊）
  19. Zheng F, Devoogdt N, Amanda Sparkes, Chlotthys P, Muyldermans S, De Baetselier P, Devoogdt N, Schoonooghe S, Raes G*. Monitoring resident liver macrophages using Nanobodies targeting Vsig4 : Concanavalin A induced acute hepatitis as paradigm. Immunobiology, 2015 Feb;220(2):200-9. （SCI IF：3.4）
  20. 郑芳; 罗思羽; 韩燕; 宁启兰; 温玉荣*，靶向巨噬细胞膜蛋白Vsig4特异性纳米抗体的构建和筛选，西安交通大学学报(医学版), 2017.1, 38(1): 7~12，核心期刊
  21. 郑芳; 罗思羽; 韩燕; 宁启兰; 温玉荣*，靶向巨噬细胞膜蛋白Vsig4特异性纳米抗体的构建和筛选，西安交通大学学报(医学版), 2017.1, 38(1): 7~12，核心期刊
  22. Fang ZHENG; Yurong WEN(*)，The Necessity of Experimental Animal Training Program in Chinese Institution and University， 2016 International Conference on Education, Science and Education Management (ESEM 2016).

获得专利 Patents

1. De Baetselier P, Raes G, Zheng F, Schoonooghe S, Lahoutte T and Devoogdt N. “Immunoglobulin single variable domains targeting Vsig4 and uses thereof. Patent application number: EP 13183753.6[5]

2. Yurong Wen, Zheng F. A Clec4F nanobody and uses thereof. Chinese patent application number: 201611047459.2
3. Zheng F, Yurong Wen. A method for antigen and nanobody epitope detection . Chinese patent application number: 201610601325.4

学术交流

1.   Canadian society for immunology(CSI),加拿大免疫学会 2019年年会 ，班夫，加拿大，April 12 – 15

2.  Radiological Society of North American （RSNA）2017，芝加哥，美国 

3.  World Molecular Imaging Congress (WMIC) 2017, 费城，美国

4.   The 5th Hsien Wu and Ray Wu Symposia，西安，中国

5.  International Congress of Immunology 2016，墨尔本，澳大利亚

6.  World Molecular Imaging Congress (WMIC) 2014, 首尔. 韩国

7.  全国生物化学与分子生物学年会 2016，中国，杭州

8.   BIT's 4th Annual World Gene Convention-2013 (WGC) conference, 2013, 海口, 中国

9.   Annual Conference of the European Macrophage and Dendritic Cell Society (EMDS), 2013, Erlangen, 德国

10. VIB seminar, 2013, Blankenberge, Belgium.

11. The Belgium Immunology Socity meeting (BIS), 2013, Liege, Belgium

12. World Molecular Imaging Congress (WMIC) 2012, Dublin, Ireland 

13. 5th ESF/Affinomics Workshop: Affinity Proteomics, 2011, Alpbach, Austria