基本信息

 

 

 

 

周芙玲

副教授,副主任医师,博士生导师。

任职单位:西安交大第二附属医院血液内科

 

 

2011-2013年美国州大学M.D.安德森癌症中心及斯坦福研究所做博士后研究,研究方向白血病信号传导及肿瘤免疫治疗。

2010-2011年度获评西安交大第二附属医院“优秀教师”。

2009年度西安交大第二附属医院临床考核优秀。

2008年度获评 “十大青年科技之星”。

2006年获医学博士学位,毕业论文被评为西安交通大学医学院2006年“优秀博士学位论文”。

长期从事恶性肿瘤的科研及临床工作,熟悉分子生物学及免疫学的实验技能。

主持国家自然科学基金3项,中央高校科研基金1项,省基金1项,院重点项目1项,市基金1项,新技术新疗法1项。

指导博士研究生1名,硕士研究生4名。发表科研论文30篇,在Blood Rev, Cancer Immunol Immunother及J Biol Chem 等国际知名杂志第一作者发表SCI收录论文8篇。

 

 

 

 

Fuling Zhou, M.D., Ph.D., doctoral supervisor,works in the Departments of Hematology at the second affiliated hospital of Xi’an Jiao tong University. As a hematologist, she received prestigious awards such as “Best doctors” in 2009, “Star of top ten youth scientists” in 2008 and 2014, and “Outstanding teachers” in 2010-2011 in hospital. She went to MD Anderson Cancer Center as a visiting professor for signal transduction study between 2011 and 2013, and to Stanford research institution as a postdoc for cancer immunology study between 2013 and 2014 in USA. From a clinical perspective, she is dedicated to offer a compassionate and individualize care through an integrated multi-specialty team with an expertise on hematologic malignancies disease.

     She has an enthusiastic and positive attitude on research. Her dissertation was nominated as "Outstanding graduation thesis of medical school in Xi'an Jiaotong University". She received continuous funding from The National Natural Science Foundation of China, and served as an expert of review panels in several journals. Her research group has worked extensively on immunology in hematopoietic malignancies and developed several new therapeutic peptides approaches for myeloma. Over the last decade, she has made major contributions to the understanding of immune escape and the role of ROS-derived relapse in leukemia. The long-term goal of of her research is to identify critical signaling pathways and novel molecular targets that can be translated into new therapeutic approaches for patients. Her outstanding productivity was seen through her excellent track record of publication, with over 20 first author papers published in the past 5 years, including 8 articles cited by Science Citation Index (SCI).

 

 

 

 

Articles cited by SCI:

1) Zhou F, Meng S, Song H, Claret FX. Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention. Blood Rev. 2013;27(6):261-7. (IF= 6.0)

2) Zhou F, Shen Q, Claret FX. Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia. J Leukoc Biol. 2013 ;94(3):423-9. (IF= 4.3)

3) Pan Y, Zhou F, Zhang R, Claret FX. Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PLoS One. 2013;8(1):e54565. (IF= 3.5)

4) Zhou FL, Meng S, Zhang WG, Wei YC, Cao XM, Bai GG, Wang BY. Peptide-based immunotherapy for multiple myeloma: current approaches. Vaccine. 2010;28(37):5939-46. (IF= 3.5)

5) Zhou FL, Zhang WG, Wei YC, Meng S, Bai GG, Wang BY, Yang HY, Tian W, Meng X, Zhang H, Chen S.Involvement of oxidative stress in the relapse of acute myeloid leukemia. J Biol Chem. 2010;285(20):15010-5. (IF= 5.3)

6) Zhou FL,Zhang WG,Wei YC,et al.The changes of oxidative stress and human 8-hydroxy- guanine glycosylase1 gene in depressive patients with acute leukemia. Leuk Res, 2007;31(3):387-393. (IF= 2.7)

7) Zhou FL,Zhang WG,Chen G,et al. Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma. Cancer Immunol Immunother, 2006; 55 (8): 910-917. (IF= 3.9)

8) Zhang WG,Zhou FL,Cao X,et al. Successful treatment of primary refractory anemia with a combination regimen of all-trans retinoic acid, calcitriol, and androgen, Leuk Res, 2006;30 (8):935-942. (IF= 2.7)

9) Zhou FL,Zhang WG,Wei YC,et al. Impact of comorbid anxiety and depression on quality of life and cellular immunity changes in patients with digestive tract cancers. World J Gastroentero, 2005;11(15):2313-2318. (IF= 2.4)

10) Wei YC, Zhou FL, He DL, Bai JR, Ding H, Wang XY, Nan KJ. Oxidative stress in depressive patients with gastric adenocarcinoma. Int J Neuropsychopharmacol. 2009 Mar 10:1-8. (IF= 5.3)

11) Wei YC, Zhou FL, He DL, Bai JR, Hui LY, Wang XY, Nan KJ.The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma. J Psychosom Res. 2009;66(3):259-266. (IF= 2.8)

  

 

 

Projects (leading)

2008.1-2010.12 Identification of biological function and epitope encoded by the novel MMSA-1 gene of multiple myeloma. This project was supported by the National Natural Science Foundation of China ((NO, 30700337) National Natural Science Foundation of China     Principal Investigator

2013.1-2016.12 The role of ROS-mediated signal transduction mechanisms in the relapse of acute myeloid leukemia.This project was supported by the National Natural Science Foundation of China (NO, 81270597) National Natural Science Foundation of China     Principal Investigator

2012.1-2015.12 The development of multi-epitope vaccines based on MMSA-1 and DKK1 antigen: epitope identification, vaccine design and evaluation. This project was supported by the National Natural Science Foundation of China (NO, 81172257) National Natural Science Foundation of China      Principal Investigator

2008.1-2011.12 The relationship between oxidative stress and relapse in the development of leukemia patients with depression Natural Science Foundation of shaanxi province     Principal Investigator

2006.1-2009.12 Anti-tumor effect of MMSA - CTL epitope peptide pulse DC in multiple myeloma. Jiaotong university second hospital youth fund     Principal Investigator

2011.1.1-2013.12.31 The construction of epitope-based vaccine and preliminary study in multiple myeloma Xi 'an science and technology projects     Principal Investigator

2011.6-2013.6 The application of Quantum dots in labeling mitochondrial injury of acute myeloid leukemia The Fundamental Research Funds for the Central Universities.     Principal Investigator

 

 

 

 

 

 

联系方式

 

研究生报考联系方式:fuling@mail.xjtu.edu.cn

zhoufuling@163.com

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白血病复发信号传导途径
骨髓瘤骨病生物免疫治疗
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