科研论文

一、代表性学术论文:

已发表SCI论文71篇,其中第一作者/通讯作者SCI论文49篇,第一作者/通讯作者JCR1区论文20篇,第一作者/通讯作者论文累计IF>210

主要代表性论文如下:

1.     Zhang F, Wen Y, Guo X, Zhang Y, Wang X, Yang TL, et al. Genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. Arthritis Rheumatism. 2015;67(1):176-81SCIIF: 9.0

2.       Fan QR, Zhang F (并列第一作者,通讯作者), Xu JW, Hao JC, He AW, Wen Y, Li P, Liang X, Du YN, Liu L, Wu CY, Wang S, Wang X, Ning YJ, Guo X. GWAS summary-based pathway association analysis correcting for the genetic confounding impact of environmental exposures. Briefing in Bioinformatics 2017, doi: 10.1093/bib/bbx025.SCIIF: 9.1

3.     Wen Y, Zhang F (并列第一作者,通讯作者), Ma X, Fan Q, Wang W, Xu J, Zhu F, Hao J, He A, Liu L, Liang X, Du Y, Li P, Wu C, Wang S, Wang X, Ning Y, Guo X. eQTLs Weighted Genetic Correlation Analysis Detected Brain Region Differences in Genetic Correlations for Complex Psychiatric Disorders. Schizophr Bull. 2018 Jun 15. doi: 10.1093/schbul/sby080. [Epub ahead of print]SCIIF: 7.76

4.      Liu L, Wen Y, Zhang L, Xu P, Liang X, Du Y, Li P, He A, Fan Q, Hao J, Wang W, Guo X, Shen H, Tian Q, Zhang F (通讯作者).Deng HW. Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study. J Clin Endocrinol Metab. 2018 May 1;103(5):1850-1855. SCIIF: 5.57

5.      Zhang F, Wen Y, Guo X. CRISPR/Cas9 for genome editing: progress, implications and challenges. Hum Mol Genet. 2014 ;23(R1):R40-R46 SCIIF: 6.68

6.      Zhao Y, Ning Y, Zhang F(并列第一/通讯作者), Ding M, Wen Y, Shi L, Wang K, Lu M, Sun J, Wu M, Cheng B, Ma M, Zhang L, Cheng S, Shen H, Tian Q, Guo X, Deng HW PCA-based GRS analysis enhances the effectiveness for genetic correlation detection. Brief Bioinform. 2018. doi: 10.1093/bib/bby075. [Epub ahead of print] SCIIF: 9.1

7.     Liu L, Wu CY, Zhao HM, Liu L, Du YN, Li P, Wen Y, Zhao Y, Ding M, Cheng BL, Zhang F (通讯作者), Deng HW. Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis.Bone [Epub ahead of print] SCIIF: 4.45

8.    Wen Y, Wang W, Guo X, Zhang F(通讯作者). PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries. Bioinformatics. 2016;32(6):946-948.SCIIF: 7.30

9.     Wang WY, Hao JC, Wen Y, Zheng SY, Zhang F(通讯作者). Tissue-specific pathway association analysis using genome-wide association study summaries. Bioinformatics. 2016, in press.SCIIF: 7.30

10.   Zhang F, Guo X, Zhang Y, Wen Y,Wang WZ, Wang S, Yang TL, et al. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Hum Genet. 2014 Jun;133(6):793-9SCIIF: 5.12

11.    Wu C, Wen Y, Guo X, Yang T, Shen H, Chen X, Tian Q, Tan L, Deng HW, Zhang F(通讯作者).Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease. Osteoarthritis Cartilage. 2017, 25(2):281-286. SCIIF: 4.74

12.   Wen Y, Li P, Hao J, Duan C, Han J, He A, Du Y, Liu L, Liang X, Zhang F, Guo X. Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis. Arthritis Res Ther. 2018 Mar 7;20(1):

13.    Wen Y, Guo X, Hao J, Xiao X, Wang W, Wu C, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW, Zhang F(通讯作者).Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients. Osteoporos Int. 2016;27:1041-1046SCIIF: 3.59

14.    Liu RY, Liu Q, Wang KZ, Dang XQ, Zhang F(通讯作者). Comparative analysis of gene expression profiles between normal human hip cartilage and the one with necrosis of femoral head. Arthritis Research & Therapy. 2016;18(1):98.SCIIF: 4.12

15.   Zhang F, Guo X, Wen Y, Zhang Y, Wang S, Yang TL, et al. Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. Bone, 2015;71:36-41.SCIIF:4.14

16.  Wang WY, Hao JC, Zheng SY, Xiao X, Wen Y, He AW, Guo X, Zhang F(通讯作者). Association between CILP and degeneration of intervertebral disc. Spine. 201641(20):E1244-E1248. SCIIF:2.50

17.   Xiao X, Hao J, Wen Y, Wang W, Guo X,Zhang F(通讯作者).Genome-wide association studies and gene expression profiles of rheumatoid arthritis: An analysis. Bone Joint Res. 2016 Jul;5(7):314-9.SCIIF:2.60

18.   Wang W, Liu Y, Hao J, Zheng S, Wen Y, Xiao X, He A, Fan Q, Zhang F(通讯作者), Liu R. Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis. Gene. 2016;591(1):43-7.SCIIF:2.42

19.    Wen Y, Hao J, Xiao X, Wang W, Guo X, Lin W, Yang T, Liu X, Shen H, Tan L, Chen X, Tian Q, Deng HW, Zhang F.PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Funct Integr Genomics. 2016;16(4):459-63 SCIIF: 3.50

20.    Zhang F, Dai L, Lin W, Wang W, Liu X, Zhang J, Yang T, Liu X, Shen H, Chen X, Tan L, Tian Q, Deng HW, Xu X, Guo X. Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease. Funct Integr Genomics. 2016.16:13-17 SCIIF: 3.50

21.    Wen Y, Hao J, Xiao X, Guo X, Wang W, Yang T, Shen H, Tian Q, Tan L, Deng HW, Zhang F(通讯作者). Evaluation of the relationship and genetic overlap between Kashin-Beck disease and body mass index. Scand J Rheumatol. 2016 7:1-6. SCIIF: 2.67

22.    Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. A whole genome linkage scan for QTLs underlying peak bone mineral density. Osteoporosis International. 2008 Mar;19(3):303-310.SCIIF: 4.89

23.    Zhang F, Guo X, Duan C, Wu SX, Yu, HJ, Lammi M. Identification of Differently Expressed Genes and Pathways Between Primary Osteoarthritis and Endemic Osteoarthritis Kashin-Beck Disease. Scand J Rheumatol. 2013 Jan;42(1),71-9SCIIF: 2.24

24.    Wen Y, Hao J, Guo X, Xiao X, Wu C, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW, Zhang F(通讯作者). SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. J Biomed Inform. 2015 Jul 15. pii: S1532-0464(15)00135-5. (SCI, IF:2.19)

25.    Zhang F, Xiao X, Hao J, Wang S, Wen Y, Guo X. CPAS: a trans-omics pathway analysis tool for jointly analyzing DNA copy number variations and mRNA expression profiles data. J Biomed Inform. 2015 Feb;53:363-6. (SCI, IF:2.19)

26.   Zhang F, Wen Y, Guo X, Yang TL, Hui S, et al. Trans-omics pathway analysis suggest eQTLs contribute to chondrocyte apoptosis of Kashin-Beck disease through regulating apoptosis pathway expression. Gene, 2014, 15;553(2):166-9. (SCI, IF:2.08 )

27.    Zhang F, Deng HW. Confounding from Cryptic Relatedness in Haplotype-based Association Studies. Genetica. 2010 Oct; 138(9-10):945–950.SCIIF: 2.36

28.    Zhang F. Correcting for cryptic relatedness in population-based association studies. Human Heredity. 2010;69(1):28-33.SCIIF: 2.24

29.    Zhang F, Liu J, et.al. HAPSIMU: a genetic simulation platform for population-based association studies. BMC Bioinformatics. 2008 Aug 5;9:331.SCIIF: 3.78

30.    Zhang F, Xiong DH, et.al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. Biochem.Biophys.Res.Commun.2006 Oct; 348(4):1378-1382.SCIIF: 2.55

31.     Zhang F, Zhang L, Deng HW. A PCA-based method for ancestral informative markers selection in structured populations. Science in China: Life Sciences. 2009 Oct;52(10):972-976.SCIIF: 2.02

32.    Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu X, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet. 2010 Jan 8;6(1):e1000806.SCIIF: 9.54,

33.    Zhang YG, Zhang F, Sun ZM, Guo WT, Liu J, Liu M, Guo X. A controlled case study of the relationship between environmental risk factors and apoptotic gene polymorphism and lumbar disc herniation. American Journal of Pathology. American Journal of Pathology. 2013 Jan;182(1):56-63.SCIIF: 4.89

34.    Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis Cartilage. 2014 Nov;22(11):1774-83SCIIF: 4.66

35.    Ning Y, Wang X, Wang S, Zhang F, Zhang L, Lei Y, Guo X. Is It the Appropriate Time to Stop Applying Selenium Enriched Salt in Kashin-Beck Disease Areas in China? Nutrients. 2015 Jul 28;7(8):6195-212 SCIIF: 3.75

36.   Wang S, Duan C, Zhang F, Ma WJ, Guo X. Regulatory gene networks and signaling pathways from primary osteoarthritis and Kashin-Beck disease, an endemic osteoarthritis, identified by three analysis software. Gene. 2013 Jan, 512(1),89-96. SCIIF: 2.34

37.   Wu SX, Wang WZ, Zhang F, Wu CY, Dennis BS, Qu CJ, Bai YD, Guo X. Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis. Gene. 2013 Dec, 1119(13)01576-XSCIIF: 2.34

38.    He SL, Tan WH, Zhang ZT, Zhang F, Qu CJ, Lei YX, Zhu YH, Yu HJ, Xiang YZ, Guo X. Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy. Exp Cell Res. 2013 Oct 15;319(17):2604-16SCIIF: 3.55.

39.    Zhang, LS, Guo, YF, Liu, YZ, Liu, YJ , Xiong, DH, Liu, XG, Wang, LA , Yang, TL , Lei, SF, Guo, Y , Yan, H, Pei, YF, Zhang, F , Papasian, CJ, Recker, RR, Deng, HW. Pathway-Based Genome-Wide Association Analysis Identified the Importance of Regulation-of-Autophagy Pathway for Ultradistal Radius BMD. J Bone Miner Res. 2010 Jul;25(7):1572-80. SCIIF: 6.13

40.    Chen Y, Xiong DH, Guo YF, Pan F, Zhou Q, Zhang F, Deng HW.Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. Bone. 2010 Jan;46(1):129-136.SCIIF: 4.60

41.   Zhang YP, Liu YZ, Guo Y, Liu XG, Xu XH, Guo YF, Chen Y, Zhang F, Pan F, Zhu XZ, Deng HW. Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures. PLoS One. 2011;6(7):e21835. (SCIIF: 4.35

42.   Zhang YP, Deng FY, Yang TL, Zhang F, Chen XDShen H, Zhu XZ, Tian Q. Genome-Wide Association Study Identified CNP12587 Region Underlying Height Variation in Chinese Females. PLoS ONE. 2012,Sep;7(9): e44292. SCIIF:4.03

43.   Zhang ZX, Lei SF, Deng FY, Zhang F, Liu YJ, Recker RR, Papasian CJ, Deng HW. Bivariate genome-wide linkage analysis for traits BMD and AAM: Effect of menopause on linkage signals. Maturitas. 2009;62(1):16-20.SCIIF: 2.09

44.   Yang F, Xiong DH, Guo Y, Shen H, Xiao P, Zhang F, Jiang H, Recker RR, Deng HW. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. Human Genetics. 2007 Mar;121(1):35-42.SCIIF: 3.97

45.   Jiang H, Xiong DH, Guo YF, Shen H, Xiao P, Yang F, Chen Y, Zhang F, Recker RR, Deng HW. Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. International Journal of Obesity. 2007 Aug;31(8):1319-1324.SCIIF: 3.56

二、参编专著
1.  
国家十二五规划教材《预防医学学习指导与习题集(八年制)》,人民卫生出版社(ISBN 978-7-117-21206-9)编委

2. 《地方病分子生物学基础与应用》,西安交通大学出版社(ISBN 978-7-5693-0288-2)副主编

3. 《软骨分子生物学基础与临床应用》,西安交通大学出版社(ISBN 978-7-5603-4101-3)编委