科研论文

  1. Zhang F, Wen Y, Guo X, Zhang Y, Wang X, Yang TL, et al. Genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. Arthritis Rheumatism. 2015;67(1):176-81
  2. Fan QR, Zhang F (corresponding author), Xu JW, Hao JC, He AW, Wen Y, Li P, Liang X, Du YN, Liu L, Wu CY, Wang S, Wang X, Ning YJ, Guo X. GWAS summary-based pathway association analysis correcting for the genetic confounding impact of environmental exposures. Briefing in Bioinformatics 2017, doi: 10.1093/bib/bbx025.（SCI，IF: 8.40）
  3. Zhang F, Wen Y, Guo X. CRISPR/Cas9 for genome editing: progress, implications and challenges. Hum Mol Genet. 2014 ;23(R1):R40-R46 
  4. Wen Y, Wang W, Guo X, Zhang F(corresponding author). PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries. Bioinformatics. 2016;32(6):946-948.
  5. Wang WY, Hao JC, Wen Y, Zheng SY, Zhang F(corresponding author). Tissue-specific pathway association analysis using genome-wide association study summaries. Bioinformatics. 2016, in press.
  6. Zhang F, Guo X, Zhang Y, Wen Y,Wang WZ, Wang S, Yang TL, et al. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Hum Genet. 2014 Jun;133(6):793-9
  7. Wu C, Wen Y, Guo X, Yang T, Shen H, Chen X, Tian Q, Tan L, Deng HW, Zhang F（corresponding author）.Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease. Osteoarthritis Cartilage. 2017, 25(2):281-286. 
  8. Wen Y, Guo X, Hao J, Xiao X, Wang W, Wu C, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW, Zhang F（corresponding author）.Integrative analysis of genome-wide association studies and gene expression profiles identified candidate genes for osteoporosis in Kashin-Beck disease patients. Osteoporos Int. 2016;27:1041-1046（SCI，IF: 3.59）
  9. Liu RY, Liu Q, Wang KZ, Dang XQ, Zhang F(corresponding author). Comparative analysis of gene expression profiles between normal human hip cartilage and the one with necrosis of femoral head. Arthritis Research & Therapy. 2016;18(1):98.
  10. Zhang F, Guo X, Wen Y, Zhang Y, Wang S, Yang TL, et al. Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. Bone, 2015;71:36-41.
  11. Hao J, Wang W, Wen Y, Xiao X, He A, Guo X, Yang T, Liu X, Shen H, Chen X, Tian Q, Deng HW, Zhang F(corresponding author). A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease. Sci Rep. 2016;6:31792 
  12. Hao J, Wang W, Wen Y, Xiao X, He A, Wu C, Wang S, Guo X, Zhang F（corresponding author）.Genome-wide association study identifies COL2A1 locus involved in the hand development failure of Kashin-Beck disease. Sci Rep. 2016;7:40020. 
  13. Wu W, He A, Wen Y, Xiao X, Hao J, Zhang F (corresponding author), Guo X. Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis. Sci Rep. 2017;7(1):540. doi: 10.1038/s41598-017-00522-z.
  14. Fan Q, Wang W, Hao J, He A, Wen Y, Guo X, Wu C, Ning Y, Wang X, Wang S, Zhang F（corresponding author）. Integrating genome-wide association study and expression quantitative trait loci data identifies multiple genes and gene set associated with neuroticism. Prog Neuro-psychopharmacol Biol Psychiatry. 2017, 78:149-152. doi: 10.1016/j.pnpbp（SCI，IF: 4.19）
  15. Du Y, Wen Y, Guo X, Hao J, Wang W, He A, Fan Q, Li P, Liu L, Liang X, Zhang F（corresponding author）. A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis. Cell Mol Neurobiol. 2017, doi: 10.1007/s10571-017-0512-2.
  16. Wang WY, Hao JC, Zheng SY, Xiao X, Wen Y, He AW, Guo X, Zhang F（corresponding author）. Association between CILP and degeneration of intervertebral disc. Spine. 2016，41(20):E1244-E1248. 
  17. Xiao X, Hao J, Wen Y, Wang W, Guo X,Zhang F(corresponding author).Genome-wide association studies and gene expression profiles of rheumatoid arthritis: An analysis. Bone Joint Res. 2016 Jul;5(7):314-9.
  18. Wang W, Liu Y, Hao J, Zheng S, Wen Y, Xiao X, He A, Fan Q, Zhang F(corresponding author), Liu R. Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis. Gene. 2016;591(1):43-7.
  19. Wen Y, Hao J, Xiao X, Wang W, Guo X, Lin W, Yang T, Liu X, Shen H, Tan L, Chen X, Tian Q, Deng HW, Zhang F.PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Funct Integr Genomics. 2016;16(4):459-63 
  20. Zhang F, Dai L, Lin W, Wang W, Liu X, Zhang J, Yang T, Liu X, Shen H, Chen X, Tan L, Tian Q, Deng HW, Xu X, Guo X. Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease. Funct Integr Genomics. 2016.16:13-17 
  21. Wen Y, Hao J, Xiao X, Guo X, Wang W, Yang T, Shen H, Tian Q, Tan L, Deng HW, Zhang F(corresponding author). Evaluation of the relationship and genetic overlap between Kashin-Beck disease and body mass index. Scand J Rheumatol. 2016 7:1-6. 
  22. Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. A whole genome linkage scan for QTLs underlying peak bone mineral density. Osteoporosis International. 2008 Mar;19(3):303-310
  23. Zhang F, Liang J, Guo X, Zhang Y, Wen Y, Li Q, Zhang Z, Ma W, Dai L, Liu X, Yang L, Wang J. Exome sequencing and functional analysis identifies a novel mutation in EXT1 gene that causes multiple osteochondromas. PLoS One. 2013 Aug 29;8(8):e72316.
  24. Zhang F, Guo X, Duan C, Wu SX, Yu, HJ, Lammi M. Identification of Differently Expressed Genes and Pathways Between Primary Osteoarthritis and Endemic Osteoarthritis Kashin-Beck Disease. Scand J Rheumatol. 2013 Jan;42(1),71-9
  25. Wen Y, Hao J, Guo X, Xiao X, Wu C, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW, Zhang F(corresponding author). SWGDT: A sliding window-based genotype dependence testing tool for genome-wide susceptibility gene scan. J Biomed Inform. 2015 Jul 15. pii: S1532-0464(15)00135-5.