联系方式

Email:gaomeili@mail.xjtu.edu.cn

Tel:15349218702

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基本信息

 

高美丽,女,博士,副教授。
办公地点:教二楼北(生命学院)415室
办公电话:029-82668463转802
Email:gaomeili@mail.xjtu.edu.cn
通信地址:陕西省西安市咸宁西路28号,西安交通大学生命科学与技术学院生物生物科学与工程系 (710049)
 

研究领域
★ 肿瘤免疫治疗, 天然有机物逆转剂筛选及机制研究,肿瘤精准治疗与药物筛选;
★ 环境毒理,环境致癌物检测分析,致癌机制及表观遗传机制研究;
★ 营养与健康,营养与疾病研究;
★ 中药与复方的物质基础、药效及作用机理研究;
★ 微生物工程与环境保护,微生物产品与发酵工艺优化;
★ 功能性饮料研发及食品功能性分子机制研究。

 欢迎对以上研究领域感兴趣的相关专业学生咨询及报考!

 

科研与教学

近年主持科研项目
[1] 国家自然科学基金一项
[2] 西安交通大学-加速器质谱专项基金一项
[3] 西安交通大学校科研业务费国际交流与合作项目一项
[5] 陕西省博士后基金一项

[6] 陕西省自然科学基金一项

[7] 陕西省重点研发计划项目一项

[8] 榆林市科技计划项目一项

[9] 陕西省颅颌面精准医学研究重点实验室开放课题一项

[10] 指导国家级大学生创新项目四项、省大学生创新项目三项,校级实践基金八项

 

讲授课程

[1] 微生物发酵工程 (生物工程专业必修课)

[2] 发酵综合实验 (生物工程专业必修课)

[3] 基因药物与基因工程技术 (药学专业必修课)

[4] 细胞综合实验 (生物工程专业必修课)

 

近期发表的论文

[1].Meili Gao*, Jiangang Long, Yongfei Li, Walayat Shah Ling Fu , Jiankang Liu , Yili Wang. Mitochondrial decay is involved in BaP-induced cervical damage. Free Radical Biology & Medicine 2010, 49: 1735-1745. 
[2]. Meili Gao*, Li Yongfei, Jiangang Long, Walayat Shah
Ling Fu , Baochang LaiYili Wang. Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutation Research 2011, 719: 52-59. 
[3]. Meili Gao*, Yongfei Li, Yu Kong
Ying Sun, Shuiyun Yang, Yili Wang Jiangang Long*. Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic & Clinical Pharmacology & Toxicology 2011, 109: 398-406. 
[4]. Meili Gao*, Yongfei Li, Ying Sun, Jiangang L ong, Yu Kong, Shuiyun Yang, Yili Wang. A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutation Research 2011, 724: 69-75. 
[5]. Meili Gao* , Yongfei Li, Jianxiong Yang, Yili Wang. Modification of oxidative stress in acute exhaustive exercise mice with n-butanol and water fractions from Pedicularis decora Franch root treatment. African Journal of Pharmacy and Pharmacology 2011, 5 (7): 853-861. 
[6]. Meili Gao*, Yongfei Li, Jianxiong Ya ng, Yili Wang. Effects of n-butanol and water fractions from Pedicularis decora Franch on oxidative stress in mice induced by a single bout of swimming exercise. Journal of Medicinal Plants Research 2011, 6 (39), 5186-5195.
[7]. Meili Gao*, Yongfei Li, Jianxiong Yang, Y ili Wang. Protective effects of Pedicularis decora Franch root extracts on oxidative stress and hepatic injury in alloxan-induced diabetic mice. Journal of Medicinal Plants Research 2011, 5 (24), 5848-5856. 
[8]. Li Yongfei, Gao meili, Wu Qing. Vinyl polymerization of norbornene by nickel(II) complexes bearing β -diketiminate ligands. Applied Organometallic Chemistry 2007
21965-969. 
[9]. Li Yongfei, Gao meili, Wu Qing. Styrene polymerization with nickel complexes /methylaluminoxane catalytic system. Applied Organometallic Chemistry 2008
22659-663. 
[10]. Li Yongfei, Gao Meili, Gao Haiyang
Wu Qing. Synthesis and structural characterization of ethylene-norbornene copolymer with high norbornene content catalyzed by beta-diketiminato nickel/methylaluminoxane. European Polymer Journal 2011, 47:1964-1969.
[11]. Jiangang Long, Meili Gao, Yu Kong, Xian Shen, Xiaoyang Du, Young-Ok Son, Xianglin Shi, Jiankang Liu, Xiaoyan Mo. Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine 2012, 19: 672-676. 
[12]. Li Yongfei, Wu Qin, Minyu Shan, Gao meili. Copolymerization of styrene and norbor- nene with β-diketiminato nickel/methylaluminoxane catalytic system. Applied Organometallic Chemistry 2012
doi 10.1002/aoc.2843.
[13]. Li Yongfei, Wu Qin, Gao meili. Polymerization of lactide catalyzed by diketiminato iron ( 
) alkoxide complex. Advanced Materials Research 2012, 393-395:1346-1349. 
[14]. Li Yongfei, Wu Qin, Gao meili. Synthesis of stereoregular pol ylactide. Advanced Materials Research 2012, 391-392:107-110. 
[15]. Meili Gao, Yongfei Li, Xiaochang Xue, Jiangang Long, Lan Chen, Walayat Shah, Yu Kong. Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Asian Pac J Cancer Prev 2014, 15 (6), 2699-2705.

[16]. Yu Kong, Chong Wei, Zilong Wang, Zhanwu Hou, Hua Li, Jiang Yu, Jiaqiang Yuan, Yongxi Zhao, Jiangang Long, Yuhai Tang, Meili Gao*. Determination of melamine in quail egg and milk with capillary zone electrophoresis. American Journal of Analytical Chemistry,2014, 5, 258-265.

[17]. Guo-dong Feng, Xiao-chang Xue, Mei-li Gao, Xian-feng Wang,Zhen Shu, Nan Mu, Yuan Gao, Zeng-lu Wang, Qiang Hao, Wei-na Li, Meng Li, Cun Zhang, Wei Zhang, and Ying-qi Zhang. Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis. Biomed Res Int. 2014, 2014:854954, doi: 10.1155/2014/854954.

[18]. Yongfei Li, Yaping Lei,Meili Gao, Weixing Chen, Gaohong Li. Atmospheric reactivity of ethylene catalyzed by β -diketiminato Ni(II)/methylaluminoxane system. Appl. Organometal. Chem. 2014, 28, 441-444.

[19]. Kong Y, Wei C, Hou Z, Wang Z, Yuan J, Yu J, Zhao Y, Tang Y, Gao M*. Stacking and analysis of melamine in milk products with acetonitrile-salt stacking technique in capillary electrophoresis. J Anal Methods Chem. 2014;2014: 212697, doi: 10.1155/2014/212697.

[20]. Gao ML, Chen L, Li YF, Xue XC, Chen L, Wang LN, Shah W, Kong Y. Synergistic increase of oxidative stress and tumor markers in PAH-exposed workers.Asian Pac J Cancer Prev. 2014;15(17):7105-7112.

[21]. Gao M, Li Y, Zheng A, Xue X, Chen L, Kong Y. Lymphocyte oxidative stress/genotoxic effects are related to serum IgG and IgA levels in coke oven workers. Scientific World Journal. 2014; 2014:801346, doi: 10.1155/2014/801346.

[22]. Kong, Y,Li, YF, Ji, XY,Gao, ML*. GENOTOXIC EFFECT OF BENZO(A) PYRENE ON BCL-2, KI-67, C-MYC AND P53, BAX, CASPASE-3 IN VARIOUS REGIONS OF CEREBRAL CORTEX AND HIPPOCAMPUS. Basic & Clinical Pharmacology & Toxicology 2015, 117(S1): 8-8.

[23]. Meili Gao*, Lei Chen, Xiaoying Ji. Effects of DNA damage in cells of liver, kidney, brain, lung, stomach and cervix in vitro. CITCS 2015 (ISBN: 978-1-60595-229-1):621-625.

[24]. Xiaoying Ji#, Yongfei Li#,Jianlong He, Walayat Shah, Xiaochang Xue, Guodong Feng, Huqin Zhang, Meili Gao*,Depletion of Mitochondrial Enzyme System in Liver, Lung, Brain, Stomach and Kidney Induced by Benzo(a)pyrene. Environmental Toxicology and Pharmacology, 2016, 43: 83-93.

[25]. Meili Gao, Yongfei Li, Xiaoying Ji, Xiaochang Xue, Lan chen, Guodong Feng, Huqin Zhang, Huichun Wang, Walayat Shah, Zhanwu Hou, Yu Kong*. Disturbance of Bcl-2, Bax, Caspase-3, Ki-67 and C-myc Expression in Acute and Subchronic Exposure to Benzo(a)pyrene in Cervix, Acta Histochemica, 2016, 118: 63-73.

[26]. Jianlong He, Xiaoying Ji, Yongfei Li, Xiaochang Xue, Guodong Feng, Huqin Zhang, Huichun Wang, Meilii Gao*, Subchronic Exposure of Benzo(a)pyrene Interferes With the Expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in Sub-regions of Cerebral Cortex and Hippocampus, Experimental and Toxicologic Pathology, 2016, 68: 149–156.

[27]. Fenrong Chen, Hong Li, Yan Wang, Meili Gao, Yan Cheng, Dong Liu, Miao Jia, Jun Zhang.Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway. 2016, Journal of Functional Foods, 2016,Doi: 10.1016/j.jff.2016.06.027.

[28]. Hongyan Zhao, Yongfei Li, Xiaoying Ji, Shuyan Qi, Meilili Gao*. CONTAMINATED BENZO(A)PYRENE IS ASSOCIATED WITH DIFFERENT PROCESS IN MEATS ACCOMPANIED BY VARIOUS CANCER POTENTIALITY. Fresenius Enviromental Bulletin, 2017, 26, 944-954.

[29]. 李永飞高美丽伍青后过渡金属催化烯烃以及环烯烃聚合的研究进展现代化工,2007,27(2): 52-55.
[30]. 
李永飞吴勤高美丽外消旋丙交酯立体选择聚合研究进展高分子通报,2012, 118-124.
[31]. 
杨水云,马晓明,刘勇,谭丹,吴宥伸,高美丽。乳及溶液中淀粉检测试纸的制备及淀粉的检测方法. 2008, 国家发明专利 (ZL 2008 1 0232196.1)

[32] 冀晓莹,高美丽*,降解多环芳烃(PAHs)微生物研究进展,生物技术世界,2016,5:14-17.

[33] 赵红艳,冀晓莹,高美丽*。植物功能性饮料的现状与发展趋势。2016,食品工业科技,1537)390-396.

[34] 冀晓莹,高美丽*苯并(a)芘神经毒性研究进展。2016, 生态毒理,113):47-52.

[35] 邓春,赵红艳,高美丽。PAHs致毒机制及其微生物降解研究进展。2017,环境保护前沿,7 (4), 315-324.