Basic Information

 
Name: Hai-xia Lu
Department: Institute of Neurobiology
Place of birth: Huaxian, Shaanxi Province, P.R. China
Nationality: P.R.China
 
 
 
Education
1990.09-1997.07
Master of Obstetrics and Gynecology，Clinical Medicine in Xi’an Medical University，Xi'an，China
1999.09-2002.12
Ph.D of Human Anatomy and Histoembryology in Xian Jiaotong University Health Science Center, Xi'an，China
2006.06-2008.02
Postdoctoral Fellow in Department of Biomedical Science, University of Nottingham
2009.09-2010.02
Visiting Scholarship in Department of Biomedical Science, University of Nottingham

 

Education and Career

Working Experience
1995.09-1997.07
Clinical training in the Department of Obstetrics & Gynecology, The Second Affiliated Hospital, Xi’an Jiaotong University College of Medicine
1997.07-2006.06
Clinical doctor in the Department of Obstetrics & Gynecology, The Second Affiliated Hospital, Xi’an Jiaotong University College of Medicine
2006.07-2008.01
Postdoctoral research fellow sponsored by ‘UK/China scholarships for excellent young academic researcher’ in School of Biomedical Science, Queen’s Medical Center, University of Nottingham, UK
2007.11-2008.01
Research coordinator in Nottingham UK-China Collaboration on Complementary and Alternative Medicine (NUCCAM), Department of Epidemiology, Queen’s Medical Center, University of Nottingham. UK
2008.02-2008.05
Senior doctor in the Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Xi’an Jiaotong University
2008.05-2013.12
Associate professor in Institute of Neurobiology, Xi’an Jiaotong University Health Science Center
2009.09-2010.02
Research fellow (supported by Innovation China UK) in School of Biomedical Science, University of Nottingham, UK
2014.01-
Professor in Institute of Neurobiology, Xi’an Jiaotong University Health Science Center

 

Scientific Research

1. Neural Stem Cells

    Biological behaviour of Neural stem cell

    Therapeutic application of neural stem cells

2. Neural Inflammation, Nerual Regeneration and Brain Repair

    Ischemic stroke, Traumatic Brain Injury

    Cerebellar ataxia

    Neurogenesis and angiogenesis

    Interaction between astrocyte, microglia and neuron 

3. Tissue Engineer

    Neural stem cell combined with PHA’s for brain repair

Contact

No76, Yan Ta Xi Lu

Institute of Neurobiology

Xi'an Jiaotong University Health Science Center
Xi'an 710061

E-mail address: hxl01@mail.xjtu.edu.cn

Tel: 86 29 82657064

      

Teaching

  • Undergraduate
  1. Lecture for students in 8-year program (Neurobiology-Organ-Systems-Based Integration Curriculum)
  2. Problem based learning (PBL) tutorial for students in 8-year program
  3. Interdisciplinary Topics，Introduction to Scientific Research Methods，Basic Scientific Research Training, ect)Lecture for students in Basic Medical Sciences and Clinical Medicine (Neurobiology, Systematic Anatomy，
  4. Lecture for overseas students in English (Ob&G)    （1997-1999）
  5. Lecture for students in 7-year and 5-year program (Ob&G) （1997-2008）
  • Postgraduate

     1. Lecture in Progress of Stem Cell Research and Application (Course Leader）

     2. Lecture in Advanced Medical Research Initiation (Medical English Practice Course)，Analysis of Nobel Prize Papers，

        Scientific paper writing，ect)

 

Prizes and Awards

1. Wang Kuancheng Yucai Award，2020

2. The 10th Youth Science and Technology Award of Shaanxi Province， 2014

3. Award from Symington Request Fund for travel to UK for ASGBI summer meeting, 2008

4. Scholarship from ‘UK/China scholarships for excellent young academic researcher’, 2005

5. First prize in ‘teaching competition in foreign Language’ in Xi’an Jiaotong University 2005   

Publications

 

Publications (last 5 years)   

  1. Ge Qian#, Hu Xiaoxuan#, Ma Ning, Sun Meiqi, Zhang Liyun, Cai Zhenlu, Tan Ruolan, Lu Haixia*. Maternal high-salt diet during pregnancy impairs synaptic plasticity and memory in the offspring. The FASEB Journal. 2021;35(4):e21244. doi: 10.1096/fj.202001890R
  2. Cai Zhenlu, Hu Xiaoxuan, Tan Ruolan, Feng Yunran, Sun Miqi, Ma Ning, Li Xingxing, Huang Li, An jing, Ge Qian*, Lu Haixia*. Neuroprotective effect of green tea extractives against oxidative stress by ehancing the survival and proliferation of PC12 cells. Mol Cell Toxicol. 2019, 15,391-397 
  3. Lu pengfei, Han Donghe, Zhu Kunming, Jin Meihua, Mei Xifan, Lu Haixia*. Effects of SIRT1 on microglia in spinal cord injury: Involvement of Wnt/β-catenin signaling pathway. Neuroreport. 2019, 30(13):867–874 
  4. Wang Leilei, Yang Zhiqian, Fang Fan, Sun Shuhong, Wu Xingjuan, Lu Haixia*, Lu Xiaoyun*. PHBHHx facilitated the residence, survival and sternness maintain of transplanted neural stem cells in traumatic brain injury rats. Biomacromolecules. 2019, 20(9): 3294-3302. doi: 10.1021/acs.biomac.9b00408.  
  5. Li Xingxing, Tan Ruolan, Hu Xiaoxuan, Jiao Qian, Md Saidur Rahman, Chen Xinlin, Zhang Pengbo, An Jing*, Lu Haixia*, Liu Yong. Neural stem cells derived factors inhibit the growth and invasion of U87 stem-like cells in vitro. J Cell Biochem. 2019, 120(4): 5472-5479. https://doi.org/10.1002/jcb.27826    
  6. Wu Gang#, Zhao Xixi#, Wang Feidi, Tan Ruolan, Wang Jin, Li Xingxing, Chen Chen, Cai Zhenlu, An Jing, Lu Haixia*. Short-term exposure to oxycodone altering survival, proliferation and differentiation of rat embryonic neural stem cell in vitro. Brain Res Bull. 2018, 143, 66-72   
  7. Shang Sen, Wang Leilei, Zhang Yali, Lu Haixia*, Lu Xiaoyun*. The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome. Cell Mol Neurobiol. 2018, 38(8):1479-1489 doi: 10.1007/s10571-018-0617-2.                   
  8. Lu Na, Li Xingxing, Tan Ruolan, An Jing, Cai Zhenlu, Hu Xiaoxuan, Wang Feidi, Wang Haoruo, Lu Chengbiao, Lu Haixia*. HIF-1α/Beclin1-mediated autophagy is involved in neuroprotection induced by hypoxic preconditioning. J Mol Neurosci. 2018, 66(2):238-250. DOI: 10.1007/s12031-018-1162-7      
  9. Hu Erling, Du Huan, Zhu Xinliang*, Wang Leilei, Shan Sen, Wu Xinjuan, Lu Haixia*, Lu Xiaoyun*. Beta-hydroxybutyrate promotes the expression of BDNF in hippocampal neurons under adequate glucose supply. Neuroscience. 2018, 386:315-325. DOI:10.1016/j. neuroscience. 2018.06.036      WOS:000440325500026 
  10. Huang Li, Zhang Che, Gu Jiaowei, Wu Wei, Shen Zhujun, Zhou Xihui, Lu Haixia* A randomized, placebo-controlled trial of human umbilical cord blood mesenchymal stem cell infusion for children with cerebral palsy. Cell Transplantation. 2018, 27(2):325-334. DOI: 10.1177/0963689717729379  
  11. An Jing#, Yan Hanqi#, Li Xingxing, Tan Ruolan, Chen Xinlin, Zhang Zhichao, Liu Yingfei, Tan Jing, Zhang Pengbo, Lu Haixia*, Liu Yong. The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells. Oncotarget. 2017, 8(44):76949-76960. doi: 10.18632/oncotarget.       
  12.  Jiao Qian, Li Xingxing, An Jing, Zhang Zhichao, Chen Xinlin, Tan Jing, Zhang Pengbo, Lu Haixia*, Liu Yong*. Cell-cell connection enhances proliferation and neuronal differentiation of rat embryonic neural stem/progenitor cells. Front Cell Neurosci. 2017, 11: 200. doi: 10.3389/fncel.2017.00200. eCollection 2017.  
  13. An Jing, Zhang Yumeng, Fudge Alexander D, Lu Haixia, Richardson William D, Li Huilaing. G protein-coupled receptor GPR37-like 1 regulates adult oligodendrocyte generation. Dev Neurobiol. 2021,81(8):975-984.
  14. Zhang Zhichao, Zheng Xiaoyan, Liu Yingfei, Luan Yan, Wang Li, Zhao Lingyu, Zhang Jianshui, Tian Yumei, Lu Haixia, Chen Xinlin*, Liu Yong*. Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression. J Neurochem. 2021, 156(4):465-480.
  15. .Li Weisong, Lu Pan, Lu Yang, Wei Haidong,Wang Kui, Zhang Hong, Li Rong, Qiu Zhenguo, Wang Ning, Jia Pengyu, Zhang Yan, Zhang Shuyue, Lu Haixia, Chen Xinlin, Liu Yong, Zhang Pengbo. 17β-Estradiol Protects Neural Stem/Progenitor Cells Against Ketamine-Induced Injury Through Estrogen Receptor β Pathway. Front Neurosci. 2020, 14:576813. doi: 10.3389/fnins.2020.576813.
  16. Zhang Zhichao, Liu Yingfei , Luan Yan, Zhu Kun, Hu Baoqi, Ma Bo, Chen Li, Liu Xuan, Lu Haixia, Chen Xinlin, Liu Yong, Zheng Xiaoyan. Activation of Type 4 Metabotropic Glutamate Receptor Regulates Proliferation and Neuronal Differentiation in a Cultured Rat Retinal Progenitor Cell Through the Suppression of the cAMP/PTEN/AKT Pathway. Front Mol Neurosci. 2020, 13:141. doi: 10.3389/fnmol.2020.00141.
  17. Zhang Zhichao, Zheng Xiaoyan, Liu Yingfei , Luan Yan, Wang li, Zhao Lingyu, Zhang Jianshui, Tian Yumen, Lu Haixia, Chen Xinlin, Liu Yong. Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression. J Neurochem. 2020, doi: 10.1111/jnc.14984.  Online ahead of print.
  18. Rahman MS, Yang Jianbo, Luan Yan, Qiu Zhenguo, Zhang Jianshui, Lu Haixia, Chen Xinlin, Liu Yong. Attenuation of Acute Intracerebral Hemorrhage-Induced Microglial Activation and Neuronal Death Mediated by the Blockade of Metabotropic Glutamate Receptor 5 In Vivo. Neurochem Res. 2020, 45(5):1230-1243. 
  19. Li Qianqian, Qiu Zhengguo, Lu Yang, Lu Pan, Wen Jieqiong, Wang Kui, Zhao Xijuan, Li Rong, Zhang Hong, Zhang Yan, Jia Pengyu, Fan Pei, Zhang Yuanyuan, Zhang Shuyue, Lu Haixia, Chen Xinlin, Liu Yong, Zhang Pengbo. Edaravone protects primary-cultured rat cortical neurons from ketamine-induced apoptosis via reducing oxidative stress and activating PI3K/Akt signal pathway. Mole cellul neurosci. 2019, 100:103399. doi: 10.1016/j.mcn.2019.103399. 
  20. Zhang Zhichao, Liu Yingfei, Wang Ke, Zhu Kun, Zheng Xiaoyan, Wang Li, Luan Yab, Wang Xinyang, Lu Haixia, Wu Kaijie, Chen Xinlin, He Dalin, Liu Yong. Activation of type 4 metabotropic glutamate receptor promotes cell apoptosis and inhibits proliferation in bladder cancer. J Cell Physiol. 2019, 234(3):2741-2755.
  21. Li Weisong, Li Huixian, Wei Haidong, Lu Yang, Lei Shan, Zheng Juan,Lu Haixia, Chen Xinlin,  Liu Yong and Zhang Pengbo*. 17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal Rats. Front Cell Neurosci. 2019, 13: 251 | https://doi.org/10.3389/fncel.2019.00251
  22. Lu Pan, Lei Shan, Li Weisong, Lu Yang, Zheng Juan, Wang Ning, Xia Yongjun, Lu Haixia, Chen Xinlin, Liu Yong, Zhang Pengbo. Dexmedetomidine Protects Neural Stem Cells from Ketamine-Induced Injury. Cell Physiol Biochem. 2018, 47(4):1377-1388. doi: 10.1159/000490823.  
  23. Wang Ning, Lu Yang, Wang Kui, Li Wei-Song, Lu Pan, Lei Shan, Li Rong, Zhang Hong, Zheng Juan, Lu Hai-Xia, Chen Xin-Lin, Liu Yong, Zhang Peng-Bo. Simvastatin Attenuates Neurogenetic Damage and Improves Neurocongnitive Deficits Induced by Isoflurane in Neonatal Rats. Cell Physiol Biochem. 2018;46(2):618-632.  doi: 10.1159/000488630. 
  24. Zhang Zhichao, Liu Yingfei, Wang Ke, Zhu Kun, Zheng Xiaoyan, Wang Li, Luan Yan, Wang Xinyang, Lu Haixia, Wu Kaijie, Chen Xinlin*, He Dalin*, Liu Yong*. Activation of type 4 metabotropic glutamate receptor promotes cell apoptosis and inhibits proliferation in bladder cancer. J Cell Physiol. 2018;1–15.  
  25. Zhang Zhichao, Zheng Xiaoyan, Luan Yan, Liu Yingfei, Li Xingxing, Liu Chongxiao, Lu Haixia, Chen Xinlin, Liu Yong. Activity of Metabotropic Glutamate Receptor 4 Suppresses Proliferation and Promotes Apoptosis with Inhibition of Gli-1 in Human Glioblastoma Cells. Front in Neurosci. 2018                                                                             
  26. Giri Praveen K., Lu Yang, Lei Shan, Li Weisong, Zheng Juan, Lu Haixia, Chen Xinlin, Liu Yong, Zhang Pengbo*. Pretreatment with minocycline improves neurogenesis and behavior performance after midazolam exposure in neonatal rats. Neuroreport. 2018, 29(3):153-159. doi: 10.1097/WNR.0000000000000937.  
  27. Lu Yang, Giri Praveen K., Lei Shan, Zheng Juan, Li Weisong, Wang Ning, Chen Xinlin, Lu Haixia, Zuo Zhiyi, Liu Yong, Zhang Pengbo*. Pretreatment with minocyclone restores neurogenesis on the subventricular zone and subgranular zone of the hippocampus after ketamine exposure on neonatal rats. Neuroscience. 2017:352, 144-154. DOI: 10.1016/j.neuroscience.2017.03.057.     
  28. Zhang Xiaohua, Hu Ming, Zhang Lin, An Jing, Yan Wenhui, Zhang Zhichao, Liu Jianxin, Lu Haixia, Chen Xinlin, Liu Yong. MTEP Impedes the Neuronal Polarization and the Activity of the Akt-NF-kappa B Pathway in Rat Hippocampal Neurons. J Neurosci Res. 2017, 95 ( 9): 1730-1744. DOI: 10.1002/jnr.24002.