学术成果

        研究团队围绕细胞能量代谢的核心细胞器-线粒体的代谢和退变机制等重要科学问题，在探索衰老、老年痴呆症、2型糖尿病发生的线粒体机制，以及研究靶向干预线粒体退变损伤等方面取得一些重要的原创性发现，为衰老、老年痴呆症、2型糖尿病等的防治提出了新的治疗靶点和防治策略。

一、创新线粒体营养素与药物理论，发现若干有效改善认知、缓解衰老相关退行性病变的功能分子，在衰老及相关疾病防治中具有重要应用潜力。
二、率先提出并论证细胞脂质代谢中产生的醛类所引起的线粒体退变机制，揭示外周与中枢代谢紊乱是脑认知损伤的关键因素，为Harman博士提出的经典的自由基衰老理论增添了新的理论内容和实验依据。
三、提出线粒体是微重力、极端环境应激的关键感受器，靶向调节线粒体代谢可有效改善应激所致中枢与外周损伤。
四、在2型糖尿病研究中获得重要发现：胰岛素抵抗的发生伴随细胞自噬异常，后者参与调控线粒体自身代谢。该研究首次揭示了能量代谢的核心细胞器-线粒体自身代谢在糖尿病中的基本调节规律，对于解答糖尿病发生的基本科学问题及其预防有重要意义。
上述研究工作的开展，得到国家基金委、相关国际基金以及教育部“985工程”建设的大力支持。目前，研究团队针对衰老、老年痴呆症、2型糖尿病等重要的线粒体相关疾病，专注于探索其线粒体代谢规律及疾病防治策略，已经形成特色鲜明、有一定国际影响力的学科方向。

 

学术论文 |  学术专著  |  学术专利

 

 

学术论文

 

（英文论文  |  中文论文）

 

英文论文 Publication (* corresponding author)

论文发表：2024 | 2023 | 2022 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2010... 

 

2024

  1. Jia Y, Chen K, Du M, Zhao W, Chen Y, Cheng J, Zhao L, Liu J, Long J*. Auricularia auricula-judae Attenuates the Progression of Metabolic Syndrome in High-Fat Diet-Induced Obese Rats: Enzymatic Pre-Digestion Technology Is Superior to Superfine Grinding Method. Foods. 2024 Jan 26;13(3):406. （中科院2区，IF=5.2）

 

2023

  1. Xu F, Yang Z, Wang L, Meng D, Long J*. MESPool: Molecular Edge Shrinkage Pooling for hierarchical molecular representation learning and property prediction. Brief Bioinform. 2023 Nov 22;25(1):bbad423. （中科院1区，IF=9.5）
  2. Cheng D, Long J, Zhao L, Liu J. Hydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System. Antioxidants (Basel). 2023 Nov 12(12), 2062. （中科院1区，IF=7.0）
  3. Liu X, Zhang X, Zhao L, Long J, Feng Z, Su J, Gao F, Liu J. Mitochondria as a sensor, a central hub and a biological clock in psychological stress-accelerated aging. Ageing Res Rev. 2023 Nov 27:102145. （中科院1区，IF=13.1）
  4. Han X, Yang F, Zhang Z, Hou Z, Sun Q, Su T, Lv W, Wang Z, Yuan C, Zhang G, Pi X, Long J*, Liu H. 4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes. J Biol Chem. 2023 Nov 299(11):105315. （中科院2区，IF=4.8）

  5. Liang B, Shi L, Du D, Li H, Yi N, Xi Y, Cui J, Li P, Kang H, Noda M, Sun X, Liu J*, Qin S*, Long J*. Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study. Antioxidants (Basel). 2023 Jun 9;12(6):1245.（中科院1区，IF=7.675）

  6. Sun Q, Shi L, Li S, Li J, Zhang R, Huang X, Shao Y, Feng Z, Peng Y, Yang Z, Liu J, Liu H*, Long J*. PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria-encoded cytochrome C oxidase 1 synthesis. Free Radic Biol Med. 2023 Aug 20;205:13-24.（中科院1区，IF= 7.4）

  7. Yang Z, Fu X, Zhao Y, Li X, Long J, Zhang L. Molecular insights into the inhibition mechanism of harringtonine against essential proteins associated with SARS-CoV-2 entry. Int J Biol Macromol. 2023 Jun 15;240:124352.（中科院1区，IF=8.2）

  8. Ma Q, Gao J, Fan Q, Yang T, Zhao Z, Zhang S, Hu R, Cui L, Liang B, Xie X, Liu J, Long J*. Thinned young apple polyphenols may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in the cerebral cortex of high-fat diet-induced diabetic mice. Food Funct. 2023 Apr 3;14(7):3279-3289.（中科院1区，IF=6.317 ）

  9. Liu X, Fang L, Wang J, Huang S, Li A, Liu H, Lu Z, Long J, He M. Preparation of ZIF-8@[C2mim][BF4]/Pebax mixed-matrix membranes through a impregnation strategy for enhancing the separation of difluoromethane (R32) from refrigerant blend R410A. Chem Eng Res Des. 2023,199, 530-540. （中科院3区，IF=3.9）

2022

  1. Wang X, Zhang X, Cao K, Zeng M, Fu X, Zheng A, Zhang F, Gao F, Zou X, Li H, Li M, Lv W, Xu J, Long J, Zang W, Chen J, Gao F, Ding J, Liu J, Feng Z. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nat Commun. 2022 Jul 8;13(1):3947.（中科院1区，IF= 17.694）

  2. Yang Z, Zhang Z, Zhao Y, Ye Q, Li X, Meng L, Long J, Zhang S, Zhang L. Organelle Interaction and Drug Discovery: Towards Correlative Nanoscopy and Molecular Dynamics Simulation. Front Pharmacol. 2022 Jun 20;13:935898. （中科院2区，IF=5.988）

  3. Guo Q, Wang L, Liu Z, Wang H, Wang L, Long J, Liao S. Different effects of maternal homocysteine concentration, MTHFR and MTRR genetic polymorphisms on the occurrence of fetal aneuploidy. Reprod Biomed Online. 2022 Dec 45(6):1207-1215. （中科院2区，IF=4.567）

  4. Gao J, Wang Z, Gao P, Fan Q, Zhang T, Cui L, Shi L, Liu Z, Yang Z, He L, Wang C, Li Y, Qu L, Liu J, Long J*. Daphnetin Alleviates Senile and Disuse Osteoporosis by Distinct Modulations of Bone Formation and Resorption. Antioxidants (Basel). 2022 Nov 29;11(12):2365.（中科院1区，IF=7.675）
  5. Wang Y, Hu X, Long J, Diao J. Epigenetic optical sensing of 5-hydroxymethylcytosine at the single-molecule level. Sens Actuators B Chem. 2022 358, 131500（中科院1区，IF=8.4）

  6. Chen Y, Hu S, Wu X, Xie Z, Wang Y, Wang B, Li X, Pei Y, Gu Y, Huang K, Huo J, Wei A, Bi C, Lu Z, Song Q, Xu H, Kang X, Shao S, Long J, Liu J, Zhou Z, Huang R, Chai Z, Wang C.Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2111051119. （中科院1区，IF=11.205）

  7. Gao P, Wang Z, Lei M, Che J, Zhang S, Zhang T, Hu Y, Shi L, Cui L, Liu J, Noda M, Peng Y, Long J*.Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease. Pharmacol Res. 2022 Jun 180:106227 （中科院I区，IF=10.334）

  8. Peng Y, Liu H, Liu J, Long J*.Post-translational modifications on mitochondrial metabolic enzymes in cancer. Free Radic Biol Med. 2022 Feb 1;179:11-23. （中科院2区，IF=7.4）

  9. Peng Y, Liu J, Wang Z, Cui C, Zhang T, Zhang S, Gao P, Hou Z, Liu H, Guo J, Zhang J, Wen Y, Wei W, Zhang L*, Liu J*, Long J*. Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Cell Death Differ. 2022 Sep 29(9):1730-1743. （中科院1区，IF=15.828）

  10. Wang X, Lv W, Xu J, Zheng A, Zeng M, Cao K, Wang X, Cui Y, Li H, Yang M, Shao Y, Zhang F, Zou X, Long J, Feng Z*, Liu J*. Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits.  Adv  Sci (Weinh). 2022 Jan 17:e2105587. （中科院1区，IF=16.806）

2021

  1. Zeng M, Xu J, Zhang Z, Zou X, Wang X, Cao K, Lv W, Cui Y, Long J, Feng Z, Liu J. Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes. Redox Biol. 2021 May;41:101948. （中科院1区，IF=9.986）

  2. Cao K, Lv W, Wang X, Dong S, Liu X, Yang T, Xu J, Zeng M, Zou X, Zhao D, Ma Q, Lin M, Long J, Zang W, Gao F, Feng Z, Liu J. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance. Adv Sci (Weinh). 2021 May 2;8(11):2004507.（IF=15.84，中科院1区）

  3. Liu R, Chen L, Wang Z, Zheng X, Hou Z, Zhao D, Long J, Liu J. Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis. J Nutr Biochem. 2021.88.（中科院2区，IF=4.873）

  4. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG Jr, Liu J, Wei W. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2021 Jan;31(1):80-93. （中科院1区，IF=20.507）

  5. Lu Z, Hu Y, Wang Y, Zhang T, Long J*, Liu J. Topological reorganizations of mitochondria isolated from rat brain after 72 hours of paradoxical sleep deprivation, revealed by electron cryo-tomography. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C17-C25（中科院2区，IF=4.25）

  6. Lu Z, Liu X, He M, Long J, Liu J. Dynamic motions and architectural changes in DNA supramolecular aggregates visualized via transmission electron microscopy without liquid cells. Nanoscale. 2021 Sep 15. （中科院1区，IF=6.895）
  7. Noda M, Liu J, Long J. Neuroprotective and preventative effects of molecular hydrogen. Curr Pharm Des. 2021 27(5) 585-591.（中科院3区，IF=2.208）

  8. Zhang T, Zhang S, Peng Y*, Wang Y, Gao P, Hu Y, Wang Z, Noda M, Hiramatsu M, Liu J, Long J*. Safflower leaf ameliorates cognitive impairment through moderating excessive astrocyte activation in APP/PS1 mice. Food Funct. 2021;12(22):11704-11716.（中科院1区，IF=5.396）

  9. Cui Y, Xiong Y, Li H, Zeng M, Wang Y, Li Y, Zou X, Lv W, Gao J, Cao R, Meng L, Long J, Liu J, Feng Z. Chalcone derived Nrf2 activator protects cognitive function via maintaining neuronal redox status. Antioxidants （Basel）. 2021, 10(11): 1811.（中科院2区，IF= 6.313）

  10. Lu Z, Hu Y, Wang Y, Zhang T, Long J*, Liu J. Topological reorganizations of mitochondria isolated from rat brain after 72 hours of paradoxical sleep deprivation, revealed by electron cryo-tomography. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C17-C25. （中科院2区，IF=4.25）

2020

  1. Shi L, Du D, Peng Y, Liu J*, Long J*. The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer. Oncogenesis. 2020 Oct 31;9(10):98.（中科院2区，IF=6.119）
  2. Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, Wang Y, Liu J*, Long J*. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020 Dec;14(12):3169-3183. （中科院2区，IF=6.574）
  3. Qin C, Hu S, Zhang S, Zhao D, Wang Y, Li H, Peng Y, Shi L, Xu X, Wang C, Liu J, Cheng Y*, Long J*. Hydroxytyrosol Acetate Improves the Cognitive Function of APP/PS1 Transgenic Mice in ERβ-dependent Manner. Mol Nutr Food Res. 2020 Dec 9:e2000797. （中科院1区，IF=5.309）
  4. Liu J, Peng Y, Zhang J, Long J, Liu J, Wei W. Targeting SCF E3 Ligases for Cancer Therapies. Adv Exp Med Biol. 2020 217:123-146. （中科院3区，IF=2.450）
  5. Liu R, Chen L, Wang Z, Zheng X, Hou Z, Zhao D, Long J, Liu J. Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis. J Nutr Biochem. 2020 Sep 19;88:108503. 
  6. Wang XP, Xing CY, Zhang JX, Zhou JH, Li YC, Yang HY, Zhang PF, Zhang W, Huang Y, Long J, Gao F, Zhang X, Li J. Time-restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling. FASEB J. 2020 Nov 34(11):15180-15196. 

  7. Peng Y,Gao P,Shi L,Chen L,Liu J,Long J*. Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention. Antioxid Redox Signal. 2020 32(16):1188-1236.  (comprehensive invited review)IF=7

  8. Liu J, Peng Y, Zhang J, Long J*, Liu J, Wei W.  Targeting SCF E3 Ligases for Cancer Therapies. Adv Exp Med Biol. 2020, 1217:123-146. IF=2.450
  9. Liu R, Chen L, Wang Z, Zheng X, Wang Y, Li H, Noda Mami, Liu J, Long J*. Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice. Free Radic Biol Med. 2020 Feb 20;148:42-51. IF=6.170
  10. Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, Wang Y, Liu J, Long J*. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020 14(12): 3169-3183. IF=6.574.
  11. Shi L, Du D, Peng Y, Liu J*, Long J*. The functional analysis of Cullin7 E3 ubiquitin ligases in cancer. Oncogenesis. 2020 9(10): 98. IF=7.845.

2019

  1. Zhao D, Zhang S, Wang X, Gao D, Liu J, Cao K, Chen L, Liu R, Liu J, Long J*.  ATG7 regulates hepatic Akt phosphorylation through the c-JUN/PTEN pathway in high fat diet-induced metabolic disorder. FASEB J. 2019 Dec 33(12):14296-14306. IF=4.966

2018

  1. Wang D, Meng L, Fei Z, Hou C, Long J*, Zeng L, Dyson Paul J, Huang P. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity. Nanoscale. 2018 10(18).  IF=6.895
  2. Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018 25(2): 229. IF=8.339
  3. Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L, Long J*, Chao H*. A mitochondria-targeting hetero-binuclear Ir (III)-Pt (II) complex induces necrosis in cisplatin-resistant tumor cells. Chem Commun (Camb). 2018 Jun 14; 54(49):6268-6271. IF=6.319
  4. Hou C, Peng Y, Qin C, Fan F, Liu J, Long J*. Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance. Free Radic Res. 2018 Dec 52（11-12):1311-1312. IF=3.18
  5. Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J. Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms. Free Radical Res. 2018 Dec 52(11-12):1256-1265. IF=3.18

2017

  1. Hou C, Wang Y, Liu J, Wang C, Long J*. Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Front Mol Neurosci. 2017 Mar 21;10:66. IF 5.154
  2. Xie Z, Long J, Liu J, Chai Z, Kang X, Wang C. Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons. Front Mol Neurosci. 2017 Mar 13;10-47. IF 5.154
  3. Qing Y, Tian Z, Bi Y, Wang Y, Long J, Song CX, Diao J. Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine. Bioessays. 2017 May 39(5). IF 4.725
  4. Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y*, Long J*. A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res. 2017 Mar 61(3). IF 4.551
  5. Shi L, Zhao D, Hou C, Peng Y, Liu J, Zhang S, Liu J, Long J*. Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65. Neurobiol Aging. 2017 Aug 56:115-126. IF 5.117
  6.  Lu Z, Li H, Hou C, Peng Y, Long J, Liu J. Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells. Eur Biophys J. 2017 Jul 46(5):415-424. IF 1.444
  7. Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y, Long J*. A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res. 2017 Mar 1(3). IF 4.55.

2016

  1. Wang Y, Li L, Hou C, Lai Y, Long J, Liu J, Zhong Q, Diao J. SNARE-mediated membrane fusion in autophagy. Semin Cell Dev Biol. 2016 Dec;60:97-104. IF 5.181
  2. Peng Y, Hou C, Yang Z, Li C, Jia L, Liu J, Tang Y, Shi L, Li Y, Long J, Liu J. Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 2016 Nov 0(11):2331-2342. IF 4.551
  3. Yan C, Sun W, Wang X, Long J, Liu X, Feng Z, Liu J. Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res. 2016 May 60(5):1139-1149. IF 3.842
  4. Hu R, Diao J, Li J, Tang Z, Li X, Leitz J, Long J, Liu J, Yu D, Zhao Q. Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep. 2016 Feb 11;6:20776. IF 5.228
  5. Wang P, Jia L, Chen B, Zhang L, Liu J, Long J, Li Y. Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock. 2016 Sep 6(3):312-318. IF 3.048
  6. Huang H, Yang L, Zhang P, Qiu K, Huang J, Chen Y, Diao J, Liu J, Ji L, Long J*, Chao H*. Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials. 2016 83: 321-331. IF 8.387
  7. Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, Qiu Y, Shen H, Sun X, Feng Z, Liu J, Long J*. Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol. 2016 Mar 1;103:85-97. IF 5.091
  8. Liu J, Peng Y, Wang X, Fan Y, Qin C, Shi L, Tang Y, Cao K, Li H, Long J, Liu J. Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm. 2016 Jan 4;13(1):73-84.  IF 4.384
  9. Tang Y, Peng Y, Liu J, Shi L, Wang Y, Long J, Liu J. Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer's disease. J Neurochem. 2016 Feb136(4):791-803. IF 4.281

2015

  1. Tang Y, Liu J, Long J*. Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig. 2015 3, 250-255. IF 1.8
  2. Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng Z. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr. 2015 111667-11176. IF 3.453
  3. Sun L, Liu T, Li H, Yang L, Meng L, Lu Q, Long J. Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces. 2015 8, 4990-4997. IF 6.723

2014

  1. Luo C, Li Y, Yang L, Zheng Y, Long J*, Jia J, Xiao S, Liu J. Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine. 2014 9,4763-4772. IF 4.383
  2. Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, Chen C, Luo C, Li Y, Gao J, Pang W, Zhao J, Zhao F, Li H, Zheng A, Sun W, Long J, Szeto IM, Zhao Y, Dong Z, Zhang P, Wang J, Lu W, Zhang Y, Liu J, Feng Z. Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014 Oct 10 21(11):1557-1570. IF 7.67
  3. Zhao L, Zou X, Feng Z, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F, Liu J. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol. 2014 Aug 56:3-12. IF 3.53
  4. Tang Y, Mi C, Liu J, Gao F, Long J. Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol. 2014 Mar-Apr 23(2):101-106. IF 2.4
  5. Peng Y, Liu J, Tang Y, Liu J, Han T, Han S, Li H, Hou C, Liu J, Long J. High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci. 2014 Aug 8;8:225. IF 4.18
  6. Luo C, Li Y, Zhou B, Yang L, Li H, Feng Z, Li Y, Long J, Liu J. A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis. 2014 Mar 19(3):542-553. IF 3.61
  7. Luo C, Li Y, Yang L, Zheng Y, Long J, Jia J, Xiao S, Liu J. Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine. 2014 Oct 10;9:4763-4772. IF 4.20
  8. Luo C, Li Y, Yang L, Wang X, Long J, Liu J. Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses. Arch Toxicol. 2015 Mar 89(3):357-569. IF 5.1
  9. Liu Y, Long J, Liu J. Mitochondrial free radical theory of aging: who moved my premise? Geriatr Gerontol Int. 2014 Oct 14(4):740-749. IF 1.58
  10. Liu J, Tang Y, Feng Z, Liu J, Liu J, Long J. (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki rats. Free Radic Res. 2014 Aug 48(8):898-906. IF 3.00
  11. Liu J, Tang Y, Feng Z, Hou C, Wang H, Yan J, Liu J, Shen W, Zang W, Liu J, Long J. Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism. 2014 Oct 3(10):1314-1323. IF 3.61
  12. Liu J, Peng Y, Feng Z, Shi W, Qu L, Li Y, Liu J, Long J. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med. 2014 Apr 69:116-128. IF 5.71
  13. Chen C, Han X, Zou X, Li Y, Yang L, Cao K, Xu J, Long J, Liu J, Feng Z. 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem. 2014 Jun 13;289(24):17184-17194. IF 4.6
  14. Chang L, Liu X, Liu J, Li H, Yang Y, Liu J, Guo Z, Xiao K, Zhang C, Liu J, Zhao-Wilson X, Long J. D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food. 2014 Mar 7(3):357-364. IF 2.5
  15. Cao K, Zheng A, Xu J, Li H, Liu J, Peng Y, Long J, Zou X, Li Y, Chen C, Liu J, Feng Z. AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med. 2014 Oct 75:156-166. IF 5.71
  16. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2014 Feb 7:396-407. IF 5.71

2013

  1. Luo C, Wang H, Chen X, Cui Y, Li H, Long J, Mo X, Liu J. Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae. Phytomedicine. 2013 21, 20-24. IF 3.3
  2. Luo C, Li Y, Yang L, Feng Z, Long J, Liu J. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology. 2013 14, 503-511. IF 3.2
  3. Luo C, Li Y, Wang H, Feng Z, Long J*, Liu J. Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem. 2013 114, 212-219. IF 3.4
  4. Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Wang Y, Wurtz K, Weber P, Long J*, Liu J. Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr Cancer Drug Targets. 2013 13, 625-639. IF 4.3
  5. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2013 67C, 396-407. IF 5.3
  6. Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD. A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordr). 2013 35, 23-33. IF 6.2

2012

  1. Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J*, Liu J. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem. 2012 23, 716-724. IF 4.2
  2. Long J, He P, Shen Y, Li R. New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-beta. J Alzheimers Dis. 2012 30, 545-558. IF 4.2
  3. Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X. Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine. 2012 19, 672-676. IF 3.3
  4. Long J, Aksenov V, Rollo CD, Liu J. A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mech Ageing Dev. 2012 Aug 133(8):523-9. IF 4.2
  5. Liu J, Peng Y, Long J*. The Role of Brain Mitochondrial Estrogen Receptor beta in The Pathogensis of Female Alzheimer's Disease. Progress In Biochemistry And Biophysics. 2012 785-790. IF 0.5
  6. Liu J, Peng Y, Cui Z, Wu Z, Qian A, Shang P, Qu L, Li Y, Long J*. Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading. IUBMB Life. 2012 64(11):901-10. IF 3.8

2011

  1.  Hao J, Shen W, Sun L, Long J, Sharman E, Shi X, Liu J. Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. Br J Nutr. 2011 106, 648-655. IF 3.2
  2. Gao M, Li Y, Sun Y, Shah W, Yang S, Wang Y, Long J* . Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic Clin Pharmacol Toxicol. 2011 109, 398-406. IF 2.3
  3. Gao M, Li Y, Sun Y, Long J, Kong Y, Yang S, Wang Y. A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutat Res. 2011 724, 69-75. IF 3.2
  4. Gao M, Li Y, Long J, Shah W, Fu L, Lai B, Wang Y. Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutat Res. 2011 719, 52-59. IF 3.2

2010

  1. McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R. Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J Neurosci. 2010 30, 7326-7334. IF 7.2
  2. Gao M, Long J, Li Y, Shah W, Fu L, Liu J, Wang Y. Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med. 2010 49, 1735-1745. IF 5.7
  3. Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J. Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res. 2010 35, 33-41. IF 2.7
  4. Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD. Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med (Maywood). 2010 235, 66-76. IF 2.7

2010...

  1. Long J, Ma J, Luo C, Mo X, Sun L, Zang W, Liu J. Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci. 2009 85, 276-280. IF 2.5
  2. Long J, Liu C, Sun L, Gao H, Liu J. Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res. 2009 34, 786-794. IF 2.7
  3. Long J, Gao H, Sun L, Liu J, Zhao-Wilson X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res. 2009 12, 321-331. IF 4.1
  4. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009 34, 755-763. IF 2.7
  5. Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009 13, 701-711. IF 4.6
  6. Luo C, Long J, Liu J. An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta. 2008 395, 38-41. IF 2.85
  7. Long J, Liu C, Sun L, Gao H, Liu J. Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria. Neurochem Res. 2009 34(4):786-94. IF 2.1
  8. Shen H, Zhang Y, Xu J, Long J, Qin H, Liu F, Guo J. Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res. 2007 119, 166-174. IF 1.5
  9. Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J. D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology. 2007 8, 373-381. IF 3.0
  10.  Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, Liu J. Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem. 2007 103, 2690-2700. IF 4.1
  11. Sun L, Luo C, Long J, Wei D, Liu J. Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion. 2006 6, 136-142. IF 3.7
  12. Luo C, Wang X, Long J, Liu J. An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods. 2006 68, 101-111. IF 2.2
  13.  Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Liu J. Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci. 2006 79, 1466-1472. IF 2.5
  14. Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res. 2006 83, 1584-1590. IF 2.9

 

 

  中文论文：(*通讯作者)

  1. 彭韵桦,刘莎,崔莉,刘健康,龙建纲.靶向蛋白质泛素修饰及降解在前列腺癌治疗中的机遇与挑战[J].生物化学与生物物理进展,2023,50(4):782-794．
  2. 雷梦瑶,高佩佩,龙建纲.中药有效成分对AD相关认知功能的改善作用及其机制研究进展[J].药学学报,2022,57(7):1925-1936.

  3. 樊思越,王文昊,罗宁烽,张天培,王珍,高佩佩,龙建纲.瑞香素药动学、毒理学、生物活性的研究进展[J].中成药,2022,44(02):524-528.

  4. 冯晗珂,崔玉婷,毕金淼,米捷,高月华,陈杰巃,龙建纲,李华,孔宇.UPLC-UV法分离分析橄榄叶及生物样本中的羟基酪醇[J].分析试验室,2020,39(07):800-805.

  5. 张婷华,胡亚冲,龙建纲,许小红.羟基酪醇丁酸酯的处方前研究[J].国际药学研究杂志,2020,47(04):300-303.

  6. 李斯珩,雷洲权,李晨玉,朱璇,杨韬,胡亚冲,谢振丽,刘健康,龙建纲.线粒体的温度及其检测技术[J].航天医学与医学工程,2019,32(04):364-369.

  7. 高佩佩,王珍,刘静,龙建纲.氧化苦参碱的药代动力学、毒理学及药理作用[J].中国药理学通报,2019,35(07):898-902.

  8. 王珍,高佩佩,彭韵桦,刘健康,龙建纲.阿尔茨海默病病理发生中的性别差异[J].生物化学与生物物理进展,2019,46(05):449-455.

  9. 郭谦楠,王莉,李涛,肖海,冯战启,刘红彦,候巧芳,康冰,廖世秀,龙建纲.MTRR66A>G基因多态性与410例原发性男性不育患者的相关性研究[J].重庆医学,2019,48(01):44-47+51.

  10. 张爽曦, 龙建纲, 刘健康. 胰岛素降解酶与阿尔兹海默病的发生[J]. 中国生物化学与分子生物学报, 2018.

  11. 樊璠, 龙建纲*, 刘健康. AD早期诊断的体液生物标志物[J].  生命科学研究,2017,212(4):370-376.

  12. 田芷淇, 胡亚冲, 龙建纲, 刘健康, 刁佳杰*. 单分子生物物理技术在神经递质释放研究中的应用[J].  生物化学与生物物理学进展,2016,43(10):946-951.

  13. 杨子琪, 龙建纲*, 刘健康. 羟基酪醇的生物学活性及其代谢特征[J].  中国药理学报,2016,32(9):1189-1193.

  14. 李彩霞, 胡亚冲, 龙建纲*, 刘健康. 线粒体DNA甲基化研究进展[J].  中国科学：生命科学,2016,46(7):880-885.

  15. 龙建纲, 刘健康. 线粒体营养素[J].  肿瘤代谢与营养电子杂志：专家论坛,2016,3(2):71-76.

  16. 罗成, 李艳, 龙建纲*. 纳米材料模拟酶的研究进展[J].  中国科学：化学,2015,45(10):1026-1041. 

  17. 罗成, 李艳, 龙建纲*. 四氧化三铁纳米颗粒过氧化物酶样活性的应用[J]. 科学通报,2015,60(35):3478-3488.

  18. 贾丽妍, 龙建纲, 刘健康. 氢分子对心肌损伤的防护效应及机制[J]. 生物化学与生物物理进展,2015,42(8):713-720.

  19. 时乐, 龙建纲*, 刘健康. 酮体代谢与阿尔兹海默病[J]. 生物化学与生物物理进展,2015,42(4):323-328.

  20. 刘静, 龙建纲*, 刘健康. 运动与氧化还原信号调控[J].  生理科学进展,2014,04:263-266.

  21. 刘烨, 孙文艳, 龙建纲. 刘健康. S100A7的生物学特征及其与疾病的关系[J].  医学研究生学报,2014,307:767-771.

  22. 高静, 龙建纲, 刘健康. 骨质疏松症发生与防治的线粒体机制[J].  航天医学与医学工程,2013,26(006),491-494.

  23. 纪元, 龙建纲, 刘健康. 自噬发生中的ROS调节机制[J]. 中国生物化学与分子生物学报,2014,30,321-327.

  24. 刘静, 龙建纲, 刘健康. 后肢失负荷诱导的骨骼肌萎缩中线粒体功能紊乱[J].  航天医学与医学工程,2013,26(002),140-144.

  25. 王逊, 龙建纲, 刘健康. 运动和营养素的细胞内作用靶点—线粒体:阿尔茨海默病防治的新思路[J]. 体育科研,2013,34(6).

  26. 鲁卓阳, 龙建纲*, 李涤尘, 刘健康. 基于原子力显微镜的细胞弹性测量及分析方法[J].  电子显微学报,2012,31(4),54-60. 

  27. 侯晨, 龙建纲*, 刘健康. 氢医学研究及可能的线粒体机制[J]. 医学综述,2012. 

  28. 李华, 龙建纲*, 刘健康. 阿尔茨海默病(Alzheimer's disease)与动力相关蛋白1(dynamin-related protein1, Drp1)[J].  生物学杂志.2012. 

  29. 刘健康, 彭韵桦, 龙建纲. 脑内线粒体雌激素受体茁在女性阿尔茨海默病发生过程中的作用[J].  生物化学与生物物理学进展,2012,39(8):785-790.

  30. 龙建纲, 王学敏, 高宏翔, 刘志, 缪明永, 刘健康. 黄素单核苷酸对羟自由基损伤的大鼠肝线粒体复合物I的保护作用[J].  第二军医大学学报,2005,26:1136-1139.

  31. 龙建纲, 王洁, 缪明永,王学敏. 改良PCR-RFLP法测定异质性线粒体基因的相对含量[J].  第二军医大学学报,2004,25:1036-1037.

  32. 龙建纲, 张燕琴, 沈慧, 秦海宏,王福俤. 锌对断乳小鼠金属离子转运体mRNA表达的影响[J].  中国公共卫生,2004,20:772-774.

  33. 龙建纲, 张燕琴, 沈慧, 秦海宏, 王福俤,王海明.基因芯片技术筛选孕期缺锌仔鼠脑中差异表达基因[J].  营养学报,2004,26:89-93.

  34. 龙建纲, 汪振诚,王学敏. 线粒体:新的细胞内药物作用靶点[J].  中国药理学通报,2003,19:859-863.

  35. 龙建纲, 陈坚, 王福俤. 小鼠ZnT3cDNA片断的克隆及其mRNA表达[J].  卫生研究,2003,31:103-105.

  36. 龙建纲, 王福俤. 二价金属子子转运体DMT1的研究进展[J].  国外医学: 卫生学分册,2002,29:97-100.

  37. 龙建纲, 王福俤, 王海明. 锌转运体研究进展[J].  国外医学 (卫生学分册),2001,28:33-37.

  38. 刘芳, 许家军, 龙建纲, 向正华, 沈慧, 张传森,王福俤. 地高辛原位杂交显示锌转运体3mRNA在脑、脊髓和脊神经节中的分布[J].  解剖学杂志,2001,31:747-750.

  39. 韩秋成, 朱有华, 朱雄伟, 龙建纲,刘健康. SMO保存液对犬肾低温保存期间线粒体功能的保护作用[J].  中华器官移植杂志,2007,28:239-241.

  40. 张元勋, 龙建纲, 王荫淞, 李德禄, 王福俤, 沈慧, 李爱国, 张桂林, 黄宇营，何玮. 小鼠脑中Zn元素和ZnT3mRNA表达的研究[J].  中国病理生理杂志,2006,22:1784-1787.

  41. 王洁, 王学敏, 龙建纲, 于军, 汪振诚,焦炳华.人肝癌SMMC-7721细胞株部分线粒体基因表达的研究[J].  第二军医大学学报,2006,27:46-50.

  42. 孙青菊, 龙建纲, 汪振诚, 缪明永,王学敏.人胚肺二倍体成纤维细胞WI-38年轻和衰老细胞中线粒体量和mtDNA相对含量以及功能变化的比较[J].  第二军医大学学报,2006,27:1290-1294.

  43. 沈慧, 秦海宏, 龙建纲, 王福俤，郭俊生.锌对Caco2细胞ZIP4mRNA表达的影响[J].  卫生研究,2006,35:426-427.

  44. 沈慧, 秦海宏, 龙建纲, 王福俤，郭俊生.锌对Caco2细胞锌转运体mRNA表达的影响[J].  中国临床康复,2006,10:87-189

  45. 龙建纲. 衰老及相关疾病中线粒体损伤与保护机制研究[D].第二军医大学,2006.

  46. 王洁, 王学敏, 龙建纲, 汪振诚,高建国. 60C0照射后SMMC-7721细胞线粒体DNA部分非编码区断裂敏感位点初探[J]. 第二军医大学报,2005,26:615-617.

  47. 龙建纲,王学敏,高宏翔,刘志,缪明永,刘健康. 黄素单核苷酸对羟自由基损伤的大鼠肝线粒体复合物Ⅰ的保护作用[J]. 第二军医大学学报,2005,10:1136-1139.

  48. 沈慧, 秦海宏, 王福悌, 龙建纲,郭俊生. 锌铁调控蛋白4cDNA片断的获得及mRNA表达[J].  中国公共卫生,2005,21:155-156.

  49. 沈慧, 龙建纲, 王福俤, 秦海宏,郭俊生. 不同锌营养状态小鼠肾MT-1mRNA表达的观察[J].  解放军预防医学杂志,2005,23:98-298.

  50. 张燕琴, 龙建纲, 沈慧, 秦海宏,王福俤. 不同饲料锌水平对哺乳期后幼鼠大脑及睾丸组织ZnT3mRNA表达的影响[J].  第二军医大学学报,2004,25:838-841.

  51. 王洁, 龙建纲, 缪明永, 王学敏. 人线粒体DNA复制控制区与疾病和衰老的关系[J].  生命的化学,2004,24:36-38.

  52. 沈慧, 龙建纲. 金属硫蛋白-3研究进展[J].  国外医学：卫生学分册,2003,30:37-39.

 

学术专著

    《线粒体医学与健康》副主编,科学出版社,2012.8出版

 

 

学术专利

 

名称

专利类型

发明人

申请号

申请日

实审生效日

去泛素化酶OTUD6A在制备防治前列腺癌药物中的应用

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龙建纲;彭韵桦;王珍;祁红斌;刘健康

CN202110965067.9

 20210820 20210823

 化合物3-羟基-3’,4’-二羟基-丁酸苯乙酯制备方法和用途

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龙建纲;胡亚冲;王永耀;王珍;马庆庆;张豫霞;蒋庆林;许小红;张婷华;刘健康;

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3-羟基-3’,4’-二羟基-丁酸苯乙酯在制备改善主动脉内皮细胞功能药物中的应用

发明

刘健康;柳絮云;朱才悦;楼静;赵琳;龙建纲

CN201910746807.2

20190814

20191203

瑞香素在制备改善主动脉内皮细胞功能的药物中的应用

发明

龙建纲;柳絮云;刘健康

CN201910746863.6

20190814

20191206

瑞香素改善衰老相关认知能力衰退的药物应用

发明

龙建纲;高佩佩;王珍;祁红斌;熊跃;马庆庆;梁冰;刘健康

CN201910342763.7

20190426

20200717

一种增强免疫力的组合物及其制备方法和用途

发明

刘健康;曹可;彭韵桦;郑阿迪;王潇捷;龙建纲

CN201810473474.6

20180517

20180907

一种辅助降血糖组合物及其制备方法和用途

发明

刘健康;曹可;彭韵桦;郑阿迪;王潇捷;龙建纲

CN201810473995.1

20180517

20181016

基于线粒体营养素理论的缓解体力疲劳的组合物及用途

发明

刘健康;樊璠;刘静;李华;胡亚冲;祁红斌;龙建纲

CN201810256191.6

20180327

20181009

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20171229

20180518

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20160628

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20160628

20161214

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发明

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20161221

20190726（发明专利申请公布后的视为撤回）

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20140530

20141015

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发明

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20140120

20141022

20170630（发明专利申请公布后的视为撤回）

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20120517

20130612

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20190503（专利权的终止）