Basic Information


Jiangang LongPH. D.

Biology Professor

​​​​​​​Vice Dean of Graduate School, Xi’an Jiaotong University

Institute of Mitochondrial Biology and Medicine of Xi’an Jiaotong University School of Life Science and Technology

Research Interests

Mitochondrial Degeneration & Therapeutic Intervention in Aging, Neurodegenerative Diseases and Metabolic Syndromes

Contact Information

Tel:+86-29-8266 4232

Fax:+86-29-8266 5849


Web Page:​​​​​​​

 No. 28 W. Xianning Road, Xi’an 710049, China




2006     Ph.D. Biochemistry and Molecular Biology

Dept. of Chemistry and Molecular Biochemistry, Second Military Medical University and Institute for  
  Nutritional Sciences, Chinese Academy of Sciences

2002     M.S. Public Health

            Dept. of Public Health, Second Military Medical University

1996     B.S. Pharmacy

  Pharmacy school, Second Military Medical University


Working Experience

2016-          Vice Dean, Graduate School, Xi’an Jiaotong University

2014-2015  Vice Dean, School of Life Science

2011-           Professor, Xi’an Jiaotong University School of Life Science and Technology, Xi’an, China

2009- 2011  Associate Professor, Xi’an Jiaotong University School of Life Science and Technology,

2008- 2009  Postdoctoral fellow, Banner (Sun) Health Research Institute, AZ, USA

2006-2008   Postdoctoral fellow, Institute for Brain Aging and Dementia, University of California,

                    Irvine, CA, and Children’s Hospital Oakland Research Institute, CA,USA

1999-2006   Pharmacist, the 10th Hospital of PLA, Wuwei, Gansu, China ​​​​​​​



 Publication (* corresponding author)

  1. Chen Y, Hu S, Wu X, Xie Z, Wang Y, Wang B, Li X, Pei Y, Gu Y, Huang K, Huo J, Wei A, Bi C, Lu Z, Song Q, Xu H, Kang X, Shao S, Long J, Liu J, Zhou Z, Huang R, Chai Z, Wang C.Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2111051119. (中科院1区,IF=11.2)
  2. Gao P, Wang Z, Lei M, Che J, Zhang S, Zhang T, Hu Y, Shi L, Cui L, Liu J, Noda M, Peng Y, Long J*.Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease. Pharmacol Res. 2022 (中科院2区,IF=7.7)

  3. Peng Y, Liu H, Liu J, Long J*.Post-translational modifications on mitochondrial metabolic enzymes in cancer. Free Radic Biol Med. 2022 Feb 1;179:11-23. (中科院2区,IF=7.4)

  4. Peng Y, Liu J, Wang Z, Cui C, Zhang T, Zhang S, Gao P, Hou Z, Liu H, Guo J, Zhang J, Wen Y, Wei W, Zhang L*, Liu J*, Long J*. Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Cell Death and Differentiation, Epub Feb 25, 2022. (中科院1区,IF=15.8)

  5. Wang X, Lv W, Xu J, Zheng A, Zeng M, Cao K, Wang X, Cui Y, Li H, Yang M, Shao Y, Zhang F, Zou X, Long J, Feng Z*, Liu J*. Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits.  Advanced  Science 2022 Jan 17:e2105587. (中科院1区,IF=16.8)

  6. Zeng M, Xu J, Zhang Z, Zou X, Wang X, Cao K, Lv W, Cui Y, Long J, Feng Z, Liu J. Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes[J]. Redox Biology. 2021 May;41:101948. (IF=9.986,中科院1区)

  7. Cao K, Lv W, Wang X, Dong S, Liu X, Yang T, Xu J, Zeng M, Zou X, Zhao D, Ma Q, Lin M, Long J, Zang W, Gao F, Feng Z, Liu J. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance[J]. Advanced Science (Weinh). 2021 May 2;8(11):2004507.(IF=15.84,中科院1区)

  8. Run Liu, Lei Chen, Zhen Wang, Xuewei Zheng, Zhanwu Hou, Daina Zhao, Jiangang Long, Jiankang Liu*. Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis [J]. The Journal of Nutritional Biochemistry, 2021.88.(IF=4.873,中科院2区)

  9. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG Jr, Liu J, Wei W. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle[J]. Cell Research. 2021 Jan;31(1):80-93. (IF=20.507,中科院1区)

  10. Lu Z, Hu Y, Wang Y, Zhang T, Long J*, Liu J. Topological reorganizations of mitochondria isolated from rat brain after 72 hours of paradoxical sleep deprivation, revealed by electron cryo-tomography. Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C17-C25. (中科院2区,IF=4.25)
  11. Shi L, Du D, Peng Y, Liu J*, Long J*. The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer. Oncogenesis. 2020 Oct 31;9(10):98.(中科院2区,IF=6.119)
  12. Shi L, Liu J, Peng Y, Zhang J, Dai X, Zhang S, Wang Y, Liu J*, Long J*. Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission. Mol Oncol. 2020 Dec;14(12):3169-3183. (中科院2区,IF=6.574)
  13. Qin C, Hu S, Zhang S, Zhao D, Wang Y, Li H, Peng Y, Shi L, Xu X, Wang C, Liu J, Cheng Y*, Long J*. Hydroxytyrosol Acetate Improves the Cognitive Function of APP/PS1 Transgenic Mice in ERβ-dependent Manner. Mol Nutr Food Res. 2020 Dec 9:e2000797. (中科院1区,IF=5.309)
  14. Noda M, Liu J, Long J. Neuroprotective and preventative effects of molecular hydrogen. Curr Pharm Des. 2020 Oct 18. doi: 10.2174/1381612826666201019103020. Epub ahead of print. PMID: 33076798.
  15. Liu J, Peng Y, Zhang J, Long J, Liu J, Wei W. Targeting SCF E3 Ligases for Cancer Therapies. Adv Exp Med Biol. 2020;1217:123-146. doi: 10.1007/978-981-15-1025-0_9. PMID: 31898226. (中科院3区,IF=2.450)
  16. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG Jr, Liu J, Wei W. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2020 Jul 15. doi: 10.1038/s41422-020-0372-z. Epub ahead of print. Erratum in: Cell Res. 2020 (中科院1区,IF=20.507)
  17. Liu R, Chen L, Wang Z, Zheng X, Hou Z, Zhao D, Long J, Liu J. Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis. J Nutr Biochem. 2020 Sep 19;88:108503. doi: 10.1016/j.jnutbio.2020.108503. Epub ahead of print. PMID: 32956825.
  18. Wang XP, Xing CY, Zhang JX, Zhou JH, Li YC, Yang HY, Zhang PF, Zhang W, Huang Y, Long J, Gao F, Zhang X, Li J. Time-restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling. FASEB J. 2020 Nov;34(11):15180-15196. doi: 10.1096/fj.202001246RR. Epub 2020 Sep 21. PMID: 32954538.
  19. Peng Y,Gao P,Shi L,Chen L,Liu J,Long J*. Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.[J]. Antioxidants and Redox Signaling,2020,32(16).  (comprehensive invited review, IF=7,中科院2区)

  20. Liu J,Peng Y,Zhang J,Long J*,Liu J,Wei W. Targeting SCF E3 Ligases for Cancer Therapies.[J]. Advances in experimental medicine and biology,2020,1217.  IF=2.450
  21. Liu R,Chen L,Wang Z,Zheng X,Wang Y,Li H,Noda Mami,Liu J,Long J*. Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice.[J]. Free Radical Biology and Medicine,2020,148.  IF=6.170
  22. Zhao D,Zhang S,Wang X,Gao D,Liu J,Cao K,Chen L,Liu R,Liu J,Long J*. ATG7 regulates hepatic Akt phosphorylation through the c-JUN/PTEN pathway in high fat diet-induced metabolic disorder[J]. FASEB journal : official publication of the Federation of American Societies for Experimental Biology,2019,33(12).  IF=4.966
  23. Wang D,Meng L,Fei Z,Hou C,Long J*,Zeng L,Dyson Paul J,Huang P. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity.[J]. Nanoscale,2018,10(18).  IF=6.895
  24.  Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long JLi Z, Shen W, Liu J. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress [J]. Cell Death and Differentiation,2018, 25(2): 229. (IF=8.339,中科院1区)

  25.  Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L, Long J*, Chao H*. A mitochondria-targeting hetero-binuclear Ir (III)-Pt (II) complex induces necrosis in cisplatin-resistant tumor cells[J]. Chemical Communications, 2018. (IF=6.319,中科院1区)
  26.  Hou C, Peng Y, Qin C, Fan F, Liu J, Long J*. Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance[J]. Free Radical Research, 2018: 1-12. (IF=3.18,中科院3区)
  27.  Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J. Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms[J]. Free Radical Research, 2018: 1-10. (IF=3.18,中科院3区)
  28.  Hou C, Wang Y, Liu J, Wang C, Long J*.(2017)Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Front Mol Neurosci. [Epub ahead of print] IF 5.154
  29. Xie Z, Long J, Liu J, Chai Z, Kang X, Wang C. (2017)Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons. Front Mol Neurosci. [Epub ahead of print] IF 5.154
  30. Qing Y, Tian Z, Bi Y, Wang Y, Long J, Song CX, Diao J. (2017)Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine.Bioessays. [Epub ahead of print] IF 4.725
  31. Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y*, Long J*. (2017)A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res [Epub ahead of print]IF 4.551
  32. Shi L, Zhao D, Hou C, Peng Y, Liu J, Zhang S, Liu J, Long J   (2017).Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65.Neurobiol Aging. [Epub ahead of print] IF 5.117
  33. Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J.  (2017)SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.Cell Death Differ.[Epub ahead of print] IF 8.339
  34.  Lu Z, Li H, Hou C, Peng Y, Long J*, Liu J* (2017). Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells.Eur Biophys J. [Epub ahead of print] IF 1.444
  35. Chen, L., L. Liu, C. Li, C. Hu, F. Su, R. Liu, M. Zeng, D. Zhao, J. Liu, Y. Guo and J. Long* (2016). Apple pomace polysaccharides improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice." Mol Nutr Food Res. [Epub ahead of print] IF 4.551
  36.  Wang, Y., L. Li, C. Hou, Y. Lai, J. Long, J. Liu, Q. Zhong and J. Diao (2016). SNARE-mediated membrane fusion in autophagy. Semin Cell Dev Biol. 60:97-104. IF 5.181
  37. Peng, Y., C. Hou, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li, J. Long* and J. Liu* (2016). Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 60(11):2331-2342. IF 4.551
  38. Yan, C., W. Sun, X. Wang, J. Long, X. Liu, Z. Feng and J. Liu* (2016). Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res 60(5): 1139-1149. IF 4.551
  39. Peng, Y., J. Liu, L. Shi, Y. Tang, D. Gao, J. Long* and J. Liu* (2016). Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons. J Neurochem 137(5): 701-713. IF 3.842
  40. Hu, R., J. Diao, J. Li, Z. Tang, X. Li, J. Leitz, J. Long, J. Liu, D. Yu and Q. Zhao (2016). Intrinsic and membrane-facilitated alpha-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep 6: 20776. IF 5.228
  41. Wang, P., L. Jia, B. Chen, L. Zhang, J. Liu, J. Long* and Y. Li* (2016). Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock 46(3): 312-318. IF 3.048
  42. Huang, H., L. Yang, P. Zhang, K. Qiu, J. Huang, Y. Chen, J. Diao, J. Liu, L. Ji, J. Long* and H. Chao* (2016). Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials 83: 321-331. IF 8.387
  43. Hou, C., Y. Wang, E. Zhu, C. Yan, L. Zhao, X. Wang, Y. Qiu, H. Shen, X. Sun, Z. Feng, J. Liu* and J. Long* (2016). Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol 103: 85-97. IF 5.091
  44. Liu, J., Y. Peng, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li, J. Long* and J. Liu* (2016). Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm 13(1): 73-84. IF 4.384
  45. Tang Y, Peng Y, Liu J, Shi L, Wang Y, Long J*, Liu J*. (2015) Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer's disease. J Neurochem. 2015 Nov 18. doi: 10.1111/jnc.13437. [Epub ahead of print] IF 4.281
  46. Tang Y, Liu J, Long J*. (2015) Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig 3, 250-5. IF 1.8
  47. Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng Z.(2015) Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr, 111667-76. IF 3.453
  48. Sun L, Liu T, Li H, Yang L, Meng L, Lu Q, Long J.(2015) Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces 8, 4990-7.IF 6.723
  49. Luo C, Li Y, Yang L, Zheng Y, Long J, Jia J, Xiao S, Liu J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine 9,4763-72. IF 4.383
  50. Zou, X., Yan, C., Shi, Y., Cao, K., Xu, J., Wang, X., Chen, C., Luo, C., Li, Y., Gao, J., Pang, W., Zhao, J., Zhao, F., Li, H., Zheng, A., Sun, W., Long, J., Szeto, I. M., Zhao, Y., Dong, Z., Zhang, P., Wang, J., Lu, W., Zhang, Y., Liu, J., and Feng, Z. (2014) Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal 21, 1557-1570. IF 7.67
  51. Zhao, L., Zou, X., Feng, Z., Luo, C., Liu, J., Li, H., Chang, L., Wang, H., Li, Y., Long, J*., and Gao, F. (2014) Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol 56, 3-12.IF 3.53
  52. Tang, Y., Mi, C., Liu, J., Gao, F., and Long, J*. (2014) Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol 23, 101-106. IF 2.4
  53. Peng, Y., Liu, J., Tang, Y., Han, T., Han, S., Li, H., Hou, C., and Long, J*. (2014) High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AbetaPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci 8, 225. IF 4.18
  54. Luo, C., Li, Y., Zhou, B., Yang, L., Li, H., Feng, Z., Long, J., and Liu, J. (2014) A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis 19, 542-553. IF 3.61
  55.  Luo, C., Li, Y., Yang, L., Zheng, Y., Long, J., Jia, J., Xiao, S., and Liu, J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine 9, 4763-4772. IF 4.20
  56. Luo, C., Li, Y., Yang, L., Wang, X., Long, J., and Liu, J. (2014) Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses. Arch Toxicol . IF 5.1
  57. Liu, Y., Long, J., and Liu, J. (2014) Mitochondrial free radical theory of aging: who moved my premise? Geriatr Gerontol Int 14, 740-749. IF 1.58
  58. Liu, J., Tang, Y., Feng, Z., and Long, J*. (2014) (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki (GK) rats. Free Radic Res 48, 898-906. IF 3.00
  59. Liu, J., Tang, Y., Feng, Z., Hou, C., Wang, H., Yan, J., Shen, W., Zang, W., and Long, J*. (2014) Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism 63, 1314-1323. IF 3.61
  60. Liu, J., Peng, Y., Feng, Z., Shi, W., Qu, L., Li, Y., and Long, J*. (2014) Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med 69, 116-128. IF 5.71
  61. Chen, C., Han, X., Zou, X., Li, Y., Yang, L., Cao, K., Xu, J., Long, J., Liu, J., and Feng, Z. (2014) 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem 289, 17184-17194. IF 4.6
  62. Chang, L., Liu, X., Liu, J., Li, H., Yang, Y., Guo, Z., Xiao, K., Zhang, C., Zhao-Wilson, X., and Long, J*. (2014) D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food 17, 357-364. IF 2.5
  63. Cao, K., Zheng, A., Xu, J., Li, H., Liu, J., Peng, Y., Long, J., Zou, X., Li, Y., Chen, C., and Feng, Z. (2014) AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med 75, 156-166. IF 5.71
  64. Cao, K., Xu, J., Zou, X., Li, Y., Chen, C., Zheng, A., Li, H., Szeto, I. M., Shi, Y., Long, J., Liu, J., and Feng, Z. (2014) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67, 396-407. IF 5.71
  65. Luo C, Wang H, Chen X, Cui Y, Li H, Long J, Mo X, Liu J (2013) Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae. Phytomedicine 21, 20-24.IF 3.3
  66. Luo C, Li Y, Yang L, Feng Z, Long J, Liu J (2013) A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology 14, 503-511. IF 3.2
  67. Luo C, Li Y, Wang H, Feng Z, Long J*, Liu J (2013) Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem 114, 212-219. IF 3.4
  68. Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Wang Y, Wurtz K, Weber P, Long J*, Liu J (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr Cancer Drug Targets 13, 625-639. IF 4.3
  69. Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z (2013) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67C, 396-407. IF 5.3
  70. Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD (2013) A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordr) 35, 23-33. IF 6.2
  71. Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J*, Liu J (2012) Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem 23, 716-724. IF 4.2
  72. Long J, He P, Shen Y, Li R (2012) New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-beta. J Alzheimers Dis 30, 545-558. IF 4.2
  73. Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X (2012) Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine 19, 672-676. IF 3.3
  74. Long J, Aksenov V, Rollo CD, Liu J (2012) A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mech Ageing Dev. IF 4.2
  75. Liu J, Peng Y, Long J* (2012) The Role of Brain Mitochondrial Estrogen Receptor beta in The Pathogensis of Female Alzheimer's Disease. Progress In Biochemistry And Biophysics, 785-790. IF 0.5
  76.  Liu J, Peng Y, Cui Z, Wu Z, Qian A, Shang P, Qu L, Li Y, Long J* (2012) Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading. IUBMB Life. IF 3.8
  77.  Hao J, Shen W, Sun L, Long J, Sharman E, Shi X, Liu J (2011) Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. Br J Nutr 106, 648-655. IF 3.2
  78. Gao M, Li Y, Sun Y, Shah W, Yang S, Wang Y, Long J* (2011) Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic Clin Pharmacol Toxicol 109, 398-406. IF 2.3
  79. Gao M, Li Y, Sun Y, Long J, Kong Y, Yang S, Wang Y (2011) A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutat Res 724, 69-75. IF 3.2
  80. Gao M, Li Y, Long J, Shah W, Fu L, Lai B, Wang Y (2011) Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutat Res 719, 52-59. IF 3.2
  81. McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R (2010) Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J Neurosci 30, 7326-7334.(co-first)IF 7.2
  82. Gao M, Long J, Li Y, Shah W, Fu L, Liu J, Wang Y (2010) Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med 49, 1735-1745. IF 5.7
  83. Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J (2010) Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res 35, 33-41.IF 2.7
  84. Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD (2010) Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med (Maywood) 235, 66-76.IF 2.7
  85. Long J, Ma J, Luo C, Mo X, Sun L, Zang W, Liu J (2009) Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci 85, 276-280.IF 2.5
  86. Long J, Liu C, Sun L, Gao H, Liu J (2009) Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res 34, 786-794.IF 2.7
  87. Long J, Gao H, Sun L, Liu J, Zhao-Wilson X (2009) Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res 12, 321-331.IF 4.1
  88. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J (2009) Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res 34, 755-763.IF 2.7
  89. Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J (2009) Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med 13, 701-711. IF 4.6
  90. Luo C, Long J, Liu J (2008) An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta 395, 38-41. IF 2.85
  91. Long J, Liu C, Sun L, Gao H, Liu J (2008) Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria. Neurochem Res.IF 2.1
  92. Shen H, Zhang Y, Xu J, Long J, Qin H, Liu F, Guo J (2007) Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res 119, 166-174. IF 1.5
  93. Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J (2007) D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8, 373-381. IF 3.0
  94.  Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, Liu J (2007) Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem 103, 2690-2700.IF 4.1
  95. Sun L, Luo C, Long J, Wei D, Liu J (2006) Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion 6, 136-142. IF 3.7
  96.  Luo C, Wang X, Long J, Liu J (2006) An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods 68, 101-111. IF 2.2
  97.  Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Liu J (2006) Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci 79, 1466-1472. IF 2.5
  98. Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res 83, 1584-1590. IF 2.9