基本信息

 

丁健, 教授。 陕西省“千人计划”青年学者, 西安交通大学青年拔尖人才”(A类)。 

本科和硕士毕业于南京大学(生物学)。 博士毕业于美国爱荷华州立大学(生物化学)。 2010年起在美国哈佛医学院/波士顿儿童医院从事博士后研究。2014年晋升为哈佛医学院Instructor  2017年入职西安交大生命学院 研究方向为发育遗传学以及线粒体生物学。 从事科研工作以来第一作者身份在Nature Genetics(2016年影响因子 31.616)、Circulation Research (2016年影响因子 11.551等知名期刊发表多篇文章。

联系方式:电子邮箱) jiandingATmail.xjtu.edu.cn;  jianATmolbio.mgh.harvard.edu  (请将邮箱地址中AT改成@)

 欢迎有志于有兴趣从事科研工作的同学加盟!

 研究方向:

(一)线粒体与肌肉(心肌、骨骼肌)生理病理

(二)基因表达调控与组织器官发育及功能

已发表期刊论文/书刊章节:

期刊论文(*通讯作者):

Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J* (2018) Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms. Free Radical Research  In press  

Diniz G*, Huang Z-P, Liu J, Chen J, Ding J, Fonseca R, Barreto-Chaves ML, Donato J, Hu X,   Wang D-Z* (2017) Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increase energy expenditure without affecting cardiac hypertrophy. Clinical Science 131:2885-2099  (封面文章)

Ding J*, Lin Z-Q, Jiang J-M, Seidman CE, Seidman JG, Pu WT,  Wang D-Z* (2016) Preparation of rAAV9 to overexpress or knockdown genes in mouse heart. Journal of Visualized Experiments 118:e54787, doi:10.3791/54787 (*Co-corresponding author)

Ding J, Nie M, Liu J, Hu X, Ma L, Deng Z-L,  Wang D-Z* (2016) Trbp is required for differentiation and normal regeneration of skeletal muscle. PLoS ONE. 11:e0155349. doi:  10.1371/journal.pone.0155349

Ding J Wang D-Z* (2015) Mystery of Trbp, tale of a RBP in the miRNA pathway. Cell Cycle. 14:3007-3008

Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng Z-L, Pu WT, Wang D-Z* (2015) Trbp regulates heart function through miRNA-mediated Sox6 repression. Nature Genetics 47: 776-783

Huang Z-P, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng Z-L, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2015)   Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. The Journal of Clinical Investigation 125: 4122-4134

Ambrosio L*, Morriss S, Riaz A, Bailey R, Ding J,  MacIntosh GC* (2014) Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. PLoS ONE. 9:e105444. doi:10.1371/journal.pone.0105444

Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang D-Z, Li K, Wang J, Wangders RA, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK*,  Pu WT* (2014) Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine.  20:616-623

Seok H, Chen J, Kataoka M, Huang Z-P, Ding J, Yan J, Hu X, Wang D-Z* (2014) Loss of microRNA-155 protects the heart from pathological cardiac hypertrophy. Circulation Research. 114:717-729

Chen J, Huang Z-P, Seok H, Ding J, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang D-Z* (2013) miR-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circulation Research. 112:1557-1568

Ding J, Wang D-Z* (2011) “RISCing” the heart: In vivo identification of cardiac miRNA targets by RISCome. Circulation Research 108:3-5

Mckay J, Wang X, Ding J, Buss JE, Ambrosio L* (2011) H-RAS resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813:298-307

Ding J, Tchaicheeyan O, Ambrosio L* (2010) Drosophila Raf’s N-terminus contains a novel conserved region and can contribute to Torso RTK signaling. Genetics. 184:717-729 

Ding J, Shi S, Jiang B-H, Yang Y-H*, Huang J, Shen H-G, Xia K, Zhang J, Jiang X (2004) Effects of methyl jasmonate with IAA and 6-BAP on the secondary metabolism of cultured Onosma paniculatum cells. In Vitro Cellular & Developmental Biology-Plant 40:581–585    

Yang Y-H*, Huang J, Ding J (2003) Interaction between exogenous Brassinolide, IAA and BAP in secondary metabolism of cultured Onosma paniculatum cells. Plant Growth Regulation 39: 253–261  

书刊章节:

Ding J,  Wang D-Z (2013) “Role of microRNAs in cardiac hypertrophy and post-infarction remodeling” Cardiac Remodeling. “Advances in Biochemistry in Health and Disease” 5: 293-311. Springer, New York.

 

 

欢迎有志于有兴趣从事科研工作的同学加盟!

 

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