基本信息

                  

            孔光耀,教授,博士生导师 

   西安交大“青年拔尖人才支持计划” A类

           陕西省“百人计划”入选者

     国家优秀青年科学基金项目获得者

 

研究领域

白血病致病机制研究

造血干细胞研究

白血病靶向治疗

小鼠动物模型构建

临床前动物模型构建

 

联系方式

西安交通大学

生物诊断治疗国家地方联合工程研究中心

邮箱地址: konggy@xjtu.edu.cn

通讯地址: 陕西省西安市西五路157号, 710004

站点计数器
个人简介

教育及工作经历

 

2000-2007  陕西师范大学                               本硕连读(生物学基地班、生态学)

2008-2011  南开大学                                       博士(生物化学与分子生物学)

2011-2016  美国威斯康星大学麦迪逊分校    博士后(Research Associate)、副研究员(Associate Researcher)

2017-至今  西安交通大学                                教授

 

2016年入选西安交通大学青年拔尖人才支持计划A类(教授)

2017年入选陕西省第九批百人计划青年项目

2017年入选西安交大医学部首批攀登人才计划

2019年获国家优秀青年科学基金项目

 

主要学术业绩

       近年来致力于白血病领域的研究工作,利用基因工程小鼠研究Ras诱导的骨髓增殖性肿瘤(包括慢性粒单核细胞白血病和幼年型粒单核细胞白血病)的发病机制、疾病动物模型的构建及其靶向治疗等,并取得了一系列的研究成果。迄今共发表SCI论文40余篇,其中,以第一作者或通讯作者在J Clin Invest.、Blood、Leukemia、Science Advances等国际著名学术期刊上发表学术论文20余篇。并曾3次获美国血液学年会Abstract Achievement Award。

 

主持科研项目
 

国家自然科学基金青年项目 Notch信号通路在幼年型粒单核细胞白血病中细胞自主性和非细胞自主性作用的研究 2017.01-2019.12 18万 主持

国家自然科学基金面上项目 Runx1在慢性粒单核细胞白血病中的作用及其机制研究 2018.01-2021.12 50万 主持

国家自然科学基金优秀项目 骨髓异常增生/骨髓增殖性肿瘤 2020.01-2022.12 120万 主持

国家重点研发计划课题 跨器官通讯影响病理状态下造血稳态的作用和机理 2019.12-2024.11 344万 课题负责人

 

代表性论文

1. Li J, Li R, Jiang W, Sun J, Li J, Guo Y, Zhu K, Zhang C, Kong G#, Li Z#. Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway. Dig Liver Dis. 2020 (#corresponding author)

2. Zhang H, Zhang S, Zhang J, Zhou R, Nie Y, Ren S, Li J, Feng K, Ji F, Kong G#, Li Z#. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Platelets. 2019 (#corresponding author)

3. Zhu K, Li J, Li J, Sun J, Guo Y, Tian H, Li L, Zhang C, Shi M, Kong G#, Li Z#. Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019 (#corresponding author)

4. Sun J, Guo Y, Bie B, Zhu M, Tian H, Tian J, Li J, Yang Y, Ji F, Kong G#, Li Z#. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. J Cell Biochem. 2019 (#corresponding author)

5. You X, Wen Z, Chang YI, Ranheim EA, Zhou Y, Zhou L, Kong G#, Zhang J#. Systemic Notch downregulation promotes KrasG12D -induced myeloproliferative neoplasm. Br J Haematol. 2019 (#corresponding author)
6. Kong G*#, You X*, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J.#. Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019 (#corresponding author)
7. Lu Z*, Hong CC*, Kong G*, Assumpção ALFV#, Ong IM, Bresnick EH, Zhang J, Pan X. Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep. 22(6):1545-1559. 2018(*equal contribution)
8. Li Y, Jiang W, Li ZZ, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Repetitive restraint stress changes spleen immune cell subsets through glucocorticoid receptor or β-adrenergic receptor in a stage dependent manner. Biochem Biophys Res Commun. 2018 (#corresponding author)
9. Wang P, Li Z, Ren S, Li J, Yang J, Kong G#, Jiang A#, Li Z#.Spleen Regulates Hematopoietic Stem/Progenitor Cell Functions Through Regulation of EGF in Cirrhotic Hypersplenism.Dig Dis Sci.2018 (#corresponding author)
10. Li L, Wei W, Li Z, Chen H, Li Y, Jiang W, Chen W, Kong G#, Yang J#, Li Z#. The Spleen Promotes the Secretion of CCL2 and Supports an M1 Dominant Phenotype in Hepatic Macrophages During Liver Fibrosis. Cell Physiol Biochem. 2018 (#corresponding author)
11. Jiang W, Li Y, Sun J, Li L, Li JW, Zhang C, Huang C, Yang J, Kong GY#, Li ZF#. Spleen contributes to restraint stress induced changes in blood leukocytes distribution. Sci Rep. 2017 (#corresponding author)
12. Zhang J*, Kong G*, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017 (*equal contribution)
13. Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. Leukemia. 2016
14. Kong G*, Chang Y-I*, Damnernsawad A*, You X*, Du J, Ranheim E, Lee W, Ryu M, Zhou Y, Xing Y, Chang Q, Burd C, Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. Leukemia. 2016 (*equal contribution)
15. Johnson, K. D.*, Kong, G*, Gao, X., Chang, Y-I., Hewitt, K. J., Sanalkumar, R., Sanalkumar, P., Ranheim, R. A., Dewey, C. N., Zhang, J., and Bresnick, E. H. Cis-regulatory Mechanisms Governing Stem and Progenitor Cell Transitions. Science Advances. Science Advances 2015 (*equal contribution)
16. Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. The Journal of Clinical Investigation. 2014
17. Wang J*, Kong G*, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood. 2013 (*equal contribution)
18. Kong G*, Du J*, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J. Notch1 mutations target Kras G12D CD8+ cells and contribute to their leukemogenic transformation. J Biol Chem. 2013 (*equal contribution)
19. Zhang W*, Kong G*, Zhang J, Wang T, Ye L, Zhang X. MiR-520b inhibits growth of hepatoma cells by targeting cyclin D1 and MEKK2. PLoS ONE, 2012 (*equal contribution)
20. Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS ONE. 2011
21. Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Hepatitis B Virus x protein promotes proliferation of hepatoma cells via upregulation of MEKK2. Acta Pharmacologica Sinica, 2011.
 

 

 

       欢迎对肿瘤及白血病研究感兴趣的同学报考研究生!

 

 

版权所有:西安交通大学 站点设计:网络信息中心 陕ICP备05001571号 联系电话:82668579 82668902 QQ群号:496666580
欢迎您访问我们的网站,您是第 位访客
推荐分辨率1024*768以上 推荐浏览器IE7 Firefox 以上