论文期刊

Magnetic silicium hydroxyapatite nanorods for enhancing osteoblast response in vitro and biointegration in vivo




作者: Kai Li&, Fang Dai&, Ting Yan, Yang Xue, Lan Zhang*, Yong Han
发表/完成日期: 2019-04-24
期刊名称: ACS BIOMATERIALS SCIENCE & ENGINEERING
期卷:
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论文简介
Osteoblast behavior playing an important role in biointegration of Ti implant with host bone in vivo can be regulated by surface properties and magnetic field. In order to endow Ti surface with good osteogenesis activity, Si mon-substituted and Fe and Si co-substituted hydroxyapatite (HAp) nanorods were fabricated on microporous TiO2 by micro-arc oxidation (MAO) followed with hydrothermal treatment (HT). The surface properties including microstructure, micro-roughness, hydrophilicity, ion-releasing, magnetic property, cytocompatibility and biointegration of substituted HAp nanorods were observed and evaluated, together with pure HAp nanorods and MAOed TiO2 as controls. After doped with Fe, MAOed TiO2 has no changes in phase composition and micro-roughness, whereas it displays weakly ferromagnetic behavior and can enhance osteoblast differentiation in vitro and formation of new bone in vivo, compared with the undoped one. The substituted HAp nanorods adhere firmly to TiO2, and have almost the same wettability and micro-roughness but additional Si, Fe and/or Ca released into medium, compared with pure HAp nanorods. Moreover, the co-substituted HAp has a small ferromagnetic signal, while its saturation magnetization value is less than the MAOed doped with Fe. Compared to pure HA nanorods, the substituted HAp nanorods do not only improve cell proliferation and differentiation in vitro, but also enhance ability of bone integration in vivo, especially for the co-substituted one, which should be ascribed to the combined effect of microstructure, magnetic property and released ions.