论文期刊

A superparamagnetic Fe3O4-TiO2 composite coating on titanium by micro-arc oxidation for percutaneous implants




作者: Kai Li, Shiyu Liu, Yang Xue, Lan Zhang*, Yong Han
发表/完成日期: 2019-07-19
期刊名称: Journal of Materials Chemistry B
期卷:
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论文简介
Micro-magnetic field can affect cell response and the followed tissue integration of implants. Focused on the weak skin integration of percutaneous implant Ti, superparamagnetic TiO2 coatings with Fe3O4 nanoparticles (NPs) have been fabricated by micro-arc oxidization, and the induced magnetic field gradient by Fe3O4 was expected to enhance fibroblast response in vitro and bio-sealing in vivo. The surface properties of TiO2 coatings with different amount of Fe3O4 were investigated; fibroblast and Staphylococcus aureus response in vitro as well as skin integration in vivo were evaluated. The obtained results showed that with the increased amount of Fe3O4 NPs in electrotype, more Fe3O4 were incorporated in TiO2 coatings, and Fe content could reach to 4.41 Wt%. The incorporation of Fe3O4 endowed TiO2 with superparamagnetism but didn’t change the surface properties including phase composition, Ca2+ releasing, roughness and hydrophilicity. Fe3O4 NPs with a size of about 10 nm mainly distributed in the near-surface region of TiO2. With the increased amount of Fe3O4 in TiO2, magnetism property of TiO2 increased and the fibroblasts response including proliferation, phenotype and extracellular collagen secretion were improved. Compared to pure TiO2, TiO2 with 4.41 Wt% Fe reduced bacterial reproduction to about 60 %, and it prevented soft tissue recession and inflammatory reaction efficiently, showing a good integration with skin tissue. We give a potential coating which could be applied on Ti percutaneous implants.