个人信息

姓名:郭立

性别:男

国籍:中国

出生年月:1983-12-20

现任职单位:西安交通大学

现任专业技术职位:副教授

 

联系方式

西安交通大学电子与信息学部

教育部智能网络与网络安全实验室

Email:guo_li@mail.xjtu.edu.cn

Office:彭康楼105室

Tel: 029-82664961

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研究经历和兴趣

郭立副教授,博士生导师2012年在美国宾夕法尼亚州立大学植物病理与环境微生物系获得博士学位,2012-2016年在美国马萨诸塞大学生物化学与分子生物学系继续从事博士后科学研究201610月进入西安交通大学电子与信息工程学部从事教学科研工作。

主要研究方向为基因组变异和进化、植物和微生物互作、次生代谢产物合成与调控

主持国家自然科学基金面上基金、青年基金、中国博士后基金和西安交通大学基本科研业务交叉学科研究等4科研项目,参与国家重点研发项目子课题1项。

现已在Science, Nature Communications, New Phytologist, Genomics, Proteomics & Bioinformatics (GPB), Molecular Plant Pathology, Frontiers in Plant Science, IEEE Transactions on Computational Biology and Bioinformatics等多个国际权威期刊发表高水平SCI论文20篇,其中第一作者发表SCI论文9篇, 参与编写专著2部。为多个国际权威期刊担任同行审稿人20余次。参加国际国内学术会议16次,做特邀报告5次,担任国际研讨会Workshop特邀讲员2次。2019年被评为西安交通大学“十大学术新人”。现为中国植物生理学和分子生物学协会CSPB、美国植物病理学协会 APS、美国植物学家协会ASPB、美国科学发展促进会AAAS和美国人类遗传学协会ASHG成员。

教育经历

2006 to 2012     博士     美国宾夕法尼亚州立大学植物病理学 (Penn State)

                                            (Supervisor: Dr. Gretchen Kuldau)

2002 to 2006     学士     西北农林科技大学植物保护学院       

                                       

工作经历

2016/10 to present     副教授          西安交通大学

2012/03 to 2016/09    博士后          美国马萨诸塞大学生化和分子生物学系

                                                                (Supervisor: Dr. Li-Jun Ma)

发表论文和著作

1.    Guo, L#., M. Ji, and K. Ye#. (2020) Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin production and sexual reproduction in Fusarium graminearumBMC Genomics. 21:179  PDF  (#: Corresponding Author)

2.     Jia, P., X. Yang, L. Guo, B. Liu, J. Lin, H. Liang, J. Sun, C. Zhang, and K. Ye. (2020) MSIsensor-pro: fast, accurate and matched-normal-sample-free detection of microsatellite instability. Genomics, Proteomics & Bioinformatics. In Press PDF

3.     Zhang, Y., H. Yang, D. Turra, S. Zhou, D.H. Ayhan, G.A. DeIulio, L. Guo, K. Broz, N. Wiederhold, J.J. Coleman, K.O. Donnell, I. Youngster, A.J. McAdam, S. Savinov, T. Shea, S. Young, Q. Zeng, M. Rep, E. Pearlman, D.C. Schwartz, A. Di Pietro, H.C. Kistler, and L.-J. Ma. (2020) The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes. Communications Biology3(1): p. 50.  PDF

4.     Guo L., Ye K. (2019) Mapping genome variants sheds light on genetic and phenotypic differentiation in Chinese. Genomics, Proteomics & Bioinformatics. 17(3):226-228. PDF

5.   Guo L*, Winzer T*, Yang X*, Li Y*, Ning Z*, He Z, Teodor R, Lu Y, Bowser TA, Graham IA, Ye K. (2018) The opium poppy genome and morphinan production. Science. 362(6412): p. 343-347. (*Co-first author) PDF

6.    Chaisson, M.J.P., A.D. Sanders, X. Zhao, A. Malhotra*, D. Porubsky*, T. Rausch*, E.J. Gardner*, O. Rodriguez*L. Guo*, R.L. Collins*, X. Fan*, J. Wen*, R.E. Handsaker*, S. Fairley*, Z.N. Kronenberg*, X. Kong*, F. Hormozdiari*, D. Lee*, A.M. Wenger*, A. Hastie*, D. Antaki*, P. Audano, H. Brand, S. Cantsilieris, H. Cao, E. Cerveira, C. Chen, X. Chen, C.-S. Chin, Z. Chong, N.T. Chuang, C.C. Lambert, D.M. Church, L. Clarke, A. Farrell, J. Flores, T. Galeev, D. Gorkin, M. Gujral, V. Guryev, W. Haynes Heaton, J. Korlach, S. Kumar, J.Y. Kwon, J.E. Lee, J. Lee, W.-P. Lee, S.P. Lee, S. Li, P. Marks, K. Viaud-Martinez, S. Meiers, K.M. Munson, F. Navarro, B.J. Nelson, C. Nodzak, A. Noor, S. Kyriazopoulou-Panagiotopoulou, A. Pang, Y. Qiu, G. Rosanio, M. Ryan, A. Stutz, D.C.J. Spierings, A. Ward, A.E. Welch, M. Xiao, W. Xu, C. Zhang, Q. Zhu, X. Zheng-Bradley, E. Lowy, S. Yakneen, S. McCarroll, G. Jun, L. Ding, C.L. Koh, B. Ren, P. Flicek, K. Chen, M.B. Gerstein, P.-Y. Kwok, P.M. Lansdorp, G. Marth, J. Sebat, X. Shi, A. Bashir, K. Ye, S.E. Devine, M. Talkowski, R.E. Mills, T. Marschall, J.O. Korbel, E.E. Eichler, and C. Lee. (2019) Multi-platform discovery of haplotype-resolved structural variation in human genomes. Nature Communications(*Leading analyst) 10:1764 PDF 

7.     Gao S, Gold SE, Wisecaver JH, Zhang Y, Guo L, Ma LJ, Rokas A, Glenn AE. (2019). Genome-wide analysis of Fusarium verticillioides reveals potential contribution of horizontal gene transfer to the expansion of metabolism. Fungal Genetics and Biology. 128:60-73 PDF

8.     Guo L, Zhao G, Gao L, Xu JR, Kistler HC, Ma LJ. (2016) Compartmentalized gene regulatory network of a pathogenic fungus Fusarium graminearumNew Phytologist 211(2): p. 527-541. PDF 

9.     DeIulio GA, Guo L, Zhang Y, Goldberg JM, Kistler HC, Ma LJ. (2018) Kinome expansion in the Fusarium oxysporum species complex driven by accessory chromosomes. mSphere 3: e00231-18. https://doi.org/10.1128/mSphere .00231-18.  PDF

10.   Zhang Y, Guo L, Ma LJ. (2018) A Computational Protocol to Analyze Metatranscriptomic Data Capturing Fungal–Host Interactions. Wenbo Ma and Thomas Wolpert (eds.), Plant Pathogenic Fungi and Oomycetes. Methods in Molecular Biology, Vol. 1848. PDF

11.   Zhao G, Guo L, Zhang Y, Gao L, Ma LJ. (2018) Identifying TF binding motifs from partial target gene sets and its application to regulatory network inference. IEEE/ACM Transactions on Computational Biology and Bioinformatics. In Press. PDF

12.   Ye K, Guo L, Yang X, Lamijer EW, Raine K, Ning Z. (2018) Split-Read Indel and Structural Variant Calling Using PINDEL. Derek Bickhart (ed.), Copy Number Variants: Methods and ProtocolsMethods in Molecular Biology, vol. 1833. PDF 

13.   DeIuilo, GA, Guo L, Zhang Y, Goldberg J, Kistler HC, Ma LJ. (2018) Kinome expansion in the Fusarium oxysporum species complex driven by accessary chromosomes. bioRxiv doi: https://doi.org/10.1101/308064. PDF 

14.   Guo L, Breakspear A, Zhao G, Gao L, Kistler HC, Xu JR, Ma LJ. (2016) Conservation and divergence of the cyclic adenosine monophosphate–protein kinase A (cAMP–PKA) pathway in two plant-pathogenic fungi: Fusarium graminearum and F.verticillioidesMolecular Plant Pathology 17(2): 196-209. PDF

15.  Guo L, Allen KS, Deiulio GA, Zhang Y, Wick RL, Ma LJ. (2016) A de-novo-assembly-based pipeline for data mining in plant obligate parasite metatranscriptomic studies. Frontiers in Plant Science. doi: 10.3389/fpls.2016.00925 PDF

16.   Guo L, Wenner N, Kuldau GA. (2016) FvSO regulates vegetative hyphal fusion, asexual growth, fumonisin B1 production, and virulence in Fusarium verticillioidesFungal Biology 119(12): 1158-1169. PDF

17.   Wyenandt, C.A., J.E. Simon, R.M. Pyne, K. Homa, M.T. McGrath, S. Zhang, R.N. Raid, LJ. Ma, R. Wick, L. Guo, and A. Madeiras. (2015) Basil Downy Mildew (Peronospora belbahrii): Discoveries and Challenges Relative to Its Control. Phytopathology 105(7): 885-894. PDF

18.   Guo L, Blatt, A., Geiser, D., Jiménez-Gasco, M. D. M. and Kuldau, G. (2015) Mating type and spore killing characterization of Fusarium verticillioidesstrains. Mycological Progress, 14, 1-6. PDF

19.   Guo L and Ma LJ. (2014) Fusarium graminearum Genomics and Beyond. Genomics of Plant-Associated Fungi: Monocot Pathogens, eds Dean RA, Lichens-Park A, & Kole C (Springer Berlin Heidelberg), pp 103-122.  PDF

20.   Zhao G, Guo L, Ma LJ, Gao L. (2014) Inferring regulatory networks through orthologous gene mapping. 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM),Shanghai China, pp 76-83. DOI: 10.1109/BIBM.2013.673273 PDF

21.   Peng Xu, Timothy Kennell, Jr., Min Gao, Chaisson, M.J.P., A.D. Sanders, X. Zhao, A. Malhotra, D. Porubsky, T. Rausch, E.J. Gardner, O. Rodriguez, L. Guo, R.L. Collins, X. Fan, J. Wen, R.E. Handsaker, S. Fairley, Z.N. Kronenberg, X. Kong, F. Hormozdiari, D. Lee, A.M. Wenger, A. Hastie, D. Antaki, P. Audano, H. Brand, S. Cantsilieris, H. Cao, E. Cerveira, C. Chen, X. Chen, C.-S. Chin, Z. Chong, N.T. Chuang, C.C. Lambert, D.M. Church, L. Clarke, A. Farrell, J. Flores, T. Galeev, D. Gorkin, M. Gujral, V. Guryev, W. Haynes Heaton, J. Korlach, S. Kumar, J.Y. Kwon, J.E. Lee, J. Lee, W.-P. Lee, S.P. Lee, S. Li, P. Marks, K. Viaud-Martinez, S. Meiers, K.M. Munson, F. Navarro, B.J. Nelson, C. Nodzak, A. Noor, S. Kyriazopoulou-Panagiotopoulou, A. Pang, Y. Qiu, G. Rosanio, M. Ryan, A. Stutz, D.C.J. Spierings, A. Ward, A.E. Welch, M. Xiao, W. Xu, C. Zhang, Q. Zhu, X. Zheng-Bradley, E. Lowy, S. Yakneen, S. McCarroll, G. Jun, L. Ding, C.L. Koh, B. Ren, P. Flicek, K. Chen, M.B. Gerstein, P.-Y. Kwok, P.M. Lansdorp, G. Marth, J. Sebat, X. Shi, A. Bashir, K. Ye, S.E. Devine, M. Talkowski, R.E. Mills, T. Marschall, J.O. Korbel, E.E. Eichler, C. Lee, Robert P Kimberly, Zechen Chong. (2019) MRLR: unraveling high-resolution meiotic recombination by linked reads. Bioinformatics, doi: 10.1093/bioinformatics/btz503  PDF

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