基本信息

       李冬民  博士/教授/博士生导师

    西安交通大学基础医学院院长助理、生物化学与分子生物系主任;西安交通大学本科生院医学生物学系副主任;西安交通大学教学后备名师;西安交通大学医学部名师。高等学校国家级实验教学示范中心联席会首届高等学校基础医学创新创业协同育人工作组副组长;中国生物化学与分子生物学教学专业委员会委员;陕西省生物化学与分子生物学会常务理事;中国生物物理学会代谢生物学分会会员;《西安交通大学学报(医学版)》 第二届责任编委;国家及多个省市自然科学基金函评专家。20102011年在美国辛辛那提大学医学院代谢性疾病研究所公派留学。201610月,被选派加州大学伯克利分校参加“Berkeley Faculty Development Program for XJTU”项目研修。承担医学各专业本科生生物化学和分子生物学,硕士、博士研究生医学分子生物学,以及留学生本科生“Biochemistry”和留学生硕士、博士研究生“Molecular Biology”课程的教学工作。

学术成绩:主持国家自然科学4项、省部级科研项目9项(重点2项);参与7项;在HepatologyJ. Am. Chem. Soc.Free Radical Biology & Medicine等国际著名期刊发表SCI收录论文32篇;荣获2020年陕西省第十四届自然科学优秀学术论文奖-二等奖1项。  主持国家级虚拟仿真实验一流课程1门;主持部、省、校级课程建设及教学改革项目12项;主编、副主编、参编规划教材12部。指导国家级、省级及校级大学生创新训练项目19项,指导开放实验项目12项。指导大学生获第十四届全国挑战杯二等奖1项,陕西省挑战杯一等奖1项,西安交通大学腾飞杯特等奖1项、二等奖1项;个人荣获优秀指导教师称号。    

联系方式

手机:13379091389

Email:lidongm@mail.xjtu.edu.cn

个人主页:http://gr.xjtu.edu.cn/web/lidongm

 

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研究领域

主要研究方向:

(1)肥胖、非酒精性脂肪肝等代谢性疾病的发病机制及靶向治疗;

(2)糖脂代谢的表观遗传调控;

(3)肠道菌群、免疫代谢与非酒精性脂肪肝病。 

代表性论文(#共同第一作者;*通讯作者): 

  • Farooq Riaz, Qian Chen, Kaikai Lu, Ezra Kombo Osoro, Litao Wu, Lina Feng, Rong Zhao, Luyun Yang, Yimeng Zhou, Yingli He, Li Zhu, Xiaojuan Du, Muhammad Sadiq,  Xudong Yang and Dongmin Li*. Inhibition of miR-188-5p alleviates Hepatic Fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN/PI3K/AKT pathway. Journal of Cellular and Molecular Medicine(JCMM), 2021, doi.org/10.1111/jcmm.16376SCI, IF= 4.486)
  • Jing Li#, Qian Chen#, Jing Yi, Xi Lan, Kaikai Lu, Xiaojuan Du, Zizhen Guo, Yuanxu Guo, Manman Geng, Dongmin Li*and Shemin Lu*. IFN-γ Contributes to the Hepatic Inflammation in HFD-Induced Nonalcoholic Steatohepatitis by STAT1β/TLR2 Signaling Pathway. Molecular Immunologyaccepted)(SCI, IF= 3.641)
  • Kaikai Lu, Qian Chen, Mengda LiLei HeFarooq RiazTianyun Zhang and Dongmin Li*. Programmed Cell Death Factor 4 (PDCD4), a Novel Therapy Target for Metabolic Diseases besides Cancer. Free Radic Biol Med. 2020 Nov 1;159:150-163.SCI, IF= 6.17)
  • Kaiting Ning#, Kaikai Lu#, Qian Chen, Zizhen Guo, Xiaojuan Du, Farooq Riaz, Lina Feng, Yuping Fu, Chunyan Yin, Fujun Zhang, Litao Wu and Dongmin Li*.  Epigallocatechin Gallate Protects Mice against Methionine-Choline-Deficient-Diet induced Non-alcoholic Steatohepatitis by Improving Gut Microbiota to Attenuate Hepatic Injury and Regulate Metabolism. ACS Omega 2020, 5, 33, 20800–20809SCI, IF= 2.87)
  • Dong Liang, Ezra K. Osoro, Shuai Tan, Xi Lan, Wenhua Zhu, Litao Wu, Xiaojuan Du, Dongmin Li* and Shemin Lu*. Effects and Mechanisms of Autophagy Induced by Solubilized-Cholesterol in Hepatocytes: A Comparative Study Among Solvents. Cell Biochemistry and Biophysics. 2020 Sep;78(3):357-366.SCI, IF= 2.323)
  • Litao Wu, Juan Sun, Li Liu, Xiaojuan Du, Yan Liu, Xiaofei Yan, Ezra Kombo Osoro, Fujun Zhang, Lina Feng, Dong Liang, Yazhao Li, Qian Chen, Sha Sun, Lei Zhang, Xi Lan*, Dongmin Li* and Shemin Lu. Anti-toll-like receptor 2 antibody ameliorates hepatic injury, inflammation, fibrosis and steatosis in obesity-related metabolic disorder rats via regulating MAPK and NF-κB pathways. Int Immunopharmacol. 2020 Mar 6;82:106368.SCI, IF= 3.943)
  • Lan X, Wu L, Wu N, Chen Q, Li Y, Du X, Wei C, Feng L, Li Y, Osoro EK, Sun M, Ning Q, Yan X, Yang X, Li D, Lu S. Long Noncoding RNA lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through miR-130b-3p. Mol Ther-Nucleic Acids. 2019 Oct 25;18:954-965.SCI, IF= 7.032)
  • Riaz F, Li D*. Non-coding RNA associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis. Curr Gene Ther. 2019 Nov 6. 2019;19(5):305-317.SCI, IF= 2.431)
  • Sha Sun*Yuxuan YangDongmin LiJin Zhu. Large Chiral Nanotubes Self-Assembled by DNA Bricks. J. Am. Chem. Soc. 2019, 141, 50, 19524–19528SCI, IF= 14.695)
  • Yao Y#, Mao J#, Xu S, Zhao L, Long L, Chen L, Li D*, Lu S*. Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells. J Cell Physiol. 2019 Feb; 234(2):1758-1767. (SCI, IF= 3.923)
  • Yao Y, Li R, Du J, Li X, Zhao L, Long L, Li D*, Lu S*. Tumor necrosis factor-α and diabetic retinopathy: Review and meta-analysis. Clin Chim Acta. 2018 Jun 28;485:210-217.SCI, IF=2.926) 
  • Guo Y, Min Z, Jiang C, Wang W, Yan J, Xu P, Xu K, Xu J, Sun M, Zhao Y, Hussain S, Zhang R, Wang Q, Han Y, Zhang F, Zhu W, Li D, Meng L, Sun J, Lu S. Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis. Cell Death Dis. 2018 Jun 13;9 (6):699. (SCI, IF=5.638)
  • Yue Li, Xiaomeng Wang, Juan Ren, Xi Lan, Jing Li, Jing Yi, Li Liu, Yan Han, Sanqi Zhang, Dongmin Li*, Shemin Lu*. Identification and application of anti-inflammatory compounds screening system based on RAW264.7 cells stably expressing NF-κB-dependent SEAP reporter gene. BMC Pharmacol Toxicol. 2017 Jan 18;18(1):5.SCI, IF=2.228)
  • Liu L, Sun Q, Bao R, Roth M, Zhong B, Lan X, Tian J, He Q, Li D, Sun J, Yang X, Lu S. Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. Sci Rep. 2016 Feb 25; 6:21810. doi: 10.1038/srep21810. SCI, IF=5.228
  • Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D*, Lu S*. A Novel Long Non-coding RNA Lnc-HC Binds hnRNPA2B1 to Regulate Expressions of Cyp7a1 and Abca1 in Hepatocytic Cholesterol Metabolism. Hepatology 2016; 64(1):58-72.SCI, IF= 14.679)
  • Xuan Wang#, Meichen Wang#, Hongmin Li, Xi Lan, Li Liu, Jiaxi Li, Yue Li, Jing   Li, Jing Yi, Xiaojuan, Jidong Yan, Yan Han, Fujun Zhang, Min Liu, Shemin Lu, Dongmin Li*.Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptorJMol Cell Endocrinol. 2015 Nov 15;416:57-69. (SCI, IF=3.859)
  • Dongmin Li#, Xuan Wang#, Xi Lan, Yue Li, Li Liu, Jing Yi, Jing Li, Qingzhu Sun, Yili Wang, Hongmin Li, Nannan Zhong, Rikard Holmdahl and Shemin Lu*. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 ratsJ. Mol Cell Endocrinol. 2015, 402(C):1-12.SCI, IF=3.859)
  • Xi Lan#, Dongmin Li#, Bo Zhong, Juan Ren, Xuan Wang, Qingzhu Sun, Yue Li, Lee Liu, Li Liu, Shemin Lu*. Identification of Differentially Expressed Genes Related to Metabolic Syndrome Induced with High Fat Diet in E3 Rats. Experimental Biology and Medicine {Exp Biol Med (Maywood)}. 2015,240: 235–241.SCI, IF= 2.258
  • Ren J, Li D, Li Y, Lan X, Zheng J, Wang X, Ma J, Lu S. HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes. Mol Cell Endocrinol. 2013; 374(1-2): 35-45. (SCI, IF=4.039)
  • Dongmin Li#, Xuan Wang#, Wuchao Ren, Juan Ren, Xi Lan, Feimiao Wang, Hongmin Li, Fujun Zhang, Yan Han, Tianbao Song, Rikard Holmdahl, Shemin Lu, High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 ratsJ. Mol Cell Endocrinol. 2011; 344(1-2):69-80.SCI, IF=4.119)
  • Jie Ma#, Dong-Min Li#, Rui Zhang, Xu-Dong Yang, Cheng-Ge Gao, She-Min Lu, Sheng-Nan Wu, and Lei Wang. Genetic analysis of glutamate cysteine ligase modifier (GCLM) gene and schizophrenia in Han ChineseJSchizophr Res. 2010 Jun;119(1-3):273-4.SCI, IF: 4.458)
  • Dongmin Li, Wuchao Ren, Xuan Wang, Feimiao Wang, Yu Gao, Qilan Ning, Yan Han, Tianbao Song, Shemin Lu. A Modified Method using TRIzol® Reagent and Liquid Nitrogen Produces High-Quality RNA from Rat PancreasJ. Appl Biochem Biotechnol,  2009158:253-261SCI, IF= 1.687)
  • Zhang XTSong TBDu BLLi DMLi XM. Caspase-3 antisense oligodeoxynucleotides inhibit apoptosis in gamma-irradiated human leukemia HL-60 cells. Apoptosis. 200712(4):743-751SCI, IF=4.043)