Introduction

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Interest

     The major focus of our group is to unravel the molecular mechanisms that underline the processes of cell growth and differentiation relate to intestinal barrier. Intestinal bacteria could translocate into liver by portal vein in the normal circumstance and this phenomenal will increase when intestinal barrier impair and/or intestinal bacteria over growth. Our various ongoing projects relate to understanding the differentiation process in the contexts of:

1. Normal development

2. Homeostasis within the adult

3. Pathological conditions such as starvation, cancer, aging, diabetes and alcohol consumption. 

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Publications

1.     Liu Y, Zhang ZY. Serotonin receptor agonist quipazine promotes proliferation and apoptosis of human hepatocyte strain of L-02 strain. Hepatobiliary Pancreat Dis Int[J], 2009, 8(3): 278-281.

2.     Liu Y, Wang J, Yang P, et al. Delayed rearterialization unlikely leads to nonanastomotic stricture but causes temporary injury on bile duct after liver transplantation. Transpl Int[J], 2015, 28(3): 341-351.

3.     Liu Y, Li YM, Yang WB, et al. [Endovenous laser ablation versus conventional surgery for great saphenous varicose veins:meta-analysis of randomized trials]. Zhonghua yi xue za zhi[J], 2013, 93(23): 1822-1826.

4.     Liu Y, Li Y, Yang W, et al. Anti-hepatoma activity in mice of a polysaccharide from the rhizome of Anemone raddeana. Int J Biol Macromol[J], 2012, 50(3): 632-636.

5.     Liu Y, Li Y, Yang W, et al. H2 S inhibits the activation of hepatic stellate cells and downregulates the expression of urotensin II. Hepatol Res[J], 2013, 43(6): 670-678.

6.     Liu Y, Li Y, Ma J, et al. A modified Hassab's operation for portal hypertension: experience with 562 cases. J Surg Res[J], 2013, 185(1): 463-468.

7.     Zhang J, Pang Q, Song S, et al. Role of Serotonin in MODS: Deficiency of Serotonin Protects Against Zymosan-Induced Multiple Organ Failure in Mice. Shock[J], 2015, 43(3): 276-284.

8.     Wang JZ, Liu Y, Wang JL, et al. Sequential vs simultaneous revascularization in patients undergoing liver transplantation: A meta-analysis. World J Gastroenterol[J], 2015, 21(22): 7036-7046.

9.     Wang JZ, Liu Y, Wang JL, et al. Hepatic artery bridging lessens temporary ischemic injury to bile canaliculi. World J Gastroenterol[J], 2015, 21(35): 10113-10125. 

10.  Lu L, Wang J, Lu H, et al. MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARgamma expression: A rat fibrosis model study. Biochem Biophys Res Commun[J], 2015, 465(3): 387-393.

Grants

 Past

Year(s) funded

Grant title

 

Grant agency type and number Grant title

 

Role on Project (if PI, multiple PI  or site PI, total direct costs)

 

Description of the major goalsDescription of the major goals

01/2009-12/2011

Platelet derived serotonin role in activation of hepatic satellite cell

 

National Natural Science Foundation of China   30872482

 

Co-Investigator (PI: Liu Chang)

 

The major goal of the study is to seek whether the platelet derived serotonin take part in the activation of the hepatic satellite cell.

Current

Year(s) funded

Grant title

 

Grant agency type and number Grant title

 

Role on Project (if PI, multiple PI  or site PI, total direct costs)

 

Description of the major goalsDescription of the major goals

01/2013-12/2016

A ERCP automation equipment development.

 

National Natural Science Foundation of China   81270562

 

Co-Investigator (PI: Cao Gang)

 

The major goal of the study is to design and develop an automation equipment which can perform the ERCP.

01/2014-12/2016

Platelet derived serotonin role in hepatocellular carcinoma

 

Scientific Foundation of Second Affiliated Hospital, Xi’an Jiaotong University. RC(XM)201308

 

PI (¥ 30,000 - total direct costs)

 

This project seek the role of the platelet counts and platelet derived serotonin in hepatocellular carcinoma growth.

01/2015-12/2016

Chronic alcohol consumption accelerates hepatocellular carcinoma genesis  by intrahepatic translocation of intestinal bacteria

 

Natural Science Foundation of Shannxi Province of China    2015JM8389

 

PI (¥ 50,000 - total direct costs)

 

The major goal of the project is to define the role of  intestinal bacteria in alcoholic hepatocellular carcinoma genesis.

01/2017-12/2019

Chronic alcohol consumption accelerates hepatocellular carcinoma genesis via activation TLR9 mediated by the formation of NETs following intrahepatic translocation of intestinal bacteria

 

National Natural Science Foundation of China    81602401

 

PI (¥ 170,000 - total direct costs)

 

This study seek the reason why the incidence of hepatocellular carcinoma is increase during chronic alcohol consumption.

Patents

 

Innovation (date if applicable)

Patent, if any, pending or awarded /If described in print/on web, provide citation

 

Describe the influence or potential influence of the innovation on research or clinical care, including how the material is used locally (at HMS), regionally, nationally or internationally; if developed as a member of a team, describe your contribution (1-2 sentences)

A new auxiliary automatic equipment for encoscopic retrograde cholangio-pancreatography.

China Patent Application, 201010244305.9, filed November 24 2011/ http://cpquery.sipo.gov.cn

 

I, together with my colleague, designed an automatic equipment which can perfume ERCP by remote control. We only built an prototype of a machine for experiment test, but not put in to practice.  In this patent, I provide the idea.

A new auxiliary automatic equipment for percutaneous transhepatic cholangial drainage

China Patent Application, 2010102442836, filed December 29 2010/ http://cpquery.sipo.gov.cn

 

I, together with my colleague, designed an automatic equipment which can perfume PTCD by remote control. This equipment is still in development, but not put in to practice.  In this patent, I provide the idea.

A new auxiliary automatic equipment for vascular interventional technique.

China Patent Application, 201010244273.2, filed August  02 2010/ http://cpquery.sipo.gov.cn

 

I, together with my colleague, designed an automatic equipment which can perfume vascular interventional technique by remote control. This patent isn’t put into practice since less of funding support.  In this patent, I provide the idea.

A pulsatile blood pump for portal vein

China Patent Application, 201020211779.9, filed June 01 2010/ http://cpquery.sipo.gov.cn

 

This equipment which can increase the blood flow into the liver is use for the patient with portal hypertension. The equipment isn’t put in to clinical use since some deficient couldn’t be solved.

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