科研项目

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项目编号 项目名称 项目来源 起讫时间 承担角色 项目类别
No. 81371288 脑靶向PI3Kgamma抑制剂纳米缓释载体对缺血性脑卒中的保护作用研究 国家自然科学基金项目 2014-1~ 负责人 纵向项目
No. 2013KW32-04 常见肿瘤治疗方法及作用机理研究—PI3K抑制剂纳米新剂型及其靶向抗肿瘤研究 其他 2013-1~ 负责人 横向项目
No. 81172170 高肿瘤组织渗透性多功能靶向纳米载药系统的构建及其在结直肠癌治疗中的应用研究 国家自然科学基金项目 2012-1~ 负责人 纵向项目
No. 31101266 硫酸酯壳聚糖对胰岛β细胞氧化损伤的保护作用及其机制研究 国家自然科学基金项目 2012-1~ 负责人 纵向项目
20110546 3-羟基丁酸的生物活性研究 其他 2011-1~ 负责人 横向项目
No. 08143011 硫酸酯壳聚糖对氧化应激诱导胰岛细胞损伤的抑制作用及机制 其他 2011-1~ 骨干成员 纵向项目
No. 30801059 基于PHB 生物聚酯纳米微球的MHC-II 限制性肿瘤排斥抗原筛选系统的建立及其免疫活性研究 国家自然科学基金项目 2008-1~ 负责人 纵向项目
No. 200806981053 生物可降解羟基丁酸-羟基己酸共聚酯与神经干细胞生物相容性的研究 国家教育部项目 2008-1~ 负责人 横向项目
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学术论文

1.     Fan Fan, Dan Tan, Sen Shang, Xing-Juan Wu, Ji-Ping Zhao, Gan-Qiao Ran, Xiao-Yun Lu. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) Biopolyester Based Nanoparticles as NVP-BEZ235 Delivery Vehicle for Tumor Targeting Therapy. Biomacromolecules. 2019, 20, 3313-3323. 

2.     Gan-Qiao Ran, Dan Tan, Ji-Ping Zhao, Fan Fan, Qiang Zhang, Xing-Juan Wu, Xin-Lei Fang, Pei-Yao Fan, Xiao-Yun Lu. Functionalized polyhydroxyalkanoate nano-beads as a stable biocatalyst for cost-effective production of the rare sugar D-allulose. Bioresour Technol. 2019, 289:121673.

3.     Sen Shang, Lin Liu, Xing-Juan Wu, Fan Fan, Eer-Ling Hu, Lei-Lei Wang, Yan Ding, Ya-Li Zhang, Xiao-Yun Lu. Inhibition of PI3Kγ by AS605240 Protects tMCAO Mice by Attenuating Pro-Inflammatory Signaling and Cytokine Release in Reactive Astrocytes. Neuroscience. 2019, 415:107-120. 

4.     Lei-Lei Wang, Zhi-Qian Yang, Fan Fan, Shu-Hong Sun, Xing-Juan Wu, Hai-Xia Lu*, Xiao-Yun Lu*. PHBHHx Facilitated the Residence, Survival and Stemness Maintain of Transplanted Neural Stem Cells in Traumatic Brain Injury Rats. Biomacromolecules. 2019, 20(9):3294-3302. 

5.     Dan Tan1, Ji-Ping Zhao1, Gan-Qiao Ran, Xin-Liang Zhu, Yan Ding, Xiao-Yun Lu. Highly efficient biocatalytic synthesis of L-DOPA using in situ immobilized Verrucomicrobium spinosum tyrosinase on polyhydroxyalkanoate nano-granules. Appl Microbiol Biotechnol. 2019, 103(14):5663-5678.

6.     Fan Fan, Xingjuan Wu, Jiping Zhao, Ganqiao Ran, Sen Shang, Mingchuan Li, Xiaoyun Lu*: A Specific Drug Delivery System for Targeted Accumulation and Tissue Penetration in Prostate Tumors Based on Microbially Synthesized PHBHHx Biopolyester and iRGD Peptide Fused PhaP. ACS Applied Bio Materials 2018, 1(6):2041-2053.

7.     Yong Jiale, Huo Jinglan, Yang Qing, Chen Feng, Fang Yao, Wu Xingjuan, Liu Lin, Lu Xiaoyun, Zhang Jingzhou, Hou Xun: Femtosecond Laser Direct Writing of Porous Network Microstructures for Fabricating Super‐Slippery Surfaces with Excellent Liquid Repellence and Anti‐Cell Proliferation. Advanced Materials Interfaces 2018, 5(7):1701479.

8.     Shang Sen, Wang Leilei, Zhang Yali, Lu Haixia, Lu Xiaoyun*: The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome. Cellular and Molecular Neurobiology 2018, 38(8):1479-1489.

9.     Hu Erling, Du Huan, Zhu Xinliang, Wang Leilei, Shang Sen, Wu Xingjuan, Lu Haixia, Lu Xiaoyun*: Beta-hydroxybutyrate Promotes the Expression of BDNF in Hippocampal Neurons under Adequate Glucose Supply. Neuroscience 2018, 386:315-325.

10.  Fan Fan, Wang Leilei, Ouyang Zhenlin, Wen Yurong, Lu Xiaoyun*: Development and optimization of a tumor targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification. Applied Microbiology and Biotechnology 2018, 102(7):3229-3241.

11.  Ran Ganqiao, Tan Dan, Dai Weier, Zhu Xinliang, Zhao Jiping, Ma Qi, Lu Xiaoyun*: Immobilization of alkaline polygalacturonate lyase from Bacillus subtilis on the surface of bacterial polyhydroxyalkanoate nano-granules. Applied Microbiology and Biotechnology 2017, 101(8):3247-3258.

12.  Fan Fan, Ma Jiangang, Lu Xiaoyun*, Niu Teng, Wu Zhimin: Development of tumor targeting PHBHHx nanoparticles by PhaP mediated immobilization of EGFR-targeting peptide. Chinese Journal of Biotechnology 2017, 33(6):1-9.

13.  Ran Ganqiao, Tan Dan, Lu Xiaoyun*: Polyhydroxyalkanoate Nanoparticles: Structure, Biosynthesis, and Applications in Biotechnology and Biomedicine. Chinese Journal of Biochemistry and Molecular Biology 2016, 32(7):745-754.

14.  Zhu Xinliang, Yu Fengchao, Yang Zhu, Liu Shichang, Dai Chen, Lu Xiaoyun, Liu Chenyu, Yu Weichuan, Li Ning: In planta chemical cross‐linking and mass spectrometry analysis of protein structure and interaction in Arabidopsis. Proteomics 2016, 16(13):1915-1927.

15.  Lin Huali, Lei Ying, Zhang Bo, Dai Zunxiao, Lu Xiaoyun*: Common variants of HTR1A and SLC6A4 confer the increasing risk of Schizophrenia susceptibility: A population-based association and epistasis analysis. American Journal of Medical Genetics 2015, 168(8):749-755.

16.  Ding Yan, Peng Wenyu, Lu Shangwei, Ma Jiangang, Lu Xiaoyun*: The Application of Tumor-penetrating Peptide iRGD in Cancer Therapy. Biotechnology Frontier 2015, 4(1):15-20.

17.  Lu Xiaoyun*, Li Mingchuan, Zhu Xinliang, Fan Fan, Wang Leilei, Ma Jiangang: Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor. BMC biotechnology 2014, 14(1):4-4.

18.  Lu Haixia, Yang Zhiqian, Jiao Qian, Wang Yuanyuan, Wang Li, Yang Pengbo, Chen Xinlin, Zhang Pengbo, Wang Peng, Chen Mingxia, Lu Xiaoyun*, Liu Yong*: Low concentration of serum helps to maintain the characteristics of NSCs/NPCs on alkali-treated PHBHHx film in vitro. Neurological Research 2014, 36(3):207-214.

19.  Dang Wei, Zhang Qian, Zhu Yongsheng, Lu Xiaoyun*: The Evidence for the Contribution of the Autism Susceptibility Candidate 2 (AUTS2) Gene in Heroin Dependence Susceptibility. Journal of Molecular Neuroscience 2014, 54(4):811-819.

20.  Fan Fan, Lu Xiaoyun*, Ma Jiangang: Phosphatidylinositol 3-Kinase γ/δ in Inflammatory Diseases. Chinese Journal of Biochemistry and Molecular Biology 2014, 30(10):963-972.

21.  Fan Fan, Lu Xiaoyun*, Ren Kai, Ma Jiangang: Entrapment and sustained release of hydrophobic drugs from PHBHHx-PEG NPs. Chinese Journal of Biomedical Engineering 2014, 23(2):66-73.

22.  Zhang Junyu, Cao Qian, Li Shaowu, Lu Xiaoyun, Zhao Yongxi, Guan Jisong, Chen Jinchun, Wu Qiong, Chen Guoqiang*: 3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism. Biomaterials 2013, 34(30):7552-7562.

23.  Lu Xiaoyun, Wang Leilei, Yang Zhiqian, Lu Haixia*: Strategies of polyhydroxyalkanoates modification for the medical application in neural regeneration/nerve tissue engineering. Advances in Bioscience and Biotechnology 2013, 04(06):731-740.

24.  Lu Xiaoyun, Guo Hui, Sun Lijun, Zhang Liyu, Zhang Yali*: Protective effects of sulfated chitooligosaccharides with different degrees of substitution in MIN6 cells. International Journal of Biological Macromolecules 2013, 52:92-98.

25.  Li Mingchuan, Zhang Yali, Lu Xiaoyun*, Zhu Xinliang, Chen Xu, Li Chong, Ma Xingfeng, Tang Bingtao: Application of PHBHHx nanoparticles as sustained drug release carrier for rapamycin. Journal of Xi'an Jiaotong University(Medical Sciences) 2013, 34(2):144-148.

26.  Zhang Yali, Lu Xiaoyun*, Liu Qianqian, Li Mingchuan, Yang Zhiqian, Ma Jiangang: Production and characterization of poly(3-hydroxybutyrate co -3-hydroxyhexanoate)-poly(ethylene glycol) hybird copolymer with adjustable molecular weight. Chinese Journal of Polymer Science 2012, 30(1):101-111.

27.  Lu Xiaoyun, Mo Xiaoyan, Guo Hui, Zhang Yali*: Sulfation modification and anticoagulant activity of the polysaccharides obtained from persimmon (Diospyros kaki L.) fruits. International Journal of Biological Macromolecules 2012, 51(5):1189-1195.

28.  Lu Xiaoyun, Guo Hui, Zhang Yali*: Protective effects of sulfated chitooligosaccharides against hydrogen peroxide-induced damage in MIN6 cells. International Journal of Biological Macromolecules 2012, 50(1):50-58.

29.  Li Mingchuan, Liu Qianqian, Lu Xiaoyun*, Zhang Yali, Wang Leilei: Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent. BMC biotechnology 2012, 12(1):43-43.

30.  Lu Haixia, Yang Zhiqian, Lu Xiaoyun*, Li Mingchuan, Jiao Qian, Chen Xinlin, Wang Yuanyuan, Zhang Yali: Biocompatibility of surface modified PHBHHx with rat embryonic neural stem cells. Chinese Journal of Biotechnology 2012, 28(10):1216-1226.

31.  Lu Xiaoyun*, Yang Zhiqian, Lu Haixia, Jiao Qian, Wang Yuanyuan, Feng Minjuan, Zhang Yali, Liu Yong: Effect of 3-hydroxybutyrate on the proliferation and differentiation of rat cortical neural stem cells in vitro. Journal of Xi'an Jiaotong University(Medical Sciences) 2012, 33(6):689-692.

32.  Zhang Yali, Lu Xiaoyun, Fu Zhongbin, Wang Zibao, Zhang Jianbao*: Sulphated modification of a polysaccharide obtained from fresh persimmon (Diospyros kaki L.) fruit and antioxidant activities of the sulphated derivatives. Food Chemistry 2011, 127(3):1084-1090.

33.  Sun Lijun, Zhang Jianbao, Lu Xiaoyun, Zhang Liyu, Zhang Yali*: Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves. Food and Chemical Toxicology 2011, 49(10):2689-2696.

34.  Lu Xiaoyun, Wu Daocheng, Li Zhengjun, Chen Guoqiang*: Chpater 7 - Polymer Nanoparticles. Progress in Molecular Biology and Translational Science 2011, 104:299-323.

35.  Lu Xiaoyun, Ciraolo Elisa, Stefenia Rachele, Chen Guoqiang, Zhang Yali, Hirsch Emilio*: Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines. Applied Microbiology and Biotechnology 2011, 89(5):1423-1433.

36.  Guasconi Margherita, Lu Xiaoyun*, Massarotti Alberto, Caldarelli Antonio, Ciraolo Elisa, Tron Gian Cesare, Hirsch Emilio, Sorba Giovanni, Pirali Tracey: Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors. Organic and Biomolecular Chemistry 2011, 9(11):4144-4149.

37.  Zhang Yali, Zhang Jianbao*, Mo Xiaoyan, Lu Xiaoyun, Zhang Yuning, Qin Liguo: Modification, characterization and structure-anticoagulant activity relationships of persimmon polysaccharides. Carbohydrate Polymers 2010, 82(2):515-520.

38.  Zhang Yali, Lu Xiaoyun, Zhang Yuning, Qin Liguo, Zhang Jianbao*: Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit. International Journal of Biological Macromolecules 2010, 46(1):67-71.

39.  Lu Xiaoyun*, Zhang Yali, Wang Liang: Preparation and in vitro drug-release behavior of 5-fluorouracil-loaded poly(hydroxybutyrate-co-hydroxyhexanoate) nanoparticles and microparticles. Journal of Applied Polymer Science 2010, 116(5):2944-2950.

40.  Ciraolo Elisa, Morello Fulvio, Hobbs Robin M, Wolf Frieder, Marone Romina, Iezzi Manuela, Lu Xiaoyun, Mengozzi Giulio, Altruda Fiorella, Sorba Giovanni*: Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility. Molecular Biology of the Cell 2010, 21(5):704-711.

41.  Braccini Laura, Ciraolo Elisa, Morello Fulvio, Lu Xiaoyun, Hirsch Emilio*: PI3K signaling: a crossroads of metabolic regulation. Expert Review of Endocrinology & Metabolism 2009, 4(4):349-357.

42.  Lu Xiaoyun, Zhang Wanjiao, Jian Jia, Wu Qiong, Chen Guoqiang*: Molecular cloning and functional analysis of two polyhydroxyalkanoate synthases from two strains of Aeromonas hydrophila spp. Fems Microbiology Letters 2005, 243(1):149-155.

43.  Lu Xiaoyun, Wu Qiong, Zhang Wanjiao, Zhang Guang, Chen Guoqiang*: Molecular cloning of polyhydroxyalkanoate synthesis operon from Aeromonas hydrophila and its expression in Escherichia coli. Biotechnology Progress 2004, 20(5):1332-1336.

44.  Lu Xiaoyun, Wu Qiong, Chen Guoqiang*: Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) with flexible 3-hydroxyhexanoate content in Aeromonas hydrophila CGMCC 0911. Applied Microbiology and Biotechnology 2004, 64(1):41-45.

45.  Lu Xiaoyun, Zhang Jinyu, Wu Qiong, Chen Guoqiang*: Enhanced production of poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) via manipulating the fatty acid β‐oxidation pathway in E. coli. Fems Microbiology Letters 2003, 221(1):97-101.

会议论文

1.     Wu Xingjuan, Guo Kaihong, Lu xiaoyun*: Effects of acute UWB pulse exposure on KM mouse. American Electromagnetics Symposium 2018. Santa Barbara, USA. August 26-31.

2.     Lu xiaoyun*, Guo Kaihong, Guo Jun, Xie Yanzhao: The acute UWB pulse exposure induced the temporary hyperglycaemia and hepatic injury of KM mouse. European Electromagnetics Symposium 2016. London, UK. July 11-14.

3.     Ran Ganqiao, Tan Dan, Dai Weier, Lu xiaoyun*: Immobilization of alkaline polygalacturonate lyase from bacillus subtilis on the surface of bacterial polyhydroxyalkanoate nano-granules. The 13th International Symposium on the Genetics of Industrial Microorganisms 2016. Hubei, China. October 18-21.

4.     Peng Wenyu, Ma Jiangang, Lu xiaoyun*, Xie Yanzhao: The effect of standard cell culture encironment on cellular electromagnetic effects study. ASIAEM 2015. Jeju Island, South Korea. August 2-7.

5.     Lu xiaoyun*, Li Keji, Peng Wenyu, Xie Yanzhao: An incubator combined with TEM-cell for cellular electromagnetic effects study. AMEREM 2014. New Mexico, USA. July 27-31.

6.     Lu Haixia, Lu xiaoyun*, Yang Zhiqian, Wang Yuanyuan, Jiao Qian, Wang Li, Liu Yong: Cyto-compatibility of NaOH treated PHBHHx film with rat neural stem cell. 2nd international Conference on Tissue Science and Regenerative Medicine 2013. North Carolina, USA. August 26-28.

7.     Li Mingchuan, Zhang Yali, Wang leilei, Lu xiaoyun*: Construction of a PHA-based tumor-penetrating drug delivery nano-system. International Symposium on Biopolymers 2012. Cairns, Australia. October 7-10.

8.     Lu Haixia, Yang zhiqian, Lu xiaoyun*, Jiao Qian, Chen Xinlin, Wang Yuanyuan: Biocompatibility and bioactivity of PHBHHx as supporting material for NSCs transplantation. International Symposium on Biopolymers 2012. Cairns, Australia. October 7-10.

9.     Lu xiaoyun*, Rachele Stefenia, Zhang Yali, Elisa Ciraolo, Emilio Hirsch: Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines. International Symposium on Biopolymers 2010. Stuttgart, Germany. October 3-7.

10.  Lu Haixia, Lu xiaoyun*, Yang Zhiqian, Li Mingchuan, Liu Yong: Surface modification of PHBHHx membrane and its histocompatibility with rat embryonic neural stem cells. Neurobiology annual meeting 2011. Henan, China. July 8-10.