78. Acid Responsive and Biologically Degradable Polyphosphazene Nanodrugs for Efficient Drug Delivery, Na Zhou,  Zhe Zhi, Daomeng Liu, Daquan Wang, Yongping Shao, Kai Yan, Lingjie Meng* and Demei Yu*, ACS Biomaterials Science & Engineering, 2020,  https://doi.org/10.1021/acsbiomaterials.0c00378

      To enhance the therapeutic effects and reduce damage to normal tissues in cancer chemotherapy, it is indispensable to develop drug delivery carriers with controllable release and well biocompatibility. In this work, an acid responsive and degradable polyphosphazene nanoparticles were synthesized by reaction of hexachlorotripolyphosphonitrile (HCCP) with 4-hydroxy-benzoic acid (4-hydroxy benzylidene) hydrazide (HBHBH) and anticancer drug doxorubicin (DOX)The controlled release of DOX could be realized based on the acid responsiveness of acylhydrazone in HBHBH. It was found that the resulting polyphosphazene nanoparticles remain stable in body's normal fluids (pH~7.4), while they were degraded and controllable release of DOX in acid environment such as tumors (pH~6.8), and lysosome and endosome (~5.0) in cancer cells. In particularly, the DOX loading ratio was fair high and could be tuned from 10.6% to 52.6% by changing the dosing ratio of DOX to HBHBH. Meanwhile, the polyphosphazene nanodrugs showed  excellent toxicity to tumor cells and reduced side effect to normal cells both in vitro and in vivo due to their enhanced  permeability and retention effect and pH sensitive degradation properties. Therefore, the constructed pH sensitive drug delivery system has great potential for cancer chemotherapy. 


77. Versatile Nanoplatforms with enhanced Photodynamic Therapy: Designs and Applications, Kai Yan, Yabin Zhang, Chenglong Mu, Qunna Xu, Xunan Jing, Daquan Wang, Dongfeng Dang, Lingjie Meng and Jianzhong Ma, Theranostics, 2020, in publishing.


       As an emerging antitumor strategy, photodynamic therapy (PDT) has attracted intensive attention for the treatment of various malignant tumors owing to its noninvasive nature and high spatial selectivity in recent years. However, the therapeutic effect is unsatisfactory on some occasions due to the presence of some unfavorable factors including nonspecific accumulation of PS towards malignant tissues, the lack of endogenous oxygen in tumors, as well as the limited light penetration depth, further hampering practical application. To circumvent these limitations and improve real utilization efficiency, various enhanced strategies have been developed and explored during the past years. In this review, we give an overview of the state-of-the-art advances progress on versatile nanoplatforms for enhanced PDT considering the enhancement from targeting or responsive, chemical and physical effect. Specifically, these effects mainly include organelle-targeting function, tumor microenvironment responsive release photosensitizers (PS), self-sufficient O2 (affinity oxygen and generating oxygen), photocatalytic water splitting, X-rays light stimulate, surface plasmon resonance enhancement, and the improvement by resonance energy transfer. When utilizing these strategies to improve the therapeutic effect, the advantages and limitations are addressed. Finally, the challenges and prospective will be discussed and demonstrated for the future development of advanced PDT with enhanced efficacy.


76. Cui Yuting, Li Yuan, Huang Na, Xiong Yue, Cao Ruijun, Meng Lingjie, Liu Jiankang*, Feng Zhihui*. Structure based  modification of chalcone analogue activates Nrf2 in the human retinal pigment epithelial cell line ARPE-19.Free Radical Biology and Medicine. 2020, 148(20): 52-59.

              Oxidative stress-induced degeneration of retinal pigment epithelial (RPE) cells is known to be a key contributor to the development of age-related macular degeneration (AMD). Activation of the nuclear factor-(erythroid-derived 2)-related factor-2 (Nrf2)-mediated cellular defense system is believed to be a valid therapeutic approach. In the present study, we designed and synthesized a novel chalcone analogue, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), as a Nrf2 activator. The potency of Tak was measured in RPE cells by the induction of the Nrf2-dependent antioxidant genes HO-1, NQO-1, GCLc, and GCLm, which were regulated through the Erk pathway. We also showed that Tak could protect RPE cells against oxidative stress-induced cell death and mitochondrial dysfunction. Furthermore, by modifying the α, β unsaturated carbonyl entity in Tak, we showed that the induction of antioxidant genes was abolished, indicating that this unique feature in Tak was responsible for the Nrf2 activation. These results suggest that Tak is a potential candidate for clinical application against AMD.


75. Wang jinkai,Wang Hongkang*,Yao Tianhao,Liu Ting,Tian Yapeng, Li Chao, Li Fang, Meng Lingjie, Cheng Yonghong.Porous N-doped carbon nanoflakes supported hybridized SnO2/Co3O4 nanocomposites as high-performance anode for lithium-ion batteries. Journal Of  Colloid and Interfaces Science. 2020,560:546-554.

      Alloy-/conversion-type metal oxides usually exhibit high theoretical lithium storage capacities but suffer from the large volume change induced electrode pulverization and the poor electric conductivity, which limit their practical applications. Hybrid/mixed metal oxides with different working mechanisms/potentials can display advantageous synergistic enhancement effect if delicate structure engineering is performed. Herein, atomically hybridized SnO2/Co3O4 nanocomposites with amorphous nature are successfully cast onto the porous N-doped carbon (denoted as NC) nanoflakes through facile pyrolysis of the tin (II) 2-ethylhexanoate (C16H30O4Sn) and cobalt (II) 2-ethylhexanoate (C16H30O4Co) mixture within NC nanoflakes in air at 300 degrees C for 1 h. The Sn/Co atomic ratio and the loading amount of SnO2/Co3O4 can be readily controlled, whose effect on lithium storage are investigated as anodes for lithium ion batteries (LIBs). Notably, SnO2/Co3O4@NC (R-Sn/(Co) = 1.25) nanoflakes exhibit the most excellent lithium storage properties, delivering a reversible capacity of 1450.3 mA h g(-1) after 300 cycles at 200 mA g(-1), which is much higher than that of the single metal oxide SnO2@NC and Co3O4@NC electrodes.


74. Duo Xi, Yanzi Xu, Ruohan Xu, Zhi Wang, Daomeng Liu, Qifei Shen, Ling Yue, Dongfeng Dang*, and Lingjie Meng*. A Facilely Synthesized Dual‐State Emission Platform for Picric Acid Detection and Latent Fingerprints Visualization. Chemistry, A Europen Journal. 2020, 26(12):2741-2748.

        To achieve a highly efficient dual‐state emission platform for picric acid (PA) detection and latent fingerprints (LFPs) visualization, flexible alkyl chains were facilely attached to the commercial organic dye, then providing target molecules of PTCA‐C4, PTCA‐C6, and PTCA‐C12. Interestingly, all these molecules exhibited impressive fluorescence characteristics with high photoluminescence quantum yields (PLQYs) of ~93.0% in dilute solution. Also, emissive features can be achieved in their solid state due to the prevented close molecular packing, especially for PTCA‐C6 with high PLQY value of 49.0%. Benefiting from its impressive fluorescence performance in both solution and aggregates, PTCA‐C6 was used as a dual‐state emission platform for PA detection and also LFPs visualization. Among them, a double‐responsive fluorescence quenching in solution was observed in the PA detection, resulting high quenching constant values ( Ksv ) and also low limit of detection values (LOD). On the other hand, PTCA‐C6‐based fingerprint powder also provided impressive performance on various substrates in terms of fluorescence intensity and resolution, thereby clearly providing the specific details in latent fingerprint. These results further demonstrated that this facilely synthesized PTCA‐C6 with efficient dual‐state emission exhibited great potentials in the real‐world applications of PA detection and latent fingerprint visualization.


73. Yanzi XuHaoke ZhangNing ZhangXiaochi WangDongfeng Dang*Xunan JingDuo XiYing HaoBen Zhong Tang* and Lingjie Meng*. Deep-Red Fluorescent Organic Nanoparticles with High Brightness and Photostability for Super-Resolution in Vitro and in Vivo Imaging Using STED Nanoscopy. ACS Advanced Materials & Interfaces. 2020,DOI: 10.1021/acsami.9b18336.


        To achieve super-resolution imaging in biological research using stimulated emission depletion (STED) nanoscopy, organic luminescent materials and their corresponding fluorescent nanoparticles with high brightness and photostability are of great significance. Herein, donor-acceptor-typed DBTBT-4C8 bearing flexible alkyl chains was developed, not only to afford deep-red emission from 600 to 800 nm but also to obtain high fluorescent brightness with the absolute photoluminescence quantum yields of 25%. After that, well-defined and monodispersed spherical nanoparticles using DBTBT-4C8 with bright emission, excellent biocompatibility, and photostability, which can easily mix with amphipathic block polymers, were then produced for super-resolution in vitro and in vivo imaging using STED nanoscopy. The observations showed that in contrast to confocal microscopy with a full width at half-maximum (FWHM) value of ≈400 nm, superior resolution with a significantly improved FWHM value of only 100 nm was achieved in biomedical cell imaging, which was also used to reconstruct three-dimensional images of stained HeLa cells at an ultrahigh resolution. More importantly, by using the prepared fluorescent organic nanoparticles (FONPs) in STED nanoscopy, in vivo imaging in glass catfish with largely enhanced resolution was also successfully achieved, demonstrating that these developed deep-red FONPs here are highly suitable for super-resolution in vitro and in vivo imaging using STED nanoscopy.


72. Xunan Jing, Ning Zhang, Huanhuan Song, Yanzi Xu,Guoqing Zhou, Daquan Wang, Yongping Shao, Lingjie Meng*.  Multistage tumor microenvironment-responsive theranostic nanopeanuts: Toward multimode imaging guided chemo-photodynamic therapy. Chemical Engineering Journal. 2020,385,123893.

           It is of great importance to develop tumor microenvironment (TME) responsive and adjustable theranostic nano-systems for specific and efficient cancer treatment. However, carrier-based nanomedicines are often inefficacious in vivo due to low drug-loading efficiency, lack of synergistic effects, poor targeting specificity and limited drug accumulation in tumor tissues. Herein, we report a new multimodal theranostic nanoplatform which is assembled from Fe3O4 nanoclusters, MnO2 nanosheets with multifunctional and cross-linked polyphosphazene. This peanut-like nanoplatform exhibited enhanced chemo/photodynamic therapy (CT/PDT) effect as well as significant tumor-targeting capacity. In addition, Fe3O4cores and MnO2 nanoshells enables T1/T2 magnetic resonance imaging (MRI) of tumor tissues, while photosensitizer methylene blue (MB) allows for fluorescence imaging and PDT simultaneously. Importantly, nanopeanut agents could dual-regulate intracellular oxygen and glutathione (GSH) levels in TME by MnO2 shells, to relieve hypoxic condition and produce enough ROS to induce cell apoptosis. Our research demonstrated that the multistage TME-responsive nanoplatform is ideally suitable for tumor specific drug delivery and real-time disease tracking with enhanced theranostic properties.




71. Dongfeng Dang*, Haoke Zhang, Yanzi Xu, Ruohan Xu, Zhi Wang, Ryan T. K. , KwokJacky, W. Y. Lam, Lei Zhang, Lingjie Meng*, BenZhong Tang*. Super-Resolution Visualization of Self-Assembling Helical Fibers Using Aggregation-Induced Emission Luminogens in Stimulated Emission Depletion Nanoscopy. ACS Nano, 2019,13(10):11863-11873.

         Organic fluorophores for stimulated emission depletion (STED) nanoscopy usually suffer from quenched emission in the aggregate state and inferior photostability, which largely limit their application in real-time, in situ, and long-term imaging at an ultrahigh resolution. Herein, an aggregation-induced emission (AIE) luminogen of DP-TBT with bright emission in solid state (photoluminescence quantum yields = 25%) and excellent photostability was designed to meet the requirements in STED nanoscopy. In addition to its excellent fluorescence properties, DP-TBT could also easily form self-assembling helixes and finally be well-visualized by super-resolution STED nanoscopy. The observations showed that helical fibers of DP-TBT as dashed lines had a much decreased fiber width with also a full width at half-maximum value of only 178 nm, which is ∼6 times higher than solid lines obtained by confocal microscopy (1154 nm). The STED nanoscopic data were also used to reconstruct 3D images of assembled helixes. Finally, by long-term tracking and dynamic monitoring, the formation and growth of helical fibers by DP-TBT in self-assembly processes were successfully obtained. These findings imply that highly emissive AIEgens with good photostability are highly suitable for real-time, in situ, and dynamic imaging at super-resolution using STED nanoscopy.


70.Jianhui Li, Wei Wei*, Lingjie Meng*. Liquid-phase exfoliated-graphene-supporting nanostructural sulfur as high-performance lithium–sulfur batteries cathode. Composites Communications. 2019,15,149-154.

     Lithium-sulfur (Li–S) batteries with high energy density are promising candidates to satisfy emerging energystorage demands. Nevertheless, the poor conductivity of sulfur and fast capacity decay of the sulfur-based electrodes restrict its practical applications. Here, we report a facile and simple titration method to synthesize nano-sulfur@liquid-phase exfoliated graphene (Nano-S@LEGr) composites by in situ growth of nanostructural sulfur on the LEGr surface. The as-prepared Nano-S@LEGr with tunable sulfur morphologies exhibited excellent electrochemical performance as the cathode material for Li–S batteries. In particular, the spherical Nano-S@LEGr composites with 68 wt% sulfur displayed a reversible capacity of 552.8 mAh g−1 after 100 cycles at a current density of 0.5C. Even at a high current density of 1C, a discharge capacity of 532.8 mAh g−1 could be delivered. Compared to rod-like Nano-S@LEGr and the graphene oxide derived cathode, the as-prepared spherical Nano-S@LEGr showed higher specific capacity, superior cycling stability and rate capability.


69.Xunan Jing, Yanzi Xu, Daomeng Liu,Youshen Wu,Na Zhou, Daquan Wang,Kai Yan  and  Lingjie Meng*. Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform.Nanoscale, 2019,11(33):15508-15518.

      Although the collaborative therapy of chemotherapy (CT) and photodynamic therapy (PDT) is much more efficient for tumor treatment than monotherapies, premature leakage of drugs from nanocarriers and hypoxia in the tumor microenvironment (TME) result in systemic toxicity and suboptimal therapy efficiency. To overcome these limitations, we developed an intelligent nanoflower composite (termed FHCPC@MnO2) by coating functionalized polyphosphazene on superparamagnetic Fe3O4 nanoclusters and then growing MnO2 nanosheets as an outer shell. The FHCPC@MnO2 nanoflowers with multistage H2O2/pH/GSH-responsive properties could fully exploit TME characteristics, including supernormal glutathione (GSH) levels, low pH and high H2O2, to realize the specific release of drugs in tumors and maximum synergetic therapeutic effects. The MnO2 nanosheets can elevate O2 concentration by catalytic decomposition of H2O2 and can be simultaneously reduced to Mn2+ by overexpressed GSH in the acidic TME. Meanwhile, the inner polyphosphazene containing (bis-(4-hydroxyphenyl)-disulfide) is GSH- and pH-sensitively biodegradable to release the anticancer drug curcumin (CUR) and photosensitizer chlorin e6 (Ce6) in the TME. Therefore, the “triple-responsive” and synergetic strategy simultaneously endows the nanoflowers with specific drug release, relieving hypoxia and the antioxidant capability of the tumor and achieving significant optimization of CT and PDT. In addition, the resulting Mn2+ ions and Fe3O4 core enable in vivo T1/T2 magnetic resonance imaging (MRI), while the released Ce6 can simultaneously provide a fluorescence imaging (FL) function. Unsurprisingly, the intelligent nanoflowers exhibited remarkable multimodal theranostic performance both in vitro and in vivo, suggesting their great potential for precision medicine.


68.Fei Wang, Jing Liu,Daquan Wang,Zhiwei Yang, Kai Yan and  Lingjie Meng*. One-step synthesis of cross-linked and hollow microporous organic-inorganic hybrid nanoreactors for selective redox reactions .Nanoscale, 2019,11(33):15017-15022. 

      Hollow microporous nanostructures (HMNs) are powerful platforms for multiple promising applications, including energy storage, drug/gene delivery, nanoreactors/catalysis, adsorption, and separation. Herein, we report a facile one-step method to synthesize highly cross-linked organic–inorganic hybrid poly(cyclotriphosphazene-co-4,4′-sulfonyldiphenol) (PZS) HMNs via a salt-induced liquid–liquid separation process. The size of inner cavities can be properly tuned by modulating the concentration of the NaOH solution. The regulation mechanism of the PZS HMNs was further confirmed by encapsulating water-dispersed Pt nanoclusters into the cavities. Interestingly, the resulting yolk–shell Pt@PZS serves as nanoreactors and exhibits excellent substrate selectivity and recyclability for the catalytic oxidation of 1,3,5-trimethylbenzene.


67.Zhiwei Yang, Yizhen Zhao, Dongxiao Hao, Shunlin Ren, Xiaohui Yuan, Lingjie Meng, Shengli Zhang.Bindings of PPARγ ligand-binding domain with 5-cholesten-3β, 25-diol, 3-sulfate: accurate prediction by molecular simulation.Journal of Biomolecular Structure and Dynamics. 2019,doi.org/10.1080/07391102.2019.1577175.

             Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been identified as an attractive target for atherosclerosis intervention. Given potential relevance of 5-cholesten-3β, 25-diol, 3-sulphate (CHOS) and PPARγ, an integrated docking method was used to study their interaction mechanisms, with the full considerations to distinct CHOS conformations and dynamic ensembles of PPARγligand-binding domain (PPARγ-LBD). The results revealed that this novel platform is satisfactory to the accurate determination of binding profiles, and the binding pattern of CHOS is rather similar as those of current PPARγ full/partial agonists. CHOS contributes to the stabilization of the AF2 and β-sheet surfaces of PPARγ-LBD and promotes the configuration adjustment of Ω loop, in order to inhibit the Cdk5-mediated PPARγ phosphorylation. Nonetheless, there are clear differences in term of occupation of full or partial agonist-like binding models. The energetic and geometric analyses further revealed that CHOS may be fond of partial agonist-like binding, and its sulfonic group and carbon skeleton are helpful for the binding process. We hope that the results will aid our understanding of recognitions involving CHOS with PPARγ-LBD and warrant the further aspects to pharmacological experiments.


66.Jianhui Li, Shaobo Han, Chgenyu Zhang, Wei Wei*, Meng Gu*, Lingjie Meng*. High-Performance and Reactivation Characteristics of High-Quality, Graphene-Supported SnS2 Heterojunctions for a Lithium-Ion Battery Anode. ACS Applied Materials & Interfaces 2019, 11, 22314-22322.(IF=8.097)

      SnS2 has received tremendous attention as an anode material for lithium-ion batteries owing to its high theoretical capacity and low cost. However, its applications are limited by its inferior cycling stability and poor rate performance. In this study, graphene@SnS2 heterojunction nanocomposites are synthesized using a microwave-assisted solvothermal approach on liquid-phase exfoliated graphene (LEGr). Compared with graphene oxides, LEGr layers with an intrinsic atomic structure show extraordinary conductivity and serve as robust substrates for in situ growth of SnS2 with improved interfacial contact. A LEGr-derived SnS2 hybrid shows remarkable storage capacity, superior rate capability, and excellent cycling stability. The storage capacity remains at 664 mAh g–1 after 200 cycles at 300 mA g–1 current density. Furthermore, lithiation-induced reactivation of LEGr-based SnS2 is investigated using in situ transmission electron microscopy, giving an in-depth explanation of the electrochemical reaction mechanisms.


65.Xunan Jing, Zhe Zhi, Liming Jin, Fei Wang, Youshen Wu, Daquan Wang, Kai Yan, Yongping Shao and Lingjie Meng*.  pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy. Nanoscale. 2019, 19(11):9457-9467 .(IF=7.233)

          Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy. We report herein a simple and effective approach to directly assemble an anticancer drug (curcumin), a photodynamic agent (Ce6) and tumor environment-sensitive molecules into cross-linked polyphosphazene and coat on superparamagnetic Fe3O4 nanoclusters to form discrete nanoparticles (termed as FHCPCe NPs). FHCPCe NPs have high physiological stability and good biocompatibility, and can enhance accumulation in tumor tissue via the enhanced permeability and retention effect. Meanwhile, the FHCPCe NPs exhibit an effective performance of dual-modality magnetic resonance imaging (MRI) due to the Fe3O4 cores and fluorescence imaging (FL) in the xenografted HeLa tumor because of the fluorescence of Ce6. Importantly, under the conditions of supernormal glutathione levels and acidic microenvironment in tumor tissue, curcumin and Ce6 can be effectively released by the degradation of FHCPCe NPs. Therefore, excellent anti-tumor effects both in vitro and in vivo have been achieved by synergistic chemotherapy/photodynamic therapy (CT/PDT) using multifunctional NPs. Our study highlights the promise of developing multifunctional nanomaterials for accurate multimodal imaging-guided highly sensitive therapy of cancer.


64.Jianhui Li, Hongkang Wang, Wei Wei*, Lingjie Meng*. Advanced MoS2 and graphene heterostructures as high-performance anode for sodium-ion batteries. Nanotechnology. 2019, 30(10):104003.(IF=3.404)


           Layer-structured MoS2 is a promising anode material for sodium-ion batteries (SIBs) because of its high storage capacity, abundance in nature, and cost-effectiveness. However, the use of MoS2 is limited by its low electronic conductivity, inferior cycling stability, and poor rate capability. To overcome these drawbacks, liquid-phase exfoliated graphene (LEGr) was used as the support, for which MoS2@LEGr heterostructures with a tunable loading amount of MoS2 were fabricated by a microwave-assisted solvothermal method. LEGr with its exceptional atomic structure not only serves as a robust structural support of MoS2 but also provides rapid electrical and ionic transfer pathways of the electrode material. When MoS2@LEGr heterostructures were applied for SIB anodes, the heterostructures exhibited a considerably enhanced sodium storage performance compared to pure MoS2, including higher sodium storage capacity as well as superior cycling stability and rate capability.




63.Jianhui Li, Haiting Yan, Wei Wei, Lingjie Meng*.  Microwave-assisted mass synthesis of Mo1−xWxS2 alloy composites with a tunable lithium storage property. Dalton Transction. 2018, p1-3.(IF=4.099)

     Mo1−xWxS2 (0 ≤ x ≤ 1) alloyed nanomaterials were successfully synthesized by a facile but high-efficiency one-pot microwave-assisted solvothermal method, and the relationship between structure of Mo1−xWxS2 and their properties such as characteristic Raman scattering, electronic conductivity and lithium storage properties are investigated as well.


62. Jianhui Li, Haiting Yan, Wei Wei, Lingjie Meng*.  Salt and water co-assisted exfoliation of graphite in organic solvent for efficient and large scale production of high-quality graphene. Journal of Colloid and Interface Science, 2018, P92-99. (IF=5.091)



      Graphene has attracted enormous attention due to its unique physical properties and attractive applications in many fields. However, it is an ongoing challenge to develop a facile and low-cost method for the large scale preparation of high-quality graphene (HQGr). In this work, we have developed an improved liquid-phase exfoliation method to mass produce HQGr. This method is quite simple but efficient by exfoliation of graphite in organic solvent with the co-assistance of sodium citrate and water. Remarkably, the concentration of as-exfoliated HQGr was as high as 0.71 mg/mL under optimal conditions, while the oxygen content in HQGr was only 2.39%. After annealing at 500 °C for 2 h in argon atmosphere, the mean conductivity of annealed HQGr was as high as 1.4 × 104 S m−1. Therefore, this facile method for liquid-phase exfoliation of graphite has excellent potential in the industrial-scale production of HQGr for numerous applications in energy storage, optical and electronic fields.


61. Jing Liu, Lingjie Meng*, Zhaofu Fei*, Paul J Dyson, Lei Zhang. On the origin of the synergy between the Pt nanoparticles and MnO2 nanosheets in Wonton-like 3D nanozyme oxidase mimics. Biosensor & Bioelectronics. 2018., p159-165. (IF=8.173)

           We describe a 3-dimensional scaffold nanocomposite oxidase nanozyme (termed PtNPs@MnO2) formed from 2-dimensional MnO2 nanosheets grown on the surface of large platinum nanoparticles (PtNPs). The two components act synergistically in the catalytic oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB), due to the intimate contact between the two components and mutual electron transfer phenomena. The Wonton-like 3-dimensional structure of the nanocomposite is highly stable and was characterized by cryogenic electron microscopy (cryo-EM). The PtNPs@MnO2 nanocomposite was employed in a sensing assay for the determination of glutathione (GSH) and dopamine (DA) with a linear range of 0.2 μM − 11 μM for GSH and 0.1 μM − 1.1 μM for DA. The limit of detection (LOD) and limit of quantification (LOQ) of GSH are 0.05 μM (S/N=3) and 0.17 μM (S/N=10), respectively. The LOD and LOQ for DA were estimated as 0.025 μM and 0.083 μM. The method was applied to analyze GSH in human serum samples and DA in pharmaceuticals.


60. Jianhui Li, Haiting Yan, Wei Wei*, Xifei Li, Lingjie Meng*. Enhanced Lithium Storage Performance of Liquid‐Phase Exfoliated Graphene Supported WS2 Heterojunctions. ChemEletroChem,2018,https://doi.org/10.1002/ celc.201800926.(IF=4.446)


       To improve the electrical conductivity and the cycling stability of layered transition metal disulfides (TMDs) as lithium‐ion battery anode, graphene@WS2 heterojunction composites are prepared by a facile one‐pot process, involving liquid‐phase exfoliation of graphene in N‐methylpyrrolidone, followed by in‐situ growth of WS2 in the graphene dispersion induced by a microwave‐assisted solvothermal method. The liquid‐phase exfoliated graphene (LEGr) with exceptional atomic structure not only serves as a substrate to couple WS2, but also serves as a mini‐current collector for the rapid transport of electrons within the anode. The LEGr‐based heterojunction WS2 composites exhibit improved lithium storage performance compared to the counterpart based on graphene oxide (GO), including higher lithium storage capacity, superior rate capability and outstanding cycling stability. This protocol enables processing and construction of advanced TMD heterojunction electrodes based on LEGr using an economical pathway.


59.  Yanzi Xu, Lin Ren, Dongfeng Dang*, Ying Zhi, Xiaochi Wang, Lingjie Meng*. A Strategy of "Self‐Isolated Enhanced Emission" to Achieve Highly Emissive Dual‐State Emission for Organic Luminescent Materials.Chem. Eur. J. 2018, https://doi.org/ 10.1002/chem.201802201. (IF=5.317)

         Currently, the commonly developed organic luminescent materials (OLMs) usually exhibit poor luminescent performance in aggregated solid states compared with their well‐dissolved solution states, making it a tough goal to achieve the highly emissive dual‐state emission. To overcome this limitation, "Self‐Isolated Enhanced Emission" (SIEE) strategy through flexible alkyl chains to suppress the emission‐quenched π‐π stacking in solids is proposed here and based on this guideline, remarkable emission efficiency with photoluminescence quantum yields up to 99.72% in solution and 77.46% in solid state are finally achieved for the SIEE constructed DBBT‐C8, which is then successfully used in the solid state display and data encryption.


58. Dongfeng Dang, Xiaochi Wang, Daquan Wang, Zhiwei Yang, Dongxiao Hao, Yanzi Xu, Shengli Zhang, and Lingjie Meng*.  Fluorescent Organic Nanoparticles Constructed by a Facile “Self-Isolation Enhanced Emission” Strategy for Cell Imaging. ACS Appl. Nano Mater., 2018, 1 (5), pp 2324–2331

To achieve the highly emissive features and overcome the troublesome photobleaching for fluorescent organic molecules, a facile and versatile strategy named “self-isolation enhanced emission (SIEE)” was developed to prevent the π–π stacking of organic fluorophores by linking alkyl chains on their conjugated backbones. As a proof-of-concept, one or two octyl groups were grafted onto the backbone of 4,7-di(thiophen-2-yl)benzo[c][1,2,5]thiadiazole (termed as DTBT-0), resulting in two different molecules, termed as DTBT-1 and DTBT-2, respectively. Compared with DTBT-0, DTBT-1 and DTBT-2 exhibited remarkably enhanced fluorescent properties in both aggregated thin films and nanoparticles, demonstrating that the SIEE method could isolate the fluorophores effectively and then prevent their π–π stacking to achieve the impressive fluorescent properties. After proper surface modification, excellent water dispersibility, biocompatibility, and improved resistance to photobleaching were also achieved for highly emissive DTBT-2-based nanoparticles, which were then successfully applied for cellular imaging.


57. Daquan Wang, Lingjie Meng*, Zhaofu Fei, Chen Hou, Jiangang Long, Leli Zeng, Paul J. Dyson and Peng Huang. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity.  Nanoscale, 2018,10, 8536-8546 . (IF=7.233)

     Multi-layered single-walled carbon nanotubes, termed SWNT@BSA@Au-S-PEG-FA@DOX, which integrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and cut single-walled carbon nanotubes (SWNTs) were coated with bovine serum albumin (BSA) to provide abundant active sites for the nucleation of Au seeds, which are subsequently converted into gold nanoparticles (Au NPs) by in situ reduction. The resulting SWNT@BSA@Au material exhibits ideal photothermal properties. Further modification of the nanomaterial with folic acid terminated-polyglycol (FA-PEG-SH) and subsequent loading with doxorubicin (DOX) afford the SWNT@BSA@Au-S-PEG-FA@DOX. The FA terminated PEG endows the material with high water-dispersibility, biocompatibility and cancer cell selectivity. A high drug loading ratio for DOX of up to 590% was achieved, with the drug release being pH and temperature dependent, adding to the selectivity of the system. High efficacy of the SWNT@BSA@Au-S-PEG-FA@DOX material, when combined with photothermal therapy (irradiation of the tumor with an 808 nm laser, 1 W cm−2 for 5 min, 24 h after systemic injection of the nanomedicine), was demonstrated in vivo, resulting in complete tumor eradication. Remarkably, the side effects are negligible with only minor damage to normal tissues including the liver and kidneys being observed. 


56. Zhi, Ying ; Zhao, Baofeng ; Cao, Ruijun; Xu, Yanzi ; Wang, Jianguo; Dang, Dongfeng* ; Gao, Chao; Meng, Lingjie*. Triphenylamine cored electron-donors for solution-processed organic solar cells: From tri-armed molecules to tetra-armed molecules.DYES AND PIGMENTS, 153: 291-299. (IF=3.767)



     A novel tetra-armed D-A type small molecule 4BTF-DTPA-T was designed here by utilizing the thiophene connected ditriphenylamine (DTPA) core and fluorinated benzothiadiazole (BTF) arms. To make a better comparison, tri-armed (star-shaped) 3BTF-TPA was also synthesized. Although a similar absorption spectra covering from 300 to 600 nm was observed for 3BTF-TPA and 4BTF-DTPA-T, much higher extinction coefficient was achieved for tetra-armed 4BTF-DTPA-T in both solution and thin films. Bulk hetero-junction (BHJ) organic solar cells were also fabricated to investigate their photovoltaic performance and as anticipated, a moderate PCE value of 2.61% with a V-oc of 1.00 eV was observed in 3BTF-TPA-based solar cells. However, when the tetra-armed 4BTF-DTPA-T was employed as the electron-donors, much enhanced J(EC) and FF values up to 9.33 mA/cm(2) and 44.80% were achieved for its homogeneous morphology in solar cells, finally leading to the maximum PCE value of 3.68%, indicating that the tetra-armed small molecules could be the promising electron-donors for solution processed organic solar cells.


55. Haiting Yan, Jianhui Li, Daomeng Liu, Xunan Jing, Daquan Wang and Lingjie Meng*. Controlled preparation of high quality WS2nanostructures by a microwave-assisted solvothermal method. CrystEngComm, 2018,20, 2324-2330. (IF=3.304)

     Thin-layered WS2 nanostructures have attracted great attention owing to their superior structures and properties when compared to MoS2, including larger layer-spacing, higher energy gap and better photothermal and lubrication properties. However, it is still challenging to prepare high-quality WS2 nanosheets and assemble them into large quantities. In this work, we report a facile and efficient microwave-assisted solvothermal method for the synthesis of WS2 nanostructures in N-methyl-2-pyrrolidone (NMP) using cheap tungsten hexachloride (WCl6) and elemental sulfur (S) as starting materials. The formation of WS2 nanosheets and their controlled assembly into different morphologies (such as nanocones and nanoworms) were studied by adjusting the reactant concentration and reaction temperature. This method has also been successfully applied for preparation of other transition-metal dichalcogenides such as MoS2. The resulting WS2 and MoS2 nanomaterials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The photothermal properties of WS2nanostructures have been investigated and it was found that the WS2 nanosheets have the best photothermal efficiency and stable photothermal capacity, exhibiting great potential for photothermal therapy and other fields.


54. Xunan JingZhe ZhiDaquan WangJing LiuYongping Shao, and Lingjie Meng* .Multifunctional Nanoflowers for Simultaneous Multimodal Imaging and High-Sensitivity Chemo-Photothermal Treatment.Bioconjugate Chem.201829 (2), pp 559–570.  (IF=4.485)

     Liver cancer is currently among the most challenging cancers to diagnose and treat. It is of prime importance to minimize the side effects on healthy tissues and reduce drug resistance for precise diagnoses and effective treatment of liver cancer. Herein, we report a facile but high-yield approach to fabricate a multifunctional nanomaterial through the loading of chitosan and metformin on Mn-doped Fe3O4@MoS2 nanoflowers. Mn-doped Fe3O4 cores are used as simultaneous T1/T2 magnetic resonance imaging (MRI) agents for sensitive and accurate cancer diagnosis, while MoS2 nanosheets are used as effective near-infrared photothermal conversion agents for potential photothermal therapy. The surface-functionalized chitosan was able not only to improve the dispersibility of Mn-doped Fe3O4@MoS2 nanoflowers in biofluids and increase their biocompatibility, but also to significantly enhance the photothermal effect. Furthermore, metformin loading led to high suppression and eradication of hepatoma cells when photothermally sensitized, but exhibited negligible effects on normal liver cells. Due to its excellent combination of T1/T2 MRI properties with sensitive chemotherapeutic and photothermal effects, our study highlights the promise of developing multifunctional nanomaterials for accurate multimodal imaging-guided, and highly sensitive therapy of liver cancer.


53. Wang, Junli ; Dou, Chenxi ; Chen, Lei ;Yan, Haiting; Meng, Lingjie ; Zhu, Jiangfeng; Wei, Zhiyi. High energy passively Q-switched Er-doped fiber laser based on Mo0.5W0.5S2 saturable absorber. Optical Materials Express. 2018,8:324-331. (IF=2.566)


           A passively Q-switched Er-doped fiber laser based on a novel transition metal sulfide (TMDs) Mo0.5W0.5S2 absorber is reported for the first time. There are two different types of Mo0.5W0.5S2-based saturable absorbers (SAs) that achieve Q-switching operation, one of which is depositing the Mo0.5W0.5S2 on the surface of the tapered fiber, and the maximum single pulse energy of 172.91 nJ and minimum pulse width of 1.42 mu s is obtained. While the other is transferring Mo0.5W0.5S2-PVA(polyvinyl alcohol: PVA) SA film onto a standard FC/APC fiber end face, the high single pulse energy of 246.5 nJ and the minimum pulse width is 1.92 mu s is obtained, and the modulation depth of SAs detected by the twin-detector method is 15%. The experiment results show that Mo0.5W0.5S2 can be considered as a promising candidate for pulse fiber laser applications and other photoelectric devices. 


52.  Hongxiao Wang, Xiaohui Zhang*, Yugang Duan,and Lingjie Meng*Experimental and Numerical Study of the Interfacial Shear Strength in Carbon Fiber/Epoxy Resin Composite under Thermal LoadsInternational Journal of Polymer Science. 2018,doi.org/10.1155/2018/3206817.  (IF=1.718)



          This study examined the influence mechanism of temperature on the interfacial shear strength (IFSS) between carbon fiber (CF) and epoxy resin (EP) matrices under various thermal loads using experimental and numerical simulation methods. To evaluate the change in IFSS as a function of the increase in temperature, a microbond test was performed under controlled temperature environment from 23 ∘ C to 150 ∘ C. The experimental results showed that IFSS values of CF/EP reduce significantly when the temperature reaches near glass transition temperature. To interpret the effect of thermal loads on IFSS, a thermal-mechanical coupling finite element model was used to simulate the process of fiber pull-out from EP. The results revealed that temperature dependence of IFSS is linked to modulus of the matrix as well as to the coefficients of thermal expansion of the fiber and matrix.




51.  Daquan Wang, Yibo Ren, Yongping Shao and Lingjie Meng*. Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy. Polymer Chemistry. 2017,8,6938-6942.  (IF=4.927)

        It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent for effective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligibly affected normal cells. Hence, this DDS demonstrates the proof-of-concept for effective chemo-photothermal synergistic therapy.


50. Daquan Wang, Yibo Ren, Yongping Shao, Demei Yu, Lingjie Meng*. Facile Preparation of Doxorubicin-Loaded and Folic Acid-Conjugated Carbon Nanotubes@Poly(N-vinyl pyrrole) for Targeted Synergistic Chemo–Photothermal Cancer Treatment. Bioconjugate Chemistry. 2017,DOI: 10.1021/acs.bioconjchem.7b00515.  (IF=4.485)


      We developed a bifunctional nanoplatform for targeted synergistic chemo–photothermal cancer treatment. The nanoplatform was constructed through a facile method in which poly(N-vinyl pyrrole) (PVPy) was coated on cut multiwalled carbon nanotubes (c-MWNTs); FA-PEG-SH was then linked by thiol–ene click reaction to improve the active targeting ability, water dispersibility, and biocompatibility and to extend the circulation time in blood. The PVPy shell not only enhanced the photothermal effect of c-MWNTs significantly but also provided a surface that could tailor targeting molecules and drugs. The resulting MWNT@PVPy-S-PEG-FA possessed high drug-loading ratio as well as pH-sensitive unloading capacity for a broad-spectrum anticancer agent, doxorubicin. Owing to its outstanding efficiency in photothermal conversion and ability in targeted drug delivery, the material could potentially be used as an efficient chemo–photothermal therapeutic nanoagent to treat cancer.


49. Songxia Yu, Zhiqiang Wang, Ruijun Cao, Lingjie Meng*. Microwave-Assisted Synthesis of Small and Water-Dispersible Lanthanide-Doped NaGdF4 Nanocrystals for PL/CT/MR Multimodal Imaging. SM Journal Clinical and Medical Imaging. 2017,3(1), 1011-1016.



     Multimodal imaging is advantageous in overcoming the deficiencies of individual imaging modalities. Herein, small, monodisperse and water-dispersible NaGdF4: Ln (Ln = Eu, Tb, Dy) Nano Crystals (NCs) were successfully prepared in a facile manner by one-pot microwave-assisted solvothermal reaction in ethylene glycol. The morphology, size distribution, zeta potential, and crystal structure of the resulting NCs were well characterised by transmission electron microscopy, Nano-ZS90 Zetasizer, and X-ray diffraction analyses. These as-synthesised NaGdF4: Ln (Ln = Eu, Tb, Dy) NCs exhibited a low cytotoxicity for Hela and C9H2 cells. Moreover, the doping concentrations of Eu3+, Tb3+, and Dy3+ ions were optimised for efficient Photoluminescence (PL) under the excitation of 273 nm in water. Furthermore, these NCs exhibited excellent relaxivity parameters (r1) in Magnetic Resonance (MR) imaging and Hounsfield units in X-ray Computed Tomography (CT) imaging in vitro. Therefore, these NCs have great potential to construct a unique platform for PL/CT/MR multimodal imaging simultaneously.



48. Songxia Yu, Zhiqiang Wang, Ruijun Cao, Lingjie Meng*. Microwave–assisted synthesis of water–disperse and biocompatible NaGdF4: Yb,Ln@NaGdF4 nanocrystals for UCL/CT/MR multimodal imaging. Journal of Fluorine Chemistry, 2017, 200, 77-83. (IF=1.879)

          In this paper, we have developed a series of rare earth fluoride nanocrystals (NCs) that can be used for multimodal imaging applications. Three highly monodisperse and water dispersible NaGdF4:Yb,Ln@NaGdF4 (Ln = Er, Tm, Ho) upconversion luminescence (UCL) NCs with an average size of 75 nm were prepared using a facile and efficient microwave–assisted solvothermal reaction in ethylene glycol (EG). The morphology, crystal structures, size distributions and zeta potentials of the resulting NCs were fully characterized by transmission electron microscopy (TEM), X–ray diffraction (XRD) and Nano–ZS90 Zetasizer. The obtained NaGdF4:Yb,Ln@NaGdF4 (Ln = Er, Tm, Ho) NCs could emit bright blue, green and red luminescence in water upon laser excitation at 980 nm. Furthermore, these core–shell NCs exhibited low cytotoxicity for HeLa and C9H2 cells, separately. Moreover, these NCs also displayed excellent Hounsfield units (HU) values in X–ray computed tomography (CT) imaging and high relaxivity parameters (r1) in magnetic resonance (MR) imaging in vitro. Thus, these small, water–dispersible and biocompatible NCs show excellent potential as contrast agents for UCL/CT/MR multimodal imaging and other biomedical applications.



47.Dongfeng Dang*, Ying Zhi, Xiaochi Wang, Baofeng Zhao*, Chao Gao*, Lingjie Meng*.A1-A-A1 type small molecules terminated with naphthalimide building blocks for efficient non-fullerene organic solar cells. Dyes and Pigments. 2017, 137, 43-49.  (IF=3.767)

           Novel non-fullerene acceptors with an A1-A-A1 framework were designed and synthesized, in which benzothiadiazole and diketopyrrolopyrrole building blocks were employed as the A unit and naphthalimide units were incorporated as the A1 units. Both acceptor systems exhibited a broadened absorption spectra from 300 nm to 700 nm in contrast to that of fullerene derivatives. Meanwhile, high-lying LUMO energy levels were also observed for both developed acceptors. To investigate photovoltaic properties of the acceptors, bulk-heterojunction organic solar cells were fabricated using an established electron donating polymer as the donor material. As anticipated, efficient non-fullerene OSCs with high Voc values up to 1.01–1.12 V were achieved when the new molecules were employed as electron acceptors, leading to the PCE values of 1.23% and 1.64% in their solar cells. Our results here demonstrate that the A1-A-A1 type small molecule containing naphthalimide building blocks in molecular backbone could be the promising electron acceptor in organic solar cells.



46.Sweejiang Yoo, Jin Hou, Wenhui Yi*, Yingchun Li, Weiping Chen, Lingjie Meng*, Jinhai Si & Xun Hou. Enhanced Response of Metformin towards the Cancer Cells due to Synergism with Multi-walled Carbon Nanotubes in Photothermal Therapy. Sci Rep. 2017,DOI:10.1038/s41598-017-01118-3. (IF=4.122)


45.Daquan Wang, Chen Hou, Lingjie Meng,* Jiangang Long, Jiange Jing,Dongfeng Dang, Zhaofu Fei and Paul J. Dyson.Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of Doxorubicin combined with photothermal therapy. Journal of Material Chemistry B, 2017, 5, 1380 - 1387. (IF=4.776)


44. Liu Jing, Lingjie Meng*, Zhaofu Fei, Paul J Dyson, Jing Xunan, Liu Xing. MnO2 Nanosheets as an Artificial Enzyme to Mimic Oxidase for Rapid and Sensitive Detection of Glutathione. Biosensor and Bioelectronics. 2017,69-74. (IF=8.173)





43. Dang Dongfeng*, Zhou Pei, Zhi Ying,  Bao Xichang*, Yang Renqiang, Meng Lingjie*, Zhu Weiguo*. Spirobifluorene-cored small molecules containing four diketopyrrolopyrrole arms for solution-processed organic solar cells. Journal of Materials Science, 2016,51(7):8018-8026. (IF=2.993)


          Spirobifluorene-linked three-dimensional small molecules of SF(DPP)(4) and SF(TDPP)(4) containing four diketopyrrolopyrrole arms were designed and synthesized. Both molecules displayed a broad and strong absorption in the region of 300-700 nm with suitable HOMO and LUMO energy levels as well as high charge carrier mobility. Meanwhile, solution-processed organic solar cells with a device structure of ITO/PEDOT:PSS/active layer/Ca/Al was also fabricated to investigate the photovoltaic properties of SF(DPP)(4) and SF(TDPP)(4). In contrast to that of star-shaped TPA(DPP)(3) in solar cells, enhanced photovoltaic performance with an impressive open circuit voltage of 0.95 V and short-circuit current density of 9.12 mA/cm(2) was achieved, leading to the maximum power conversion efficiency of 3.72 %. Our result here demonstrated that the three-dimensional-type small molecule in a D-A framework is a promising candidate as electron-donor materials for efficient organic solar cells.


 42. Dang Dongfeng*, Wang Xiaochi, Zhi Ying, Meng Lingjie, Bao Xichang*, Yang Renqiang, Zhu Weiguo*. Synthesis and characterization of D-A-A type regular terpolymers with narrowed band-gap and their application in high performance polymer solar cells. Organic Electronics. 2016,32, 237-243.(IF=3.68)


          Two novel D-A-A type regular terpolymers of PBDT-DTQ and PIDT-DTQ were designed and synthesized, in which benzodithiophene and indacenodithiophene building blocks were employed as the D unit, and quinoxaline building block was introduced as the A unit. Owing to the strong intra-molecular charge transfer effect in polymer backbone, much broader absorption spectra covering from 320 to 800 nm with the narrowed band-gap were obtained for the developed D-A-A type polymers in contrast to their corresponding D-A type polymers. On the other hand, compared with PBDT-DTQ, PIDT-DTQ exhibited a deeper HOMO energy level and also higher charge carrier mobility. To investigate the photovoltaic properties of PBDT-DTQ and PIDT-DTQ in detail, bulk hetero-junction polymer solar cells with a structure of ITO/PEDOT: PSS/Active Layer/Ca/Al were fabricated. PBDT-DTQ-based solar cells exhibited a moderate PCE value of 3.84%, however, an increased J(sc) of 11.42 mA/cm(2), V-oc of 0.86 V and FF of 65.77% was achieved for PIDT-DTQ-based device, leading to the maximum PCE up to 6.41%. Our results here demonstrated that using the regular terpolymers as electron donor materials could be an efficient way to broaden the absorption of polymers and improve the photovoltaic performance of PSCs.


4   41. Min Hu*, Dandan Ma, Chengcheng Liu, Jing Wang, Zhenxi Zhang and Lingjie Meng*. Intense white emission from a single-upconversion nanoparticle and tunable emission colour with laser power. Journal of Material ChemistryC 2016,4,6975.(IF=5.976)


    40. Dandan Ma, Xiang Xu, Min Hu,* Jing Wang, Zhenxi Zhang, Jian Yang, and Lingjie Meng*. Rare-Earth Based Nanoparticles with Simultaneously Enhanced Near-Infrared (NIR)-Visible (Vis) and NIR-NIR Dual-Conversion Luminescence for Multimodal Imaging. Chemistry-An Asian Journal 2016,11(7),1050-1058. (IF=3.692)



2015 年


39. Daquan Wang, Ying Hu, Lingjie Meng,* Xiaochi Wang and Qinghua Lu. One-pot synthesis of fluorescent and cross-linked polyphosphazene nanoparticles for highly sensitive and selective detection of dopamine in body fluids.RSC Advances 2015, 5, 92762-92768. (IF=2.936)


38. Songxia Yu, Ruijun Cao, Jun Li, Lingjie Meng*.  Controlled synthesis of NdF3 and NaNdF4 micro- or nanocrystals by one-pot microwave-assisted hydrothermal reaction. Journal of Fluorine Chemistry 2015, 178, 286-290.(IF=2.213)


37.  王晓驰,常刚,曹瑞军,孟令杰*。近红外荧光染料的结构、性质及生物荧光成像应用。化学进展,2015,27(7)794-805.



36.Dandan Ma, Lingjie Meng, Yuzhong Chen, Min Hu,* Yanke Chen, Chen Huang,* Jin Shang, Ruifeng Wang, Youmin Guo and Jian Yang. NaGdF4:Yb3+/Er3+@NaGdF4:Nd3+@Sodium-Gluconate: Multifunctional and Biocompatible Ultrasmall Core.Shell Nanohybrids for UCL/MR/CT Multimodal Imaging.ACS Applied Materials & Interfaces 2015, 7, 16257-16265.(IF=8.097)



35. 刘天辉,常刚,曹瑞军,孟令杰*超顺磁性Fe3O4纳米粒子在磁共振造影中的应用。化学进展,2015,27(5):601-613.

34. Lingjie Meng*, Chengqiang Xu, Tianhui Liu, Hua Li, Qinghua Lu* and Jiangang Long:One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging. Polymer Chemistry 2015, 6,3155-3163. (IF=4.927)



 33. Zhao Chen, Xiaochi Wang, Hua Li, Chao Li, Qinghua Lu, Guang Yang,Jiangang Long and Lingjie Meng*:Controllable and mass fabrication of highly luminescent N-doped carbon dots for bioimaging applications. RSC Advances 2015, 5, 22343-22349. (IF=2.936)



 32. Lijuan Sun, Tianhui Liu, Hua Li, Liang Yang, Lingjie Meng*, Qinghua Lu*, and Jiangang Long: Fluorescent and Cross-linked Organic−Inorganic Hybrid Nanoshells for Monitoring Drug Delivery.  ACS Applied Materials & Interfaces 2015, 7, 4990-4997.  (IF=8.097)



2014 年


 31.  Meng Lingjie*, Xia Wenjian, Liu Li, Niu Lvye, Lu Qinghua*. Golden Single-Walled Carbon nanotubes Prepared Using Double Layer Polysaccharides Bride for Photothermal Therapy. ACS Applied Materials and Surface, 2014,30, 4485-64. (IF=8.097)


30. Hu Ying, Meng Lingjie*, Lu Qinghua*. "Fastening" Porphyrin in Highly Cross-linked Polyphosphazene Hybrid Nanoparticles: Powful Red Fluorescent Probe for Detecting Mercury Ion. Langmuir, 2014, 6(7):4989-96.  (IF=3.789)





2013 年


29. Hu ying, Meng Lingjie*, Niu Lvye, Lu Qinghua*. Facile Synthesis of Superparamagnetic Fe3O4@polyphosphazene@Au Shells for Magnetic Resonance Imaging and Photothermal Therapy. ACS Applied Materials and Surface, 2013, 5(11), 4586-91. (IF=8.019)





28.      Hu ying, Meng Lingjie*, Niu Lvye, Lu Qinghua*. Highly Cross-linked and Biocompatible Polyphosphazene Coated Fe3O4 Nanoparticles for Magnetic Resonance Imaging. Langmuir, 2013, 29(29):9156-63. (IF=3.789)




27. Niu Lvye, Meng Lingjie*, Lu Qinghua*. Folate-Conjugated PEG on Single Walled Carbon Nanotubes for Targeting Delivery of Doxorubicin to Cancer Cells. Macromolecular Bioscience 2013, 13(6):735-44. (IF=3.392)


 26. Meng Lingjie, Niu Lvye, Li Ling, Lu Qinghua*, Fei Zhaofu, Dyson Paul J*. Gold nanoparticles grown on ionic liquid-functionalized single-walled carbon nanotubes: new materials for photothermal therapy. Chemistry-A European Journal, 201218(42) , 13314-13319. (IF=5.319)



25.      Hongdan Peng, Lingjie Meng, Lvye Niu, Qinghua Lu. Simultaneous Reduction and Surface Functionalization of Graphene Oxide by Natural Cellulose with the Assistance of the Ionic Liquid. J. Phys. Chem. C, 2012, 116 (30), pp 16294–16299。 (IF=4.484)



 24.      Peng, Hongdan, Meng, Lingjie, Lu, Qinghua, Zhaofu Fei, Paul J Dyson. Fabrication of reduced graphene oxide hybrid materials that exhibit strong fluorescence. Journal of Material Chemisty, 2012, 20(26): 5493-8.  (IF=6.010)



23.      Meng Lingjie, Zhang Xiaoke, Lu Qinghua*, Fei Zhaofu, Dyson Paul J. Single walled carbon nanotubes as drug delivery vehicles:targeting doxorubicin to tumors. Biomaterials, 2012, 33, 1689-1697.  (IF=8.806)



22.      Ji Zongfei, Lin Gaofeng, Lu Qinghua, Meng Lingjie*, Shen Xizhong, Dong Ling, Fu Chuanlong, Zhang Xiaoke. Targeted Therapy of SMMC-7721 Liver Cancer in Vitro and in Vivo with Carbon Nanotubes Based Drug Delivery System. Joural of Colloid and Interface Science, 2012, 365,143-149.  (IF=5.019)



21. Da Xi, Sheng Dong, Xiaoxi Meng, Qinghua Lu, Lingjie Meng* and Jin Ye ,Gold nanoparticles as computerized tomography (CT) contrast agents. RSC Adv., 2012,2, 12515-12524.  (IF=2.293)






20.      Zhou Junfeng, Meng Lingjie*, Lu Qinghua*, Feng Xinliang. One-pot Synthesis of Highly Magnetic Sensitive Nanochains Coated with Highly Cross-Linked and Biocompatible Polymer. Angew Chemistry International Edit. 2010, 49, 8476-80.  (IF=12.102)

19.      Zhou Junfeng, Meng Lingjie*, Lu Qinghua*. Core@Shell Nanostructures for Photothermal Conversion: Tunable Noble Metal Nanoshells on Cross-linked Polymer Submicro-spheres. Journal of Material Chemisty, 2010, 20(26): 5493-8. (IF=6.01)

18.      Meng Lingjie*, Fu Chuanlong, Lu Qinghua, Fei Zhaofu*, Dyson Paul J. Photochemical Behavior of High Quantum Yield SWNTs Functionalized with Anthracene Salts. Chemistry-A Asian Journal, 2010, 9(5):1988-1991.  (IF=4.592)

17.      Meng Lingjie*, Fu Chuanlong, Lu Qinghua, Fei Zhaofu*, Dyson Paul J. Coordination chemistry on the surface of single-walled carbon nanotubes. Inorg. Chim. Acta. 2010, 363, 3926-31. (IF=2.264)

16.      Zhang Xiaoke, Meng Lingjie, Wang Xuefeng, Lu Qinghua. Preparation and Cellular Uptake of pH-Dependent Fluorescent Single-Wall Carbon Nanotubes. Chemistry-A European Journal, 2010,16,556-61.  (IF=5.019)


15. Lin Gaofeng,  Meng Lingjie, Zhang Xiaoke, Lu Qinghua: Non-Covalent Separation of Metallic and Semiconducting Single-Walled Carbon Nanotubes. Progress in Chemistry. 2010, 22, 331-337.




14. Xia Wenjian, Meng Lingjie, Liu Li, Lu Qinghua: Carbon Nanotubes Decorated with Noble Metal Nanoparticles. Progress in Chemistry. 2010, 22, 2298-2308.


13.      Fei Zhaofu, Zhu Dunru, Yang Xue, Meng Lingjie, Lu Qinghua, et al. An Internal Fluorescent Probe Based on Anthracene to 8319)


12.  Meng Lingjie, Fu Chuanlong, Lu Qinghua (2009). Advanced technology for functionalization of carbon nanotubes. Process in Naturnal Science, 2009,19,801-810.

11.  Zhou Junfeng, Meng Lingjie, Lu Qinghua, Fu Jianwei, Huang Xiaobin. Superparamagnetic submicro-megranates: Fe3O4 nanoparticles coated with highly cross-linked organic/inorganic hybrids. Chemical Communications, 2009, 42:6370-2.  (IF=6.29)

10.  Zhang Xiaoke, Meng Lingjie, Lu Qinghua, Fei Zhaofu, Dyson Paul J. Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials, 2009, 30: 6041-7.  (IF=8.557)

9.  Zhang Xiaoke, Meng Lingjie, Lu Qinghua. Cell behaviors on polysaccharide-wrapped single-wall carbon nanotubes: a quantitative study of the surface properties of biomimetic nanofibrous scaffolds. ACS Nano, 2009, 3:3200-6.  (IF=13.709)


8.  Li Ling, Meng Lingjie, Zhang Xiaoke, Fu Chuanlong,Lu Qinghua. Ionic liquid- associated synthesis of water-soluble and biocompatible cellulose/SWCNTs complex. Journal of Material Chemisty, 2009, 19, 3612-7.  (IF=6.101)




7.  Fu Chuanlong, Meng Lingjie, Lu Qinghua, Fei Zhaofu, Dyson Paul J. A facile strategy for preparation of fluorescent SWNT complexes with high quantum yields based on ion exchange. Advanced Functional Materials. 2008, 18, 857-64. (IF=13.325)

6.  Zhang Jichun, Meng Lingjie, Zhao Dongbin, Fei Zhaofu, Lu Qinghua, Dyson Paul J. Fabrication of dendritic fold nanoparticles by use of an ionic polymer template. Langmuir, 2008, 24, 2699-704.  (IF=4.457)

5.  Ren Lanzheng, Meng Lingjie, Lu Qinghua, Fei Zhaofu, Dyson Paul J. Fabrication of gold nano- and microstructures in ionic liquids - A remarkable anion effect. Joural of Colloid and Interface Science, 2008, 323, 260-6. (IF=5.019)

 4. Ren Lanzheng,Meng Lingjie, Lu Qinghua. Mass Synthesis of Large, Single-crystal Gold Nanoplates Using a Pyridinium-based Ionic Liquid. 2008,2nd IEEE International Nanoelectronics Conference.


3. Ren Lanzheng,Meng Lingjie, Lu Qinghua. Fabrication of octahedral gold nanostructures using an alcoholic ionic liquid. Chemistry Letter. 2008,37,106-107. (IF=1.625).

2. Fu ChuanLong; Meng LingJie; Lu QingHua. 'Hierarchical self-assembly' of helical amylose/SWNTs complex. Science in China Series B-Chemistry. 2008, 51, 269-274.



1.  Fu Chuanlong, Meng Lingjie, Lu Qinghua, Zhang Xiaoke, Gao Chao. Large-scale production of homogeneous helical amylose/single-walled nanotubes complexes with good biocompatibility. Macromolecule Rapidly Commmunacation, 2007, 28, 2180-4.  (IF=4.441)






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