(1.)Basic Information



Peng Hou, Ph.D.
Professor of Medicine and Oncology
Associate editor of American Journal of Cancer Research
Associate editor of International Journal of Medicine and Medical Sciences

(3.)Education

Div. of Endocrinology and Metabolism,
The Johns Hopkins University School of Medicine
Postdoctoral Fellow
2005.9 – 2009.8
Oncology & Endocrinology
Southeast University, Nanjing, China.
Ph.D.
2001.9 – 2004.7
 
Biomedical Engineering
 
Lanzhou University, Lanzhou, China
 
M.S.
 
1998.9 – 2001.7
 
Biology
 
Lanzhou University, Lanzhou, China.
 
B.S.
1994.9 – 1998.7
Biology
(4.)Honors

Aug,2003: Governmental Scholarship of Changzhou City
Oct, 2004:   Best poster presentation award in the second International Forum on Post-Genome Technologies
Nov, 2005:  Excellent technical thesis award of Nanjing City
Sep, 2006:  Excellent Doctoral Dissertation of Jiangsu Province
Oct, 2007:  Travel Award for the 79th Annual Meeting of American Thyroid Association
Jun, 2008: Travel Award for the 90th Annual Meeting of Endocrine Society
Mar, 2011: Program for New Century Excellent Talents in University
(5.)Scientific Research

Research interests:  cancer biology, genetics, epigenetics, cancer therapy,  thyroid cancer, gastric cancer

MEMBERSHIP
2005 –present:  Endocrine Society of American
2007 -present:  American Thyroid Association
2011 -present:  Endocrine Society of Shaanxi Provience

PUBLICATIONS (peer-reviewed articles)
1.      Shi J, Zhang G, Yao D, Liu W, Wang N, Ji M, He N, Shi B, Hou P*. Prognostic significance of aberrant gene methylation in gastric cancer. Am J Cancer Res. 2012, 2(1).* corresponding author
2.      Hou P, Liu D, Dong J, Xing M. The BRAFV600E causes widespread alterations in gene methylation in the genome of melanoma cells. Cell Cycle 2011 (accepted)
3.      Ye F, Hou P*, Wu X, Ma X, Gao L, Wu L, Xu L, Shi B. Expression and significance of immune-related molecules in Graves’ disease animal model. Autoimmunity. 2011 Oct 21. [Epub ahead of print]  * corresponding author
4.      Hou P, Liu D, Xing M.Genome-wide alterations in gene methylation by the BRAF V600E mutation in papillary thyroid cancer cells. Endocr Relat Cancer. 2011 Sep 21. [Epub ahead of print]
5.      Zhang L, Shi J, Xu L, Shi B, Hou P, Ji M.Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter. Thyroid Res. 2011 Oct 12;4(1):15. [Epub ahead of print]
6.      Ji M, Zhang Y, Shi B, Hou P*.  Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC). Diagnostic Pathology. 2011, 6:48.  *corresponding author
7.      Ji M, Guan H, Gao C, Shi B, Hou P*. Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC). BMC Cancer. 2011, 11:147. *corresponding author
8.      Ji M, Guan H, Shi B, Hou P*. Concomitant hypermethylation of multiple genes in non-small cell lung cancer (NSCLC). Folia Histochem Cyto. 2011, 49:132-41.  *corresponding author
9.      Wu L, Xun L, Yang J, Xu L, Tian Z, Gao S, Zhang Y, Hou P, Shi B. Induction of Murine Neonatal Tolerance Against Graves' Disease Using Recombinant Adenovirus Expressing the TSH Receptor A-Subunit. Endocrinology. 2011; 152(3):1165-1171.
10.   Walsh JP, Berry J, Liu S, Panicker V, Dayan CM, Brix TH, Hegedüs L, Hou P, Shi B, Morahan G. The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype. Clin Endocrinol (Oxf). 2011; 74:508-512.
11.   Ye F, Shi B, Wu X, Gao L, Ma DX, Xu L, Wu L, Hou P. Experience with lentivirus-mediated CD40 gene silencing in a mouse model of Graves’ disease. J Endocrinol. 2011; 208:285-291.
12.  Guo F, Hou P, Shi B. Detection of BRAF Mutation on Fine Needle Aspiration Biopsy Specimens: Diagnostic and Clinical Implications for Papillary Thyroid Cancer. Acta Cytologica2010; 54:291-5.
13.   Hou P, Bojdani E, Xing M.  Induction of Thyroid Gene Expression and Radioiodine Uptake in Thyroid Cancer Cells by Targeting Major Signaling Pathways. J Clin Endocrinol Metab2010; 95(2):820-8.
15.   Hou P, Liu D, Ji M, Liu Z, Engles JM, Wahl RL, Xing M. Induction of thyroid gene expression and radioiodine uptake in melanoma cells: novel therapeutic implications. PLoS One. 2009; 4(7):e6200.
16.   Guan H, Ji M, Bao R, Yu H, Wang Y, Hou P, Zhang Y, Shan Z, Teng W, Xing M. Association of high iodine intake with the T1799A BRAF mutation in papillary thyroid cancer. J Clin Endocrinol Metab. 2009; 94(5):1612-7.
18.   Liu Z, Hou P, Ji M, Guan H, Studeman K, Jensen K, Vasko V, El-Naggar AK, Xing M. Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers. J Clin Endocrinol Metab. 2008 ; 93(8):3106-16.
20. Wang Y, Ji M, Wang W, Miao Z, Hou P, Chen X, Xu F, Zhu G, Sun X, Li Y, Condouris S, Liu D, Yan S, Pan J, Xing M. Association of the T1799A BRAF mutation with tumor extrathyroidal invasion, higher peripheral platelet counts, and over-expression of platelet-derived growth factor-B in papillary thyroid cancer. Endocr Relat Cancer. 2008; 15(1):183-90.
23. Wang Y*, Hou P*, Yu H, Wang W, Ji M, Zhao S, Yan S, Sun X, Liu D, Shi B, Zhu G, Condouris S, Xing M. High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors. J Clin Endocrinol Metab. 2007 ; 92(6):2387-90.  *contributed equally
25.  Hou P, Liu D, Shan Y, Hu S, Studeman K, Condouris S, Wang Y, Trink A, El-Naggar AK, Tallini G, Vasko V, Xing M. Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res. 2007; 13(4):1161-70.
27.  Hou P*, Chen Z, Ji M, He N, Lu Z. Real-time PCR assay for ultrasensitive quantification of DNA-binding proteins. Clin Chem. 2007; 53(4):581-6.  *corresponding author
29. Chen BA, Jiang N, Ji MJ, Hou P, Lu ZH, Gao C, Ding JH, Sun YY, Wang J, Cheng J, Zhao G. A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006; 14(6):1069-73.
30. Li S, Liu H, Wang Z, Hou P, Guo Y, He Q, He N. Magnetic-particles-based high-throughput genotyping method with dual-color fluorescence hybridization. Anal Biochem. 2006; 359(2):277-9.
31.  Li S, Ji M, Hou P, He N, Chen H. Application of micro array-based method for functional SNP genotyping in the risk of gastric carcinoma in Chinese population. Rare Metal Materials & Engineering 2006, 35: 467-70.
32. Liu N, Wen L, Huang Z, Hou P. Introgressive hybridization between Alectoris magna and A. chukar in the Liupan Mountain Region. Acta Zoologica Sinica. 2006; 52: 153-159.
33. Hou P, Ji M, Lu Z. A profile of current methods for DNA methylation analysis. Current Analytical Chemistry 2006, 2: 309-322.
35.  Chen Z, Ji M, Hou P*, Lu Z. Exo-Dye-based assay for rapid, inexpensive, and sensitive detection of DNA-binding proteins. Biochem Biophys Res Commun. 2006; 345(3):1254-63.  * corresponding author
36. Hou P, Ji M, Yang B, Chen Z, Qiu J, Shi X, Lu Z. Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. Cancer. 2006; 106(7):1602-9.
37.  Hou P, Ji MJ, Shen JY, He NY, Lu ZH. Detection of p16 hypermethylation in gastric carcinomas using a seminested methylation-specific PCR. Biochem Genet. 2005; 43(1-2):1-9.
38. Shen JY, Hou P, Ji MJ, Li S, He NY. A methylation-specific oligonuceotide microarray for quantitative analysis of p16 gene. Chem J Chinese U. 2005; 26: 449-451.
39. Liu ZC, He QG, Hou P, Xiao PF, He NY, Lu ZH. Electroless plating of copper through successive pretreatment with silane and colloidal silver. Colloids and Surfaces A. 2005; 257-58: 283-286.
40. Hou P, Shen JY, Ji MJ, He NY, Lu ZH. Microarray-based method for detecting methylation changes of p16(Ink4a) gene 5'-CpG islands in gastric carcinomas. World J Gastroenterol. 2004; 10(24):3553-8.
41.  Ji M, Hou P, Lu Z, He N. Covalent immobilization of DNA onto functionalized mica for atomic force microscopy. J Nanosci Nanotechnol. 2004; 4(6):580-4.
43. Hou P, Ji M, Li S, He N, Lu Z. High-throughput method for detecting DNA methylation. J Biochem Biophys Methods. 2004; 60(2):139-50.
45.  Ji M, Hou P, Li S, He N, Lu Z. Colorimetric silver detection of methylation using DNA microarray coupled with linker-PCR. Clin Chim Acta. 2004; 342(1-2):145-53.
46. Hou P, Ji M, He N, Lu Z. Microarray-based method to evaluate the accuracy of restriction endonucleases HpaII and MspI. Biochem Biophys Res Commun. 2004; 314(1):110-7.
47.  Li S, Tang J, Ji M, Hou P, He N. A novel substrate for in situ synthesis of oligonucleotides: hydrolyzed microprous polyamide-6 membrane. Chinese chemical letters. 2004, 15:837-840.
48. Hou P, Ji M, Ge C, Shen J, Li S, He N, Lu Z. Detection of methylation of human p16(Ink4a) gene 5'-CpG islands by electrochemical method coupled with linker-PCR. Nucleic Acids Res. 2003; 31(16):e92.
50. Hou P, Ji M, Liu Z, Shen J, Cheng L, He N, Lu Z. A microarray to analyze methylation patterns of p16(Ink4a) gene 5'-CpG islands. Clin Biochem. 2003; 36(3):197-202.
51.  Hou P, Ji M, He N, Lu Z. Methylation oligonucleotide microarray: a novel tool to analyze methylation patterns. SPIE-Bioengineered and Bioinspired Systems. 2003, 5119: 60-7.
52.  Ji M, Hou P, Lu Z, He N. AFM studies on DNA covalently immobilized on mica modified by APTES-GA. Chem J Chinese U. 2003, 9: 1621-3.
53.  Shen J, Xiao P, Hou P, Ji M, Lu Z. Assembly fabrication of linkers on glass surface and their effect on DNA synthesis and hybridization. Journal of southeast university.  2003, 19: 149-55.
54.   Hou P, Wei M, Zhang L, Liu N. Genetic structure of edge population in Przewalski’s rock partridge (Alectoris magna). Acta Zoologica Sinica. 2002; 48: 333-8.
55.   Wei M, Hou P, Huang Z, Liu N. Effects of environmental factors on the population genetic structure in Alectoris magna.Acta Ecologica Sinica2002; 22: 528-34.

PATENTS
1.     Zuhong Lu, Peng Hou, and Meiju Ji. PCR method for detecting DNA methylation. International patent number: CN1415761-A.
2.     Peng Hou, Zuhong Lu, Meiju Ji, and Nongyue He. A low cost method for preparation of oligonucleotide microarray. Patent number: CN1438324-A.
3.    Zuhong Lu, Meiju Ji, Peng Hou, and Nongyue He. A method for preparation of genomic DNA microarray. Patent number: CN1438325-A.
 
PATENTS
1.      Zuhong Lu, Peng Hou, and Meiju Ji. PCR method for detecting DNA methylation. International patent number: CN1415761-A.
2.      Peng Hou, Zuhong Lu, Meiju Ji, and Nongyue He. A low cost method for preparation of oligonucleotide microarray. Patent number: CN1438324-A.
3.     Zuhong Lu, Meiju Ji, Peng Hou, and Nongyue He. A method for preparation of genomic DNA microarray. Patent number: CN1438325-A.
 
CONFERENCES
1.      Peng Hou. Oligonucleotide microarray: A powerful tool for methylation studies. The first international symposium on frontiers of biomedical sciences “Epigenetics in Development and Diseases” Shanghai, 24th -26th October, 2003, Page 414.
2.     Peng Hou. Methylation detection of multiple genes using DNA microarray coupled with Linker-PCR. The Tenth International Conference on Organized Molecular Films. Beijing, 5th -10th October, 2003, P173.
3.     Peng Hou. Preparation and application of methylation microarray on p16 tumor suppressor gene (1) - Feasibility analysis of methylation microarray. HGM2002, Shanghai, 14th-17th April, 2002, P618.
4.      Peng Hou. A microarray-based method to evaluate the effect of single base mismatches and methylation on the accuracy of restriction endonucleases HpaII and MspI. The Second International Forum on Post-Genome Technologies (2’ IFPT) Genomic Analysis and Bio-Nanoscience, Nanjing, 26th-27th, May, 2004, Page 242.
5.      Peng Hou. Genetic alteration in PIK3CA, Ras, and PTEN genes in the PI3K/Akt pathway in thyroid tumors. The endocrine society’s 88th Annual Meeting, Boston, Massachusetts, June 24-27, 2006.
6.      Peng Hou. Functional Characterization of Three New BRAF Mutations in Papillary Thyroid Cancer: T1790A, T1799-1801del and G1799-1816ins. The endocrine society’s 89th Annual Meeting, Toronto, Canada, June 2-5, 2007.
7.     Peng Hou. Inhibition of Thyroid Cancer Cells and Re-expression of Thyroid Genes by Dual Knockdown of the PI3K/Akt and MAP Kinase Pathways. 78th Annual meeting of American Thyroid Association, New York, October 4-7, 2007.
8.     Peng Hou. Association of the PTEN Gene Methylation with Genetic Alterations in the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Thyroid Tumors. The Endocrine Society's 90th Annual Meeting, San Francisco, June 15-18, 2008.
9.     Peng Hou. Epigenetic events in thyroid cancer. the 54th Annual Meeting of Japan Thyroid Association, Osaka, Japan, November 21-23, 2011.
 
GRANTS
1)The National Natural Science Foundation of China (2010.1-2012.12, No. 30901459)
2)The National Natural Science Foundation of China (2010.1-2012.12, No. 30973372)
3)The National Natural Science Foundation of China (2012.1-2014.12, No. 81171969)
4)The National Key Program for Developing Basic Research (2010-2014, No. 2010CB933903)
5)The Fundamental Research Funds for the Central Universities (2010.1-2014.12No. 08143001)
6) Program for New Century Excellent Talents in University
 
REVIEWER
1)       PLoS ONE
2)      International Journal of Biomedical Science
3)      Journal of Pediatric Biochemistry
4)      Journal of Biotechnology
5)      Journal of Cancer Research and Experimental Oncology
6)      Archives of Medical Research
7)      Methods in MolecularBiology
8)      International Journal of Medicine and Medical Sciences
9)      FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
(7.)Contact

Tel: 86-029-85324039
Email: phou@mail.xjtu.edu.cn