学术论文

课题组发表论文专利情况:

1)2013年课题组成立以来,发表生物医用材料领域通讯作者论文60余篇,其中代表性论文26篇(IF>10), 曾入选ESI高被引论文6篇。

2)授权国内外发明专利10余项。

代表性学术论文:

1M. Yu, Y. Du, Y. Han, B. Lei*. Biomimetic Elastomeric Bioactive Siloxane-Based Hybrid Nanofibrous Scaffolds with miRNA Activation: A Joint Physico-Chemical-Biological Strategy for Promoting Bone Regeneration. Advanced Functional Materials, 2020, 30(4), 1906013 (IF 16.8).

2Y. Xi, J. Ge, M. Wang, M. Chen, W. Niu, W. Cheng, Y. Xue, C. Lin, B. Lei*. Bioactive anti-inflammatory, antibacterial, antioxidative silicon-based nanofibrous dressing enables cutaneous tumor photothermo-chemo therapy and infection-induced wound healing. ACS Nano, 2020, 14(1),2904-2916. (IF 14.5)

3Y. Xue, W. Niu, M. Wang, M. Chen, Y. Guo, B. Lei*. Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration. ACS Nano, 2020, 14(1),442-453. (IF 14.5)

4L. Zhou, Y. Xi, Y. Xue, M. Wang, Y. Liu, Y. Guo, B. Lei*. Injectable SelfHealing Antibacterial Bioactive PolypeptideBased Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, SkinTumor Therapy, and Enhancing Wound Healing. Advanced Functional Materials, 2019, 29(22)1806883 (IF 16.8).

5M. Wang, C. Wang, M. Chen, Y. Xi, W. Cheng, C. Mao*, T. Xu, X. Zhang, C. Lin, W. Gao, Y. Guo, B. Lei*. Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release. ACS Nano, 2019, 13(9),10279-10293. (IF 14.5)

6J. Yan, S. Yan, P. Hou, W. Lu, P. Ma, W. He*, B. Lei*. A Hierarchical Peptide–Lanthanide Framework To Accurately Redress Intracellular Carcinogenic Protein–Protein Interaction. Nano Letters, 2019, 19(11), 7918-7926. (IF 11.2)

7Y. Xi, J. Ge, Y. Guo, B. Lei*, P Ma. Biomimetic elastomeric polypeptide-based nanofibrous matrix for overcoming multidrug-resistant bacteria and enhancing full-thickness wound healing/skin regeneration. ACS Nano, 2018, 12(11),10772-10784. (IF 14.5).

8J. Yan, W. He*, S. Yan, F. Niu, T. Liu, B. Ma, Y. Shao, Y. Yan, G. Yang, W. Lu, Y. B. Lei*, P. Ma. Self-assembled peptide–lanthanide nanoclusters for safe tumor therapy: overcoming and utilizing biological barriers to peptide drug delivery. ACS Nano, 2018, 12(2),2017-2026. (IF 14.5).

9Y. Du, M. Yu, J. Ge, P.Ma*, X. Chen, B. Lei*.Development of a multifunctional platform based on strong, intrinsically photoluminescent and antimicrobial silicapoly (citrates)based hybrid biodegradable elastomers for bone regeneration. Advanced Functional Materials, 2015, 25(31), 5016-5029. (IF 16.8, 1区).

10M. Wu, Y. Xue, N. Li, H. Zhao, B. Lei*, M. Wang, Y. Du*, C. Yan. TumorMicroenvironmentInduced Degradation of Ultrathin Gadolinium Oxide Nanoscrolls for MagneticResonanceImagingMonitored, Activatable Cancer Chemotherapy. Angewandte Chemie International Edition, 2019, 58(21), 6880-6885. (IF 12.9).

11M. Wang, M. Chen, W. Niu, D.D. Winston, W. Cheng, B. Lei*. Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy. Biomaterials, 2020, 261,12031. (IF10.2).

12L. Zhou, H. Zheng, S. Wang, F. Zhou, B Lei*, Q Zhang*. Biodegradable conductive multifunctional branched poly (glycerol-amino acid)-based scaffolds for tumor/infection-impaired skin multimodal therapy. Biomaterials, 2020, 261,120300. (IF10.2).

13L. Xu, Y. Xue, J. Xia, X. Qu, B. Lei*, T. Yang, X. Zhang, N. Li, H. Zhao, M. Wang, M. Luo, C. Zhang, Y. Du*, C. Yan. Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics. Biomaterials, 2020, 230,119670. (IF10.2).

14M. Wang, Y. Guo, Y. Xue, W. Niu, M. Chen, P. Ma, B. Lei*. Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo. Biomaterials, 2019, 199,10-21. (IF10.2).

15Y. Li, N. Li, J. Ge, Y. Xue, W. Niu, M. Chen, Y. Du, P. Ma, Bo Lei*. Biodegradable thermal imaging-tracked ultralong nanowire-reinforced conductive nanocomposites elastomers with intrinsical efficient antibacterial and anticancer activity for enhanced biomedical application potential. Biomaterials, 2019, 201,68-76. (IF 10.2)

16Y. Du, J. Ge, Y. Li, P. Ma, B. Lei*. Biomimetic elastomeric, conductive and biodegradable polycitrate-based nanocomposites for guiding myogenic differentiation and skeletal muscle regeneration. Biomaterials, 2018, 157, 40-50. (IF10.2, ESI highly cited.

17J. Ge, K. Liu, W. Niu, M. Chen, M. Wang, Y. Xue, C. Gao, P. Ma, B. Lei*. Gold and gold-silver alloy nanoparticles enhance the myogenic differentiation of myoblasts through p38 MAPK signaling pathway and promote in vivo skeletal muscle regeneration. Biomaterials, 2018, 175,19-29 (IF 10.2).

18F. Zhao, B. Lei*, X. Li, Y. Mo, R. Wang, D. Chen*, X. Chen*. Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes. Biomaterials, 2018, 178,36-47 (IF 10.2).

19J. Yan, W. He, N. Li, M. Yu, Y. Du, B Lei*, P. Ma*. Simultaneously targeted imaging cytoplasm and nucleus in living cell by biomolecules capped ultra-small GdOF nanocrystals. Biomaterials, 2015, 59, 21-29. (IF 10.2).

20Y. Guo, L. Zhou, M. Wang, Y. Li, B. Lei*. Biodegradable antibacterial branched glycerol-polypeptide with efficient in vitro/in vitro miRNA-29b delivery for promoting osteogenic differentiation of stem cells and bone regeneration. Chemical Engineering Journal, 2021, 405,127085. (IF 10.6)

21L Zhang, M Wang, M Chen, W Niu, W Liu, T Leng, W Ji, B Lei*. A safe and efficient bioactive citrate-lysine/miRNA33 agonist nanosystem for high fat diet-induced obesity therapy.

Chemical Engineering Journal, 2021, 405, 127304. (IF 10.6)

22W Cheng, M Wang, M Chen, W Niu, Y Li, Y Wang, M Luo, C Xie, T Leng, B Lei*. Injectable Antibacterial Antiinflammatory Molecular Hybrid Hydrogel Dressing for Rapid MDRB-Infected Wound Repair and Therapy. Chemical Engineering Journal, 2021, 405, 128140.

23Y. Xue, L. Wang, Y. Shao, J. Yan, X. Chen, B. Lei*. Facile and green fabrication of biomimetic gelatin–siloxane hybrid hydrogel with highly elastic properties for biomedical applications. Chemical Engineering Journal, 2014, 251, 158-164. (IF 10.6)

24Y. Xi, Y. Guo, M. Wang, J. Ge, Y. Liu, W. Niu, M. Chen, Y. Xue, D.D. Winston, W. Dai, B. Lei*, C. Lin*. Biomimetic bioactive multifunctional poly (citrate-siloxane)-based nanofibrous scaffolds enable efficient multidrug-resistant bacterial treatment/non-invasive tracking in vitro/in vivo. Chemical Engineering Journal, 2020, 383, 123078. (IF 10.6)

25F. Zhao, C. Zhang, J. Liu, L. Liu, X. Cao, X. Chen*, B. Lei*, L. Shao*. Periosteum structure/function-mimicking bioactive scaffolds with piezoelectric/chem/nano signals for critical-sized bone regeneration. Chemical Engineering Journal, 2020, 402, 126203. (IF 10.6)

26 J. Xia#, Y. Xue#, B. Lei#, L. Xu, M. Sun, N. Li, H. Zhao, M. Wang, M. Luo, C. Zhang, B. Huang*, Y. Du*, C. Yan. Multi-modal channel cancer chemotherapy by 2D functional gadolinium metal-organic framework. National Science Review, 2020, https://doi.org/10.1093/nsr/nwaa221. (IF 16.6) (# Co-first author).