基本信息

王胜鹏 教授 

Ph.D. 博导

国家级青年人才

陕西省杰出青年基金获得者

西交大中德心血管联合研究中心主任

西交大‘A 类青年拔尖人才’

联系方式

西安交通大学医学部基础医学院心血管研究中心

 Email: shengpeng.wang@xjtu.edu.cn

 通讯地址:陕西省西安市雁塔区雁塔西路76号西安交通大学医学部, 西安,710061

 

教育经历

2009.052015.01  

德国马普所及法兰克福大学,分子药理学,博士

导师:Stefan Offermanns(院士) Ingrid Fleming(院士)

 2006.092009.04  

西安交通大学,药理学,硕士

导师:臧伟进(教授,博导)

 2002.092006.05  

西安交通大学,药学专业,学士

工作经历

2017.09至今      

西安交通大学,医学部基础医学院

教授,博士生导师

 2014.122017.06  

德国马普院心肺所,博士后

Group leader,导师:Stefan Offermanns院士

获奖与荣誉

国家级青年人才

欧洲循环协会ESM

ESM-SERVIER奖(2017

 德国心脏协会

Dieter-Klaus-Forde奖(2016

德国微循环及血管生物协会

Young Inverstigator Award2016

 北美血管生物协会

(NAVBO)-Del Vecchio奖(2015

站点计数器

科研背景

          2006年于西安交通大学药学院获理学学士学位;2009年于西安交通大学医学部获药理学硕士学位;2015年于德国马普所及法兰克福大学分子医学博士学位;2014-2018年于德国马普心肺所从事博士后研究,担任Group leader2015年获得北美血管生物协会(NAVBO) Del Vecchio奖;2016获得德国微循环及血管生物协会Young Inverstigator Award和德国心脏协会Dieter-Klaus-Forde奖;2017年获得欧洲循环协会(ESM) ESM-SERVIER奖;2017年入选西安交通大学青年拔尖人才A计划;2019获得陕西省杰出青年基金,并担任西安交通大学中德心血管联合研究中心主任;2022年获得国家优秀青年科学基金;主持了一项国家自然科学基金面上项目,1项科技部战略发展项目,在PVB等在国内外重要学术会议上应邀报告12次。

在国际权威学术期刊发表研究论文32篇,14篇影响因子>10累计影响因子~265,被NatureCellScience等杂志他引527;以第一或共同通讯作者在Blood(一篇,影响因子22.113)、Journal of Clinical Investigation 2015/2016 (2篇,影响因子12.784)Nature Communications 2020 (2, 影响因子12.2)Journal of Hepatology 2021 (影响因子20.58)Circulation Research 2021 (影响因子14.47)等杂志发表论文12篇,其中影响因子大于12分的研究论文6篇。以参与作者在European Respiratory Journal, Nature Communications,Journal of Clinical Investigation, Cardiovascular ResearchJ Mol Cell Cardiol, Journal of Experimental Medicine等国际权威杂志发表论文15篇,多次受邀担任elife,Nature Communications,Journal of Clinical Investigation等杂志审稿人。

研究进展

           主要研究方向包括:1高血压及动脉粥样硬化疾病中血管稳态及代谢调控揭示了血管稳态及血压维持的新的力学调控机制;2肥胖发生的力学机制证明Piezo1是脂肪细胞感知膜张力的机械受体,率先从力学角度阐述了脂肪增生、炎症及肥胖发生的新机制。3肿瘤及免疫细胞迁移及侵袭的分子机制实验室拥有分选型流式细胞仪(BD Aira III)Leica SP5型激光共聚焦显微镜、低氧工作站、超速离心机、植入子(血压)无线遥测系统、实时定量PCR仪、活细胞成像工作站等大型仪器,具有多种敲除小鼠模型及剪切力模拟系统等特色技术,致力于血管力学生物学研究,聚焦血管稳态调控的力学感知瓶颈问题,在机械力受体发现、高血压及肥胖的力学调控方面取得了一系列突破进展。

科研项目

  1. 国家优秀青年科学基金,2022,主持,
  2. 国家自然科学基金委员会,面上项目,2019,主持.
  3. 陕西省科学技术厅,陕西省杰出青年科学基金项目, 2020,主持.
  4. 陕西省科学技术厅,陕西省一般项目社会发展领域, 2021,主持.
  5. 西安交通大学“青年拔尖人才项目A 类计划”,2017, 主持.
  6. 科技部,战略科技发展类,2019,主持.
  7. 德国ECCPS的青年项目,2016-2018,主要负责人.
  8. 德国科学基金会DFG重点项目,2012-2017,核心科学家(Core Scientist.

代表性论文

  1. Sheng peng Wang*, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S*. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood. 2022 Apr 20:blood.2021014614. IF=22.113, First & Corresponding author
  2. Liran XuNina Wettschureck* Zuyi Yuan*Shengpeng Wang*Myofibroblast is dispensable for liver fibrosisJournal of Hepatology2021.Mar 3:S0168-8278(21)00160-4.IF=25.582Corresponding author
  3. Yuyang Lei*, Jiao Zhang*, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang*, Zu-Yi Yuan*, and John Y-J. Shyy*SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2Circulation Research2020 Dec 4:2020.12.04.409144.IF=17.467Corresponding author
  4. Wang Shengpeng*; Cao Shuang; Arhatte Shuang; Li Dahui; Shi Yue; KurzSabrina; Hu Jiong; Wang Lei; Shao Jingchen; Atzberger Ann; Wang Zheng; WangChanghe; Zang Weijin; Fleming Ingrid; Wettschureck Nina; Honoré Eric;Offermanns Stefan*; Adipocyte Piezo1 mediates obesogenic adipogenesis throughthe FGF1/FGFR1 signaling pathway in miceNature Communications202011(1):2023.IF=14.878First & Corresponding author
  5. Lei Wang*, ShengPeng Wang*, Yue Shi, Rui Li, Stefan Günther, Zuyi Yuan, Lius, Stefan Offermanns*#YAP and TAZ protect against white adipocyte cell death during obesityNature Communications2020 Oct 28;11(1):5455.IF=14.878Corresponding author
  6. Chengzhuo Li, Jin Yang, Fengshuo Xu, Didi Han, Shuai Zheng, Rahel Elishilia Kaaya,Shengpeng Wang* and Jun LyuA prognostic nomogram for the cancerspecific survival of patients with upper-tract urothelial carcinoma based on the Surveillance, Epidemiology, and End Results DatabaseBMC Cancer202020:534.IF=2.933Corresponding author
  7. Wang Shengpeng; Chennupati Ramesh; Kaur Harmandeep; Iring Andras;Wettschureck Andras; Offermanns Stefan*; Endothelial cation channel PIEZO1controls blood pressure by mediating flow-induced ATP releaseJ Clin Invest2016126(12)4527-4536. IF=14.782First authorFaculty1000特别推荐
  8. Wang Shengpeng; Iring Andras; Strilic Boris; Juarez Julian Albarran;Kaur Harmandeep; Troidl Kerstin; Tonack Sarah; Burbie Joachim C.; MuellerChrista E.; Fleming Ingrid; Lundberg Jon O.; Wettschureck Nina; OffermannsStefan*; P2Y and GqG₁₁ control blood pressure by mediating endothelialmechanotransductionJ Clin Invest2015125(8)3077-3086. IF=14.782First authorNature Review Nephrology亮点评述
  9. Wang Shengpeng; Zhang Yan; Wier W. Gil; Yu Xiaojiang; ZhaoMing; Hu Hao;Sun Lei; He Xi; Wang Youhua; Wang Bing; Zang Weijin*; Role of store-operatedCa2+ entry in adenosine-induced vasodilatation of rat small mesenteric artery,AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY2009297(1):H347-H354. IF=4.048First author
  10. Kwon Hyouk Bum;Wang Shengpeng; Helker Christian S. M.; Rasouli S.Javad; Maischein Hans-Martin; Offermanns Stefan; Herzog Wiebke; Stainier DidierY. R.*; In vivo modulation of endothelial polarization by Apelin receptorsignallingNat Commun.20167(11805)1-12.IF=11.878
  11. Wang Shengpeng; Zang Weijin*; Kong Shanshan; Yu Xiaojiang; Sun Lei; Zhao Xinfeng; Wang Shixiang; Zheng Xiaohui*; Vasorelaxant effect of isopropyl 3-(3,4-dihydroxyphenyl) -2-hydroxypropanoate, a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery, Eur J Pharmacol., 2008, 579(1- 3): 283-288. IF=3.17First author

其它论文 (按时间倒序排列)

  1. Wang L, Rice M, Swist S, Kubin T, Wu F, Shengpeng Wang, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T. BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation. 2020 Dec 18. IF=23.603
  2. Wang L, Chennupati R, Jin YJ, Li R, Shengpeng Wang, Günther S, Offermanns S. YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells. iScience. 2020 Nov 26;23(12):101860. IF=4.447
  3. Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Shengpeng Wang, Offermanns S, Ercanoglu MS, Kwon HB, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Communications Biology. 2020 May 26;3(1):265.  IF=4.165
  4. Li C, Yang J, Zheng S, Xu F, Han D, Bai L, Wei YL, Wang S, Lyu J. Establishment and Validation of a Nomogram for Tonsil Squamous Cell Carcinoma: A Retrospective Study Based on the SEER Database. Cancer Control. 2020 Jan-Dec;27(1):1073274820960481. IF=3.103
  5. Han D, Yang J, Xu F, Huang Q, Bai L, Wei YL, Kaaya RE, Shengpeng Wang, Lyu J. Prognostic factors in patients with gallbladder adenocarcinoma identified using competing-risks analysis: A study of cases in the SEER database. Medicine (Baltimore). 2020 Jul 31;99(31):e21322. IF=1.552
  6. Wu Jiayuan; Zhou Quan; Pan Zhenyu; Wang Yufeng; Hu Liren; Chen Guanghua; Shengpeng Wang *; Lyu Jun*; Development and validation of a nomogram for predicting long-term overall survival in nasopharyngeal carcinoma A population-based study, Medicine, 2019, 99:4(e18974). IF=1.552Corresponding author
  7. Yin Wenguang; Kim Hyun Taek; Shengpeng Wang; Gunawan Felix; Li Rui; Buettner Carmen; Grohmann Beate; Sengle Gerhard; Sinner Debora; Offermanns Stefan; Stainier Didier Y R*; Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis,  European Respiratory Journal2019 53(3): 0-1800840. IF=11.807
  8. Iring Andras; Jin Young June; Albarran Juarez Julian; Siragusa Mauro; ShengPeng Wang; Dancs Peter T; Nakayama Akiko; Tonack Sarah; Chen Min; Kuenne Carsten; Sokol Anna M; Guenther Stefan; Martinez Alfredo; Fleming Ingrid;Wettschureck Nina; Graumann Johannes; Weinstein Lee S; Offermanns Stefan*; Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure, Journal of Clinical Investigation, 2019, 129(7): 2775-2791. IF=12.282
  9. Yin Wenguang*; Kim Hyun Taek; ShengPeng Wang; Gunawan Felix; Wang Lei; Kishimoto Keishi; Zhong Hua; Roman Dany; Preussner Jens; Guenther Stefan; Graef Viola; Buettner Carmen; Grohmann Beate; Looso Mario; Morimoto Mitsuru; Mardon Graeme; Offermanns Stefan; Stainier Didier Y R*; The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis, Nature Communications, 2018, 9(1): 0-2815. IF=11.878
  10. Schürmann Christoph; Dienst Franziska L.; Pálfi Katalin; VasconezAndrea E.; Oo James A.; ShengPeng Wang; Buchmann Giulia K.; Offermanns Stefan;Sluis Bart van de; Leisegang Matthias S.; Günther Stefan; Humbert Patrick O.;Lee Eunjee; Zhu Jun; Weigert Andreas; Mathoor Praveen; Wittig Ilka; Kruse Christoph; Brandes Ralf P.*; The Polarity Protein Scrib Limits Atherosclerosis Development in Mice, Cardiovascular Research, 2019, 115(14): 1963-1974. IF=7.014
  11. Liu Longzhu; He Xi; Zhao Ming; Yang Si; Shengpeng Wang; Yu Xiaojiang; Liu Jiankang; Zang Weijin*; Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats., Journal of Molecular and Cellular Cardiology, 2019, 128: 26-37. IF=5.055
  12. Juárez Julián Albarrán; Iring Andras; Shengpeng Wang; Joseph Sayali;Grimm Myriam; Strilic Boris; Wettschureck Nina; Althoff Till F; Offermanns Stefan*; Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation, Journal of Experimental Medicine, 2018, 215(10 ): 2655-2672. IF=10.892
  13. Wirth Angela*; Shengpeng Wang; Takefuji Mikito; Tang Cong; Althoff Till F.; Schweda Frank; Wettschureck Nina; Offermanns Stefan*; Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling, Cardiovascular Research2016,109(1): 131-140. IF=7.014
  14. Wang Youhua; Tian Zhenjun; Zang Weijin; Jiang Hongke; Li Youyou; Shengpeng Wang; Chen Shengfeng*; Exercise training reduces insulin resistance in postmyocardial infarction rats, Physiological Reports, 2015, 3(4). IF=1.005
  15. Sivaraj Kishor K.; Li Rui; Juarez Julian Albarran; ShengPeng Wang; Tischner Denise; Grimm Myriam; Swiercz Jakub M.; Offermanns Stefan; Wettschureck Nina*; Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis, Cardiovascular Research, 2015, 108(1):  171-180.   IF=7.014
  16. Althoff Till F.; Juarez Julian Albarran; Troidl Kerstin; Tang Cong; Shengpeng Wang; Wirth Angela; Takefuji Mikito; Wettschureck Nina; Offermanns Stefan*; Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling, Journal of Experimental Medicine, 2012, 209(12): 2277-2290. IF=10.892
  17. Wang Youhua; Shengpeng Wang; Wier W. Gil; Zhang Quanjiang; JiangHongke; Li Qiuxia; Chen Shengfeng; Tian Zhenjun; Li Youyou; Yu Xiaojiang; Zhao Ming; Liu Jinjun; Yang Jing; Zhang Jing; Zang Weijin*; Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction ratsvia a PI3K/Akt/eNOS pathway-mediated mechanism, American Journal of Physiology-Heart and Circulatory Physiology, 2010, 299(6):H2097-H2106. IF=4.048
  18. Wang YH, Hu H, Wang SP, Tian ZJ, Zhang QJ, Li QX, Li YY, Yu XJ, Sun L, Li DL, Jia B, Liu BH, Zang WJ. Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve. Eur J Appl Physiol. 2010 Feb;108(3):459-68. doi: 10.1007/s00421-009-1232-1. Epub 2009 Oct 15. IF=2.58
  19. Hu H, Li DL, Fan L, Ren J, Shengpeng Wang, Jia B, Liu BH, Sun L, Yu XJ, Zang WJ. Involvement of volume-sensitive Cl- channels in the proliferation of human subcutaneous pre-adipocytes. Clin Exp Pharmacol Physiol. 2010 Jan;37(1):29-34. doi: 10.1111/j.1440-1681.2009.05223.x. IF=2.456
  20. Wang SP, Zang WJ, Kong SS, Yu XJ, Sun L, Zhao XF, Wang SX, Zheng XH. Vasorelaxant effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate, a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery. Eur J Pharmacol. 2008 Jan 28;579(1-3):283-8. doi: 10.1016/j.ejphar.2007.10.009. IF=3.263
  21. Lu Jun; Zhu Shuming; Zang Weijin; Xu Xiaoli; Luo Hongli; Yu Xiaojiang; Shengpeng Wang; Kong  Shanshan; Wu Jie; Horie Minoru; Sun Lei*; Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide, Biology & Pharmaceutical Bulletin, 2007, 30(7): 1206-1211. IF=1.540

学术活动

组织会议

1.      西安交通大学2019心血管高端研讨会组织委员会委员, 西安, 中国 (2019.12).

 邀请报告

1.      Piezo1感知血流剪切力的作用,2019长安国际心血管会,西安,中国(invited talk, 2019.05

2.      Piezo1对血流剪切力的感知机制研究,中国病理生理学会血管医学专业委员会第三届学术研讨会,上海,中国(invited talk, 2018.11

3.      Piezo1介导的钙信号在血管机械传导中的作用,第12届国际钙信号和细胞功能研讨会,沈阳,中国(invited talk, 2018.07

4.      Piezo1 and P2Y2 mediated mechanotransduction in endothelial flow sensingMax-Planck Symposium 2017 BerlineGermanyinvited talk, 2017.10

5.      Mechanotransduction in vascular endothelial cellsPerspective in Vascular Biology 2016FrankfurtGermanyinvited talk2017.09

6.      P2Y2 mediated mechanosignalling in regualtion blood pressure,International Conference on Purinergic Signaling, Hamburg, Germanyinvited talk2015.07