主要研究方向包括：1）高血压及动脉粥样硬化疾病中血管稳态及代谢调控；2）代谢疾病发生的力学机制；3）器官纤维化的分子机制。实验室拥有分选型流式细胞仪(BD Aira III)、Leica SP 8型激光共聚焦显微镜、低氧工作站、超速离心机、植入子(血压)无线遥测系统、实时定量PCR仪、活细胞成像工作站等大型仪器，具有多种敲除小鼠模型及剪切力模拟系统等特色技术，致力于血管力学生物学研究，聚焦血管稳态调控的力学感知瓶颈问题，在机械力受体发现、高血压及肥胖的力学调控方面取得了一系列突破进展。

1. 国家优秀青年科学基金，主持，
2. 重点国合，主持.
3. 国家自然科学基金面上项目，主持.
4. 陕西省杰出青年科学基金 ，主持.
5. 陕西省科技创新团队，主持.
6. 陕西省重点研发计划，主持.
7. 西安交通大学“青年拔尖人才项目A 类计划”, 主持.
8. 科技部，战略科技发展类，主持.
9. 德国ECCPS的青年项目，主要负责人.
10. 德国科学基金会DFG重点项目，核心科学家（Core Scientist）.

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1. Xu L, Li T, Cao Y, He Y, Shao Z, Liu S, Wang B, Su A, Tian H, Li Y, Liang G, Wang C, Shyy J, Xiong Y, Chen F, Yuan JX, Liu J, Zhou B, Wettschureck N, Offermanns S, Yan Y, Yuan Z, Wang S. PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice. J Clin Invest. 2025.
2. Xu L, Yang C, Pang K, Zhang Y, He Y, Liu S, Tian H, Shao Z, Wang S, Liu X, Li T, Cao Y, Yan L, Liu J, Wang Y, Li Y, Zhao W, Wang Y, Yan Y, Wang S. Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity. Mol Metab. 2025.
3. Chen X, Shao J, Brandenburger I, Qian W, Hahnefeld L, Bonnavion R, Cho H, Wang S, Hidalgo J, Wettschureck N, Geisslinger G, Gurke R, Wang Z, Offermanns S. FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. Nat Commun. 2025.
4. Cho H, Lai CC, Bonnavion R, Alnouri MW, Wang S, Roquid KA, Kawase H, Campos D, Chen M, Weinstein LS, Martínez A, Looso M, Sanda M, Offermanns S. Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Science. 2025.
5. Jin YJ, Liang G, Li R, Wang S, Alnouri MW, Bentsen M, Kuenne C, Günther S, Yan Y, Li Y, Wettschureck N, Offermanns S. Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. Nat Cardiovasc Res. 2025.
6. Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor. Proc Natl Acad Sci U S A. 2024.
7. Liang G, Wang S, Shao J, Jin YJ, Xu L, Yan Y, Günther S, Wang L, Offermanns S. Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Circ Res. 2022.
8. Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood. 2022.
9. Jin YJ, Chennupati R, Li R, Liang G, Wang S, Iring A, Graumann J, Wettschureck N, Offermanns S. Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. J Clin Invest. 2021.
10. Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L, Shadel GS, Hepokoski M, Lei T, Wang H, Zhang J, Yuan JX, Malhotra A, Manor U, Wang S, Yuan ZY, Shyy JY. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circ Res. 2021.
11. Wang L, Rice M, Swist S, Kubin T, Wu F, Wang S, Kraut S, Weissmann N, Böttger T, Wheeler M, Schneider A, Braun T. BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation. 2021.
12. Xu L, Wettschureck N, Bai Y, Yuan Z, Wang S. Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice. J Hepatol. 2021.
13. Wang L, Wang S, Shi Y, Li R, Günther S, Ong YT, Potente M, Yuan Z, Liu E, Offermanns S. YAP and TAZ protect against white adipocyte cell death during obesity. Nat Commun. 2020.
14. Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nat Commun. 2020.
15. Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019.
16. Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP. The polarity protein Scrib limits atherosclerosis development in mice. Cardiovasc Res. 2019.
17. Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR. Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 2019.
18. Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018.
19. Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR. The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun. 2018.
20. Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016.
21. Kwon HB, Wang S, Helker CS, Rasouli SJ, Maischein HM, Offermanns S, Herzog W, Stainier DY. In vivo modulation of endothelial polarization by Apelin receptor signalling. Nat Commun. 2016.
22. Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F, Wettschureck N, Offermanns S. Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling. Cardiovasc Res. 2016.
23. Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S. P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015.
24. Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015.
25. Althoff TF, Albarrán Juárez J, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N, Offermanns S. Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J Exp Med. 2012.

组织会议

1.      西安交通大学2019心血管高端研讨会组织委员会委员, 西安, 中国 (2019.12).

 邀请报告

1.      Piezo1感知血流剪切力的作用，2019长安国际心血管会，西安，中国（invited talk, 2019.05）

2.      Piezo1对血流剪切力的感知机制研究，中国病理生理学会血管医学专业委员会第三届学术研讨会，上海，中国（invited talk, 2018.11）

3.      Piezo1介导的钙信号在血管机械传导中的作用，第12届国际钙信号和细胞功能研讨会，沈阳，中国（invited talk, 2018.07）

4.      Piezo1 and P2Y2 mediated mechanotransduction in endothelial flow sensing，Max-Planck Symposium 2017 ，Berline，Germany（invited talk, 2017.10）

5.      Mechanotransduction in vascular endothelial cells，Perspective in Vascular Biology 2016，Frankfurt，Germany（invited talk，2017.09）

6.      P2Y2 mediated mechanosignalling in regualtion blood pressure,International Conference on Purinergic Signaling, Hamburg, Germany（invited talk，2015.07）