(5.)Scientific Research

部分研究成果：
 

33. Xinyu Wang, Yahao Zhao, Xueming Wu, Leqi Cui*, Shuai Mao*, Trace Element Chemistry and Health, Frontiers in Nutrition, 2022, 9:1034577..

 
32. Yang, Xue-Yan, Bo Yuan, Hai Xiong,* Yahao Zhao, Lu Wang, San-Qi Zhang,* Shuai Mao*. Allyl Phenyl Selenides as H2O2 Acceptors to Develop ROS-Responsive Theranostic Prodrugs. Bioorganic Chemistry 2022, 129, 106154.

 

31. Shuai Mao, * Yahao Zhao, Zixuan Luo, Ruizhe Wang, Bo Yuan, Linghao Hu, San-Qi Zhang, Mingliagn Wang, and Zhengkai Chen. "Metal-free photo-induced sulfidation of aryl iodide and other chalcogenation." Frontiers in Chemistry 10:941016. DOI: 10.3389/fchem. 2022.941016.

 

30. Shuai Mao,* Bo Yuan, Xinyu Wang, Yahao Zhao, Lu Wang, Xueyan Yang, Yiming Chen, San-Qi Zhang,* Pengfei Li.* Triazene as the Directing Group Achieving Highly Ortho Selective Diborylation and Sequential Functionalization. Organic Letters 2022, 24, 3594-3598.

 

29. Ruizhe Wang,# Xinyu Wang,# Shuai Mao,* Yahao Zhao, Bo Yuan, Xueyan Yang, Jianjun Li, Zhengkai Chen.* Metal‐free Photochemical C‐Se Cross‐Coupling of Aryl Halides with Diselenides. Advanced Synthesis & Catalysis 2022, 364, 1607-1612.

 

28. Ting Deng,# Wenxin Yan,# Xiaoyu Liu,# Guizhimeng Hu, Weilie Xiao,* Shuai Mao,* Jun Lin,* Yinchun Jiao,* Yi Jin.* Cu-Catalyzed Radical Addition and Oxidation Cascade: Unsymmetrical Trimerization of Indole to Access Isotriazatruxene. Organic Letters 2022, 24, 1502-1506.

 

27. Hong-Yi Zhao, Hai-Peng Wang, Yu-Ze Mao, Hao Zhang, Minhang Xin, Xiao-Xiao Xi, Hao Lei, Shuai Mao, Dong-Hui Li, San-Qi Zhang,* Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands. J. Med. Chem. 2022, 65, 6, 4709–4726.

 

26. Xue‐Yan Yang, Hong‐Yi Zhao, Hao Lei, Bo Yuan, Shuai Mao, Minghang Xin, San‐Qi Zhang,* Synthesis and Biological Evaluation of 10‐Substituted Camptothecin Derivatives with Improved Water Solubility and Activity. ChemMedChem 2021, 16, 1000-1010.

 

25. Hao Zhang, Hong-Yi Zhao, Xiao-Xiao Xi, Yan-Jie Liu, Minhang Xin, Shuai Mao, Jun-Jie Zhang, A-Xin Lu, San-Qi Zhang,* Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). European Journal of Medicinal Chemistry 2020, 189, 112061.

 

24. Kaixiu Luo,# Shuai Mao,# Kun He, Xianglin Yu, Junhong Pan, Jun Lin,* ZhiHui Shao,* Yi Jin*. Highly Regioselective Synthesis of Multisubstituted Pyrroles via Ag-Catalyzed [4+1C]insert Cascade. ACS Catal. 2020, 10, 3733−3740.

 

23. Wenmin Chen,# Shuai Hu,# Shuai Mao, Yibin Xu, Hui Guo, Haoxi Li, Michelle T Paulsen, Xinde Chen, Mats Ljungman, Nouri Neamati.* Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells. ChemMedChem 2020, 15, 2029–2039.

 

22. Xue-Yan Yang, Ruizhe Wang, Lu Wang, Jianjun Li, Shuai Mao,* San-Qi Zhang, Nanzheng Chen. K2S2O8-promoted C–Se bond formation to construct a-phenylseleno carbonyl compounds and a,b-unsaturated carbonyl compounds. RSC Adv., 2020, 10, 28902-28905.

 

21. Shuai Mao, Kaixiu Luo, Lu Wang, Hong-Yi Zhao, Andrea Shergalis, Minhang Xin, Nouri Neamati,* Yi Jin,* and San-Qi Zhang,* Metal-Free C-2-H Alkylation of Quinazolin-4-ones with Alkanes via Cross-Dehydrogenative Coupling. Org. Lett. 2019, 21, 2365–2368.

 

20. Shuai Mao, Zhengkai Chen, Lu Wang, Daulat Bikram Khadka, Minhang Xin,Pengfei Li*, and San-Qi Zhang*，Synthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature, J. Org. Chem. 2019, 84, 463–471.

 

19. Yuan-Yuan Hei, San-Qi Zhang, Yifan Feng, Weiming Duan, Hao Zhang, Shuai Mao, Jin Wang, Haopeng Sun, Minhang Xin. Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors. Bioorg. Med. Chem. 2019, 27, 114930-114941.

 

18. Rui-Lin Liu*, Shuai Mao, Yan Wang, Lu Wang, Yan-Hui Ge, Xin-Ya Xu, Qiang Fu. A mussel-inspired hybrid copolymer adhered to chitosan-coated micro-sized carbon fiber aerogels for highly efficient nanoparticle scavenging. Environ. Sci.: Nano, 2017, 4, 2164-2174.

 

17. Xue‐Qing Zhu, Shuai Mao, Dong‐Dong Guo, Bin Li, Shi‐Huan Guo, Ya‐Ru Gao, Yong‐Qiang Wang, Copper-catalyzed isomerization and cyclization of E/Z-Ohaloaryl N-sulfonylhydrazones: Convenient access to 1H-indazoles. ChemCatChem 2017, 9, 1084−1091.

 

16. Guanghui Wang, Li Liu, Hong Wang, You-Song Ding, Jing Zhou, Shuai Mao, Pengfei Li. N, B-Bidentate Boryl Ligand-Supported Iridium Catalyst for Efficient Functional-Group-Directed C–H Borylation. J. Am. Chem. Soc. 2017, 139, 91.

 

15. Sai-Jie Zuo, Sai Zhang, Shuai Mao, Xiao-Xiao Xie, Xue Xiao, Min-Hnag Xin, Wei Xuan, Yuan-Yuan He, Yong-Xiao Cao, San-Qi Zhang*, Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents. Bioorganic & Medicinal Chemistry, 2016, 24, 179-190.

 

14. Hei Yuan-Yuan; Zhang Hao; Xie Xiao-Xiao; Mao Shuai; Xin Minhang; Zhang San-Qi. Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors. Bioorg. Med. Chem. Lett., 2016, 26, 4408-4413.

 

13. Shuai Mao, Ya-Ru Gao, Xue-Qing Zhu, Dong-Dong Guo, and Yong-Qiang Wang*, Copper-Catalyzed Radical Reaction of N–Tosylhydrazones: Stereoselective Synthesis of (E)-Vinyl Sulfones. Org. Lett. 2015, 17, 1692–1695.

 

12. Shuai Mao, Xue-Qing Zhu, Ya-Ru Gao, Dong-Dong Guo, Yong-Qiang Wang*, Silver-Catalyzed Two Csp3–H Coupling and One-pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles. Chem. Eur. J. 2015, 11335-11339. (Hot paper)

 

11. Shuai Mao, Ya-Ru Gao, Shao-Liang Zhang, Dong-Dong Guo, Yong-Qiang Wang*, Copper(II)-Promoted C–C Bond Formation by Oxidative Activation of Two C(sp3)–H Bonds Adjacent to Carbonyl Group to Construct 1,4-Diketones and Tetrasubstituted Furans. Eur. J. Org. Chem. 2015, 876–885.

 

10. Jing-Wen Yu#, Shuai Mao#, Yong-Qiang Wang*, Copper-catalyzed base-accelerated direct oxidation of C–H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant. Tetrahedron Lett. 2015, 56, 1575–1580.

 

9. Dong Yang, Shuai Mao, Ya-Ru Gao, Dong-Dong Guo, Shi-Huan Guo, Bin Li，Yong-Qiang Wang*，Palladium-Catalyzed C-7 Alkenylation of Indolines Using Molecular Oxygen as the Sole Oxidant. RSC Adv. 2015, 5, 23727–23736.

 

8. Hao Zhang, Min-Hang Xin, Xiao-Xiao Xie, Shuai Mao, Sai-Jie Zuo, She-Min Lu, San-Qi Zhang*, Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4 (3H)-one moiety. Bioorg. Med. Chem. 2015, 23, 7765-7776.

 

7. Bo-Rui Kang, Sen Li, Shuai Mao, Yong-Xiao Cao, San-Qi Zhang,* Discovery of novel 2-benzylisoquinolin-1 (2H)-ones as potent vasodilative agents. Bioorg. Med. Chem. Lett., 2015, 25, 5808-5812.

 

6. Xiao-Meng Wang, Shuai Mao, Lei Cao, Xiao-Xiao Xie, Min-Hang Xin, Jia-Fang Lian,Yong-Xiao Cao, San-Qi Zhang. Modification of N-(6-(2-methoxy-3- (4-fluorophenyl sulfonamido)pyridin-5-yl)-[1,2,4]triazolo [1,5-a]pyridin-2-yl) acetamide as PI3Ksinhibitor by replacement of the acetamide group with alkylurea. Bioorg. Med. Chem. 2015, 23, 5662–5671.

 

5. Xiao-Xiao Xie, Huan Li, Juan Wang, Shuai Mao, Min-Hang Xin, She-Min Lu, Qi-Bing Mei, San-Qi Zhang. Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d] thiazol-2-yl)urea asanticancer agents with low toxicity. Bioorg. Med. Chem. 2015, 23, 6477–6485.

 

4. Yu-Fei Wang, Ya-Ru Gao, Shuai Mao, Yan-Lei Zhang, Dong-Dong Guo, Zhao-Lei Yan, Shi-Huan Guo, and Yong-Qiang Wang*, Wacker-Type Oxidation and Dehydrogenation of Terminal Olefins Using Molecular Oxygen as the Sole Oxidant without Adding Ligand, Org. Lett. 2014, 16, 1610–1613.

 

3. Zhao-Lei Yan, Wen-Liang Chen, Ya-Ru Gao, Shuai Mao, Yan-Lei Zhang and Yong-Qiang Wang*, Palladium-Catalyzed Intermolecular C2 Alkenylation of Indoles Using Oxygen as the Oxidant. Adv. Synth. Catal. 2014, 356, 1085–1092.

 

2. Nana Li, Yan-Lei Zhang, Shuai Mao, Ya-Ru Gao, Dong-Dong Guo, and Yong-Qiang Wang*, Palladium-Catalyzed C–H Homocoupling of Furans and Thiophenes Using Oxygen as the Oxidant. Org. Lett. 2014, 16, 2732–2735.

 

1. Yanping Liu#, Jooyoung Chung#, Youngjin Jang, Shuai Mao, B. Moon Kim, Yongqaing Wang, Xiaohui Guo*, Magnetically Recoverable Nanoflake-Shaped Iron Oxide /Pt Heterogeneous Catalysts and Their Excellent Catalytic Performances in Hydrogenation Reaction. ACS. Applied Mater@Interface 2014, 6, 1887–1892.

 

知识产权：

 

6. 毛帅，杨学燕，张三奇，袁博。一种喜树碱前药、制备方法、应用及其盐，CN114591346A.

 

5. 毛帅，袁博，张三奇，赵亚浩，王欣宇，王睿喆。一种硒醚/硫醚化合物的合成方法及合成的化合物，CN 114014790 A.

 

4. 毛帅，袁博，张三奇，陈艺铭，赵亚浩，王欣宇。一种Ir-O-P型催化剂二硼酸/酯化合物的制备，CN 113980044 A.(已授权)

 

3. CPT专利：Nouri Neamati and Shuai Mao, Preparation of substituted bicyclic and tetracyclic quinones and related methods of use. WO 2020181207. （已转化）

 

2. 毛帅，张三奇，辛敏行，赵宏义，雷浩。一种非金属促进的2-烷基杂芳烃化合物的制备方法，ZL 2019 1 1033939.7(已授权)

 

1. 毛帅，李鹏飞，张海龙，徐鸣，张昌龙。一种合成L-(+)-硒代蛋氨酸的方法, CN 110563623 A

出版物

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