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课题组在国际最具影响力期刊ACS catalysis上发表研究论文


2020-02-07

 恭喜课题组在国际最具影响力期刊ACS catalysis上发表研究论文,此工作是毛帅副教授与云南大学金毅教授合作完成的,其2018年影响因子为12.22。工作的部分内容如下:

 

 

Abstract:

An efficient [4+1C]insert approach to the coupling of enaminones with donor/acceptor or donor/donor carbenes by AgOTf catalyzed C‒C bond carbenoid formal insertion/cyclization/[1,5]-shift cascade reaction was successfully developed, providing distinct chemo- and regio-selective multisubstituted pyrroles. The plausible reaction mechanism involves two catalytic cycles: in the first one, silver ions regioselectively catalyze the C–C bond insertion reaction; in the second one, silver ions chemo- and regio-selectively control the cyclization and [1,5]-shift reactions. This method not only provides convenience and applies atom economy in the synthesis multisubstituted pyrroles but also presents an entry point for further pyrrole diversification via facile modification of resulting 4-H-pyrrole products, as displayed by a short formal synthesis of the natural product lamellarin L.           


https://doi.org/10.1021/acscatal.9b05360



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