Basic Information



Sicen Wang
Ph.D.  Professor
 March,1974

Membership in Professional Associations

 

Vice Director and member of Pharmaceutical Analysis Branch, Chinese Pharmaceutical Association, China.

Director and member of Pharmaceutical Analysis Branch, Shaanxi Pharmaceutical Association, China.

Member of the council of Shaanxi Pharmaceutical Association, China.

 

 

Education

B.Sc., Pharmacy, Former Xi’an Medical University, Xi’an, China, July 1997
M.Sc., Pharmaceutical Analysis, Xi’an Jiaotong uniersity, Xi’an, China, July 2002. Title of M.Sc. thesis:“Study on the difference of in-vivo prosess between two enantiomers of nicardipine in rabbits ”.
Ph.D., Pharmaceutical Analysis, Xi’an Jiaotong uniersity, Xi’an, China, June 2006. Title of Ph.D. thesis:“ Chromatographic separation and selective differences of the enantiomers of four calcium antagonists”.

Employment

1997-1999: Teaching Assistant, Faculty of Pharmacy, Xi’an Medical University, Xi’an, China.
July.2002-March.2003: Lecturer, College of Pharmacy, Faculty of Pharmacy, Xi’an Jiaotong University
May 2006-July 2007: Lecturer
Research & Engineering Center for Natural MedicineXi’an Jiaotong University, Xi’an, China.

Aug 2007-Dec 2010: Associate professorResearch & Engineering Center for Natural MedicineXi’an Jiaotong University, Xi’an, China.

Jan 2011-Present: ProfessorSchool of PharmacyXi’an Jiaotong University, Xi’an, China. 

July 2013-Present: Vice DeanSchool of PharmacyXi’an Jiaotong University, Xi’an, China.

Contact

Food & Drug Analysis Center

School of Pharmacy
Xi’an Jiaotong University
76 Yanta West Road

Xi’an 710061

P.R. China

Tel:(86)(29)82656788
Fax:(86)(29)82655451
E-mail:
wangsc@mail.xjtu.edu.cn

Scientific Research

My research program during my postgraduate work was centered on separation the enantiomers and comparison their difference on pharmacokinetics, pharmacological activity. The techniques that have been used during this work were:
1) Chromatography techniques-TLC, GC, HPLC, CMC (cell membrane chromatography).
2) Instrumentations: UV, IR, HPLC, GC/MS.
3) Pharmacological assay of target compounds.

My current research interests are in pharmaceutical analysis and focus on developing new methods for screening the active components from natural medicines and developing new drugs; studying on the interaction differences between drug and biomembrane (or receptor) and cell with Liquid chromatography methods; development and utilization of the natural medicine and development of the drug screening methods.

Research Proposals & Projects Written & Funded

l  Pharmacokinetics and pharmacological effect of an anti-myocardial ischemia component from Redix Leontice Rhizome. Shaanxi Natural Science Foundation, 2500 USD.

l  Screening the active components from Radix caulophylli alkaloids using α1A receptor CMC-HPLC/MS method. Natural Science Foundation of China, 30,000 USD.2009-2011

l  Screening acting on EGFR components from "Qiyao" using Duo-channel EGFR cell membrane chromatography. Natural Science Foundation of China, 15,000 USD.2011-2011

l  Development and application of cell chromatography using immobilized FGFR4 over-expressed cell as stationary phase. Natural Science Foundation of China, 100,000 USD.2017-2020

l  Preclinical study on Caulophine: an new drug anti ischemia Special Program for Key Drug Developmemt Research of the Ministry of Science and Technology, China. 240,000 USD.2013-2015

Awards

March 2016– 1st Prize for Shaanxi University Award

Oct. 2012– 2nd Prize for National Award for Technological Invention

November. 2010 – Shaanxi Rising Star for Science and Technology

April. 2009 – New Century Excellent Talents in University

November. 2008 – Shaanxi Scientific Award for Natural Sciences

June. 2006 – Shaanxi Scientific Award for Natural Sciences

December. 2005 – Shaanxi Pharmaceutical Association Outstanding Pharmaceutical Scientist

November. 2004 – Chinese Scientific & Technological Development Found Award for Food & Drug monitoring

Rercent Published Papers

Articals

[1]     Xie XY, Liu X, Pan XY, Chen L, Wang SC*. Surface imprinted magnetic particles for high selective sulfonamides recognition prepared by reversible addition fragmentation chain transfer polymerization. Anal Bioanal Chem, 2016, 408:963-970

[2]     Han SL, Li CL, Huang J, Wei F, Zhang Y, Wang SC*. Cell membrane chromatography coupled with UPLC-ESI-MS/MS method to screen target components from Peucedanum praeruptorum Dunn acting on α1A adrenergic receptor. J Chromatogr B, 2016, 1011:158-162

[3]     Sun M; Lin YY; Zhang J; Wang SC*. Online solid-phase extraction with high-performance liquid chromatography and mass spectrometry for the determination of five tannins in traditional Chinese medicine injections. J Sep Sci, 2016, 39:889-894

[4]     Li M, Wang SC*, He LC. Development of an analytical method coupling cell membrane chromatography with gas chromatography-mass spectrometry via microextraction by packed sorbent and its application in the screening of volatile active compounds in natural products. J Chromatogr B, 2015, 974:9-16

[5]     Xie XY, Pan XY, Han SL, Wang SC*. Development and characterization of magnetic molecularly imprinted polymers for the selective enrichment of endocrine disrupting chemicals in water and milk sample. Anal Bioanal Chem, 2015, 407:1735–1744

[6]     Ye FQ, Chen LF, Hu LC, Chen D, Wang Y, Liang G, Liu ZG, Wang SC*. Design, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFR1. Bioorg Med Chem Lett, 2015,25:1556-1560

[7]     Xie XY, Pan XY, Han SL, Wang SC*. Preparation of molecularly imprinted polymers based on magnetic nanoparticles for the selective extraction of protocatechuic acid from plant extracts. J Sep Sci, 2015, 38, 1046–1052

[8]     Zhang P, Hou XF, Lv N, Feng LX, Wang SC*. Cell membrane chromatography with zonal elution for characterization of seven alkaloids binding to α1A adrenoreceptor. J Liq Chromatogr Rel Tech, 2015, 38(9):986-992

[9]     Sun D, Wang SC*. Enhanced-oxidation and electrochemical determination of honokiol and magnolol using NMP-exfoliated graphene nanosheets. J Mol Liq, 2015, 208:52-57

[10]     Xie XY, Chen L, Pan XY, Wang SC*. Synthesis of magnetic molecularly imprinted polymers by reversible addition fragmentation chain transfer strategy and its application in the Sudan dyes residue analysis. J Chromatogr A, 2015, 1405:32-39

[11]     Li Peng, Chen QH, Yu F, Xie XY, Wang SC*. Simultaneous determination of camptothecin and 10-hydroxycamptothecine in the Camptotheca acuminate, its medicinal preparation and in rat plasma by liquid chromatography with fluorescence detection. Biomed Chromatogr, 2015, 29(10):1522-1526

[12]     Sun M, Hou XF, Lin YY, Zhang J, Wang SC*. An improved Cell Membrane Chromatography method for simultaneous screening of two Epidermal Growth Factor Receptor antagonists from Radix scutellariae. J Sep Sci, 2015, 38:3145-3150

[13]     Ye FQ, Wang YW, Nian SY, Wang Y, Chen D, Yu SF, Wang SC*. Synthesis and evaluation of biological and antitumor activities of 5,7-dimethyl-oxazolo[5,4- d]pyrimidinev-4,6(5H,7H)-dione derivatives as novel inhibitors of FGFR1. J Enzym Inhib Med Chem, 2015, 16:1-6

[14]     Sun D, Wang SC*. Highly sensitive electrochemical sensor for paeonol using NMP-exfoliated grapheme-modified electrode. Ionics, 2015, 21(10):2905-2910

[15]     Zhang T, Ding YY, An HL, Feng LX, Wang SC*. Screening anti-tumor compounds from Ligusticum Wallichii using cell membrane chromatography combined with HPLC/MS. J Sep Sci, 2015, 38(18):3247-3253

[16]     Han SL, Huang J, Wei F, Wang SC*. Screening target compounds acting on <alpha>1A adrenergic receptor from Caulis spatholobi for treatment of benign prostatic hyperplasia using cell membrane chromatography. Anal Lett, 2014, 47:1661-1669

[17]     Han SL, Huang J, Hou JJ, Wang SC*. Screening epidermal growth factor receptor antagonists from Radix et Rhizoma Asari by two dimensional liquid chromatography: epidermal growth factor receptor/cell membrane chroma tography column combined with high performance liquid chromatography-mass spectrometry system. J Sep Sci, 2014, 37:1525-1532

[18]     Zhao G, Peng C, Du W, Wang SC*. Simultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC-MS method: application to a bioavailability and protein binding ability study in rat plasma. Biomed Chromatogr, 2014, 28: 947–956

[19]     Zhao G, Peng C, Du W, Wang SC*. Pharmacokinetic study of eight coumarins of Radix AngelicaeDahuricae in rats by gas chromatography-mass spectrometry. Fitoterapia, 2013, 89: 250-256.

[20]     Zhang T, Han S, Huang J, Wang SC*. Combined fibroblast growth factor receptor 4 cell membrane chromatography online with high performance liquid chromatography/mass spectrometry to screen active compounds in Brassica albla. J Chromatogr B, 2013, 912: 85-92.

[21]     Hou XF, Yuan XL, Zhang B, Wang SC*, Chen Q. Screening active anti-breast cancer compounds from Cortex Magnolia officinalis by 2D LC-MS. J Sep Sci, 2013, 36 (4): 706-712.

[22]     He JY, Han SL, Yang FF, Zhou N, Wang SC*. Prostate Cell Membrane Chromatography-Liquid Chromatography-Mass Spectrometry for Screening of Active Constituents from Uncariarhynchophylla. J Chromatogr Sci, 2013, 51 (10): 905-909.

[23]     Han SL, Zhang T, Feng LX, Lv N, Wang SC*. Screening of target compounds from FructusPiperis using high alpha(1)A adrenoreceptor expression cell membrane chromatography online coupled with high performance liquid chromatography tandem mass spectrometry. J Pharma Biomed Anal, 2013, 81-82: 133-137.

[24]     Du H, Lv N, Wang SC*, He LC. Rapid characterization of a novel taspine derivative-HMQ1611 binding to EGFR by a cell membrane chromatography method. Comb Chem High T Sc, 2013, 16 (4): 324-329.

[25]     Peng C , Zhang T, Zhao G, Wang SC*. Analysis on fat-soluble components of Sinapis Semina from different habitats by GC-MS. J Pharm Anal, 2013, 3(6):402–407

[26]     Lu W, Yang FF, Wang SC*. Development of an HPLC fingerprint for quality control and species differentiation of Uncariarhynchophylla (Miq.) ex Havil. Acta Chromatogr, 2012: 1-9.

[27]     He HZ, Han SL, Zhang T, Zhang J, Wang SC*, Hou JJ. Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS. J Pharm Biomed Anal, 2012, 62: 196-202.

[28]     Han SL, Zhang T, Huang J, Hu ZG, Wang SC*. Screening target components from Radix salviaemiltiorrhiae using an EGFR/CMC-online-HPLC/MS method. Anal Meth, 2012, 4 (4): 1078-1083.

[29]     Han SL, Zhang P, Wei F, Wang SC*. Screening active components acting on alpha(1A) adrenergic receptors from agrimony using a Sprague-Dawley rat prostate cell membrane chromatography online coupled HPLC/MS method. Anal Meth, 2012, 4 (10): 3351-3357.

[30]     Du H, Wang SC*, Ren J, Lv N, He LC. Revealing multi-binding sites for taspine to VEGFR-2 by cell membrane chromatography zonal elution. J Chromatogr B, 2012, 887: 67-72.

[31]     Ren J, D DD; Sun M; Wang SC*. Prostate Cell Membrane Chromatography–LC/MS Method for Screening a1A-Adrenoceptor Antagonists from Lotus Plumule. Chromatographia, 2011, 74 (5-6): 375-381.

[32]     He HZ, Han SL, Zhang T, Zhang J, Wang SC*, Hou JJ. Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae> via cell membrane chromatography online coupled with HPLC/MS. J Pharm Biomed Anal, 2011, 62: 196-202.

[33]     Du H, Ren J, Wang SC*. Rapid determination of three alkaloids from Lotus Plumule in human serum using an HPLC-DAD method with a short monolithic column. Food Chem, 2011, 129 (3): 1320-1324.

[34]     Wang SC, Zhang Z, He LC, Li H. Non-Aqueous Capillary Electrophoresis for Separation and Simultaneous Determination of Magnoflorine, Taspine, and Caulophine in CaulophyllumRobustum Collected in Different Seasons. Anal Lett, 2010, 43 (9): 1534-1542.

[35]     Wang SC, Sun M, Zhang YM, Zhang J, He LC. EGFR/cell membrane chromatography-online-high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Radix AngelicaePubescentis. Sci Chin-Chem, 2010, 53 (11): 2357-2362.

[36]     Wang SC, Sun M, Zhang Y, Du H, He L. A new A431/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening epidermal growth factor receptor antagonists from Radix sophoraeflavescentis. J Chromatogr A, 2010, 1217 (32): 5246-5252.

[37]     Wang L, Ren J, Sun M, Wang SC*. A combined cell membrane chromatography and online HPLC/MS method for screening compounds from Radix Caulophylli acting on the human α1A-adrenoceptor. J Pharm Biomed Anal, 2010, 51 (5): 1032-1036.

[38]     Sun M, Ren J, Du H, Zhang YM, Zhang J, Wang SC*, He L. A combined A431 cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening compounds from total alkaloid of Radix Caulophylli acting on the human EGFR. J Chromatogr B, 2010, 878 (28): 2712-2718.

 

Invited Review Papers

[1]     Muhammad S, Han SL, Xie XY, Wang SC*, Aziz MM. An overview of online two dimensional liquid chromatography based on cell membrane chromatography for screening target components form traditional Chinese medicines. Journal of Separation Science, 2016, DOI: 10.1002/jssc.201600773 

[2]      Hou XF, Du H, He XS, Zhang P, Wang SC*. Advances in research on the application of cell membrane chromatography in the study of drug-Receptor interactions. Progress in Pharmaceutical Sciences, 2015,39(12):882-888

[3]    Xie XY, Bu YS, Wang SC*.  Molecularly imprinting: a tool of modern chemistry for analysis and monitoring of phenolic environmental estrogens. Reviews in Analytical Chemistry, 2016; 35(2): 87–97