| 论文简介 |
Cell membrane-cloaked nanotechnology has attracted increasing attention owing to its unique bionic
properties, such as specific recognition and biocompatibility conferred by the integrated membrane
structure and receptors. However, this technology is limited by the dissociation of the cell membrane
from its carrier. Here, we report a novel type of cell membrane-cloaked modified magnetic nanoparticle
with good stability in drug discovery. High α 1A -adrenergic receptor (α 1A -AR) expressing HEK293 cell mem-
brane-cloaked magnetic nanogrippers (α 1A /MNGs) were used as a platform for the specific targeting and
binding of α 1A -AR antagonists as candidate bioactive compounds from traditional Chinese medicine
(TCM). Furthermore, using a dynamic covalent bonding approach, α 1A /MNGs showed great stability with
positive control drug recoveries of α 1A /MNGs showing almost no decline after use in five adsorption–de-
sorption cycles. Moreover, the α 1A /MNGs possessed a unilamellar membrane with magnetic features and
exhibited good binding capacity and selectivity. Ultimately, TCM and pharmacological studies of the
bioactivity of the screened compounds confirmed the considerable targeting and binding capability of
α 1A /MNGs. Application of aldehyde group modification in this drug-targeting concept further improved
biomaterial stability and paves the way for the development of new drug discovery strategies. More impor-
tantly, the successful application of α 1A /MNGs provides new insights into methodologies to improve the
integration of cell membranes with the nanoparticle platform. |
(创新港)
