基本信息

姓名:吴捷                性别: 男
职称:教授               学历:博士
电话:029-82655165       Email:wujie@mail.xjtu.edu.cn
工作地址:710061 陕西省 西安市 西安交通大学 医学部 药理学系
 
研究方向:
    心血管药理学和心血管生理学。利用膜片钳和分子生物学方法研究神经递质、药物对心脏离子通道的分子调控机制及其与心律失常的关系。
 
简 历:
    1985年本科毕业于西安交通大学信息与控制工程系生物医学电子工程与仪器专业,获工学学士学位,同年留校任教至今。2003年获西安交通大学药理学硕士学位,2009年获西安交通大学药理学博士学位。分别于2005年~2007年和2010年~2012年在日本滋贺医科大学呼吸循环内科学讲座和细胞生理学讲座进行博士后研究和工作,并担任助教职务。2015年荣获日本滋贺医科大学优秀研究者奖。
    主持和参与多项国家自然科学基金、教育部国际合作与交流重点项目基金、陕西省中医管理局基金等课题研究。发表论文50多篇。
 
主持的在研国家自然科学基金项目:
   1.遗传性隐匿性1型长QT综合征分子机制研究(No.81470378;资助经费:73万元,2015.1-2018.12)
   2.利用转基因表达心脏 Kv1.5钾离子通道研究新型房颤治疗药物(No.81273501;资助经费:70万元,2013.1-2016.12)
 
近期发表的SCI收录论文:
1.  Wu J, Ding WG, Horie M. Molecular pathogenesis of long QT syndrome type 1 (review).   J Arrhythm. 2016; January 27. [Epub ahead of print]. DOI:http://dx.doi.org/10.1016/j.joa. 2015.12.006
 
2. Wu J, Naiki N, Ding WG, Ohno S, Kato K, Zang WJ, Matsuura H, Horie  M. A Molecular Mechanism for Adrenergic-
    induced   Long QT Syndrome.  J Am Coll Cardiol. 2014; 63(8): 819. (IF:16.503)
 
3. Zhou J, Ding WG,Makiyama T, Miyamoto A, Matsumoto Y, Kimura H,  Tarutani Y, Zhao J, Wu J (通讯作者), Zang WJ,
    Matsuura H, Horie M.  A novel HCN4 mutation, G1097W, is associated with atrioventricular block. Circ J. 2014; 78(4): 938.
   IF:3.96
 
4. Wu J, Ding W-G, Matsuura H, Tsuji K, Zang W-J, Horie M. Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor
    LY294002 on the human Kv1.5 channel. Br J Pharmacol. 2009; 156:377. (IF:5.20)
 
5. Wu J, W Shimizu, W-G Ding, Ohno S, Toyoda F, Itoh H, W-J Zang, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K,
    Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M.  KCNE2 Modulation of KV4.3 Current and
    its Potential Role in Fatal Rhythm Disorders. Heart Rhythm 2010; 7:199. (IF:5.05)
 
6. Wu J, Ding WG, Matsuura H, Horie M. Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric
    channels by P2Y receptors. Pflugers Arch. 2012; 464:625. (IF:4.87)
 
7. Nakajima T, Wu J, Kaneko Y, Ashihara T, Ohno S, Irie T, Ding WG, Matsuura H, Kurabayashi M, Horie M. KCNE3 T4A
    as the genetic basis of brugada-pattern electrocardiogram. Circ J. 2012; 76: 2763.  (IF:3.58)
 
8. Wu J, Ding WG,Zhao J,Zang WJ, Matsuura H,Horie M. Irbesartan mediated AT1 receptor blockade attenuates hyposmostic-
    induced enhancement of IKs current and prevents shortening of action  potential duration in atrial myocytes. J Renin
   Angiotensin Aldosterone Syst. 2014;15: 341-347 (IF:2.4).
 
9.Itoh H, Crotti L, Aiba T, Spazzolini C,Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J,
  Hasegawa K,Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M,Murakami Y, Shimizu W, Guicheney P,
  Schwartz PJ, Horie M. The genetics underlying acquired long QT syndrome: impact for genetic screening.
  Eur Heart J. 2016; 37:1456-1464.  (IF15.503)
 
10.Kato K, Makiyama Y, Wu J, Ding WG, Kimura H, Naiki N, et. al.Cardiac Channelopathies Associated with
   Infantile Fatal Ventricular Arrhythmias: From the Cradle to the Bench. J Cardiovasc Electrophysiol. 2014;25(1): 66. (IF:3.48)
 
11.Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, et al. Phenotype variability in patients carrying KCNJ2 mutations. Cardiovasc Electrophysiol. 2014;25(5):522. (IF:3.48)
 
12.Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J,et al. Phenotype variability in patients carrying KCNJ2 mutations.Circ Cardiovasc Genet. 2012; 5: 344. (IF:6.73)
 
13.Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O,Nakai A, Higaki K, Toyoda F, Wu J, et al. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res. 2011; 108: 458. (IF:11.86)
 
14.Gong YZ, Ding WG, Wu J, Tsuji K, Horie M, Matsuura H. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. Eur J Pharmacol.
    2008; 600:18. (IF:2.79)
 
15.Lu J, Zhu SM, Zang WJ, Xu XL, Wu J, Horie M, et al. Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide. Biol Pharm Bull. 2007; 30:1206. (IF:2.00)
 
16.Nagaoka I, Matsui K, Ueyama T, Kanemoto M, Wu J, Horie M, et al.A novel mutation of plakophilin-2 associated with arrhythmogenic right ventricular cardiomyopathy. Circ J. 2006; 70:933. (IF:3.58

 

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