基本信息

       基础医学院，教授、博士生导师；

       国家优秀青年基金获得者。

联系方式

 wuyi_med@xjtu.edu.cn

站点计数器

研究方向

      主要从事重要急性期蛋白的基础生物学及诊疗应用研究；

      主持国家自然科学基金重点、优青、面上、国际合作、省产业链等科研项目30余项。

获奖及学术兼职

       国家自然科学奖二等奖（3/5）；

       贝时璋青年生物物理学家奖；

       中国生物物理学会理事；

       中国电镜学会理事；

       生物物理学报副主编；

       Biophysics Reports副主编。

代表性论文（*通讯作者）

  1. Ji S.-R.*, Zhang S.-H., Chang Y., Li H.-Y., Wang M.-Y., Lv J.-M., Zhu L., Tang P.M.K., Wu Y.* (2023) C-reactive protein: the most familiar stranger. Journal of Immunology, 210(6): 699-707. (IF 4.4)
  2. Zhou L, Chen S.-J., Chang Y., Liu S.-H., Zhou Y.-F., Huang X.-P., Hua Y.-X., An H., Zhang S.-H., Melnikov I., Gabbasov Z. A., Wu Y.*, Ji S.-R.* (2023) Monomeric C-reactive protein evokes TCR signaling-dependent bystander activation of CD4+ T cells. Molecular Immunology, 157(5): 158-166. (IF 3.6)
  3. Wang M.-Y., Zhang C.-M., Zhou H.-H., Ge Z.-B., Su C.-C., Lou Z.-H., Zhang X.-Y., Xu T.-T., Li S.-Y., Zhu L., Zhou Y.-L., Wu Y.*, Ji S.-R.* (2022) Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein. Journal of Biological Chemistry, 298(8): 102160. (IF 4.8)
  4. Cheng B., Lv J.-M., Liang Y.-L., Zhu L., Huang X.-P., Li H.-Y., Potempa L.A., Ji S.-R.*, Wu Y.* (2022) Secretory quality control constrains functional selection-associated protein structure innovation. Communications Biology, 5: 268. (IF 5.9)
  5. Li H.-Y., Tang Z.-M., Wang Z., Lv J.-M., Liu X.-L., Liang Y.-L., Cheng B., Gao N., Ji S.-R.*, Wu Y.* (2022) C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation. Cellular and Molecular Gastroenterology and Hepatology, 13(1): 289-307. (IF 7.2)
  6. Wang M.-Y., Zhou H.-H., Zhang C.-M., Su H.-X., Li S.-L., Ji S.-R.*, Wu Y.* (2020) A functional genetic variant at C-reactive protein promoter (rs3091244) is not associated with cancer risk in a Chinese population. Frontiers in Immunology, 11: 926. (IF 7.3)
  7. Liu Y., Yuan B., Peng L., Zhao J., Zhou Y., Xiang S., Zhu L.*, Wu Y.* (2020) Single-particle analysis of urea amidolyase reveals its molecular mechanism. Protein Science, 29(5): 1242-1249. (IF 8.0)
  8. Zhang S.-C., Wang M.-Y., Feng J.-R., Chang Y., Ji S.-R.*, Wu Y.* (2020) Reversible promoter methylation determines fluctuating expression of acute phase proteins. eLife, 9: e51317. (IF 7.7)
  9. Li H.-Y., Liu X.-L., Liu Y.-T., Jia Z.-K., Filep J.G., Potempa L.A., Ji S.-R.*, Wu Y.* (2019) Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein. Cardiovascular Research, 115(2): 440-452. (IF 10.8)
  10. Zhang L., Li H.-Y., Li W., Shen Z.-Y., Wang Y.-D., Ji S.-R.*, Wu Y.* (2018) An ELISA assay for quantifying monomeric C-reactive protein in plasma. Frontiers in Immunology, 9: 511. (IF 7.7)
  11. Jia Z.-K., Li H.-Y., Liang Y.-L., Potempa L.A., Ji S.-R.*, Wu Y.* (2018) Monomeric C-reactive protein binds and neutralizes receptor activator of NF-κB ligand-induced osteoclast differentiation. Frontiers in Immunology, 9: 234. (IF 7.7)
  12. Lv J.-M., Lv S.-Q., Liu Z.-P., Zhang J., Gao B.-X., Yao Z.-Y., Wu Y.-X., Potempa L.A., Ji S.-R.*, Long M.*, Wu Y.* (2018) Conformational folding and disulfide bonding drive distinct stages of protein structure formation. Scientific Reports, 8: 1494. (IF 4.6)
  13. Li Q.-Y., Li H.-Y., Fu G., Yu F.*, Wu Y.*, Zhao M.-H. (2017) Autoantibodies against C-reactive protein influence complement activation and clinical course in lupus nephritis. Journal of the American Society of Nephrology, 28(10): 3044-3054. (IF 13.6)
  14. Li H.-Y., Wang J., Meng F., Jia Z.-K., Su Y., Bai Q.-F., Lv L.-L., Ma F.-R., Potempa L.A., Ji S.-R.*, Wu Y.* (2016) An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein. Journal of Biological Chemistry, 291(16): 8795-8804. (IF 4.8)
  15. Ouyang Y., Zhu L.*, Li Y.-F., Guo M.-M., Liu Y., Cheng J., Zhao J., Wu Y.* (2016) Architectural plasticity of AMPK revealed by electron microscopy and X-ray crystallography. Scientific Reports, 6: 24191. (IF 4.6)
  16. Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, 194(11): 5243-5252. (IF 4.4)
  17. Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein gene promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508. (IF 44.1)
  18. Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289(20): 14283-14290. (IF 4.8)
  19. Ma X, Ji S.-R., Wu Y.* (2013) Regulated conformation changes in C-reactive protein orchestrate its role in atherogenesis. Science Bulletin, 58(14): 1642-1649. (IF 18.9)
  20. Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756. (IF 4.8)
  21. Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196. (IF 4.8)
  22. Zhu L., Chen L., Zhou X.-M., Zhang Y.-Y., Zhang Y.-J., Zhao J., Ji S.-R., Wu J.-W.*, Wu Y.* (2011) Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure, 19(4): 515-522. (IF 5.7)
  23. Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816. (IF 4.8)
  24. Shen Q.T., Bai X.C., Chang L.F., Wu Y., Wang H.W., Sui S.-F.* (2009) Bowl-shaped oligomeric structures on membranes as DegP’s new functional forms in protein quality control. Proceedings of the National Academy of Sciences of the United States of America, 106(12): 4858-4863. (IF 11.1)
  25. Jiang J., Zhang X., Chen Y., Wu Y., Zhou Z.H., Chang Z., Sui S.-F.* (2008) Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proceedings of the National Academy of Sciences of the United States of America, 105(33): 11939-11944. (IF 11.1)
  26. Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294. (IF 4.8)
  27. Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (IF 8.7)
  28. Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (IF 4.0)
  29. Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (IF 11.1)
  30. Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279. (IF 4.8)