2023

1. Li Gao, Hongyan Chuai, Mengyan Ma, San-Qi Zhang, Jiye Zhang, Jiyu Li, Yang Wang, Minhang Xin*, Design, synthesis and bioactivity evaluation of selenium-containing PI3Kδ inhbitors, Bioorganic Chemistry, 2023, 140: 106815.

2. Hao Lei, Weiming Duan, San-Qi Zhang, Yifan Feng, Mengyan Ma, Bo Yuan, Minhang Xin*, Discovery of potent and selective PI3Kδ inhbitors bearing amino acid fragments, Bioorganic Chemistry, 2023, 138: 106594.

2022

1. Hao Lei, San-Qi Zhang, Huanrong Bai, Hong-Yi Zhao, Jiajia Sun, Hongyan Chuai, Minhang Xin*, Discovery of novel, and selective small-molecule Menin-Mixed Lineage Leukemia interaction inhibitors through attempting introduction of hydrophilic groups, Journal of Medicinal Chemistry, 2022, 65(19): 13413-13435.

2. Huanrong Bai, San-Qi Zhang, Hao Lei, Fang Wang, Mengyan Ma, Minhang Xin*, Menin-MLL protein-protein interaction inhibitors: a patent review (2014-2021), Expert Opinion on Therapeutic Patents, 2022, 32(5): 507-522.

2021

1. Hao Lei, San-Qi Zhang, Shu Fan, Huan-Rong Bai, Hong-Yi Zhao, Shuai Mao, Minhang Xin*, Recent progress of small molecule Menin-MLL interaction inhibitors as therapeutic agents for acute leukemia, Journal of Medicinal Chemistry, 2021, 64(21): 15519-15533.

2. Hongyan Chuai, San-Qi Zhang, Huanrong Bai, Jiyu Li, Yang Wang, Jiajia Sun, Ergang Wen, Jiye Zhang, Minhang Xin*, Small molecule selenium-containing compounds: recent development and therapeutic applications, European Journal of Medicinal Chemistry, 2021, 223, 113621.

2020

1. Hao Lei, Shu Fan, Hao Zhang, Yan-Jie Liu, Yuan-Yuan Hei, Jun-Jie Zhang, A-Qun Zheng, Minhang Xin*, San-Qi Zhang*, Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors, European Journal of Medicinal Chemistry, 2020, 186, 111888.

2. Hong-Yi Zhao, Xue-Yan Yang, Hao Lei, Xiao-Xiao Xi, She-Min Lu, Jun-Jie Zhang, Minhang Xin*, San-Qi Zhang*, Discovery of potent small molecule PROTACs targeting mutant EGFR. European Journal of Medicinal Chemistry, 2020. 208, 112781.

3. Jiajia Sun, Yifan Feng, Yuan Huang, San-Qi Zhang, Minhang Xin*, Research advances on selective phosphatidylinositol 3 kinase δ (PI3Kδ) inhibitors, Bioorganic Medicinal Chemistry Letters, 2020, 30(19), 127457.

4. Minhang Xin*, Jiajia Sun, Wei Huang*, Feng Tang, Zhaoyu Liu, Qiu Jin, Jia Wang, Design and synthesis of novel phpyridazinone derivatives as potent poly(ADP-ribose)polymerase (PARP) inhibitors, Future Medicinal Chemistry, 2020,12(19), 1691-1707.

5. Minhang Xin, Hui-Yan Wang, Hao Zhang, Ying Shen, San-Qi Zhang*, Synthesis and biological evaluation of new 2,4,6-trisubstituted triazines as potent PI3K inhibitors, Journal of Chemical Research, 2020, 44(7-8): 393-402.

2019

1. Yifan Feng, Xiaochuan Cu, Minhang Xin*, PI3Kδ inhibitors for the treatment of cancer: a patent review (2015-present), Expert Opinion on Therapeutic Patents, 2019, 29(12): 925-941.

2. Yuan-Yuan Hei, San-Qi Zhang, Yifan Feng, Jin Wang, Weiming Duan, Hao Zhang, Shuai Mao, Haopeng Sun, Minhang Xin*, Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors, Bioorganic Medicinal Chemistry, 2019, 29(20): 114930.

3. Yifan Feng^#, Weiming Duan^#, Shu Fan, Hao Zhang, San-Qi Zhang, Minhang Xin*, Synthesis and biological evaluation of 4-(piperid-3-yl)amino substituted 6-pyridylquinazolines as potent PI3Kδ inhibitors, Bioorganic Medicinal Chemistry, 2019, 27(19): 115035.

4. Yifan Feng, Weiming Duan, Xiaochuan Cu, Chengyuan Liang, Minhang Xin*, Bruton’s tyrosine kinase (BTK) inhibitors in treating cancer: a patent review (2010-2018), Expert Opinion on Therapeutic Patents, 2019, 29(4): 217-241.

2018

1. Minhang Xin*, Xinyue Ji, Ladie Kimberly De La Cruz, Suresh Thareja, Binghe Wang*, Strategies to target the Hedgehog signaling pathway for cancer therapy, Medicinal Research Reviews, 2018, 38(3): 870-913. 

2. Minhang Xin, Weiming Duan, Yifan Feng, Yuan-Yuan Hei, Hao Zhang, Ying Shen, Hong-Yi Zhao, Shuai Mao, San-Qi Zhang*, Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors, Bioorganic & Medicinal Chemistry, 2018, 26(8), 2028-2040.

3. Minhang Xin, Weiming Duan, Yifan Feng, Yuan-Yuan Hei, Hao Zhang, Ying Shen, Hong-Yi Zhao, Shuai Mao, San-Qi Zhang * , Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33(1): 651-656. 

4. Minhang Xin*, Liandi Zhang, Chongxing Tu, Feng Tang, Jun Wen, Novel 4-(2-Pyrimidinylamino)benzamide Derivatives as Potent Hedgehog Signaling Pathway Inhibitors. Bioorganic & Medicinal Chemistry, 2018, 26(18): 5029-5036.

5. Chengyuan Liang*, Danni Tian, Xiaodong Ren, Shunjun Ding, Minyi Jia, Minhang Xin*, Suresh Thareja*, The development of Bruton’s tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review, European Journal of Medicinal Chemistry, 2018, 151, 315-326.

2017年

1. Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Ying Shen, San-Qi Zhang*, Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors, Bioorganic & Medicinal Chemistry Letters, 2017,27(9): 1972-1977. 

2. Minhang Xin, Yuan-Yuan Hei, Hao Zhang, Xiao-Xiao Xie, Shuai Mao, Sai-Jie Zuo, San-Qi Zhang*, Discovery of 6-benzamide containing 4-phenylquinazoline derivatives as novel PI3Kδ Inhibitors, Letters in Drug Design & Discovery, 2017, 14(2):167-174 

3. Minhang Xin*, Liandi Zhang, Jun Wen, Han Shen, Xinge Zhao, Qiu Jin, Introduction of Fluorine to Phenyl Group of 4-(2-Pyrimidinylamino)benzamides Leading to a Series of Potent Hedgehog Signaling Pathway Inhibitors, Bioorganic & Medicinal Chemistry Letters, 2017,27(15):3259-3263.

2016年

1. Minhang Xin*, Liandi Zhang, Qiu Jin, Feng Tang, Jun Wen, Liyun Gu, Lingfei Cheng, Yong Zhao, Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors, European Journal of Medicinal Chemistry, 2016, 110: 115-125.

2. Minhang Xin*, Liandi Zhang, Jun Wen, Han Shen, Zhaoyu Liu, Xinge Zhao, Mengyu Wang, Lingfei Cheng, Wei Huang, Feng Tang, Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as hedgehog signaling pathway inhibitors, Bioorganic & Medicinal Chemistry, 2016, 24(5): 1079-1088.

3. Yuan-Yuan Hei, Minhang Xin*, Hao Zhang, Xiao-Xiao Xie, Shuai Mao, San-Qi Zhang*, Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors. Bioorganic & Medicinal Chemistry Letters, 2016, 26(18): 4408-4413. 

4. 辛敏行， 张三奇*，选择性PI3Kδ抑制剂的研究进展，中国药科大学学报, 2016, 47(5): 503 -510。

2015年

1. Minhang Xin*, Hedgehog inhibitors: a patent review (2013 - present), Expert Opinion on Therapeutic Patents, 2015, 25(5): 549-565. 

2. Minhang Xin*^，#, Xinge Zhao^#, Wei Huang, Qiu Jin, Gang Wu, Yazhou Wang, Feng Tang, Hua Xiang*, Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl) thieno[3,2-c]pyridine-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23(19): 6250-6257. 

3. Xinge Zhao#, Minhang Xin#, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*, Design, synthesi and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible brution’s tyrosine kinase inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23(2): 348-364. 

4. Xinge Zhao#, Minhang Xin#, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*, Discovery of thieno[3,2-c]pyridine-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23(17): 6059-6068. 

2014年

1. Minhang Xin*, Liandi Zhang, Han Shen, Jun Wen, Chongxin Tu, Zhaoyu Liu, Lingfei Cheng, Xinge Zhao, Design, synthesis, and biological study of 6,7-dihydro-5H-pyrano[2,3-d]pyrimidine derivatives as novel hedgehog signaling pathway inhibitors, Medicinal Chemistry Research, 2014, 23(8): 3784-3792. 

2. Minhang Xin*, Liandi Zhang, Feng Tang, Chongxin Tu, Jun Wen, Xinge Zhao, Zhaoyu Liu, Lingfei Cheng, Han Shen, Design, synthesis and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors, Bioorganic & Medicinal Chemistry, 2014, 22(4): 1429-1440. 

3. Minhang Xin*, Jun Wen, Feng Tang, Chongxin Tu, Wei Huang, Han Shen, Xinge Zhao, Lingfei Cheng, Mengyu Wang, Liandi Zhang, Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway, Bioorganic & Medicinal Chemistry Letters, 2014, 24(3): 983-988. 

4. Liandi Zhang, Minhang Xin*, Han Shen, Jun Wen, Feng Tang, Chongxing Tu, Xinge Zhao, Ping Wei*, Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and hedgehog signaling pathway inhibition study. Bioorganic & Medicinal Chemistry Letters, 2014, 24(15): 3486-3492.

5. 张连第, 辛敏行*, 文珺, 唐锋, 涂崇兴, 沈晗, 韦萍*, 4-（嘧啶-2-氨基）苯甲酰胺衍生物的设计、合成及Hedgehog信号通路抑制研究. 有机化学, 2014, 34: 1407-1416.