Reasarch interest：

  1. Tumor Immunology；

  2. Leukemia Immuno-microenvironment;

Publication：

 [1] Feng W, Yang X, Wang L, Wang R, Yang F, Wang H, Liu X, Ren Q, Zhang Y, Zhu X, Zheng G. P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3[J]. Haematologica. 2020. Co-First Author

 [2] Yang F, Feng W, Wang H, Wang L, Liu X, Wang R, Chen C, Yang X, Zhang D, Ren Q, Zheng G. Monocyte-derived leukemia-associated macrophages facilitate extramedullary distribution of T-cell acute lymphoblastic leukemia cells [published online ahead of print, 2020 Jul. Cancer Res. 2020;. doi10.11580008-5472.CAN-20-0034

 [3] Wang R, Feng W, Wang H, Wang L, Yang X, Yang F, Zhang Y, Liu X, Zhang D, Ren Q, Feng X, Zheng G. Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model[J]. Cancer Lett. 2020, 469: 151-161.

 [4] Yang X, Feng W, Wang R, Yang F, Wang L, Chen S, Ru Y, Cheng T, Zheng G. Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects[J]. Oncoimmunology. 2018, 7(4): e1412910. 

 [5] Yang X, Feng W, Wang R, Yang F, Wang L, Chen S, Chen C, Ren Q, Zheng G. Hepatic leukemia-associated macrophages exhibit a pro-inflammatory phenotype in Notch1-induced acute T cell leukemia[J]. Immunobiology. 2018, 223(1): 73-80.

 [6] Wang L, Feng W, Yang X, Yang F, Wang R, Ren Q, Zhu X, Zheng G. Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-kappaB and beta-catenin/TCF signaling pathways[J]. Cell Death Dis. 2018, 9(4): 427.

 [7] Wang R, Feng W, Yang F, Yang X, Wang L, Chen C, Hu Y, Ren Q, Zheng G. Heterogeneous effects of M-CSF isoforms on the progression of MLL-AF9 leukemia[J]. Immunol Cell Biol. 2018, 96(2): 190-203. 

 [8] Yang F, Wang R, Feng W, Chen C, Yang X, Wang L, Hu Y, Ren Q, Zheng G. Characteristics of NK cells from leukemic microenvironment in MLL-AF9 induced acute myeloid leukemia[J]. Molecular Immunology. 2018, 93: 68-78.

 [9] Chen S, Yang X, Feng W, Yang F, Wang R, Chen C, Wang L, Lin Y, Ren Q, Zheng G. Characterization of peritoneal leukemia-associated macrophages in Notch1-induced mouse T cell acute lymphoblastic leukemia[J]. Molecular Immunology. 2017, 81: 35-41. 

 [10] Yang X, Feng W, Wang R, Yang F, Chen C, Wang L, Zheng G, Leukemia-Associated Macrophages Educated By Organ-Specific Leukemic Microenvironment Acquire Diverse Functions and Gene-Expression Signatures. Blood (2016) 128 (22): 2513

 [11] Liao J, Feng W, Wang R, Ma S, Wang L, Yang X, Yang F, Lin Y, Ren Q, Zheng G. Diverse in vivo effects of soluble and membrane-bound M-CSF on tumor-associated macrophages in lymphoma xenograft model[J]. Oncotarget. 2016, 7(2): 1354-1366.

 [12] Feng W, Yang F, Wang R, Yang X, Wang L, Chen C, Liao J, Lin Y, Ren Q, Zheng G. High Level P2X7-Mediated Signaling Impairs Function of Hematopoietic Stem/Progenitor Cells[J]. Stem Cell Rev. 2016, 12(3): 305-314.

 [13] Chen S Y, Yang X, Feng W L, Liao J F, Wang L N, Feng L, Lin Y M, Ren Q, Zheng G G. Organ-specific microenvironment modifies diverse functional and phenotypic characteristics of leukemia-associated macrophages in mouse T cell acute lymphoblastic leukemia[J]. J Immunol. 2015, 194(6): 2919-2929.

 [14] Chen S, Feng W, Yang X, Yang W, Ru Y, Liao J, Wang L, Lin Y, Ren Q, Zheng G. Functional expression of P2X family receptors in macrophages is affected by microenvironment in mouse T cell acute lymphoblastic leukemia[J]. Biochemical and Biophysical Research Communications. 2014, 446(4): 1002-1009.

 [15] 杨骁，陈冲. 小鼠腹腔巨噬细胞亚群对病毒拟似物Poly I:C 的免疫应答效应比较[J]. 中国比较医学杂志, 2020, 30(11) :6-22．

 [16] 陈莎燕，冯文利，杨骁，等. P2X家族受体在急性T淋巴细胞白血病小鼠腹腔巨噬细胞中的表达[J]. 中国实验血液学杂志. 2014(03): 623-628.

 [17] 冯丽，杨骁，廖金凤，等. 白血病细胞中共表达P2X7受体和Notch1胞内区[J]. 中国实验血液学杂志. 2013, 21(3): 544-549.