研究成果

5年代表性论文(通讯/一作,2016-2020)

 

1. Yang TL, Shen H, Liu A, Dong SS, Zhang L, Deng FY, Zhao Q, Deng HW. A road map for understanding molecular and genetic determinants of osteoporosis. Nature Reviews Endocrinology. 2020 Feb;16(2):91-103. [1区;IF: 28.8]

²  交大主页推送:http://news.xjtu.edu.cn/info/1004/125766.htm

²  中国青年报报道:http://news.cyol.com/app/2019-12/17/content_18287395.htm

²  澎湃新闻报道:https://www.thepaper.cn/newsDetail_forward_7641403

 

2. Chen XF#, Zhu DL#, Yang M, Hu WX, Duan YY, Lu BJ, Rong Yu, Dong SS, Hao RH, Chen JB, Chen YX, Yao S, Thynn HN, Guo Y*, Yang TL*. An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation. American Journal of Human Genetics. 2018 May 3; 102(5):776-793. [1区;IF: 10.502]

²  Cell Stem Cell (2020)Journal of Clinical Oncology (2019)Trends in Genetics (2019) 等国际顶级期刊引用28次,获第四届陕西省研究生成果展一等奖

²  交大主页推送:http://news.xjtu.edu.cn/info/1004/91518.htm

²  新浪新闻报道:http://news.sina.com.cn/o/2018-04-29/doc-ifzvpatr0563130.shtml

²  入选 “2018Hi-C技术八大突破性进展https://www.sohu.com/a/286423721_603295

 

3. Zhang C, Dong SS, Xu JY, He WM, Yang TL*. PopLDdecay: a fast and effective tool for linkage disequilibrium decay analysis based on variant call format files. Bioinformatics. 2019 May 15;35(10):1786-1788. DOI: 10.1093/bioinformatics/bty875. [1区;IF: 5.61]

²  入选入选ESI热点论文(前0.1%) 和高被引论文(前1%)。文章发表不到1年,已被Nat Genet (20202019)PNAS (2020)Nat Commun (2019) 等国际顶级期刊引用70余次。

²  软件Github链接:https://github.com/BGI-shenzhen/PopLDdecay

 

4. Dong SS, Guo Y, Yao S, Chen YX, He MN, Zhang YJ, Chen XF, Chen JB, Yang TL*. Integrating regulatory features data for prediction of functional disease-associated SNPs. Brief Bioinform. 2019 Jan 18;20(1):26-32. [1区;IF: 8.99]

²  Evol Bioinform主编Barbara Rattner邀请我们撰写评述详细解析我们的成果https://journals.sagepub.com/doi/full/10.1177/1176934319860861

²  软件Github链接:https://github.com/xjtugenetics/FDSP

 

5. Dong SS, Zhang YJ, Chen YX, Yao S, Hao RH, Rong Y, Niu HM, Chen JB, Guo Y*, Yang TL*. Comprehensive review and annotation of susceptibility SNPs associated with obesity related traits. Obesity Reviews. 2018. Mar 12. DOI: 10.1111/ obr.12677. [1区;IF: 7.310]

²  International Journal of Obesity (2020)Obesity Reviews2020, 2019)等国际知名杂志引用17次。

 

6. Yan Wang, Jing-Qi Yang, Ting-Ting Hong, Yuan-Hong Sun, Hai-Li Huang, Feng Chen, Xiong-Jin Chen, Hui-Yi Chen, Shan-Shan Dong, Li-Li Cui*, Tie-Lin Yang*. RTN4B-mediated suppression of Sirtuin 2 activity ameliorates β-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model. Aging Cell. 2020 (accepted). [1区;IF: 7.238]

 

7. Thynn HN#, Chen XF#, Hu WX, Duan YY, Zhu DL, Chen H, Wang NN, Chen HH, Rong Y, Lu BJ, Yang M, Jiang F, Dong SS, Guo Y, Yang TL*. An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation. Journal of Investigative Dermatology. 2020 Feb;140(2):348-360.e11. [1区;IF: 7.143]

²  美国辛辛那提儿童医院的Leah C. Kottyan教授在同期杂志上发表亮点评述,高度评价了该工作,认为我们发现的这种全新的功能机制可为疾病治疗提供新

的靶点,我们的工作可作为未来其他研究的一个范例”:  https://www.jidonline.org/article/S0022-202X(19)32692-2/fulltext

²  Journal of Immunological Sciences主编邀请我们撰写评论文章 详细介绍我们的成果https://www.immunologyresearchjournal.com/article/4/1

 

8. Chen XF, Guo MR, Duan YY, Jiang F, Wu H, Dong SS, Thynn HN, Liu CC, Zhang L, Guo Y*, Yang TL*. Multi-omics dissection of molecular regulatory mechanisms underlying autoimmune associated noncoding SNPs. JCI Insights. 2020 (accepted). [1区;IF: 6.205]

²  fnGWAS在线网站:http://fngwas.online/

²  软件Github链接:https://github.com/xjtugenetics/fnGWAS

 

9. Chen JB#, Dong SS#, Yao S, Duan YY, Hu WX, Chen H, Wang NN, Chen XF, Hao RH, Thynn HN, Guo MR, Zhang YJ, Rong Y, Chen YX, Zhou FL, Guo Y*, Yang TL*. Modeling circRNA expression pattern with integrated sequence and epigenetic features demonstrates the potential involvement of H3K79me2 in circRNA expression. Bioinformatics. 2020 Jun 15:btaa567. doi: 10.1093/bioinformatics/btaa567. Online ahead of print. [1区;IF: 5.61]

 

10. Zhu DL#, Chen XF#, Hu WX, Dong SS, Lu BJ, Rong Yu, Chen YX, Thynn HN, Wang NN, Guo Y*, Yang TL*. Multiple functional variants at 13q14 risk locus for osteoporosis regulate RANKL expression through long-range super-enhancer. Journal of Bone and Mineral Research. 2018, Mar 12. [1区;IF: 5.854]

 

11. Yang TL, Guo Y, Zhang JG, Xu C, Tian Q, Deng HW. Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations. The Journal of Bone and Mineral Research, 2015 Nov;30(11):2119-26. [1区;IF: 5.854]

 

12. Li M, Yao S, Duan YY, Zhang YJ, Guo Y, Niu HM, Dong SS, Qiu YS*, Yang TL*. Transcription Factor Enrichment Analysis in Enhancers Identifies EZH2 as A Susceptibility Gene for Osteoporosis. Journal of Clinical Endocrinology & Metabolism. 2020 Apr 1;105(4). [2区;IF: 5.399]

 

13. Dong SS, Yao S, Chen YX, Guo Y, Zhang YJ, Niu HM, Hao RH, Shen H, Tian Q, Deng HW, Yang TL*.Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity. International Journal of Obesity. 2019 Mar;43(3):450-456. [1区;IF: 4.419]

 

14. Dong SS, Guo Y, Zhu DL, Chen XF, Wu XM, Shen H, Chen XD, Tan LJ, Tian Q, Deng HW, Yang TL*. Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits. International Journal of Obesity. 2016 Jul;40(7):1170-6. [1区;IF: 4.419]

 

15. Yao S, Guo Y, Dong SS, Hao RH, Chen XF, Chen YX, Chen JB, Tian Q, Deng HW, Yang TL*. Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis. Human Genetics. 2017 Aug, 136(8):963-974. [2区;IF: 5.743]

 

16. Zhu DL, Guo Y, Zhang Y, Dong SS, Xu W, Hao RH, Chen XF, Yan H, Yang SY, Yang TL*. A functional SNP regulated by miR-196a-3p in the 3'UTR of FGF2 is associated with bone mineral density in the Chinese population. Human Mutation. 2017 Jun, 38(6):725-735. [2区;IF: 4.124]

 

17. Guo Y, Dong SS, Chen XF, Jing YA, Yang M, Yan H, Shen H, Chen XD, Tan LJ, Tian Q, Deng HW, Yang TL*. Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk. Sci Rep. 2016 Jul 28;6:30558. [2区;IF: 4.124]

²  Trends in Genetics (2016)Bone Research (2020) 等国际知名杂志引用23次。

²  万人基因组计划(UK10K)主席Brent Richards课题组专门针对我们的研究发表了一篇千余字的专题评述,肯定该研究对解析疾病遗传机制及风险预测诊断具有重要参考价值: http://atm.amegroups.com/article/view/13047/13458

 

发明专利

1.  杨铁林、陈晓峰、郭燕、朱东丽、卢冰婕、杨熳,一种批量设计融合PCR引物的方法,授权公告日:2018年07月17日,授权公告号:CN105975808B

2.  郭燕、杨铁林、董珊珊、陈晓峰,一种基于基因组表观调控元件特征的复杂疾病易感基因的挖掘方法,授权公告日:2019年01月29日,授权公告号:CN106682456B

3.  杨铁林、姚石、陈一霄、牛慧敏、董珊珊、郭燕,一种基于染色质调控环路检测复杂疾病上位性的方法及系统,申请号:201810119400.2

 

软件著作权

1.  杨铁林、陈一霄、姚石、郭燕、董珊珊,基于机器学习的复杂疾病易感位点预测软件【简称:FDSP】V1.0,登记号:2017SR591464

2.  郭燕、陈佳斌、董珊珊、姚石、杨铁林,基于机器学习的环状RNA表达预测软件,登记号:2019SR0282384

 

图书编著

 《人类遗传学前沿》,2011,高等教育出版社,副主编(ISBN:978-7-04-026503-3)

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