研究成果

发表论文:

 

29. Liu, H.; Cheng, Y. (co-first author); Chen. J.; Chang, F.; Wang, J.; Ding, J.; Chen, X., Component effect of stem cell-loaded thermosensitive polypeptide hydrogels on cartilage repair Acta Biomaterialia 2018, http://doi.org/10.1016/j.actbio.2018.01.035.

28. Yen, A.; Cheng, Y.; Sylvestre, M.; Gustafson, H.; Puri, S.; Pun, S. H., Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes.Mol Pharmaceutics 2018, DOI:  10.1021/acs.molpharmaceut.8b00134. IF: 4.440

27. Olden, B.R.; Cheng, Y. (co-first author); Yu, J. L.; Pun, S. H., Cationic polymers for non-viral gene delivery to human T cellsJ Control Release 2018, DOI:10.1016/j.jconrel.2018.02.043. IF: 7.441

26. Cheng, Y.; Sellers, D. L.; Tan, J. K. Y.; Peeler, D. J.; Horner, P. J.; Pun, S. H., Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriersBiomaterials2017, 127, 89-96. IF: 8.387

25. Cheng, Y.; Yumul, R. C.; Pun, S. H., Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene DeliveryAngewandte Chemie International Edition hot paper2016, 55, (39), 12013-12017. IF: 11.709

24. Cheng, Y.; Wei, H.; Tan, J. K. Y.; Peeler, D. J.; Maris, D. O.; Sellers, D. L.; Horner, P. J.; Pun, S. H., Nano-Sized Sunflower Polycations As Effective Gene Transfer VehiclesSmall 2016, 12, (20), 2750-2758. IF: 8.315

23. Cheng, Y.; He, C.; Ding, J.; Xiao, C.; Zhuang, X.; Chen, X., Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugsBiomaterials 2013, 34, (38), 10338-10347.IF: 8.387

22. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Cui, H.; Zhuang, X.; Chen, X., Versatile Biofunctionalization of Polypeptide-Based Thermosensitive Hydrogels via Click ChemistryBiomacromolecules 2013, 14, (2), 468-475. IF: 5.583
21. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Ren, K.; Yu, S.; Zhuang, X.; Chen, X., 
Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistryPolymer Chemistry 2013, 4, (13), 3851-3858. IF: 5.520
20. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Zhuang, X.; Huang, Y.; Chen, X., 
Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive GelationBiomacromolecules 2012, 13, (7), 2053-2059. IF: 5.583
19. Cheng, Y.; He, C. L.; Xiao, C. S.; Ding, J. X.; Zhuang, X. L.; Chen, X. S., 
Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol)
Polymer Chemistryhot paper 2011, 2, (11), 2627-2634. IF: 5.520
18. Cheng, Y.
Poly(ethylene glycol)-polypeptide Copolymer Micelles for Therapeutic Agent DeliveryCurr Pharm Biotechno 2016, 17, (3), 212-226. IF: 1.802
17. Ma, H.; Jiang, W.; Ding, J.; Li, M.; Cheng, Y. (coresponding aothor); Sun, S.; Fu, C.; Liu, Y., 
Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. J Nanomater 2016. IF: 1.758
16. Feldmann, D. P., Cheng, Y., Kandil, R., Xie, Y., Mohammadi, M., Harz, H., Sharma, A., Peeler, D. J., Moszczynska, A., Leonhardt, H., Pun, S. H., Merkel, O. M. 
In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cellsJ Control Release 2018, DOI: 10.1016/j.jconrel.2018.02.017. IF: 7.441

15. Wang, C.E., Yumul, R.C., Lin, J., Cheng, Y., Lieber, A., Pun, S. Junction opener protein increases nanoparticle accumulation in solid tumorsJ Control Release 2018, 272, 9-16. IF: 7.441

14. Zhao, T.; Sellers, D. L.; Cheng, Y.; Horner, P. J.; Pun, S. H., Tunable,

Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell DeliveryBiomacromolecules 2017, 18, (9), 2723-2731. IF: 5.583
13. Zheng, Y.; Cheng, Y.; Chen, J.; Ding, J.; Li, M.; Li, C.; Wang, J.; Chen, X., 
Injectable Hydrogel-Microsphere Construct with Sequential Degradation for Locally Synergistic ChemotherapyAcs Appl Mater Inter 2017, 9, (4), 3487-3496. IF: 7.145
12. Ding, J.; Cheng, Y.; Li, M.; Gref, R.; Chen, X., Smart Polymeric Nanocarriers. J Nanomater 2016. IF: 1.758
11. Ma, H.; He, C.; Cheng, Y.; Yang, Z.; Zang, J.; Liu, J.; Chen, X., 
Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma TreatmentAcs Appl Mater Inter 2015, 7, (49), 27040-27048. IF: 7.145

10. Ma, H.; He, C.; Cheng, Y.; Li, D.; Gong, Y.; Liu, J.; Tian, H.; Chen, X., PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatmentBiomaterials 2014, 35, (30), 8723-8734. IF: 8.387

9. Cui, H.; Liu, Y.; Cheng, Y.; Zhang, Z.; Zhang, P.; Chen, X.; Wei, Y., In Vitro Study of Electroactive Tetraaniline-Containing Thermosensitive Hydrogels for Cardiac Tissue EngineeringBiomacromolecules 2014, 15, (4), 1115-1123. IF: 5.583

8. Xiao, C.; Cheng, Y.; Zhang, Y.; Ding, J.; He, C.; Zhuang, X.; Chen, X., Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized PolypeptidesJ Polym Sci Pol Chem 2014, 52, (5), 671-679. IF: 3.114.

7. Ren, K.; He, C.; Cheng, Y.; Li, G.; Chen, X., Injectable enzymatically crosslinked hydrogels based on a poly(l-glutamic acid) graft copolymer. Polymer Chemistry 2014, 5, (17), 5069-5076. IF: 5.520

6. Ding, J.; Xiao, C.; Li, Y.; Cheng, Y.; Wang, N.; He, C.; Zhuang, X.; Zhu, X.; Chen, X., Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactionsJ Control Release 2013, 169, (3), 193-203. IF: 7.441

6. Ren, K.; Cheng, Y.; He, C.; Xiao, C.; Li, G.; Chen, X., The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers. Polymer 2013, 54, (9), 2466-2472. IF: 3.586

4. Yu, S.; He, C.; Ding, J.; Cheng, Y.; Song, W.; Zhuang, X.; Chen, X., pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug deliverySoft Matter 2013, 9, (9), 2637-2645. IF: 3.798

3. Ding, J.; Xiao, C.; Zhao, L.; Cheng, Y.; Ma, L.; Tang, Z.; Zhuang, X.; Chen, X., Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-AssemblyJ Polym Sci Pol Chem 2011, 49, (12), 2665-2676. IF: 3.114

2. Ding, J.; Zhuang, X.; Xiao, C.; Cheng, Y.; Zhao, L.; He, C.; Tang, Z.; Chen, X., Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug deliveryJournal of Materials Chemistry 2011, 21, (30), 11383-11391. IF: 6.626

1. Yan, Q.; Su, W.; Cheng, Y.; Luo, Y.; Zhang, Q., Luminescence and structure of Eu(DBM)(3)Phen-doped vesicles composed of amphiphilic PNIPAM-b-PAzoMJ Photoch Photobio A 2008, 200, (2-3), 101-105. IF: 2.477

 

专利:

 

1. Yilong Cheng, Suzie Pun. Membrane-lytic block copolymers, US 62/371,163/, PCT/US2017/045566.

2. Suzie Pun, Yilong ChengBrynn Olden Polymers for T-cell transfection, US 62/476,003.

3.贺超良,成一龙,肖春生,丁建勋,任凯旋,庄秀丽,陈学思。一种嵌段共聚物、其制备方法及温度敏感型水凝胶。已授权,权利转移。专利号:201110359738。技术联系人

4.贺超良成一龙庄秀丽肖春生丁建勋陈学思 聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物、其制备方法及水凝胶。 已授权,权利转移。专利号:201110023965。技术联系人

5.贺超良成一龙庄秀丽陈学思。聚氨基酸嵌段共聚物、其制备方法及温度敏感型水凝胶。授权公告号:102977362B。技术联系人

6.贺超良成一龙于双江任凯旋庄秀丽陈学思。还原敏感型聚氨基酸纳米水凝胶及其制备方法。授权公告号:103224702B。技术联系人

7.陈学思,丁建勋,成一龙,庄秀丽。一种聚醚均聚物及其制备方法。授权公告号: 102838742B

8.贺超良任凯旋成一龙李杲陈学思。聚氨基酸接枝共聚物及其制备方法、可注射性水凝胶。授权公告号:103524748B

9.贺超良任凯旋成一龙肖春生李杲陈学思。一种类糖肽及其制备方法、可注射性水凝胶。授权公告号:103936981B

10.贺超良于双江成一龙肖春生丁建勋庄秀丽陈学思。含有二硫键和三级胺基团的聚氨酯嵌段共聚物及其制备方法。已授权,权利转移。  专利号:201210032905

11.贺超良徐清华成一龙肖春生于双江陈学思。聚(ε-甲基丙烯酰基-L-赖氨酸)均聚物、嵌段共聚物及功能化聚合物。授权公告号:103524728B

 12.庄秀丽丁建勋肖春生成一龙赵丽汤朝晖陈学思。聚(L-谷氨酸)均聚物、无规共聚物、接枝共聚物及其制备方法。已授权,权利转移。  专利号:201010563665