39. Tan, J., Lei, H., Liaw, D., Chen, X., Ma, L., Cui, C., Zhong, Q., Cheng, Y.*, Zhang. Y.*, Catalyst‐Free One‐Step Preparation of Self‐Crosslinked pH‐Responsive Vesicles. Macromol. Rapid Commun. 2019, 1900149
38. Wang, C., Feng, N., Chang, F., Wang, J., Yuan, B., Cheng, Y.*, Liu, Y.*, Yu, J., Zou, J.*, Ding, J.*, Chen, X., Injectable Cholesterol-Enhanced Stereocomplex Polylactide Thermogel Loading Chondrocytes for Optimized Cartilage Regeneration. Adv. Healthcare Mater. 2019, 1900312
37. Lei, H., Wang, S., Liaw, D., Cheng, Y., Yang, X., Tan, J., Chen, X., Gu, J.*, Zhang, Y.*, Tunable and Processable Shape-Memory Materials Based on Solvent-Free, Catalyst-Free Polycondensation between Formaldehyde and Diamine at Room Temperature. ACS Macro Lett. 2019, 85, 582-587
36. Peeler, D., Thai, S., Cheng, Y., Horner, P., Sellers, D.*, Pun, S. H.*, pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery. Biomaterials 2019, 192, 235–244.
35. Ma, L., Cheng, Y. (co-first author), Liaw, D., Lei, H., Tan, J., Cui, C., Tong, H., Zhang. Y.*, Versatile preparation of vesicle from amphiphilic bottlebrush block copolymers.
34. Olden, B.R., Cheng, E., Cheng, Y., Pun, S. H.*, Identifying key barriers in cationic polymer gene delivery to human T cells., Biomater. Sci., 2019, 7, 789-797.


33. Cheng, Y., He, C.*, Ren, K., Rong, Y., Xiao, C., Ding, J., Zhuang, X., Chen, X.*, Injectable Enzymatically Cross‐linked Hydrogels with Light‐Controlled Degradation Profile. Macromol. Rapid Commun. 2018, 39, 1800272
32. Cheng, Y., Liu, G., Jain, R., Pippin, J., Shankland, S., Pun, S. H.*, Boronic acid copolymers for direct loading and acid-triggered release of Bis-T-23 in cultured podocytes. ACS Biomater. Sci. Eng. 2018, 4, 3968−3973
31. Olden, B.R.; Cheng, Y. (co-first author); Yu, J. L.; Pun, S. H.*, Cationic polymers for non-viral gene delivery to human T cells. J Control Release 2018, DOI:10.1016/j.jconrel.2018.02.043
30. Liu, H., Cheng, Y. (co-first author), Chen, J., Chang, F., Wang, J., Ding, J.*, Chen, X., Component effect of stem cell-loaded thermosensitive polypeptide hydrogels on cartilage repair. Acta Biomaterialia 2018, 73, 103–111.
29. Liu, G., Prossnitz, A., Eng, D., Cheng, Y., Subrahmanyam, N., Pippin, J., Lamm, R., Ngambenjawong, C., Ghandehari, H., Shankland, S., Pun, S. H.*, Glomerular disease augments kidney accumulation of synthetic anionic polymers. Biomaterials, 2018, 178, 317-325.
28. Feldmann, D. P., Cheng, Y., Kandil, R., Xie, Y., Mohammadi, M., Harz, H., Sharma, A., Peeler, D. J., Moszczynska, A., Leonhardt, H., Pun, S. H., Merkel, O. M.* In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. J Control Release 2018, DOI: 10.1016/j.jconrel.2018.02.017.
27. Yen, A., Cheng, Y., Sylvestre, M., Gustafson, H., Puri, S., Pun, S. H.*, Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes. Mol. Pharmaceutics, 2018, 156, 2268-2276.
26. Wang, C.E., Yumul, R.C., Lin, J., Cheng, Y., Lieber, A., Pun, S. H.*, Junction opener protein increases nanoparticle accumulation in solid tumors. J Control Release 2018, 272, 9-16.
25. Yang, X., Shen, S., Guo, L., Tan, J., Lei, H., Wu, J., Zhao, L., Xiong, T., Wu, Y., Cheng, Y., Zhang, Y.*, An Enzyme‐Responsive “Turn‐on” Fluorescence Polymeric Superamphiphile as a Potential Visualizable Phosphate Prodrug Delivery Vehicle. Macromol. Biosci. 2018, 18, 1800045.

24. Cheng, Y.; Sellers, D. L.; Tan, J. K. Y.; Peeler, D. J.; Horner, P. J.*; Pun, S. H.*, Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers. Biomaterials 2017, 127, 89-96.
23. Zhao, T.; Sellers, D. L.; Cheng, Y.; Horner, P. J.; Pun, S. H.*, Tunable, Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell Delivery. Biomacromolecules 2017, 18, (9), 2723-2731.
22. Zheng, Y.; Cheng, Y.; Chen, J.; Ding, J.*; Li, M.; Li, C.; Wang, J.*; Chen, X., Injectable Hydrogel-Microsphere Construct with Sequential Degradation for Locally Synergistic Chemotherapy. Acs Appl Mater Inter 2017, 9, (4), 3487-3496.


21. Cheng, Y.; Yumul, R. C.; Pun, S. H.*, Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery. Angewandte Chemie International Edition 2016, 55, (39), 12013-12017.
20. Cheng, Y.; Wei, H.; Tan, J. K. Y.; Peeler, D. J.; Maris, D. O.; Sellers, D. L.; Horner, P. J.*; Pun, S. H.*, Nano-Sized Sunflower Polycations As Effective Gene Transfer Vehicles. Small 2016, 12, (20), 2750-2758.
19. Cheng, Y.*, Poly(ethylene glycol)-polypeptide Copolymer Micelles for Therapeutic Agent Delivery. Curr Pharm Biotechno 2016, 17, (3), 212-226.
18. Ding, J.; Cheng, Y.; Li, M.; Gref, R.; Chen, X., Smart Polymeric Nanocarriers. J Nanomater 2016.
17. Ma, H.; Jiang, W.; Ding, J.; Li, M.; Cheng, Y.*; Sun, S.; Fu, C.; Liu, Y., Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. J Nanomater 2016.


16. Ma, H.; He, C.*; Cheng, Y.; Yang, Z.; Zang, J.; Liu, J.; Chen, X., Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment. Acs Appl Mater Inter 2015, 7, (49), 27040-27048.

15. Ma, H.; He, C.*; Cheng, Y.; Li, D.; Gong, Y.; Liu, J.*; Tian, H.*; Chen, X., PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment. Biomaterials 2014, 35, (30), 8723-8734.
14. Cui, H.; Liu, Y.; Cheng, Y.; Zhang, Z.; Zhang, P.; Chen, X.*; Wei, Y.*, In Vitro Study of Electroactive Tetraaniline-Containing Thermosensitive Hydrogels for Cardiac Tissue Engineering. Biomacromolecules 2014, 15, (4), 1115-1123.
13. Xiao, C.; Cheng, Y.; Zhang, Y.; Ding, J.; He, C.; Zhuang, X.; Chen, X.*, Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides. J Polym Sci Pol Chem 2014, 52, (5), 671-679.
12. Ren, K.; He, C.; Cheng, Y.; Li, G.*; Chen, X., Injectable enzymatically crosslinked hydrogels based on a poly(l-glutamic acid) graft copolymer. Polymer Chemistry 2014, 5, (17), 5069-5076.


11. Cheng, Y.; He, C.; Ding, J.; Xiao, C.; Zhuang, X.; Chen, X.*, Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs. Biomaterials 2013, 34, (38), 10338-10347.
10. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Cui, H.; Zhuang, X.; Chen, X.*, Versatile Biofunctionalization of Polypeptide-Based Thermosensitive Hydrogels via Click Chemistry. Biomacromolecules 2013, 14, (2), 468-475.
9. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Ren, K.; Yu, S.; Zhuang, X.; Chen, X.*, Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry. Polymer Chemistry 2013, 4, (13), 3851-3858.
8. Ren, K.; Cheng, Y.; He, C.*; Xiao, C.; Li, G.*; Chen, X., The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers. Polymer 2013, 54, (9), 2466-2472.
7. Yu, S.; He, C.*; Ding, J.; Cheng, Y.; Song, W.; Zhuang, X.; Chen, X., pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery. Soft Matter 2013, 9, (9), 2637-2645.
6. Ding, J.; Xiao, C.; Li, Y.; Cheng, Y.; Wang, N.; He, C.; Zhuang, X.*; Zhu, X.*; Chen, X.*, Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions. J Control Release 2013, 169, (3), 193-203.


5. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Zhuang, X.; Huang, Y.; Chen, X.*, Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation. Biomacromolecules 2012, 13, (7), 2053-2059.


4. Cheng, Y.; He, C. L.; Xiao, C. S.; Ding, J. X.; Zhuang, X. L.; Chen, X. S.*, Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol). Polymer Chemistry 2011, 2, (11), 2627-2634.
3. Ding, J.; Xiao, C.; Zhao, L.; Cheng, Y.; Ma, L.; Tang, Z.; Zhuang, X.; Chen, X.*, Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly. J Polym Sci Pol Chem 2011, 49, (12), 2665-2676.
2. Ding, J.; Zhuang, X.; Xiao, C.; Cheng, Y.; Zhao, L.; He, C.; Tang, Z.; Chen, X.*, Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery. Journal of Materials Chemistry 2011, 21, (30), 11383-11391.


1. Yan, Q.; Su, W.; Cheng, Y.; Luo, Y.; Zhang, Q.*, Luminescence and structure of Eu(DBM)(3)Phen-doped vesicles composed of amphiphilic PNIPAM-b-PAzoM. J Photoch Photobio A 2008, 200, (2-3), 101-105.





1. Yilong Cheng, Suzie Pun. Membrane-lytic block copolymers, US 62/371,163/, PCT/US2017/045566.

2. Suzie Pun, Yilong ChengBrynn Olden Polymers for T-cell transfection, US 62/476,003.


4.贺超良成一龙庄秀丽肖春生丁建勋陈学思 聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物、其制备方法及水凝胶。 已授权,权利转移。专利号:201110023965。技术联系人



7.陈学思,丁建勋,成一龙,庄秀丽。一种聚醚均聚物及其制备方法。授权公告号: 102838742B



10.贺超良于双江成一龙肖春生丁建勋庄秀丽陈学思。含有二硫键和三级胺基团的聚氨酯嵌段共聚物及其制备方法。已授权,权利转移。  专利号:201210032905


 12.庄秀丽丁建勋肖春生成一龙赵丽汤朝晖陈学思。聚(L-谷氨酸)均聚物、无规共聚物、接枝共聚物及其制备方法。已授权,权利转移。  专利号:201010563665