科研成果

发表论文:

 

2022年

 

1. Kaixiang Shen, Kai Xu, Mengyuan Zhang, Jing Yu, Yuxuan Yang, Xiaodan Zhao, Qiang Zhang, Youshen Wu, Yangfeng Zhang, Yilong Cheng*Multiple hydrogen bonds reinforced conductive hydrogels with robust elasticity and ultra-durability as multifunctional ionic skins, Chemical Engineering Journal, 2023, 451, 138525.

                                                            

2. Jing Yu, Yanyang Qin, Yuxuan Yang, Xiaodan Zhao, Zixi Zhang, Qiang Zhang, Yaqiong Su, Yanfeng Zhang, Yilong Cheng*Robust hydrogel adhesives for emergency rescue and gastric perforation repairBioactive Materials, 2023, 19, 703-716.

                                                            

3. Mengyuan Zhang, Peiling Lin, Xiaofan Song, Kun Chen, Yuxuan Yang, Yongliang Xu, Qiang Zhang, Youshen Wu, Yanfeng Zhang, Yilong Cheng*Injectable and self‐healing hydrogels with tissue adhesiveness and antibacterial activity as wound dressings for infected wound healingJournal of Polymer Science, 2022, 9, 1511-1520.

                                                         

4. Kai Xu, Kaixiang Shen, Jing Yu, Yuxuan Yang, Yuantao Wei, Peiling Lin, Qiang Zhang, Chunhui Xiao, Yanfeng Zhang, Yilong Cheng*Ultradurable Noncovalent Cross-Linked Hydrogels with Low Hysteresis and Robust Elasticity for Flexible ElectronicsChemistry of Materials, 2022, 7, 3311-3322.

                                                     

5. Xiaodan Zhao, Yuxuan Yang, Jing Yu, Rui Ding, Dandan Pei, Yanfeng Zhang, Gang He, Yilong Cheng*, Ang Li*, Injectable hydrogels with high drug loading through B–N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats, Biomaterials, 2022, 282, 121387.

                                                                   

6. Ruyue Wang, Xingxing Chen, Yuxuan Yang, Yongliang Xu, Qiang Zhang, Yanfeng Zhang*, Yilong Cheng*Imidazolidinyl urea reinforced polyacrylamide hydrogels through the formation of multiple hydrogen bondsReactive and Functional Polymers, 2022, 172, 105183. 

                                         

7. Xingxing Chen, Ruyue Wang, Chenhui Cui, Le An, Qiang Zhang, Yilong Cheng, Yanfeng Zhang*, NIR-triggered dynamic exchange and intrinsic photothermal-responsive covalent adaptable networksChemical Engineering Journal, 2022, 428, 131212.

 

2021年

 

1. Yuxuan Yang, Xiaodan Zhao, Jing Yu, Xingxing Chen, Ruyue Wang, Mengyuan Zhang, Qiang Zhang, Yanfeng Zhang, Shuang Wang, Yilong Cheng*Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment, Bioactive Materials, 2021, 6, 3962-3975. 

                                                              

2. Mengyuan Zhang, Jing Yu, Kaixiang Shen, Ruyue Wang, Jiaqiang Du, Xiaodan Zhao, Yuxuan Yang, Kai Xu, Qiang Zhang, Yanfeng Zhang, Yilong Cheng*, Highly stretchable nanocomposite hydrogels with outstanding antifatigue fracture based on robust noncovalent interactions for wound healingChemistry of Materials, 2021, 33, 6453-6463.

                                                              

3. Xiaodan Zhao, Dandan Pei, Yuxuan Yang, Kai Xu, Jing Yu, Yuchen Zhang, Qiang Zhang, Gang He, Yanfeng Zhang, Ang Li*, Yilong Cheng*, Xuesi Chen, Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatmentAdvanced Functional Materials, 2021, 18, 2009442.

                                                               

4. Jing Yu, Kai Xu, Xiaojing Chen, Xiaodan Zhao, Yuxuan Yang, Dake Chu, Yongliang Xu, Qiang Zhang, Yanfeng Zhang, Yilong Cheng*Highly stretchable, tough, resilient, and antifatigue hydrogels based on multiple hydrogen bonding interactions formed by phenylalanine derivativesBiomacromolecules, 2021, 22, 1297-1304.

                                                    

5. Li Guo, Zhiqian Yao, Lu Yang, Hao Zhang, Yu Qi, Lu Gou, Wang Xi, Dingxin Liu, Lei Zhang, Yilong Cheng, Xiaohua Wang, Mingzhe Rong, Hailan Chen, Michael G Kong, Chemical Engineering Journal, 2021, 421, 127742.

6. Hao Zhang, Shengduo Xu, Jishen Zhang, Zifeng Wang, Dingxin Liu, Li Guo, Cheng Cheng, Yilong Cheng, Dehui Xu, Michael G Kong, Mingzhe Rong, Paul K Chu, Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer, Biomaterials, 2021, 276, 121057.

7. Qiang Zhang, Shujuan Wang, Bin Rao, Xingxing Chen, Li Ma, Chenhui Cui, Qianyun Zhong, Zhen Li, Yilong Cheng, Yanfeng Zhang*,Hindered urea bonds for dynamic polymers: An overviewReactive and Functional Polymers, 2021, 159, 104807.

8. Rui Teng, Yuchen Meng, Xiaodan Zhao, Jie Liu, Rui Ding, Yilong Cheng, Yunhe Zhang, Yanfeng Zhang, Dandan Pei, Ang Li, Combination of polydopamine coating and plasma pretreatment to improve bond ability between PEEK and primary teethFrontiers in Bioengineering and Biotechnology, 2021, 8, 630094.

9. Tianyu Shu, Yuchen Zhang, Guo Sun, Yang Pan, Gang He, Yilong Cheng, Ang Li, Dandan Pei, Enhanced osseointegration by the hierarchical micro-nano topography on selective laser melting Ti-6Al-4V dental implantsFrontiers in bioengineering and biotechnology, 2021, 8, 621601.

10. Qianyun Zhong, Xingxing Chen, Yuxuan Yang, Chenhui Cui, Li Ma, Zhen Li, Qiang Zhang, Xiaoming Chen, Yilong Cheng, Yanfeng Zhang, Hydrogen bond reinforced, transparent polycaprolactone-based degradable polyurethaneMaterials Chemistry Frontiers, 2021, 5, 5371-5381. 

 

 2020年

 

1. Li Ma, Qiang Zhang, Chenhui Cui, Qianyun Zhong, Xingxing Chen, Zhen Li, Arumugam Mariappan, Yilong Cheng, Zhicheng Zhang, Yanfeng Zhang, Introduction of a stable radical in polymer capacitor enables high energy storage and pulse discharge efficiencyChemistry of Materials, 2021, 32, 9355-9362.

2. . Chen, X., Xu, K., Yu, J., Zhao, X., Zhang, Q., Zhang, Q., Zhang, Y., Cheng, Y.*Peptide modified polycations with pH triggered lytic activity for efficient gene delivery, Biomater. Sci.2020DOI: 10.1039/D0BM01231A. (Invited article for 2021 Biomaterials Science Emerging Investigators)

                                                       

3. . Yang, Y., Zhao, X., Yu, J., Chen, X., Chen, X., Cui, C., Zhang, J., Zhang, Q., Zhang, Y., Wang, S.*, Cheng, Y.*H-Bonding Supramolecular Hydrogels with Promising Mechanical Strength and Shape Memory Properties for Postoperative Antiadhesion ApplicationACS Appl. Mater. Interfaces 2020, 12, 30, 34161–34169.

                                               

4. . Chen, X., Zhong, Q., Cui, C., Ma, L., Liu, S., Zhang, Q., Wu, Y., An, L., Cheng, Y., Ye, S., Chen, X., Dong, Z., Chen, Q., Zhang, Y.*, Extremely Tough, Puncture-Resistant, Transparent, and Photoluminescent Polyurethane Elastomers for Crack Self-Diagnose and Healing TrackingACS Appl. Mater. Interfaces 2020, 12, 27, 30847–30855.

5. . Zhang, Q., Kunag, G., He, S., Lu, H., Cheng, Y., Zhou, D.*, Huang, Y.*, Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian CancerNano Lett. 2020, 20, 5, 3039–3049.

6. . Zhao, X., Lei, H., Cheng, Y.*, Wu, Y., Zhang, M., He, G., Pei, D., Dong, Z., Li, A.*, Zhang, Y.*, A polymeric prodrug for non-invasive, real-time reporting drug release based on “turn-on” fluorescent probesReact. Funct. Polym. 2020154, 104649.

7. . Yu, J., Chen, X., Yang, Y., Zhao, X., Chen, X., Jing, T., Zhou, Y., Xu, J., Zhang, Y.*, Cheng, Y.*Construction of supramolecular hydrogels using imidazolidinyl urea as hydrogen bonding reinforced factorJ. Mater. Chem. B2020, 8, 3058-3063.

                                                        

 

2019年


1. Tan, J., Lei, H., Liaw, D., Chen, X., Ma, L., Cui, C., Zhong, Q., Cheng, Y.*, Zhang. Y.*, Catalyst‐Free One‐Step Preparation of Self‐Crosslinked pH‐Responsive Vesicles. Macromol. Rapid Commun. 2019, 1900149
2. Wang, C., Feng, N., Chang, F., Wang, J., Yuan, B., Cheng, Y.*, Liu, Y.*, Yu, J., Zou, J.*, Ding, J.*, Chen, X., Injectable Cholesterol-Enhanced Stereocomplex Polylactide Thermogel Loading Chondrocytes for Optimized Cartilage Regeneration. Adv. Healthcare Mater. 2019, 1900312
3. Lei, H., Wang, S., Liaw, D., Cheng, Y., Yang, X., Tan, J., Chen, X., Gu, J.*, Zhang, Y.*, Tunable and Processable Shape-Memory Materials Based on Solvent-Free, Catalyst-Free Polycondensation between Formaldehyde and Diamine at Room Temperature. ACS Macro Lett. 2019, 85, 582-587
4. Peeler, D., Thai, S., Cheng, Y., Horner, P., Sellers, D.*, Pun, S. H.*, pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery. Biomaterials 2019, 192, 235–244.
5. Ma, L., Cheng, Y. (co-first author), Liaw, D., Lei, H., Tan, J., Cui, C., Tong, H., Zhang. Y.*, Versatile preparation of vesicle from amphiphilic bottlebrush block copolymers.
6. Olden, B.R., Cheng, E., Cheng, Y., Pun, S. H.*, Identifying key barriers in cationic polymer gene delivery to human T cells., Biomater. Sci., 2019, 7, 789-797.

 

2018年
1. Cheng, Y., He, C.*, Ren, K., Rong, Y., Xiao, C., Ding, J., Zhuang, X., Chen, X.*, Injectable Enzymatically Cross‐linked Hydrogels with Light‐Controlled Degradation Profile. Macromol. Rapid Commun. 2018, 39, 1800272
2. Cheng, Y., Liu, G., Jain, R., Pippin, J., Shankland, S., Pun, S. H.*, Boronic acid copolymers for direct loading and acid-triggered release of Bis-T-23 in cultured podocytes. ACS Biomater. Sci. Eng. 2018, 4, 3968−3973
3. Olden, B.R.; Cheng, Y. (co-first author); Yu, J. L.; Pun, S. H.*, Cationic polymers for non-viral gene delivery to human T cells. J Control Release 2018, DOI:10.1016/j.jconrel.2018.02.043
4. Liu, H., Cheng, Y. (co-first author), Chen, J., Chang, F., Wang, J., Ding, J.*, Chen, X., Component effect of stem cell-loaded thermosensitive polypeptide hydrogels on cartilage repair. Acta Biomaterialia 2018, 73, 103–111.
5. Liu, G., Prossnitz, A., Eng, D., Cheng, Y., Subrahmanyam, N., Pippin, J., Lamm, R., Ngambenjawong, C., Ghandehari, H., Shankland, S., Pun, S. H.*, Glomerular disease augments kidney accumulation of synthetic anionic polymers. Biomaterials, 2018, 178, 317-325.
6. Feldmann, D. P., Cheng, Y., Kandil, R., Xie, Y., Mohammadi, M., Harz, H., Sharma, A., Peeler, D. J., Moszczynska, A., Leonhardt, H., Pun, S. H., Merkel, O. M.* In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. J Control Release 2018, DOI: 7.1016/j.jconrel.2018.02.017.
27. Yen, A., Cheng, Y., Sylvestre, M., Gustafson, H., Puri, S., Pun, S. H.*, Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes. Mol. Pharmaceutics, 2018, 156, 2268-2276.
8. Wang, C.E., Yumul, R.C., Lin, J., Cheng, Y., Lieber, A., Pun, S. H.*, Junction opener protein increases nanoparticle accumulation in solid tumors. J Control Release 2018, 272, 9-16.
9. Yang, X., Shen, S., Guo, L., Tan, J., Lei, H., Wu, J., Zhao, L., Xiong, T., Wu, Y., Cheng, Y., Zhang, Y.*, An Enzyme‐Responsive “Turn‐on” Fluorescence Polymeric Superamphiphile as a Potential Visualizable Phosphate Prodrug Delivery Vehicle. Macromol. Biosci. 2018, 18, 1800045.

2017年
1. Cheng, Y.; Sellers, D. L.; Tan, J. K. Y.; Peeler, D. J.; Horner, P. J.*; Pun, S. H.*, Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers. Biomaterials 2017, 127, 89-96.
2. Zhao, T.; Sellers, D. L.; Cheng, Y.; Horner, P. J.; Pun, S. H.*, Tunable, Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell Delivery. Biomacromolecules 2017, 18, (9), 2723-2731.
3. Zheng, Y.; Cheng, Y.; Chen, J.; Ding, J.*; Li, M.; Li, C.; Wang, J.*; Chen, X., Injectable Hydrogel-Microsphere Construct with Sequential Degradation for Locally Synergistic Chemotherapy. Acs Appl Mater Inter 2017, 9, (4), 3487-3496.

 

2016年
1. Cheng, Y.; Yumul, R. C.; Pun, S. H.*, Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery. Angewandte Chemie International Edition 2016, 55, (39), 12013-12017.
2. Cheng, Y.; Wei, H.; Tan, J. K. Y.; Peeler, D. J.; Maris, D. O.; Sellers, D. L.; Horner, P. J.*; Pun, S. H.*, Nano-Sized Sunflower Polycations As Effective Gene Transfer Vehicles. Small 2016, 12, (20), 2750-2758.
3. Cheng, Y.*, Poly(ethylene glycol)-polypeptide Copolymer Micelles for Therapeutic Agent Delivery. Curr Pharm Biotechno 2016, 17, (3), 212-226.
4. Ding, J.; Cheng, Y.; Li, M.; Gref, R.; Chen, X., Smart Polymeric Nanocarriers. J Nanomater 2016.
5. Ma, H.; Jiang, W.; Ding, J.; Li, M.; Cheng, Y.*; Sun, S.; Fu, C.; Liu, Y., Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies. J Nanomater 2016.

 

2015年
1. Ma, H.; He, C.*; Cheng, Y.; Yang, Z.; Zang, J.; Liu, J.; Chen, X., Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment. Acs Appl Mater Inter 2015, 7, (49), 27040-27048.


2014年
1. Ma, H.; He, C.*; Cheng, Y.; Li, D.; Gong, Y.; Liu, J.*; Tian, H.*; Chen, X., PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment. Biomaterials 2014, 35, (30), 8723-8734.
2. Cui, H.; Liu, Y.; Cheng, Y.; Zhang, Z.; Zhang, P.; Chen, X.*; Wei, Y.*, In Vitro Study of Electroactive Tetraaniline-Containing Thermosensitive Hydrogels for Cardiac Tissue Engineering. Biomacromolecules 2014, 15, (4), 1115-1123.
3. Xiao, C.; Cheng, Y.; Zhang, Y.; Ding, J.; He, C.; Zhuang, X.; Chen, X.*, Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides. J Polym Sci Pol Chem 2014, 52, (5), 671-679.
4. Ren, K.; He, C.; Cheng, Y.; Li, G.*; Chen, X., Injectable enzymatically crosslinked hydrogels based on a poly(l-glutamic acid) graft copolymer. Polymer Chemistry 2014, 5, (17), 5069-5076.

 

2013年
1. Cheng, Y.; He, C.; Ding, J.; Xiao, C.; Zhuang, X.; Chen, X.*, Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs. Biomaterials 2013, 34, (38), 10338-10347.
2. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Cui, H.; Zhuang, X.; Chen, X.*, Versatile Biofunctionalization of Polypeptide-Based Thermosensitive Hydrogels via Click Chemistry. Biomacromolecules 2013, 14, (2), 468-475.
3. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Ren, K.; Yu, S.; Zhuang, X.; Chen, X.*, Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry. Polymer Chemistry 2013, 4, (13), 3851-3858.
4. Ren, K.; Cheng, Y.; He, C.*; Xiao, C.; Li, G.*; Chen, X., The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers. Polymer 2013, 54, (9), 2466-2472.
5. Yu, S.; He, C.*; Ding, J.; Cheng, Y.; Song, W.; Zhuang, X.; Chen, X., pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery. Soft Matter 2013, 9, (9), 2637-2645.
6. Ding, J.; Xiao, C.; Li, Y.; Cheng, Y.; Wang, N.; He, C.; Zhuang, X.*; Zhu, X.*; Chen, X.*, Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions. J Control Release 2013, 169, (3), 193-203.

 

2012年
1. Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Zhuang, X.; Huang, Y.; Chen, X.*, Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation. Biomacromolecules 2012, 13, (7), 2053-2059.

 

2011年
1. Cheng, Y.; He, C. L.; Xiao, C. S.; Ding, J. X.; Zhuang, X. L.; Chen, X. S.*, Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol). Polymer Chemistry 2011, 2, (11), 2627-2634.
2. Ding, J.; Xiao, C.; Zhao, L.; Cheng, Y.; Ma, L.; Tang, Z.; Zhuang, X.; Chen, X.*, Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly. J Polym Sci Pol Chem 2011, 49, (12), 2665-2676.
3. Ding, J.; Zhuang, X.; Xiao, C.; Cheng, Y.; Zhao, L.; He, C.; Tang, Z.; Chen, X.*, Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery. Journal of Materials Chemistry 2011, 21, (30), 11383-11391.

 

2008年
1. Yan, Q.; Su, W.; Cheng, Y.; Luo, Y.; Zhang, Q.*, Luminescence and structure of Eu(DBM)(3)Phen-doped vesicles composed of amphiphilic PNIPAM-b-PAzoM. J Photoch Photobio A 2008, 200, (2-3), 101-105.

 

 

专利:

 

1. Yilong Cheng, Suzie Pun. Membrane-lytic block copolymers, US 62/371,163/, PCT/US2017/045566.

2. Suzie Pun, Yilong ChengBrynn Olden Polymers for T-cell transfection, US 62/476,003.

3.贺超良,成一龙,肖春生,丁建勋,任凯旋,庄秀丽,陈学思。一种嵌段共聚物、其制备方法及温度敏感型水凝胶。已授权,权利转移。专利号:201110359738。技术联系人

4.贺超良成一龙庄秀丽肖春生丁建勋陈学思 聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物、其制备方法及水凝胶。 已授权,权利转移。专利号:201110023965。技术联系人

5.贺超良成一龙庄秀丽陈学思。聚氨基酸嵌段共聚物、其制备方法及温度敏感型水凝胶。授权公告号:102977362B。技术联系人

6.贺超良成一龙于双江任凯旋庄秀丽陈学思。还原敏感型聚氨基酸纳米水凝胶及其制备方法。授权公告号:103224702B。技术联系人

7.陈学思,丁建勋,成一龙,庄秀丽。一种聚醚均聚物及其制备方法。授权公告号: 102838742B

8.贺超良任凯旋成一龙李杲陈学思。聚氨基酸接枝共聚物及其制备方法、可注射性水凝胶。授权公告号:103524748B

9.贺超良任凯旋成一龙肖春生李杲陈学思。一种类糖肽及其制备方法、可注射性水凝胶。授权公告号:103936981B

10.贺超良于双江成一龙肖春生丁建勋庄秀丽陈学思。含有二硫键和三级胺基团的聚氨酯嵌段共聚物及其制备方法。已授权,权利转移。  专利号:201210032905

11.贺超良徐清华成一龙肖春生于双江陈学思。聚(ε-甲基丙烯酰基-L-赖氨酸)均聚物、嵌段共聚物及功能化聚合物。授权公告号:103524728B

 12.庄秀丽丁建勋肖春生成一龙赵丽汤朝晖陈学思。聚(L-谷氨酸)均聚物、无规共聚物、接枝共聚物及其制备方法。已授权,权利转移。  专利号:201010563665