基本信息

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成瀛  副教授

博士生导师

 

1. 中枢神经系统和外周组织对能量稳态调控的研究
2. 线粒体与复杂代谢疾病的研究
3. 造血干细胞和血液肿瘤的研究

 

 

 

 

联系方式

 

Email：yingchengxjtu.edu.cn

 

                 

站点收藏

类别/站点
中科院上海生科院
UPENN medical school
CHOP

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教育经历

  • 西安交通大学，副教授，博士生导师
  • Children's Hospital of Philadelphia，USA，Research Associate
  • University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, USA，Postdoctoral fellowship
  • 中国科学院上海生命科学研究院，博士​​​​​​​
  • 西安交通大学，学士

荣誉称号

  1. Postdoctoral Fellow Award from University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia.
  2. 上海市科学技术奖三等奖
  3. Postdoctoral fellowship from American Heart Association

 

论文发表

  1. Li Y, Fu Y, Zhang Y, Duan B, Zhao Y, Shang M, Cheng Y, Zhang K, Yu Q, Wang T*: Nuclear Fructose-1,6-Bisphosphate Inhibits Tumor Growth and Sensitizes Chemotherapy by Targeting HMGB1. Advanced Science 2023,10:e2203528. doi: 10.1002/advs.202203528
  2. Su T, Zhang Z, Han X, Yang F, Wang Z, Cheng Y*, Liu H*: Systematic Insight of Resveratrol Activated SIRT1 Interactome through Proximity Labeling Strategy. Antioxidants (Basel) 2022,11:2330. doi: 10.3390/antiox11122330
  3. Zhu D, Yao S, Wu H, Ke X, Zhou X, Geng S, Dong S, Chen H, Yang T, Cheng Y*, Guo Y*: A transcriptome-wide association study identifies novel susceptibility genes for psoriasis. Human Molecular Genetics 2022, 32:300-308. doi: 10.1093/hmg/ddab237.
  4. Zhi Z, Ouyang Z, Ren Y, Cheng Y, Liu P, Wen Y, Shao Y*: Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis. Cell Death and Differentiation 2022,29:323-336. doi: 10.1038/s41418-021-00855-3.
  5. Zhang Y, Yu X, Wang M, Ding Y, Guo H, Liu J, Cheng Y*: Hyperoside from Z. bungeanum leaves restores insulin secretion and mitochondrial function by regulating pancreatic cellular redox status in diabetic mice. Free Radical Biology and Medicine 2021;162:412-422. doi: 10.1016/j.freeradbiomed.2020.10.320.
  6. Su H, Wang M, Pang X, Guan F, Li X*, Cheng Y*: When Glycosylation Meets Blood Cells: A Glance of the Aberrant Glycosylation in Hematological Malignancies. Review of Physiology Biochemistry and Pharmacology 2021;180:85-117. doi: 10.1007/112_2021_60.
  7. Qin C, Hu S, Zhang S, Zhao D, Wang Y, Li H, Peng Y, Shi L, Xu X, Wang C, Liu J, Cheng Y*, Long J*: Hydroxytyrosol Acetate Improves the Cognitive Function of APP/PS1 Transgenic Mice in ERbeta-dependent Manner. Molecular Nutrition & Food Research 2021;65:e2000797. doi: 10.1002/mnfr.202000797.
  8. Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, Cheng Y, Pellegrino S, Warren AJ, Paralkar VR, Tong W*: HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell 2021;28:1275-1290 e1279. doi: 10.1016/j.stem.2021.02.008.
  9. Mammadli M, Huang W, Harris R, Sultana A, Cheng Y, Tong W, Pu J, Gentile T, Dsouza S, Yang Q, Bah A, August A, Karimi M*: Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT. Frontiers in Immunology 2020;11:593863. doi: 10.3389/fimmu.2020.593863.
  10. Liu R, Chen L, Wang Y, Zhang G, Cheng Y, Feng Z, Bai X, Liu J*: High ratio of omega-3/omega-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice. The Journal of Nutritional Biochemistry 2020;79:108330. doi: 10.1016/j.jnutbio.2019.108330.
  11. Lv K, Jiang J, Donaghy R, Riling CR, Cheng Y, Chandra V, Rozenova K, An W, Mohapatra BC, Goetz BT, Pillai V, Han X, Todd EA, Jeschke GR, Langdon WY, Kumar S, Hexner EO, Band H, Tong W*: CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies. Genes & Development 2017;31:1007-1023. doi: 10.1101/gad.297135.117.
  12. Kim E, Cheng Y, Bolton-Gillespie E, Cai X, Ma C, Tarangelo A, Le L, Jambhekar M, Raman P, Hayer KE, Wertheim G, Speck NA, Tong W, Viatour P*: Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression. The Journal of Experimental Medicine 2017;214:1901-1912. doi: 10.1084/jem.20160719.
  13. Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, Choi JK, Tong W*: LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. The Journal of Clinical Investigation 2016;126:1267-1281. doi: 10.1172/JCI81468.
  14. Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y, Guo F*: Leptin signaling is required for leucine deprivation-enhanced energy expenditure. The Journal of Biological Chemistry 2014;289:1779-1787. doi: 10.1074/jbc.M113.528943.
  15. Xia T, Cheng Y, Zhang Q, Xiao F, Liu B, Chen S, Guo F*: S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid. Diabetes 2012;61:2461-2471. doi: 10.2337/db11-1278. ​​​​​​​
  16. Jiang J, Balcerek J, Rozenova K, Cheng Y, Bersenev A, Wu C, Song Y, Tong W*: 14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. The Journal of Clinical Investigation 2012;122:2079-2091. doi: 10.1172/JCI59719.
  17. Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, Guo F*: Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes 2011;60:746-756. doi: 10.2337/db10-1246.
  18. Cheng Y#, Zhang Q#, Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, Guo F*: Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system. Molecular Endocrinology 2011;25:1624-1635. doi: 10.1210/me.2011-0028. (# co-first author)
  19. Wang C, Huang Z, Du Y, Cheng Y, Chen S, Guo F*: ATF4 regulates lipid metabolism and thermogenesis. Cell Research 2010;20:174-184. doi: 10.1038/cr.2010.4.
  20. Cheng Y#, Meng Q#, Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*: Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes 2010;59:17-25. doi: 10.2337/db09-0929. (# co-first author)

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