基本信息

           

               温玉荣  博士  研究员

                博士研究生导师

               西安交通大学医学部

联系方式

 

Email: Yurong.Wen@xjtu.edu.cn

           Yurong.Wen@hotmail.com

站点计数器

个人简介

 温玉荣,西安交通大学医学部,研究员,博士生导师。2014年获得比利时根特大学博士学位,2018-2019加拿大阿尔伯塔大学高级访问学者。近五年主持国家及各类省部级项目15项,包括国家自然科学基金4项,教育部留学回国基金,陕西省自然科学基金等。担任国家自然科学基金,中国博士后基金,陕西省自然科学基金评审专家。

从事使用一体化结构生物学方案进行抗感染和抗肿瘤的分子机制以及相关转化医学研究,在病原微生物对环境的响应调控以及病原宿主相互作用分子机制研究取得多个重要进展。在ACS Central ScienceNature CommunicationsNucleic Acids Research等国际一流期刊发表SCI学术论文30余篇,以第一和通讯作者发表影响因子大于10的论文4篇,总引用超500余次,单篇第一作者论文引用超150余次,获批国家发明专利2项。研究工作多次被国际国内媒体报道,并且多次受邀在国际会议上做口头报告,获得加拿大Alberta Parkinson Society Fellowship,中国生物化学与分子生物学会青年科学论坛奖等奖项。

工作和学习经历

工作经历:

2019.11- 至今            西安交通大学医学部             研究员/博士生导师     

2018.06-2019.06      加拿大阿尔伯塔大学               访问学者/博士后

2017.11-2019.12        西安交通大学生命学院           副教授/硕士生导师

2017.09-2017.12         清华大学生命学院           化学生物学进修/合作研究

2014.09-2017.10       西安交通大学生命学院                     讲师

 

学习经历:

2010.03-2014.03        比利时根特大学              生物化学与生物技术博士

2008.09-2010.02      西安交通大学医学部     生物化学与分子生物学硕士

2004.09-2008.07    西安交通大学生命学院               生物工程学士

科研项目

没有找到条目。
项目编号 项目名称 项目来源 起讫时间 承担角色 项目类别
31500051 分子伴侣CsgE/CsgF调控Curli分泌和组装的结构和功能研究 国家自然科学基金项目 2016-1~2018-12 负责人 纵向项目
XJJ2015056 肿瘤调控中信号通路交互作用的分子机制及其在抗肿瘤药物研发中的应用研究 中央高校基本科研业务费 2016-1~2018-12 负责人 纵向项目
2017T100738 多重耐药鲍曼不动杆菌二元调控系统的结构和功能研究 中国博士后特别资助 2016-1~2017-12 负责人 纵向项目
留学回国08 以抗肿瘤药物研发为导向的β-Catenin和YAP在肿瘤调控信号通路交互作用中的分子机制研究 教育部留学回国基金 2015-1~2017-12 负责人 纵向项目

代表性期刊论文

 

(21) Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen*, Steve Schoonooghe* and Geert Raes*(2021) Development and characterization of nanobodies targeting the Kupffer cell. Frontiers in Immunology 12 : 641819. (IF:6.5, 通讯作者)

(20) Yufeng Zhao, Yi Shen, Yurong Wen*, and R.E. Campbell*. (2020) High performance intensiometric direct- and inverse-response genetically encoded biosensors for citrate. ACS Central Science. 6. 1441-1450. (IF: 12.685, 通讯作者)

(19) Yibo Ren, Zhenlin Ouyang, Zhanwu Hou, Yuwei Yan, Zhe Zhi, Mengjin Shi, Mengtao Du, Huadong Liu, Yurong Wen*, Yongping Shao*. (2020) CIC is a mediator of the ERK1/2-DUSP6 negative feedback loop. iScience. 23(11): 101635. https://doi.org/10.1016/j.isci.2020.101635 (Cell 子刊, 通讯作者)

(18) Zhenlin Ouyang#, Fang Zheng#, Yingmei Pei, Jinhong Zhou, Keqing Wen, Miao Han, Peter M. Hwang, M. Joanne Lemieux, Yurong Wen*. (2019) Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. Nucleic Acids Research. 47(21):11418-11429.IF: 11.56, 作者

(17)   Zhenlin Ouyang, Jan Felix, Jinhong Zhou, Yingmei Pei, Peter M Hwang, M Joanne Lemieux, Irina Gutsche, Fang Zheng, Yurong Wen*. (2020) Trimeric structure of Kupffer cell C-type lectin receptor Clec4f. FEBS Letters. 594 (1):189-198IF: 3.1, 作者

(16) Qingye Xu, Xiaoting Hua, Jintao He, Di Zhang, Qiong Chen, Linghong Zhang, Belinda Loh, Sebastian Leptihn, Yurong Wen, Higgins Paul G., Yunsong Yu, Zhihui Zhou*. (2020) The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. International Journal of Medical Microbiology. 310 (8): 151464. (IF: 3.4)

(15)   Yurong Wen#,*, Zhenlin Ouyang#, Yue Yu, Xiaorong Zhou, Yingmei Pei, Bart Devreese, Paul G Higgins, Fang Zheng* (2017). Mechanistic insight into how multidrug resistance Acinetobacter baumannii response regulator AdeR recognize its promoter DNA. Nucleic Acids Research.45(16): 9773-9787. (IF: 11.56, 第一兼通作者)

(14)   Yurong Wen, Ester Behiels, Jan Felix, Jonathan Elegheert, Bjorn Vergauwen, Bart Devreese*, Savvas Savvides*. (2014). The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistenceNucleic Acids Research. 42(15): 10134-47.(IF: 11.56,第一作者)

(13)   Fang Zheng, Siyu Luo, Zhenlin Ouyang, Jinhong Zhou, Huanye Mo, Steve Schoonooghe, Serge Muyldermans, Patrick De Baetselier, Geert Raes*, and Yurong Wen*. (2019) NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis. International Journal of Molecular Sciences. 20(13), 3347. (IF: 4.6, 作者)

(12)   Yurong Wen#,*, Zhenlin Ouyang#, Bart Devreese, Wangxiao He, Yongping Shao, Wuyuan Lu, Fang Zheng* (2017). Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. Protein Science. 26: 2073-2082. (IF: 3.8第一兼通作者)

(11)   Yurong Wen*, Zhenlin Ouyang*, Steve Schoonooghe, Siyu Luo, Patrick De Baetselier, Wuyuan Lu, Serge Muyldermans, Geert Raes, Fang Zheng. (2017). Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity. Immunobiology. 222(6): 807-813. (IF: 3.1, 第一作者)

(10)   Yurong Wen, Frank Sobott, Bart Devreese. (2016). ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry. Analytical and Bioanalytical Chemistry. 408:5925–5933. (IF: 3.4, 第一作者)

(9)   Yurong Wen, Ester Behiels, Bart Devreese. (2014). Toxin-Antitoxin systems: their role in persistence, biofilm formation and pathogenicity. Pathogens and Disease. 70(3), 240-249.(IF: 2.5, 第一作者)

(8)    Bohan Ma, Fan Niu, Xiaoyan Qu, Wangxiao He, Chao Feng, Simeng Wang,Zhenlin Ouyang, Jin Yan, Yurong Wen, Dan Xu, Yongping Shao, Peter X. Ma,Wuyuan Lu. (2019) A tetrameric protein scaffold as a nano-carrier of antitumor peptides for cancer therapy. Biomaterials. 204, 1-12. (IF: 10.3)

(7)   Gerson Stefanie; Nowak Jennifer; Zander Esther; Ertel Julia; Wen Yurong; Krut Oleg; Seifert Harald; Higgins Paul. (2018) Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy. 73(6): 1501-1508. (IF: 5.2)

(6)   Fan Fan; Lei Lei Wang; Zhenlin Ouyang; Yurong Wen; Xiao Yun Lu. (2018) Development and optimization of a tumour targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification. Applied Microbiology and Biotechnology. 102(7): 3229-3241. (. IF: 3.4)

(5)    Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, and Peter M. Hwang*. (2018) The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C. Biochemistry and Biophysics Report. 16: 145-151.

(4)    Fang Zheng , Harris Perlman , Patrick Matthys,Yurong Wen, Tony Lahoutte, Serge Muyldermans , Shemin Lu , Patrick De Baetselier, Steve Schoonooghe, Nick Devoogdt, Geert Raes. (2016). Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies. Scientific Reports. 6:35966  (IF: 5.2)

(3)   Johan Desmet#, Kenneth Verstraete#, Yehudi Bloch, Eric Lorent, Yurong Wen, Bart Devreese, Karen Vandenbroucke, Stefan Loverix, Thore Hettmann, Sabrina Deroo, Klaartje Somers, Paula Henderikx, Ignace Lasters*, Savvas Savvides*. (2014) Structural basis of IL-23 antagonism by an AlphabodyTMprotein scaffold. Nature Communications. 5: 5237. (IF: 12.4)

(2)    Ruben Van der Meeren, Yurong Wen, Patrick Van Gelder, Jan Tommassen, Bart Devreese, and Savvas N Savvides. (2013).New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosaJournal of Biological Chemistry, 288(2): 1214–25. (IF: 4.6)

(1)     Jan Felix, Jonathan Elegheert, Irina Gutsche, Alexander V Shkumatov, Yurong Wen, Nathalie Bracke, Erwin Pannecoucke, Isabel Vandenberghe, Bart Devreese, Dmitri I Svergun, Ewald Pauwels, Bjorn Vergauwen, Savvas N Savvides. (2013). Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Structure, 21, 528–539. (IF: 5.2)

专利

没有找到条目。
专利名称 申请号 专利类型 申请日期
一种Clec4F纳米抗体及其应用 ZL201611047459.2 发明 2016.11.23
一种Vsig4纳米抗体及其抗原表位鉴定方法和应用 ZL201610601325.4 发明 2016.07.27