研究方向

研究方向:

  1. 模式识别受体介导的固有免疫调控
  2. 自噬介导的免疫调控在实验性关节炎中的作用研究
  3. 几丁质酶分子在慢性炎症疾病中的作用研究

 

主持基金

科研基金:

主持国家自然科学基金1项,博士后科学基金2项,校级基金5项。

科研论文发表

 

 发表科研论文:

1: Jiang C, Meng L, Zhu W, Shahzad M, Yang X, Lu S. Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats. Inflamm Res. 2009; 58(9):601-9. 

2: Meng L, Zhu W#, Jiang C, He X, Hou W, Zheng F, Holmdahl R, Lu S. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther. 2010;12(3):R103. (# co-first author)
3: Hou W, Meng L, Tian L, Zhu W, Jiang C, Lu S. A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Agouti rats. Clin Exp Rheumatol. 2010; 28(4):532-8. 
4: Hou WK, Meng LS, Zheng F, Wen YR, Zhu WH, Jiang CS, He XJ, Zhou Y, Lu SM. Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-γ and IL-17A expressions. J Zhejiang Univ Sci B. 2011; 12(1):40-6. 
5: Meng L, He X, Zhu W, Yang X, Jiang C, Sun Q, M B, Zhang S, Xue Q, Xie X, Lu S. TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoS One. 2011; 6(2):e17252.
6: Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, Du H, Holmdahl R, Lu S. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther. 2011; 13(3):R103. 
7: Zhu W, Meng L, Jiang C, Hou W, Xu J, Wang B, Lu S. Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Mol Biol Rep. 2012; 39(4):3667-73. 
8: Zhu W, Meng L, Jiang C, Xu J, Wang B, Han Y, Lu S. Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats. Scand J Immunol. 2012; 76(3):263-70. 
9: Jiang C, Zhu W#, Xu J, Wang B, Hou W, Zhang R, Zhong N, Ning Q, Han Y, Yu H, Sun J, Meng L, Lu S. MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. Arthritis Res Ther. 2014; 16(1):R9. (# co-first author)
10: Zhu W, Jiang C, Xu J, Geng M, Wu X, Sun J, Ma J, Holmdahl R, Meng L, Lu S. Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-α initiated p38 MAPK and NF-κB pathways. Clin Immunol. 2015; 156(2):141-53. 
11: Xu J, Jiang C, Zhu W, Wang B, Yan J, Min Z, Geng M, Han Y, Ning Q, Zhang F, Sun J, Meng L, Lu S. NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis Cartilage. 2015; 23:1575-85. 
12: Nie F, Wang X, Zhao P, Yang H, Zhu W, Zhao Y, Chen B, Valenzuela RK, Zhang R, Gallitano AL, Ma J. Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2015; 168(8):637-48.
13: Jiang CS, Wang XM, Zhang SQ, Meng LS, Zhu WH, Xu J, Lu SM. Discovery of 4-benzoylamino-N-(prop-2-yn-1-yl)benzamides as novel microRNA-21 inhibitors. Bioorg Med Chem. 2015; 23(19):6510-9. 
14: Klionsky DJ, et. al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12:1-222.
15: Jiang C, Yu H, Sun Q, Zhu W, Xu J, Gao N, Zhang R, Liu L, Wu X, Yang X, Meng L, Lu S. Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. BMC Pulm Med. 2016, 16:50.
16: Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Exp Cell Res. 2016; 344:67-75.
17: Jiang C, Meng L, Yu H, Gao N, Zhang R, Zhu W, Xu J, Lu S. A simplified and optimal RT-qPCR strategy for extracellular miRNA profiling. Int J Clin Exp Med 2016; 9:2112-2120.
18:Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D, Lu S. A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism. Hepatology. 2016; 64:58-72.
19: Xu J, Zhu W, Guo Y, Jiang C, Hussain N, Meng L, Lu S. Construction of conveniently screening pLKO.1-TRC vector tagged with TurboGFP. Appl Biochem Biotechnol. 2017 Feb;181(2):699-709.
20: Li H, Zhu C, Wang B, Zhu W, Feng Y, Du F, Wang S, Hu C, Ma J, Yu X. 17β-Estradiol Protects the Retinal Nerve Cells Suppressing TLR2 Mediated Immune-Inflammation and Apoptosis from Oxidative Stress Insult Independent of PI3K. Journal of Molecular Neuroscience. 2016 Oct;60(2):195-204.
21: Zhu W, Xu J, Jiang C, Wang B, Geng M, Wu X,  Hussain N, Gao N, Han Y, Li D, Lan X, Ning Q, Zhang F, Holmdahl R, Meng L, Lu S. Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis. Clinical Immunology. 2017, 175:56-58.

22: Hou W, Wang B, Zhou Y, Xu K, Meng L, Zhu W, Jiang C, Xu P, Lu S. IL‑22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane‑induced arthritis rat model. Mol Med Rep. 2017 Jun 9. doi:10.3892/mmr.2017.6739. 

23: Hussain N, Zhu W*, Jiang C, Xu J, Wu X, Geng M, Hussain S, Cai Y, Xu K, Xu P, Han Y, Sun J, Meng L, Lu S. Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation. J Cell Mol Med. 2018 Jan;22(1):241-250. (* Corresponding author)

24: Wang B, Zhao P, Zhou Y, Meng L, Zhu W, Jiang C, Wang L, Cai Y, Lu S, Hou W. Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats. PLoS One. 2017 Nov 28;12(11):e0188199. 

25: Jiang Congshan, Yu Hongchuan, Zhu Wenhua, Xu Jing, Lou Bowen, Sun Qingzhu, Yang Xudong, Meng Liesu, and Lu Shemin. Pediatric Allergy, Immunology, and Pulmonology. December 2017, 30(4): 227-231.

26: Hussain N, Zhu W* , Jiang C, Xu J, Geng M, Wu X, Hussain S, Wang B, Rajoka MSR, Li Y, Tian J, Meng L, Lu S. Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes. Biosci Rep. 2018 Apr 13;38(2). pii: BSR20180003.* Corresponding author)

27: Guo Y, Min Z, Jiang C, Wang W, Yan J, Xu P, Xu K, Xu J, Sun M, Zhao Y, Hussain S, Zhang R, Wang Q, Han Y, Zhang F, Zhu W, Li D, Meng L, Sun J, Lu S. Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis. Cell Death Dis. 2018 Jun 13;9(6):699. 

28: Sun M, Hussain S, Hu Y, Yan J, Min Z, Lan X, Guo Y, Zhao Y, Huang H, Feng M, Han Y, Zhang F, Zhu W, Meng L, Li D, Sun J, Lu S. Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage. Osteoarthritis Cartilage. 2019 Jun;27(6):932-944.

29: Wang S, Zhu W, Xu J, Guo Y, Yan J, Meng L, Jiang C, Lu S. Interpreting the MicroRNA-15/107 family: interaction identification by combining network based and experiment supported approach. BMC Med Genet. 2019 May 31;20(1):96.