研究方向

研究方向：

  1. 慢性炎症性疾病的动物模型构建和发病机制研究
  2. 炎症性疾病的固有免疫和代谢免疫调控

科研项目与奖项

科研基金：

主持国家自然科学基金3项，博士后科学基金2项，陕西省自然科学基金1项，校级基金5项。

 

科研获奖：

陕西省高等学校科学技术奖，实验性关节炎的发病机制研究， 2018年，一等奖，第三完成人。

科研论文发表

   发表科研论文：

  1. Han D, Li F, Zhao Y, Wang B, Wang J, Liu B, Mou K, Meng L, Zheng Y, Lu S, Zhu W*, Zhou Y*. IL-21 promoting angiogenesis contributes to the development of psoriasis. FASEB J. 2024 Jan;38(1):e23375. doi: 10.1096/fj.202201709RRRR. PMID: 38102968. (* Corresponding author)
  2. Huang F, Ren X, Yuan B, Yang W, Xu L, Zhang J, Zhang H, Geng M, Li X, Zhang F, Xu J, Zhu W, Ren S, Meng L, Lu S. Systemic mutation of Ncf1 ameliorates obstruction-induced renal fibrosis while macrophage-rescued NCF1 further alleviates renal fibrosis. Antioxid Redox Signal. 2023 Jun 30. doi: 10.1089/ars.2022.0195. Epub ahead of print.
  3. Peng Y, Chen W, Huang F, Geng M, Li X, Zhang F, Zhu W, Meng L, Holmdahl R, Xu J, Lu S. SLC38A6 expression in macrophages exacerbates pulmonary inflammation. Respir Res. 2023 Jan 27;24(1):33.
  4. Li X, Xu Y, Li X, Liu W, Yao D, Chen W, Yu H, He L, Lu S, Jiang C, Zhu W*, Meng L*. Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi'an, China, December 8, 2021, to January 20, 2022: A retrospective study. Front Immunol. 2022 Sep 23;13:978977. doi: 10.3389/fimmu.2022.978977. PMID: 36211421; PMCID: PMC9538118. (* Corresponding author)
  5. Jiang C, Jiang K, Li X, Zhang N, Zhu W, Meng L, Zhang Y, Lu S. Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications. J Pharm Anal. 2022 Oct 27. doi: 10.1016/j.jpha.2022.10.003. Epub ahead of print. PMID: 36317070; PMCID:PMC9605787.
  6. Kang Q, Li L, Pang Y, Zhu W* and Meng L*. An update on Ym1 and its immunoregulatory role in diseases. Front. Immunol. 2022, 13:891220. doi: 10.3389/fimmu.2022.891220. (* Corresponding author, Review)
  7. Liu W, Fan M, Lu W, Zhu W*, Meng L* and Lu S. Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner. Front. Immunol. 2022, 13:872167. doi: 10.3389/fimmu.2022.872167. (* Corresponding author, Review)
  8. Tian J, Li X, Jiang Y, Gao F, Ju B, Chen J, Zhu W*, He L*, Meng L*, Lu S. SLC7A5 expression is up-regulated in peripheral blood T and B lymphocytes of systemic lupus erythematosus patients, associating with renal damage. Clin Immunol. 2022 Mar 25:108987. doi: 10.1016/j.clim.2022.108987. Epub ahead of print. PMID: 35346864. (* Corresponding author)
  9. Li F, Han D, Wang B, Zhang W, Zhao Y, Xu J, Meng L, Mou K, Lu S, Zhu W*, Zhou Y*. Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice. Mediators Inflamm. 2022 Jan 11;2022:5782922. doi: 10.1155/2022/5782922. (* Corresponding author)
  10. Li M, Zhang W, Zhang J, Li X, Zhang F, Zhu W*, Meng L*, Holmdahl R and Lu S (2021) Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice. Front. Immunol. 12:783944. doi: 10.3389/fimmu.2021.783944. (*Corresponding author)
  11. Jiang C, Wu X, Li X, Li M, Zhang W, Tao P, Xu J, Ren X, Mo L, Guo Y, Wang S, Geng M, Zhang F, Tian J, Zhu W*, Meng L*, Lu S. Loss of microRNA-147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis. Eur J Immunol. 2021 Apr 17. doi: 10.1002/eji.202048850. Epub ahead of print. PMID: 33864383. (* Corresponding author)
  12. Li X#, Zhu W#, Fan M, Zhang J, Peng Y, Huang F, Wang N, He L, Zhang L, Holmdahl R, Meng L, Lu S. Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification. Comput Struct Biotechnol J. 2021;19:1933-1943. doi: 10.1016/j.csbj.2021.04.001. Epub 2021 Apr 8. PMID: 33850607; PMCID: PMC8028701. (# co-first author)
  13. Wang S, Xu J, Guo Y, Cai Y, Ren X, Zhu W, Geng M, Meng L, Jiang C, Lu S. MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis. Front Immunol. 2021 Mar 26;12:619392. doi: 10.3389/fimmu.2021.619392. PMID: 33841401; PMCID: PMC8034293.
  14. Osoro EK, Du X, Liang D, Lan X, Farooq R, Huang F, Zhu W, Ren J, Sadiq M, Tian L, Yang X, Li D, Lu S. Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5. Biochem Cell Biol. 2021 Apr 8. doi: 10.1139/bcb-2021-0028. Epub ahead of print. PMID: 33831322.
  15. Li X, Gao F, Zhu W*, Jiang C, Xu J, Zhang J, Meng L*, Lu S. Pristane promotes anaerobic glycolysis to facilitate proinflammatory activation of macrophages and development of arthritis. Exp Cell Res. 2021 Jan 1;398(1):112404. doi: 10.1016/j.yexcr.2020.112404. Epub 2020 Nov 24. PMID: 33245891. (* Corresponding author)
  16. Zhu W, Lönnblom E, Förster M, Johannesson M, Tao P, Meng L, Lu S, Holmdahl R. Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages. Sci Adv. 2020 Oct 21;6(43):eaba9337. doi:10.1126/sciadv.aba9337. PMID: 33087360; PMCID: PMC7577715.
  17. Lei H, Tian M, Zhang XG, Meng LS, Zhu WH, Liu XM, Wang MZ, Wang T, Chang PK, Chen H, Wang B, Wu RQ, Lyu Y. Compromised immune status of patients with post-liver transplant biliary complications. Chin Med J (Engl). 2020 Nov 5;133(21):2622-2624. doi: 10.1097/CM9.0000000000001088. PMID: 32969862.
  18. Xu J, Jiang C, Cai Y, Guo Y, Wang X, Zhang J, Xu J, Xu K, Zhu W, Wang S, Zhang F, Geng M, Han Y, Ning Q, Xu P, Meng L, Lu S. Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2020 Aug 31;22(1):200. doi:10.1186/s13075-020-02296-8. PMID: 32867828; PMCID: PMC7457370.
  19. Geng M, Xu K, Meng L, Xu J, Jiang C, Guo Y, Ren X, Li X, Peng Y, Wang S, Huang F, Zhang J, Wang X, Zhu W*, Lu S*. Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis. Clin Immunol. 2020 Nov; 220:108579. doi: 10.1016/j.clim.2020.108579. Epub 2020 Aug 29. PMID: 32866644. (* Corresponding author)
  20. Wang B, Han D, Li F, Hou W, Wang L, Meng L, Mou K, Lu S, Zhu W*, Zhou Y*. Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax. Apoptosis. 2020 Oct;25(9-10):663-673. doi: 10.1007/s10495-020-01623-3. PMID: 32632545; PMCID: PMC7527361. (* Corresponding author)
  21. Xu J, Jiang C, Wang X, Geng M, Peng Y, Guo Y, Wang S, Li X, Tao P, Zhang F, Han Y, Ning Q, Zhu W, Meng L, Lu S. Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling. J Immunol. 2020 Jul 1;205(1):181-192. doi: 10.4049/jimmunol.1901021. Epub 2020 Jun 5. PMID: 32503893.
  22. Liang D, Osoro EK, Tan S, Lan X, Zhu W, Wu L, Du X, Li D, Lu S. Effects and Mechanisms of Autophagy Induced by Solubilized-Cholesterol in Hepatocytes: A Comparative Study Among Solvents. Cell Biochem Biophys. 2020 Sep;78(3):357-366. doi: 10.1007/s12013-020-00917-2. Epub 2020 May 21. PMID: 32441028.
  23. Sun M, Hussain S, Hu Y, Yan J, Min Z, Lan X, Guo Y, Zhao Y, Huang H, Feng M, Han Y, Zhang F, Zhu W, Meng L, Li D, Sun J, Lu S. Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage. Osteoarthritis Cartilage. 2019 Jun;27(6):932-944. doi: 10.1016/j.joca.2019.02.797. Epub 2019 Mar 9. PMID: 30858101.
  24. Jiang C#, Xu J#, Zhu W#, Cai Y, Wang S, Guo Y, Xu K, Geng M, Hussain N, Han Y, Zhang F, Ning Q, Meng L, Lu S. Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes. Mediators Inflamm. 2019 May 28; 2019:6768504. doi: 10.1155/2019/6768504. PMID: 31275058; PMCID: PMC6558604. (# co-first author)
  25. Wang S, Zhu W, Xu J, Guo Y, Yan J, Meng L, Jiang C, Lu S. Interpreting the MicroRNA-15/107 family: interaction identification by combining network based and experiment supported approach. BMC Med Genet. 2019 May 31;20(1):96. doi: 10.1186/s12881-019-0824-9. PMID: 31151434; PMCID: PMC6544937.
  26. Guo Y, Min Z, Jiang C, Wang W, Yan J, Xu P, Xu K, Xu J, Sun M, Zhao Y, Hussain S, Zhang R, Wang Q, Han Y, Zhang F, Zhu W, Li D, Meng L, Sun J, Lu S. Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis. Cell Death Dis. 2018 Jun 13;9(6):699. doi: 10.1038/s41419-018-0729-0. PMID: 29899528; PMCID: PMC5999974.
  27. Hussain N, Zhu W*, Jiang C, Xu J, Geng M, Wu X, Hussain S, Wang B, Rajoka MSR, Li Y, Tian J, Meng L, Lu S*. Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes. Biosci Rep. 2018 Apr 13;38(2):BSR20180003. doi: 10.1042/BSR20180003. PMID: 29545315; PMCID: PMC5897746. (* Corresponding author)
  28. Hussain N, Zhu W*, Jiang C, Xu J, Wu X, Geng M, Hussain S, Cai Y, Xu K, Xu P, Han Y, Sun J, Meng L, Lu S*. Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation. J Cell Mol Med. 2018 Jan;22(1):241-250. doi: 10.1111/jcmm.13312. Epub 2017 Aug 7. PMID: 28782180; PMCID: PMC5742673. (* Corresponding author)
  29. Jiang C, Yu H, Zhu W, Xu J, Lou B, Sun Q, Yang X, Meng L, and Lu S. Neutrophil–Lymphocyte Ratio in Children with Recurrent Wheezing. Pediatr Allergy Immunol Pulmonol. 2017 Dec; 30(4): 227-231. doi.org/10.1089/ped.2017.0801.
  30. Wang B, Zhao P, Zhou Y, Meng L, Zhu W, Jiang C, Wang L, Cai Y, Lu S, Hou W. Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats. PLoS One. 2017 Nov 28;12(11):e0188199. doi: 10.1371/journal.pone.0188199. PMID: 29182672; PMCID: PMC5705111.
  31. Hou W, Wang B, Zhou Y, Xu K, Meng L, Zhu W, Jiang C, Xu P, Lu S. IL‑22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane‑induced arthritis rat model. Mol Med Rep. 2017 Aug;16(2):1109-1116. doi: 10.3892/mmr.2017.6739. Epub 2017 Jun 9. PMID: 28627588; PMCID: PMC5561976.
  32. Zhu W, Xu J, Jiang C, Wang B, Geng M, Wu X, Hussain N, Gao N, Han Y, Li D, Lan X, Ning Q, Zhang F, Holmdahl R, Meng L, Lu S. Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis. Clin Immunol. 2017 Feb; 175:56-68. doi: 10.1016/j.clim.2016.11.017. Epub 2016 Dec 7. PMID: 27940139.
  33. Xu J, Zhu W, Guo Y, Jiang C, Hussain N, Meng L, Lu S. Construction of Conveniently Screening pLKO.1-TRC Vector Tagged with TurboGFP. Appl Biochem Biotechnol. 2017 Feb;181(2):699-709. doi: 10.1007/s12010-016-2242-1. Epub 2016 Oct 11. PMID: 27730520.
  34. Li H, Zhu C, Wang B, Zhu W, Feng Y, Du F, Wang S, Hu C, Ma J, Yu X. 17β-Estradiol Protects the Retinal Nerve Cells Suppressing TLR2 Mediated Immune-Inflammation and Apoptosis from Oxidative Stress Insult Independent of PI3K. J Mol Neurosci. 2016 Oct;60(2):195-204. doi: 10.1007/s12031-016-0794-8. Epub 2016 Sep 5. PMID: 27596287.
  35. Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, Lu S. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Exp Cell Res. 2016 May 15;344(1):67-75. doi: 10.1016/j.yexcr.2016.04.014. Epub 2016 Apr 20. PMID: 27107686.
  36. Jiang C, Yu H, Sun Q, Zhu W, Xu J, Gao N, Zhang R, Liu L, Wu X, Yang X, Meng L, Lu S. Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. BMC Pulm Med. 2016 Apr 14; 16:50. doi: 10.1186/s12890-016-0216-2. PMID: 27075111; PMCID: PMC4831091.
  37. Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D, Lu S. A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism. Hepatology. 2016 Jul;64(1):58-72. doi: 10.1002/hep.28391. Epub 2016 Jan 22. PMID: 26663205.
  38. Klionsky DJ, et. al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 26799652; PMCID: PMC4835977.
  39. Jiang C, Meng L, Yu H, Gao N, Zhang R, Zhu W, Xu J, Lu S. A simplified and optimal RT-qPCR strategy for extracellular miRNA profiling. Int J Clin Exp Med 2016; 9(2):2112-2120.
  40. Jiang CS, Wang XM, Zhang SQ, Meng LS, Zhu WH, Xu J, Lu SM. Discovery of 4-benzoylamino-N-(prop-2-yn-1-yl)benzamides as novel microRNA-21 inhibitors. Bioorg Med Chem. 2015 Oct 1;23(19):6510-9. doi: 10.1016/j.bmc.2015.08.007. Epub 2015 Aug 14. PMID: 26344589.
  41. Nie F, Wang X, Zhao P, Yang H, Zhu W, Zhao Y, Chen B, Valenzuela RK, Zhang R, Gallitano AL, Ma J. Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):637-48. doi: 10.1002/ajmg.b.32348. Epub 2015 Jul 31. PMID: 26227746.
  42. Zhu W, Jiang C, Xu J, Geng M, Wu X, Sun J, Ma J, Holmdahl R, Meng L, Lu S. Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-α initiated p38 MAPK and NF-κB pathways. Clin Immunol. 2015 Feb;156(2):141-53. doi: 10.1016/j.clim.2014.11.008. Epub 2014 Dec 19. PMID: 25533241.
  43. Xu J, Jiang C, Zhu W, Wang B, Yan J, Min Z, Geng M, Han Y, Ning Q, Zhang F, Sun J, Meng L, Lu S. NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis Cartilage. 2015 Sep;23(9):1575-85. doi: 10.1016/j.joca.2015.04.016. Epub 2015 Apr 24. PMID: 25917637.
  44. Jiang C#, Zhu W#, Xu J, Wang B, Hou W, Zhang R, Zhong N, Ning Q, Han Y, Yu H, Sun J, Meng L, Lu S. MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. Arthritis Res Ther. 2014 Jan 14;16(1):R9. doi: 10.1186/ar4435. PMID: 24423102; PMCID: PMC3978458. (# co-first author)
  45. Zhu W, Meng L, Jiang C, Xu J, Wang B, Han Y, Lu S. Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats. Scand J Immunol. 2012 Sep;76(3):263-70. doi: 10.1111/j.1365-3083.2012.02724.x. PMID: 22702720.
  46. Zhu W, Meng L, Jiang C, Hou W, Xu J, Wang B, Lu S. Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Mol Biol Rep. 2012 Apr;39(4):3667-73. doi:10.1007/s11033-011-1141-3. Epub 2011 Jul 3. PMID: 21725847.
  47. Hou WK, Meng LS, Zheng F, Wen YR, Zhu WH, Jiang CS, He XJ, Zhou Y, Lu SM. Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-γ and IL-17A expressions. J Zhejiang Univ Sci B. 2011 Jan;12(1):40-6. doi: 10.1631/jzus.B1000078. PMID: 21194185; PMCID: PMC3017415.
  48. Meng L, He X, Zhu W, Yang X, Jiang C, Sun Q, M B, Zhang S, Xue Q, Xie X, Lu S. TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoS One. 2011 Feb 25;6(2):e17252. doi: 10.1371/journal.pone.0017252. PMID: 21364926; PMCID: PMC3045401.
  49. Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, Du H, Holmdahl R, Lu S. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther. 2011 Jun 27;13(3):R103. doi: 10.1186/ar3384. PMID: 21708001; PMCID: PMC3218918.
  50. Meng L#, Zhu W#, Jiang C, He X, Hou W, Zheng F, Holmdahl R, Lu S. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther. 2010;12(3):R103. doi: 10.1186/ar3034. Epub 2010 May 25. PMID: 20500834; PMCID: PMC2911891.
  51. Hou W, Meng L, Tian L, Zhu W, Jiang C, Lu S. A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Agouti rats. Clin Exp Rheumatol. 2010 Jul-Aug;28(4):532-8. Epub 2010 Aug 30. PMID: 20659408.
  52. Jiang C, Meng L, Zhu W, Shahzad M, Yang X, Lu S. Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats. Inflamm Res. 2009 Sep;58(9):601-9. doi: 10.1007/s00011-009-0027-5. Epub 2009 Apr 9. PMID: 19357809.