基本信息

 
 
 基本情况:
田中民,教授,博士生导师。生命科学与技术学院大型仪器实验共享平台副主任。
         2000年,西北大学生物系获硕士学位;
2004年,西安交通大学生物医学工程系获博士学位;
2006-2008年,美国威斯康星医学院生理系博士后;
2008年入选教育部“新世纪优秀人才”支持计划;
2009年,美国威斯康星医学院生理系访问学者;
通讯地址:西安咸宁西路28号,西安交通大学生命科学与技术学院
邮编:710049
办公室:西安交通大学生命科学与技术学院,教二北楼 523
Phone: 029-82663286 转 92
 
 

 

研究领域

 研究领域:生物化学与分子生物学,生理学
研究方向:
(1)    盐敏感高血压的差异蛋白质组学与代谢组学
(2)    盐敏感高血压的药物靶标筛选以及诊断试剂盒开发
(3)    生物质谱分析技术及食品安全检测
(4)    盐敏感高血压的生物信息学分析
 
科研项目
【1】国家自然科学基金面上项目:糖、脂代谢紊乱与盐敏感高血压形成分子机理的研究
【2】教育部新世纪优秀人才支持计划。(NCET-080434);
【3】人事部、省外专局留学人员科技活动择优资助项目《盐敏感高血压临床检测试剂盒研制》
【4】  参与科技部国家重点基础研究973计划项目《心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究》2010CB732600
【5】国家自然科学基金面上项目《延胡索酸酶基因(Fh)突变在高盐饮食肾损伤及血压盐敏感性形成中的作用》81270767
【6】国家社会科学基金重大项目“生物技术及其产业发展的法律保障机制研究”子项目
【7】国家自然科学基金面上项目 肾脏代谢反馈调节与盐敏感高血压的形成机制研究、2016/01-2019/12
[8]国家自然科学基金海外及港澳学者合作研究基金项目,81228002、肾脏细胞代谢中产物对盐敏感性高血压的调控机制研究
主要任职

中国生理学会肾脏专业委员会委员
 
招聘信息

        欢迎对高血压、糖尿病肾病等复杂疾病的蛋白质组学、代谢组学以及生物质谱分析、食品安全检测有兴趣的有志之士参与项目研究或读取硕士或博士学位。招聘: 有生物技术、实验动物学、生物化学、细胞生物学、生理学、临床医学、基础医学、微生物学及分析化学背景的博士,博士后,参与项目研究。

研究生就业方向:本实验室以色谱和质谱分析为核心技术手段,合格的毕业生可以在药检、食品检测、质控、农产品检测、出入境检测以及临床检测等政府机构或企业单位选择就业。

实验室技术支持:

·         Agilent 7890a/5975c GC-MS
·         Agilent 1100 capillary HPLC with ion trap mass spectrometry(LC-MSMS)
·         Agilent capillary electrophoresis apparatus with MSD
·         Applied Biosystems Voyager-DE PRO MALDI-TOF-MS
·         Tecan Infinite M200 Pro Reader
·         Cell culture
·         Two-Dimensional Polyacrylamide Gel Electrophoresis (2-D DIGE) .
·         Biochemical analysis.
 
2018年博士招生只考英语,没有专业科考试,详细见2018简章或email联系。
 
蛋白质组学与代谢组学(071010.04)
生物质谱分析技术(071010.05)
生物信息技术(083100.10)
 
 
硕士招生方向: 生物化学与分子生物学, 生理学
 
02 , 考试科目:① 101 思想政治理论 ② 201 英语一 ③ 302 数学二或714 生物综合④ 833 生物化学或835 细胞生物学
01蛋白质组学:考试科目① 101 思想政治理论② 201 英语一③ 302 数学二或714 生物综合或721 医学基础综合(含病理、生
理、生化)或723 物理化学④ 821 有机化学或833 生物化学或835 细胞生物学
 
教育经历

 

[1]       Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian,* Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Reports. 2017 19, 1631–1639  IF: 8.28

[2]     Yang Z, Sun N, Cheng R, Zhao C, Liu Z, Li X, Liu J, Tian Z. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials. 2017 Sep 10;147:53-67. doi: 10.1016/j.biomaterials.. SCI 一区IF:8.402

[3]   Yang Z., Sun N., Cheng R., Zhao C. Y., Liu J. and Tian Z. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Journal of Materials Chemistry B, 5: 6762-6775.      IF:4.543 SCI 一区

[4]   Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z*, Liang M*. Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. Physiol Genomics. 2017 Sep 1;49(9):496-504. IF:3.04 

 

[5]     Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, and Zhongmin Tian* Transcriptional regulation of heterogeneous nuclear ribonuc leoprotein K gene expression, Biochimie, 2015, 109, 27-35 IF: 3.2

[6]       Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF4.517

[7]       Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats.Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF: 2.4

[8]       Zhongmin Tian*, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou and Na Sun Qualitative and quantitative analysis of phosphoproteomic experimental workflow based on phosphoprotein enrichment strategy and two-dimensional difference gel electrophoresis (2D-DIGE) techniques, Current Proteomics, 2014, 11(4), 252 – 263 IF: 0.5

[9]       Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF: 7.194

[10]       Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF: 11.224

[11]       Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF: 7.194

[12]       Zhongmin Tian, Mingxi Wan, Mingzhu Lu, Xiaodong Wang. The alteration of protein profile of walker 256 carinosarcoma cells during the apoptotic process induced by ultrasound. Ultrasound in Medicine & Biology, 2005, 31 (1): 121-128. IF: 2.221

[13]    Zhongmin Tian, Mingxi Wan, Supin Wang, Juqing Kang. Effects of ultrasound and excipients on the function and structure of trypsin. Ultrasonics Sonochemistry 2004, 11(6), 399-404. IF: 2.105

[14]    Zhongmin Tian, Mingxi Wan, Bo Wang, Supin Wang, Xiaoming Wu and Yusong Ruan. Effects of ultrasound on the structure and function of tumor necrosis factor-α. Ultrasound in Medicine & Biology, 2003, 29 (9): 1331-1339. IF: 2.221

[15]    Zhongmin Tian, Mingxi Wan, Zenglu Wang, Bo Wang. The preparation of genistein and LC-MS/MS on line analysis. Drug Development Research, 2004, 66 (1): 6-12. IF: 0.891

[16]    Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin TianDomagoj MladinovIsaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF7.479

[17]    Xiaofeng He , Yong Liu , Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF3.3

[18]    Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009297:553-558. IF4.416

[19]    Yi Feng, Zhongmin Tian, Ming-Xi Wan. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974  SCI607CB

[20]    Yi Feng, Zhongmin Tian, Ming-Xi Wan, Zhao-Bin Zheng. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614  SCI :175PE

    

 

 

 

 

 

 
 
                 

 

【1】          

 

研究队伍

请为该模块添加内容!