研究领域

 研究领域:生物化学与分子生物学,生理学
研究方向:
(1)    盐敏感高血压的差异蛋白质组学与代谢组学
(2)    盐敏感高血压的药物靶标筛选以及诊断试剂盒开发
(3)    生物质谱分析技术及食品安全检测
(4)    盐敏感高血压的生物信息学分析
 
科研项目
【1】国家自然科学基金面上项目:糖、脂代谢紊乱与盐敏感高血压形成分子机理的研究
【2】教育部新世纪优秀人才支持计划。(NCET-080434);
【3】人事部、省外专局留学人员科技活动择优资助项目《盐敏感高血压临床检测试剂盒研制》
【4】  参与科技部国家重点基础研究973计划项目《心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究》2010CB732600
【5】国家自然科学基金面上项目《延胡索酸酶基因(Fh)突变在高盐饮食肾损伤及血压盐敏感性形成中的作用》81270767
【6】国家社会科学基金重大项目“生物技术及其产业发展的法律保障机制研究”子项目
【7】国家自然科学基金面上项目 肾脏代谢反馈调节与盐敏感高血压的形成机制研究、2016/01-2019/12 
【8】国家自然科学基金面上项目 海外及港澳学者合作研究基金项目81228002、肾脏细胞代谢中产物对盐敏感性高血压的调控机制研究
【9】国家自然科学基金面上项目 肾脏氨基酸代谢异常与盐敏感高血压形成机制的研究、2018/01-2021/12在研。

研究队伍

 招聘具有生化、生理、医学以及分析化学、有机化学背景的博士,博士后,讲师,副教授,教授参与科研工作。博士后年薪15-18万。

发表论文

近年发表的论文
[2]   Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF4.517
[3]   Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF: 2.4
[4]   Zhongmin Tian*, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou and Na Sun Qualitative and quantitative analysis of phosphoproteomic experimental workflow based on phosphoprotein enrichment strategy and two-dimensional difference gel electrophoresis (2D-DIGE) techniques, Current Proteomics, 2014, 11(4), 252 – 263 IF: 0.5
[5]Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF: 7.194
[6]   Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF: 11.224
[7]   Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF: 7.194
[8]   Zhongmin Tian, Mingxi Wan, Mingzhu Lu, Xiaodong Wang. The alteration of protein profile of walker 256 carinosarcoma cells during the apoptotic process induced by ultrasound. Ultrasound in Medicine & Biology, 2005, 31 (1): 121-128. IF: 2.221
[9]   Zhongmin Tian, Mingxi Wan, Supin Wang, Juqing Kang. Effects of ultrasound and excipients on the function and structure of trypsin. Ultrasonics Sonochemistry 2004, 11(6), 399-404. IF: 2.105
[10]Zhongmin Tian, Mingxi Wan, Bo Wang, Supin Wang, Xiaoming Wu and Yusong Ruan. Effects of ultrasound on the structure and function of tumor necrosis factor-α. Ultrasound in Medicine & Biology, 2003, 29 (9): 1331-1339. IF: 2.221
[11]Zhongmin Tian, Mingxi Wan, Zenglu Wang, Bo Wang. The preparation of genistein and LC-MS/MS on line analysis. Drug Development Research, 2004, 66 (1): 6-12. IF: 0.891
[12]Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian(等同第一作者)Domagoj MladinovIsaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF7.479
[13]Xiaofeng He , Yong Liu , Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF3.3
[14]Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009297:553-558. IF4.416
[15]Yi Feng, Zhongmin Tian, Ming-Xi Wan. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974  SCI607CB
[16]Yi Feng, Zhongmin Tian, Ming-Xi Wan, Zhao-Bin Zheng. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614  SCI :175PE