基本信息

张镇西教授、博士、博士生导师,1990年博士研究生毕业于西安交通大学,获生物医学工程及仪器博士学位(导师蒋大宗、林钧岫教授)。1991-1993年在中国科学技术大学进行博士后研究(合作导师方容川教授)。1993年任西安交通大学副教授,2000-2006年曾任西安交通大学生命科学与技术学院副院长。现任生物医学分析技术及仪器研究所所长、福建泰普-西安交通大学生物医学分析仪器研究中心主任、生物医学工程及生物物理学教授、博士生导师。曾五次在德国斯图加特大学、放射与环境保护研究所(幕尼黑)、洪堡大学医学院肿瘤医院(柏林)、威廉港应用大学和吕贝克应用科技大学从事科学研究。目前主要研究方向为生物医学光子学影像与光谱分析技术、光生物物理学与生物光量子调控技术。

任职:

       任教育部高等学校生物医学工程专业教学指导委员会委员(2006-2010年)、生物医学光子学教育部网上合作研究中心副主任及学术委员会委员、中国技术协会决策咨询专家、中国光学学会生物医学光子学专业委员会副主任委员、中国生物物理学会分子影像学专业委员会常务委员、中国光学学会生物医学与激光医学专业第五届委员会常务委员、中华医学学会陕西省分会激光医学专业委员会第五届副理事长、西安生命科学与技术学会理事长、《激光生物学报》和《生物医学工程学进展》副主任编委、《中国激光》常务编委、《国际生物医学工程杂志》、《世界医疗器械》、《中国医疗器械杂志》、《生物医学工程与临床》(第四届)编委(聘期为2010年12月到2015年12月)、《西安交通大学学报》(自然科学被)(第九、十届、)编委(聘期为2011年1月1日到2014年12月31日、2015年1月1日到2018年12月31日)、Frontiers of Optoelectronics编委(2013.9-2016.8)。

成果:

      目前发表论文二百余篇,正式出版译著《激光与生物组织的相互作用——原理及应用》(西安交通大学出版社1999年4月)、《医学工作者的因特网》(西安交通大学出版社2000年6月)、《分子光子学》(科学出版社2004年4月)、《激光与生物组织的相互作用原理及应用》(第3版)(学科出版社2005年8月)、《纳米光子学》(西安交通大学出版社2010年8月)(该书获2010年度(第十届)引进版科技类优秀图书奖)、《医学纳米技术与纳米医学》(西安交通大学出版社2013年12月)(该书获2013年度(第十三届)引进版科技类优秀图书奖)六部、主编《生物医学光子学新技术及应用》(科学出版社2008年5月)。获部级科技进步三等奖二项、2006年度陕西省科学技术奖二等奖一项、2006年享受政府特殊津贴、2012年陕西省师德先进个人、2013年获宝钢优秀教师奖、“生物医学光子学”获2012年度陕西省精品课程称号、生物医学工程35新兴交叉学科人才培养、基地与队伍建设的探索与实践”20151231日获陕西省人民政府教学成果一等奖。

承担课题:

       国家自然科学基金重大国际合作研究项目:

基于新型光穿孔技术的纳米尺度细胞膜微手术研究(61120106013)(2012.01.01-2016.12);
       面上项目:
       光学标测心肌组织深层荧光信息的提取与三维重建方法研究(11274249)(2013.01-2016.12);
       国家自然科学基金重点项目:
       光学标测纳米颗粒与细胞膜相互作用的功能信息表征方法研究(61335012)(2014.01-2018.12);
       国家自然科学基金国际(地区)合作与交流项目(合作研究—两岸项目):
       基于金纳米颗粒的癌细胞多功能光学标记与灭活技术—基于金纳米棒的癌细胞荧光增強标记与光动力灭活(613111068)(2014.01-2016.12);
       国家自然科学基金国际(地区)合作与交流项目--国家自然科学基金委员会与韩国国家研究基金会联合资助合作交流项目
       空气采样和病毒分子分析的第三代自主平台发展计划(61511140294)(2015.07-2017.06);
   
国家重大科学仪器设备开发专项项目核算自动化定量检测与高分辨分析设备研制及应用(2012YQ030261)的子课题
         核酸扩增产物实时荧光快速检测关键技术及部件开发(2012YQ03026102);
完成课题:
作为课题负责人承担国家自然科学基金面上完成项目:
基于ALA脂类衍生物的光动力疗法对白血病细胞的影响(60178034);
        心脏电活动高分辨光学标测技术的研究(60378018);
        基于激光技术的微粒辅助基因转染新方法研究(60578026);
        新型纳米金-ALA结合体对白血病细胞的灭活效率及机理研究(60878056);
        国家自然科学基金专项基金项目/科学仪器基础研究专款:
        基于多光谱荧光成像的在体三维光学标测系统(60927011);
韩国研发与中国战略产业的商业化支持项目
         韩国电子部品研究院(KETI)(Korea Electronics Technology Institute (KETI)):
        采集空气中病毒的空气采集器和检测平台的开发
 
完成省部级研究项目:
陕西省自然科学基金:
静止悬浮激光衍射法自动血细胞计数及分类仪器的研究(96C17);
        用于骨损伤和缺陷的骨再生材料等(2000C17);
        陕西省国际科技合作重点项目计划:
        基于激光照射纳米金靶向灭活肿瘤细胞的研究(2009KW-15)
        DAAD——CSC合作项目:
        2006年中德合作科研项目(PPP)“基因转染新方法研究-激光照射金纳米颗粒诱导细胞的选择性吸收”(2005183025);
        2011年中德合作科研项目(PPP)“跳动心脏的四维高分辨率快速成像”(201200160050);
        博士点基金:
基于多波长比值法校正运动伪迹的生物膜电位光学记录技术(200806980024)等。
 精品课程:
        陕西省精品课程《生物医学光子学》:
 教育部生物医学光子学网上合作研究中心:
       http://bmp.xjtu.edu.cn/ 
 

Prof. Dr. Zhenxi Zhang received his Ph.D. in Biomedical Engineering and Instrumentation at Xi’an Jiaotong University, China in 1990 (Supervisor: Prof. Dazong Jiang and Junxiu Lin). From 1991-1993, he made his postdoctoral research at University of Science and Technology of China (Cooperative Instructor: Prof. Rongchuan Fang). After that, he got an associate Professor position at Xi’an Jiaotong University and the Professor position in 1998. He has been the assistant dean of School of Life Science and Technology at Xi’an Jiaotong University from 2000 to 2006. He currently is the director of The Institute of Biomedical Analytical Technology and Instrumentation at Xi’an Jiaotong University and the TaiPu-XJTU Research Center for Biomedical Analytical Instruments, professor of biomedical engineering and biophysics and the doctoral supervisor. He had done his research in several Germany Universities including University of Stuttgart, the GSF-National Research Center for Environment and Health (Muenich), Robert Roessle Cancer Clinic of the Virchow University Clinic of the Humboldt University in Berlin (Berlin), Wilhelmshaven University of Applied Sciences and Lübeck University of Applied Sciences. Currently, his interests are mainly in biomedical optics, optical biophysics, biomedical optical imaging and spectral analysis method.

He has been the member of the University Teaching Instruction Committee of the Education Ministry for Biomedical Engineering (2006-2010), the deputy director of the Internet Cooperative Research Center of the Education Ministry, consultant expert of the Chinese Technology Association, the vice-chairmen and member of the Committee for Biomedical Optics of Chinese Optical Society, the member of Academic Advisory Committee for Molecular Imaging of Chinese Biophysics Society, the standing member of the fifth committee of biomedicine and laser medicine of Chinese optical society, the vice-chairmen of the subcommittee in Shaanxi of Chinese Medical Association for Laser Medicine, and the chairmen of the Life Science and Technology Society in Xi’an. He has also been the editors of several academic journals, like the vice chief editor of “Journal of Acta Laser Biology Sinica” and “Progress in Biomedical Engineering”, the editorial board of “Chinese Journal of Lasers” , the editor of “Journal of Optoelectronics·Laser”, “International Journal of Biomedical Engineering”, “International Medical Devices”, “Chinese Journal of Medical Instrumentation”, “Journal of Medical Imaging and Health Informatics”(ISSN: 2156-7018 , EISSN: 2156-7026), “Biomedical Engineering and Clinical Medicine”(4th, 2010.12-2015.12), Journal of Xi’an Jiaotong University(9th and 10th ,2011.01-2019.12) and “Frontiers of Optoelectronics”(2013.9-2016.8).

 

So far, he has published more than 200 articles in domestic and foreign academic journals. He translated six foreign books: “Laser-Tissue Interactions-Fundamentals and Applications” (Xi’an Jiaotong University Press, 1999.4), “Internet for Medical Scholar”(Xi’an Jiaotong University Press, 2000.6), “Molecular Photonics”(Science Press, 2004.4), “Laser-Tissue Interactions-Fundamentals and Applications” (Third, Enlarged Edition) (Science Press, 2005.8), “Nanophotonics”(Xi’an Jiaotong University Press, 2010.08, this book received the 2010 (10th) Outstanding Imported Technology Book Award) and “Nanotechnology and Nanomedicine”(Xi’an Jiaotong University Press, 2013.12, this book received the 2013 (13th) Outstanding Imported Technology Book Award), and edited one book: “Biomedical Photonics New Technology and Application” (Science Press, 2008.05). He has won the third prize of Ministerial Level Scientific and Technological Progress twice, and second prize of Shaanxi Province of Science and Technology Award once. He was awarded the special subsidy of Chinese government in 2006, Shannxi Ethics Advanced Individual Aword in 2012 and BaoGang Excellent Teacher Award in 2013.His main course, “Biomedical Photonics”, has received the award title “2012 Shaanxi Quality Course”, and his teaching experience, “Biomedical Engineering 35 years-New Cross Disciplinary Talents, Team and Practice Base Building” has received the first prize of Shaanxi Teaching Achievement Award in 2015.

As the team leader, he has managed numerous projects funded by the National Natural Science Foundation of China(NSFC): The influence of ALA-based PDT on Leukemia Cells (60178034)(2002.01-2004.12), The Study of the High-Resolution Optical Mapping in Cardiac Electrical Activity Measurement (60378018)(2004.01-2006.12), Laser-based Gene Transfection -Selective Cells targeting with Nanoparticles (60578026) (2006.01-2008.12), The Study on Killing Efficiency and Mechanism for Leukaemia Cells using a new Gold Nanoparticle-ALA Conjugates (60878056) (2009.01-2011.12) , Special Fund of Basic Research of Scientific Instruments: In vivo Membrane Potential Optical Mapping System based on Multispectral Fluorescence Imaging (60927011)(2010.01-2012.12), Funds for International Cooperation and Exchange: Novel Methods for Nanoscale Cellular Membrane Surgery by Photoporation (61120106013) (2012.01.01-2016.12), Optical Mapping Extraction of Deep Cardiac Tissue Fluorescence and 3D Reconstruction Method(11274249)(2013.01-2016.12), Key Projects: Optical mapping for the Characterization of Nanoparti Membrane Interaction based on functional information(61335012) (2014.01-2018.12), Funds for International Cooperation and Exchange (Cross-strait cooperation): Multifunctional Optical Techniques for Cancer Cell Labeling and Inactivation with Bio-conjugated Au Nanoparticles—Enhanced Fluorescence Imaging and Photodynamic Therapy for Cancer Cell Labeling and Inactivation with Bio-conjugated Au Nanorods(613111068) (2014.01-2016.12), Funds for International Cooperation and Exchange (NSFC-KETI): A Proposal for the Development of An Autonomous, Gen-3 Platform Capable of Performing Airsampling and Molecular Assays of Airborne Virus (61511140294) (2015.07-2017.06), Joint Research Fund for Hong Kong, Macao and Overseas Scholars (cooperating with Prof. Yin Chen from Southern Illinois University, USA): Digital Breast Tomosynthesis for the Diagnosis of Early Breast Cancer(61528501)(2016.01-2017.12), the sub-project of the Special Fund of Major Research and Development of Scientific Instruments: Nucleic Acid Automatic Detection, Quantification and High-resolution Analysis Equipment(2012YQ030261), Kkey Technologies and Components for the Rapid Real-time Fluorescence Detection of Nucleic Acid Amplification Product (2012YQ03026102), and the R&D and Commercialization Support Focused on the China National Strategic Industry by Korea Electronics Technology Institute(KETI)Development of Air Sampler for Collecting Airborne Virus and Detector Platform(2014.11-2015.10).

Other provincial and ministerial-level projects include: Automatically Counting and Classification Instrument Based the on Stationary Suspension Laser Diffraction Method (96C17), Regeneration Material for Bone Damage and Defects(2000C17), International Cooperation Key Project of Shaanxi Province: Killing Cancer Cells targeted by Gold Nanoparticles under Laser Irradiation (2009KW-15). Projects by the cooperation of China and Germany (PPP-CSC-DAAD): New Gene Transfection Method based on Selective Permeabilization of Cells by Laser Irradiated gold Nanoparticles (2005183025) in 2005 and 4D high resolution spatio-temporal imaging of the beating heart in 2011, and Ph.D. Programs Foundation of Ministry of Education of China: Correction of Motion Artifact based on Ratiometry of Transmembrane Voltage-sensitive Dye (200806980024) (2009.01-2011.12).