工作快讯

1. Guo X, Liu M, Han B, Zheng Y, Zhang K, Bao G, Gao C, Shi H, Sun Q, Zhao Z. Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice. Biochem Pharmacol. 2023 Dec 26;220:116009. doi: 10.1016/j.bcp.2023.116009. Online ahead of print. （IF=5.8 ）

2. Zhang K, Zheng Y, Bao G, Ma W, Han B, Shi H, Zhao Z. Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling. Antioxidants. 2023; 12(9):1657. https://doi.org/10.3390/antiox12091657 (IF=7.0 )

3. Hu H, Li F, Cheng S, Qu T, Shen F, Cheng J, Chen L, Zhao Z, Hu H. Alternate-day fasting ameliorated anxiety-like behavior in high-fat diet-induced obese mice. J Nutr Biochem. 2023 Nov 4;124:109526. doi: 10.1016/j.jnutbio.2023.109526. Online ahead of print. (IF=5.6 )

4. Jiang X, Zhang K, Gao C, Ma W, Liu M, Guo X, Bao G, Han B, Hu H, Zhao Z. Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics. FASEB J. 2022 Dec;36(12):e22672. doi: 10.1096/fj.202200419RR.(IF=5.834 )

5. Liang F, Zhang K, Ma W, Zhan H, Sun Q, Xie L, Zhao Z. Impaired Autophagy and Mitochondrial Dynamics Are Involved in Sorafenib-Induced Cardiomyocyte Apoptosis.Toxicology. 2022 Oct 6:153348. doi: 10.1016/j.tox.2022.153348. Online ahead of print.(IF=4.571 )

6. Zhan H, Huang F, Niu Q, Jiao M, Han X, Zhang K, Ma W, Mi S, Guo S, Zhao Z. Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets. Oxid Med Cell Longev. 2021 Oct 4;2021:8889195. doi: 10.1155/2021/8889195. eCollection 2021.(IF=6.543 )

7. Gao C, Zhang K, Liang F, Ma W, Jiang X, Wang H, Zhan H, Sonkoly E, Hu H, Zhao Z.  Inhibition of the Ras/ERK1/2 pathway contributes to the protective  effect of ginsenoside Re against intimal hyperplasia. Food Funct. 2021 Jun 12. doi: 10.1039/d1fo00015b. Online ahead of print.(IF=5.396 )

8. Xie LH, Gwathmey JK, Zhao Z. Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators. Pflugers Arch. 2021 Mar;473(3):407-416. doi: 10.1007/s00424-020-02511-0. (IF=3.657 )

9. Ma W, Liang F, Zhan H, Jiang X, Gao C, Zhang X, Zhang K, Sun Q, Hu H, Zhao Z. Activated FMS-like tyrosine kinase 3 ameliorates  Angiotensin II-induced  cardiac remodeling. Acta Physiol (Oxf). 2020 Oct;230(2):e13519. doi: 10.1111/apha.13519. (IF=7.523)

10. Cheng J, Zhang M, Cheng S, Li F, Zhang B, Sun X, Hu H, Chen L, Zhao Z, Hu H, Zhang Z. Low-dose alcohol ameliorated high fat diet-induced anxiety-related   behavior via enhancing adiponectin expression and activating the Nrf2 pathway. Food & Funct. 2021 Jan 7;12(1):241-251. doi: 10.1039/d0fo02704a.(IF=5.396 )

11. Han XM, Huang F, Jiao ML, Liu HR, Zhao ZH, Zhan HQ, Guo SY. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and   SAT1/NMDAR2B /BDNF Signal Pathway. Biol Pharm Bull. 2020 Aug 13. doi: 10.1248/bpb.b20-00093.Online ahead of print. PMID: 32788507

   

学术论文

1. XianglanWei,SiyaoLi,TingtingLi,LongzhuLiu,YuanLiu, HaoWang,YongZhou,FanfanLiang,XiaojiangYu,Weijin Zang,MingZhao,ZhenghangZhao. Pomegranate peel extract ameliorates liver fibrosis induced by carbon tetrachloride in rats through suppressing p38MAPK/Nrf2 pathway. Journal of Functional Foods. 2020; 65:10372. 2019.https://doi.org/10.1016/j.jff.2019.103712 (IF=4.451)

2. Cheng J, Li F, Sun X, Liu S, Chen L, Tian F, Zhao Z, Hu H, Li X. Low-dose alcohol ameliorated homocysteine-induced anxiety-related behavior via   attenuating oxidative stress in mice. Neurosci Lett.  2019 Oct 16;714:134568. doi: 10.1016/j.neulet.2019.134568

3.Ma W, Liu M, Liang F, Zhao L, Gao C, Jiang X, Zhang X, Zhan H, Hu H, Zhao Z. Cardiotoxicity of sorafenib is mediated through elevation of ROS level and CaMKII activity and dysregulation of calcium homeostasis. Basic Clin Pharmacol Toxicol. 2020 Feb;126(2):166-180. doi: 10.1111/bcpt.13318. Epub 2019 Oct 7.(IF=4.080)

4. Wen H, Zhao Z, Fefelova N, Xie LH. Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes. Front Physiol. 2018;9:1785.(IF=3.5)

5. MA Wen-zhou, GAO Chen-ying, LIANG-Fan-fan, JIANG Xi-xi, ZHAO Zheng-hang, Activated Flt3 Receptor protects Adverse Cardiac Remodeling in Mice. Chin J Pathophys. 2018.09.15,34(S):2~3

7. Niu Qian, Zhan He-qin, Jiang Yan, Zhao Zheng-Hang, Liu Hui-Ru, Hu Yu. Study on antidepressant effect and mechanism of self-made prescription of strengthening spleen and replenishing Qi. Chinese Pharmacological Bulletin. 2018;34(6):867~872

8. Zhao Z, Kudej RK, Wen H, Fefelova N, Yan L, Vatner DE, Vatner SF, Xie LH. Antioxidant defense and protection against cardiac arrhythmias: lessons from a  mammalian hibernator (the woodchuck). FASEB J. 2018 Feb 28:fj201701516R. doi: 10.1096/fj.201701516R(IF=5.595)

9. Zhan H, Huang F, Ma W, F Yan, Zhao Z,* J Zhang, Cui T, Yang F, Hai G,Jia X,Shi Y,Shao L.Changes in splenic function and gene expression in mice of depression induced by corticosterone. International Journal of Molecular Medicine. 2017,39(2):327-336(IF=2.786)

10. Zhan H, Huang F, Ma W, Zhao Z,* Zhang H, Zhang C. Protective Effect of Ginsenoside Rg1 on Bleomycin-Induced Pulmonary. Biol. Pharm. Bull. 2016;39(8):1284-92

11. Lu XZ, Bi XY, He X, Zhao M, Xu M, Yu XJ, Zhao Z, Zang WJ. Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. Br J Pharmacol. 2015;172(23):5619-33(IF=5.529)

12. Zhao Z, Babu GJ, Wen H, Fefelova N, Gordan R, Sui X, Yan L, Vatner DE, Vatner SF, Xie LH. Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart. Am J Physiol Heart Circ Physiol. 2015;308(3): H240-9.（IF:4.012）

13.Wang L, Meng X, Yuchi Z, Zhao Z, Xu D, Fedida D, Wang Z, Huang C. De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome. Cell Physiol Biochem. 2015;36(6):2250-62(IF=5.50)

14. Zhao Z, Xie Y, Wen H, Xiao D, Allen C, Fefelova N, Dun W, Boyden PA, Qu Z, Xie LH. Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells. Cardiovascular Research, 2012;95(3):308-16. (IF:6.064,Cited 40）

15. Zhao Z, Fefelova N, Shanmugam M, Bishara P, Babu GJ, Xie LH. Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling. Journal of Molecular and Cellular Cardiology, 2011;50(1):128-136.（IF:5.499,Cited 61）

16. Zhao Z, Wen H, Fefelova N, Allen C, Baba A, Matsuda T, Xie LH. Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents? Am J Physiol Heart Circ Physiol,2012;302(8):H1636-44.（IF:3.880,Cited 70）

17. Zhao Z, Gordan R, Wen H, Fefelova N, Zang WJ, Xie LH. Modulation of intracellular calcium waves and triggered activities by mitochondrial ca flux in mouse cardiomyocytes. PLoS One, 2013; 8(11):e80574.（IF:4.091）

18. Zhao Z, Fang M, Xiao D, Liu M, Fefelova N, Huang C, Zang WJ, Xie LH. Antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of Polygalae Radix: suppression of triggered activities in rabbit myocytes. Chem Pharm Bull, 2013;36(2):238-44.(IF1.81)

19. Zhao Z, Wen H, Fefelova N, Allen C, Guillaume N, Xiao D, Huang C, Zang W, Gwathmey JK, Xie LH. Docosahexaenoic acid reduces the incidence of early afterdepolarizations caused by oxidative stress in rabbit ventricular myocytes. Front. Physiol, 2012;3:252-59.（IF:3.5)

20. BlanksA, Zhao Z(co-first), Shmygol A, Bru-Mercier G, Astle S, Thornton S. Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium. J Physiol (London). 2007;581(3): 915-926(IF:5.139)

  

21. Gordan R, Fefelova N, Zhao Z, Xie L. Involvement of Mitochondrial Permeability Transition Pore (mPTP) in Cardiac Arrhythmias: Evidence from Cyclophilin D Knockout Mice. Circulation. 2015; 2015;132:A19344

22. Zhenghang Zhao, Dandan Xiao, Nadezhda Fefelova, Lai-Hua Xie. The effects of mitochondrial Ca2+ transport on intracellular Ca2+ waves in cardiomyocytes. Journal of Translational Medicine 2012, 10(Suppl 2):A67

23. Zhao Z, Fefelova N, Xie LH. Revisiting the Ionic Mechanisms of Early Afterdepolarizations in Cardiomyocytes:Predominant by Ca Waves or Ca Currents? Biophysical Journal. 2011; 100(3): 437- 438

24. Zhao Z, Fefelova N, Xie LH. Regulation of intracellular Ca waves and triggered activities by   mitochondrial Ca flux in mouse cardiomyocytes. Circulation. 2010;122:A17464

25. Zhao Z, J Gopal, Fefelova N, I Yoshihiro, L Kousaku, L Lo, Yan L, D. E. Vatner, S.F. Vatner, Xie LH. Overexpression of adenylyl cyclase type 5(AC5) in the heart predisposes to cardiac arrhythmias. Circulation. 2010;122:A17445

26. Zhao Z, Fefelova N, Xie LH. Angiotensin II Induces Afterdepolarizations via Reactive Oxygen Species and Calmodulin Kinase II Signaling. Circulation. 2009;120:S709

27. Hairuo Wen, Zhenghang Zhao, Nadezhda Fefelova, Charelle Allen, Lai-Hua Xie. Arrhythmogenic Effect of Store-Operated Calcium Entry in Mouse Ventricular Myocytes. Circulation. 2011; 124: A15884

28. Xie L-H, Wen H, Zhao Z, Fefelova N, Allen C. A Unique "Cellular Fibrillation" Status in Mouse Ventricular Myocytes. Circulation. 2011;124:A17427

29. L-H Xie, M. Shanmugam, J.Y. Park, B. Zhao Z, Tian, M. Periasamy J. Gopal. Loss of sarcolipin is associated with structural and electrical remodeling of atria. Circulation, 2009; 120: S675 - S676.

30. Xie LH, Yan L, Kudej RK, Zhao Z, Ge H, Fefelova N, You B, Vatner DE, Vatner SF. Arrhythmia Protection Insights From a Hibernating Animal. Circulation. 2009；120(18): S674-S675

31. Wenzhuo Ma, Chenying Gao, Zhenghang Zhao. Activated Fms-like Tyrosine Kinase 3 Receptor Prevents Ventricular Remodeling Induced by Ang Ii Through the Attenuation of Autophagy. Circulation Research. 2019.125(Suppl1): A524:1-2

32.王红英，刘敏，刘美，赵丽丽，赵正杭. 参龟固本酒对大鼠酒精性肝损伤的作用.西安交通大学学报（医学版),2015;36(5):7074-714

33. 王红英，王瑾, 马文卓, 张殿增, 赵正杭. 紫花牡荆素对佐剂性关节炎小鼠足肿胀度和细胞因子的影响, 西北药学杂志, 2017, 32(3): 326 ~ 329

34.马文卓,赵正杭.长链非编码ＲNA 在心血管疾病的研究进展.心血管病学进展,2017;38(1）:74-78

35.梁凡凡,张鑫,蒋茜茜,张凯娜,Al-maamari Ahmed,王红英,赵正杭*.舒眠胶囊镇静催眠的作用及其机制的实验研究.西安交通大学学报（医学版） 2021,42(01)：168-174

36.袁东亮,权伟,陈奕晨,龚阳泽,刘凌之,邵青,翟媛媛,赵正杭*. CXCL5基因敲除小鼠抑郁样行为及血清TNF-α、IL-1β、IL-6水平变化. 山东医药. 2022,62(14):46-49

37.李权宁,卜艳红,李辽辽,李东波,冯柯臻,赵正杭*. 左乙拉西坦注射液血管刺激性研究. 中南药学: 2022,20(03): 593-596.

 

 

 

科研项目

1. Flt3激活促进巨噬细胞M2极化及其线粒体转移改善心肌梗死后重塑(主持，陕西省重点研发计划项目-2024SF-YBXM-002,2024.1.1-2025.12.31）

2. BKCa促进线粒体呼吸超级复合体组装抑制心肌顿抑的作用及机制研究（主持，国家自然科学基金面上项目-82270296,2023.1-2026.12.31）

3. Flt3激活促进巨噬细胞M2极化改善心肌梗死（博士生张凯娜, 校基本科研业务费专项科研项目,2023.10-2024.10）

4. MCPIP1负性调控CaMKⅡγ对VSMC增殖作用及机制研究（主持，陕西省自然科学基础研究项目2020JM-029,2020.1.1-2022.12.31)

5. 乳癖散结胶囊对丙基硫氧嘧啶致大鼠甲状腺肿大的作用研究（主持，校企联合研发项目-202112152，2021.5.1-2023.12.31）

6. 舒眠胶囊镇静催眠作用的机制研究（主持，校企联合研发项目-20190326，2019.4.1-2021.12.31）

7. Fms样酪氨酸激酶3激活对压力负荷性心室重构的作用及机制研究（主持,国家自然科学基金面上项目-81470510,2015.1.1-2018.12.31）

8. 人子宫平滑肌T型钙通道在分娩启动中的分子离子机制研究(主持,国家自然科学基金面上项目81170597)

9. 中药药对续断配伍杜仲安胎作用的物质基础研究（主持,陕西省卫生厅）

10. 人子宫平滑肌T型钙通道的异质性表达及电生理功能(主持,陕西省自然科学基金SJ08C223 )

11. 氧化应激诱发心律失常的机制及其与细胞内CaMKII 信号通路的研究(主持，校光华基金)

12. 腺苷和乙酰胆碱对心肌细胞信号调控异同性的分子机制(第2，国科金30270554)

13. 家族性病态窦房结综合症离子通道及相关基因分子遗传学研究（第2，国科金30371571）