发布时间：

2025-04-30

论文名称：

PLTP is present in the nucleus, and its nuclear export is CRM1-dependent

发表刊物：

Biochim Biophys Acta

摘要：

Phospholipid transfer protein (PLTP), one of the key lipid transfer proteins in plasma and cerebrospinal fluid,
is nearly ubiquitously expressed in cells and tissues. Functions of secreted PLTP have been extensively
studied. However, very little is known about potential intracellular PLTP functions. In the current study, we
provide evidence for PLTP localization in the nucleus of cells that constitutively express PLTP (human
neuroblastoma cells, SK-N-SH; and human cortical neurons, HCN2) and in cells transfected with human PLTP
(Chinese hamster ovary and baby hamster kidney cells). Furthermore, we have shown that incubation of
these cells with leptomycin B (LMB), a specific inhibitor of nuclear export mediated by chromosome region
maintenance 1 (CRM1), leads to intranuclear accumulation of PLTP, suggesting that PLTP nuclear export is
CRM1-dependent. We also provide evidence for entry of secreted PLTP into the cell and its translocation to
the nucleus, and show that intranuclear PLTP is active in phospholipid transfer. These findings suggest that
PLTP is involved in novel intracellular functions.

合写作者：

Vuletic S, Dong W, Wolfbauer G, Day JR, Albers JJ

卷号：

2009-1793

页面范围：

584-591

是否译文：

否

发表时间：

2009-03-04