发布时间：

2025-04-30

论文名称：

PLTP regulates STAT3 and NFκB in differentiated THP1 cells and human

发表刊物：

Biochimica et Biophysica Acta

摘要：

published studies have shown that PLTP binds, transfers and neutralizes bacterial lipopolysaccharides. In the
current study we tested the hypothesis that PLTP can also regulate anti-inflammatory pathways in
macrophages. Incubation of macrophage-like differentiated THP1 cells and human monocyte-derived
macrophages with wild-type PLTP in the presence or absence of tumor necrosis factor alpha (TNFα) or
interferon gamma (IFNγ) significantly increased nuclear levels of active signal transducer and activator of
transcription 3, pSTAT3Tyr705 (pb0.01). Similar results were obtained in the presence of a PLTP mutant
without lipid transfer activity (PLTPM159E), suggesting that PLTP-mediated lipid transfer is not required for
activation of the STAT3 pathway. Inhibition of ABCA1 by chemical inhibitor, glyburide, as well as ABCA1 RNA
inhibition, reversed the observed PLTP-mediated activation of STAT3. In addition, PLTP reduced nuclear levels
of active nuclear factor kappa-B (NFκB) p65 and secretion of pro-inflammatory cytokines in conditioned
media of differentiated THP1 cells and human monocyte-derived macrophages. Our data suggest that PLTP
has anti-inflammatory capabilities in macrophages.

合写作者：

Simona Vuletic ,Weijiang Dong, John Albers

卷号：

2011(1813)

页面范围：

1917-1924

是否译文：

否

发表时间：

2010-07-21