Dental Adhesive Peptides Nanonets as Multifunctional Therapy for Caries
发布时间：2026-06-30
点击次数：
- 发布时间：
- 2026-06-30
- 影响因子：
- 11.0
- DOI码：
- 10.1002/adhm.202503597
- 论文名称：
- Dental Adhesive Peptides Nanonets as Multifunctional Therapy for Caries
- 发表刊物：
- Advanced Healthcare Materials
- 摘要：
- Dental caries poses significant therapeutic challenges due to resilient biofilms and uncontrolled demineralization. To address these challenges, by leveraging the broad antimicrobial activity and strong phosphate-binding capability of arginine peptides, we developed dental adhesive nanonets to effectively capture and kill S. mutans strain for caries management. FmocFFRRR was selected from a two-round structural screening, and was co-assembled with sodium monofluorophosphate (MFP) to construct multifunctional nanonets (F@MFP). Specifically, F@MFP nanonets adhere robustly to tooth enamel, capture S. mutans via electrostatic interactions, and kill S. mutans by disrupting bacterial membrane integrity, inducing oxidative stress, and suppressing metabolic activities. F@MFP nanonets not only inhibit biofilm formation but also effectively dismantle mature biofilms by downregulating biofilm-associated virulence genes. Furthermore, F@MFP nanonets also serve as a fluoride reservoir to inhibit demineralization and promote enamel remineralization. In vivo experiments reveal that F@MFP exhibits superior caries-inhibiting efficacy. This multifunctional platform integrates dental adhesion, a capture-and-kill antibacterial mechanism, anti-biofilm properties, and enamel repair capacity, offering a novel paradigm for targeted caries therapy.
- 卷号：
- 15
- 期号：
- 14
- 页面范围：
- e03597
- 是否译文：
- 否
- 发表时间：
- 2026-01-26
- 收录刊物：
- SCI