发布时间：

2025-04-30

论文名称：

Mechanistic Investigation on Chemiluminescent Formaldehyde Probes

发表刊物：

Chemistry – A European Journal

摘要：

Abstract A first-generation pair of chemiluminescent formaldehyde (FA) probes (CFAP540 and CFAP700) was reported recently. CFAP540 and CFAP700, with high selectivity and sensitivity to FA, are, respectively, suitable in cell and in vivo. Experimentalists have confirmed that both probes utilize a general 2-aza-Cope FA-reactive trigger and a chemiluminogenic phenoxydioxetane scaffold. The mechanism and detailed process of CFAP chemiluminescence (CL) remain largely unknown. In the present paper, (time-dependent) density functional theory calculations are performed on the entire reaction process of CFAP540 with FA to produce CL. The calculations elucidated the CL-producing process: FA initiates the decomposition of CFAP540 by dehydration condensation, and a phenoxy 1,2-dioxetane is formed through a series of reactions of aza-Cope rearrangement, hydrolysis of imine, and β-elimination of alkoxyl group. ... ....
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202004556

合写作者：

Pi, Shuang-Qi; Li, Quan-Song; Yue, Ling; Liu, Ya-Jun

卷号：

27 (18)

页面范围：

5712-5720

是否译文：

否

发表时间：

2020-11-03